ITP survival analysis:   acarbose

Intervention:   acarbose     a-glucosidase inhibitor, anti-aging
Trial code: ACA_lo Dose: 400 ppm initiated at age: 8 mo Sex: both Cohort: C2013
Trial code: ACA_mid Dose: 1000 ppm initiated at age: 8 mo Sex: both Cohort: C2013
Trial code: ACA_hi Dose: 2500 ppm initiated at age: 8 mo Sex: both Cohort: C2013
This compound had a significant effect on survival:   400 ppm females p = 0.033; 400 ppm males p < 0.0001; 1000 ppm females p = 0.0027; 1000 ppm males p < 0.0001; 2500 ppm females p = 0.0061; 2500 ppm males p < 0.0001

Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
ACA_lo effect on survival, females, test site = All
Log-rank test chisq = 4.5452 p = 0.033
Wang-Allison test odds ratio = 1.3409 p = 0.3975
Quantiles ACA_lo Control % difference
25% died before day: 759 751 +1 %
Median lifespan (days) 887 889 0 %
75% died before day: 1042 976 +7 %
90% died before day: 1123 1097 +2 %
Max lifespan observed (days) 1274 1263
Number of mice at start 139 287
Animal censor events are denoted by + marks in the plot
ACA_mid effect on survival, females, test site = All
Log-rank test chisq = 8.9906 p = 0.0027
Wang-Allison test odds ratio = 2.4334 p = 0.0065
Quantiles ACA_mid Control % difference
25% died before day: 785 751 +5 %
Median lifespan (days) 932 889 +5 %
75% died before day: 1060 976 +9 %
90% died before day: 1125 1097 +3 %
Max lifespan observed (days) 1263 1263
Number of mice at start 142 287
Animal censor events are denoted by + marks in the plot
ACA_hi effect on survival, females, test site = All
Log-rank test chisq = 7.5225 p = 0.0061
Wang-Allison test odds ratio = 1.6647 p = 0.1321
Quantiles ACA_hi Control % difference
25% died before day: 808 751 +8 %
Median lifespan (days) 922 889 +4 %
75% died before day: 1038 976 +6 %
90% died before day: 1125 1097 +3 %
Max lifespan observed (days) 1540 1263
Number of mice at start 152 287
Animal censor events are denoted by + marks in the plot
All test sites combined – male
ACA_lo effect on survival, males, test site = All
Log-rank test chisq = 21.8612 p < 0.0001
Wang-Allison test odds ratio = 2.9188 p = 0.0011
Quantiles ACA_lo Control % difference
25% died before day: 774 641 +21 %
Median lifespan (days) 918 830 +11 %
75% died before day: 1076 968 +11 %
90% died before day: 1211 1089 +11 %
Max lifespan observed (days) 1376 1294
Number of mice at start 147 273
Animal censor events are denoted by + marks in the plot
ACA_mid effect on survival, males, test site = All
Log-rank test chisq = 33.6935 p < 0.0001
Wang-Allison test odds ratio = 3.0259 p = 0.0008
Quantiles ACA_mid Control % difference
25% died before day: 823 641 +28 %
Median lifespan (days) 975 830 +17 %
75% died before day: 1107 968 +14 %
90% died before day: 1210 1089 +11 %
Max lifespan observed (days) 1418 1294
Number of mice at start 161 273
Animal censor events are denoted by + marks in the plot
ACA_hi effect on survival, males, test site = All
Log-rank test chisq = 32.7321 p < 0.0001
Wang-Allison test odds ratio = 3.4654 p < 0.0001
Quantiles ACA_hi Control % difference
25% died before day: 837 641 +31 %
Median lifespan (days) 964 830 +16 %
75% died before day: 1083 968 +12 %
90% died before day: 1181 1089 +8 %
Max lifespan observed (days) 1329 1294
Number of mice at start 163 273
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
ACA_lo effect on survival, females, test site = TJL
Log-rank test chisq = 0.6181 p = 0.4317
Wang-Allison test odds ratio = 0.7041 p = 0.7736
Quantiles ACA_lo Control % difference
25% died before day: 788 773 +2 %
Median lifespan (days) 887 890 0 %
75% died before day: 1026 984 +4 %
90% died before day: 1085 1104 -2 %
Max lifespan observed (days) 1274 1263
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
ACA_mid effect on survival, females, test site = TJL
Log-rank test chisq = 0.9709 p = 0.3245
Wang-Allison test odds ratio = 1.3778 p = 0.5725
Quantiles ACA_mid Control % difference
25% died before day: 760 773 -2 %
Median lifespan (days) 934 890 +5 %
75% died before day: 1042 984 +6 %
90% died before day: 1130 1104 +2 %
Max lifespan observed (days) 1226 1263
