ITP survival analysis:   candesartan cilexetil

Intervention:   candesartan cilexetil     angiotensin-receptor blocker
Trial code: CC Dose: 30 ppm initiated at age: 7 mo Sex: both Cohort: C2016
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
CC effect on survival, females, test site = All
Log-rank test chisq = 1.4104 p = 0.235
Wang-Allison test odds ratio = 1.8535 p = 0.0589
Quantiles CC Control % difference
25% died before day: 782 790 -1 %
Median lifespan (days) 870 875 -1 %
75% died before day: 1005 975 +3 %
90% died before day: 1087 1055 +3 %
Max lifespan observed (days) 1295 1339
Number of mice at start 132 303
Animal censor events are denoted by + marks in the plot
All test sites combined – male
CC effect on survival, males, test site = All
Log-rank test chisq = 0.8025 p = 0.3704
Wang-Allison test odds ratio = 1.1198 p = 0.7327
Quantiles CC Control % difference
25% died before day: 670 608 +10 %
Median lifespan (days) 817 782 +4 %
75% died before day: 939 935 0 %
90% died before day: 1055 1055 0 %
Max lifespan observed (days) 1306 1264
Number of mice at start 138 275
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
CC effect on survival, females, test site = TJL
Log-rank test chisq = 3.618 p = 0.0572
Wang-Allison test odds ratio = 2.4966 p = 0.1454
Quantiles CC Control % difference
25% died before day: 773 816 -5 %
Median lifespan (days) 896 883 +1 %
75% died before day: 1045 971 +8 %
90% died before day: 1198 1057 +13 %
Max lifespan observed (days) 1295 1230
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
CC effect on survival, males, test site = TJL
Log-rank test chisq = 3.8423 p = 0.05
Wang-Allison test odds ratio = 2.2463 p = 0.1582
Quantiles CC Control % difference
25% died before day: 678 608 +12 %
Median lifespan (days) 824 749 +10 %
75% died before day: 958 891 +8 %
90% died before day: 1059 1005 +5 %
Max lifespan observed (days) 1306 1262
Number of mice at start 52 94
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
CC effect on survival, females, test site = UM
Log-rank test chisq = 0.8583 p = 0.3542
Wang-Allison test odds ratio = 1.1808 p = 0.7697
Quantiles CC Control % difference
25% died before day: 753 788 -4 %
Median lifespan (days) 866 858 +1 %
75% died before day: 932 961 -3 %
90% died before day: 1038 1034 0 %
Max lifespan observed (days) 1124 1189
Number of mice at start 44 92
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
CC effect on survival, males, test site = UM
Log-rank test chisq = 0.0435 p = 0.8348
Wang-Allison test odds ratio = 0.4026 p = 0.335
Quantiles CC Control % difference
25% died before day: 712 534 +33 %
Median lifespan (days) 866 814 +6 %
75% died before day: 974 996 -2 %
90% died before day: 1052 1071 -2 %
Max lifespan observed (days) 1216 1258
Number of mice at start 38 82
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
CC effect on survival, females, test site = UT
Log-rank test chisq = 0.9308 p = 0.3347
Wang-Allison test odds ratio = 2.048 p = 0.2188
Quantiles CC Control % difference
25% died before day: 793 774 +2 %
Median lifespan (days) 876 882 -1 %
75% died before day: 1010 984 +3 %
90% died before day: 1124 1058 +6 %
Max lifespan observed (days) 1268 1339
Number of mice at start 40 116
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
CC effect on survival, males, test site = UT
Log-rank test chisq = 0.5601 p = 0.4542
Wang-Allison test odds ratio = 1.0346 p = 1.0
Quantiles CC Control % difference
25% died before day: 618 640 -3 %
Median lifespan (days) 770 799 -4 %
75% died before day: 880 936 -6 %
90% died before day: 1055 1064 -1 %
Max lifespan observed (days) 1159 1264
Number of mice at start 48 99
Animal censor events are denoted by + marks in the plot


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Statistical definitions