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
ACA_hi effect on survival, females, test site = TJL
Log-rank test chisq = 2.3535 p = 0.125
Wang-Allison test odds ratio = 1.586 p = 0.5504
Quantiles ACA_hi Control % difference
25% died before day: 819 773 +6 %
Median lifespan (days) 938 890 +5 %
75% died before day: 1050 984 +7 %
90% died before day: 1141 1104 +3 %
Max lifespan observed (days) 1242 1263
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
ACA_lo effect on survival, males, test site = TJL
Log-rank test chisq = 10.8226 p = 0.001
Wang-Allison test odds ratio = 4.6203 p = 0.0118
Quantiles ACA_lo Control % difference
25% died before day: 769 578 +33 %
Median lifespan (days) 880 802 +10 %
75% died before day: 1076 939 +15 %
90% died before day: 1248 1037 +20 %
Max lifespan observed (days) 1302 1294
Number of mice at start 45 96
Animal censor events are denoted by + marks in the plot
ACA_mid effect on survival, males, test site = TJL
Log-rank test chisq = 17.1751 p < 0.0001
Wang-Allison test odds ratio = 5.9449 p = 0.0029
Quantiles ACA_mid Control % difference
25% died before day: 784 578 +36 %
Median lifespan (days) 967 802 +21 %
75% died before day: 1081 939 +15 %
90% died before day: 1171 1037 +13 %
Max lifespan observed (days) 1302 1294
Number of mice at start 53 96
Animal censor events are denoted by + marks in the plot
ACA_hi effect on survival, males, test site = TJL
Log-rank test chisq = 15.5548 p < 0.0001
Wang-Allison test odds ratio = 4.2862 p = 0.0101
Quantiles ACA_hi Control % difference
25% died before day: 816 578 +41 %
Median lifespan (days) 960 802 +20 %
75% died before day: 1108 939 +18 %
90% died before day: 1192 1037 +15 %
Max lifespan observed (days) 1323 1294
Number of mice at start 52 96
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
ACA_lo effect on survival, females, test site = UM
Log-rank test chisq = 0.4756 p = 0.4904
Wang-Allison test odds ratio = 1.7556 p = 0.3657
Quantiles ACA_lo Control % difference
25% died before day: 729 757 -4 %
Median lifespan (days) 871 870 0 %
75% died before day: 1023 979 +4 %
90% died before day: 1139 1097 +4 %
Max lifespan observed (days) 1212 1218
Number of mice at start 43 95
Animal censor events are denoted by + marks in the plot
ACA_mid effect on survival, females, test site = UM
Log-rank test chisq = 3.5101 p = 0.061
Wang-Allison test odds ratio = 3.0603 p = 0.0681
Quantiles ACA_mid Control % difference
25% died before day: 775 757 +2 %
Median lifespan (days) 890 870 +2 %
75% died before day: 1056 979 +8 %
90% died before day: 1152 1097 +5 %
Max lifespan observed (days) 1263 1218
Number of mice at start 46 95
Animal censor events are denoted by + marks in the plot
ACA_hi effect on survival, females, test site = UM
Log-rank test chisq = 0.9838 p = 0.3213
Wang-Allison test odds ratio = 0.9049 p = 1.0
Quantiles ACA_hi Control % difference
25% died before day: 738 757 -3 %
Median lifespan (days) 931 870 +7 %
75% died before day: 1042 979 +6 %
90% died before day: 1074 1097 -2 %
Max lifespan observed (days) 1221 1218
Number of mice at start 52 95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
ACA_lo effect on survival, males, test site = UM
Log-rank test chisq = 1.6032 p = 0.2054
Wang-Allison test odds ratio = 1.9522 p = 0.3675
Quantiles ACA_lo Control % difference
25% died before day: 738 743 -1 %
Median lifespan (days) 924 912 +1 %
75% died before day: 1104 1079 +2 %
90% died before day: 1243 1158 +7 %
Max lifespan observed (days) 1376 1268
Number of mice at start 48 75
Animal censor events are denoted by + marks in the plot
ACA_mid effect on survival, males, test site = UM
Log-rank test chisq = 7.6099 p = 0.0058
Wang-Allison test odds ratio = 1.7054 p = 0.3869
Quantiles ACA_mid Control % difference
25% died before day: 906 743 +22 %
Median lifespan (days) 1032 912 +13 %
75% died before day: 1157 1079 +7 %
90% died before day: 1241 1158 +7 %
Max lifespan observed (days) 1418 1268
Number of mice at start 54 75
Animal censor events are denoted by + marks in the plot
ACA_hi effect on survival, males, test site = UM
Log-rank test chisq = 1.5632 p = 0.2112
Wang-Allison test odds ratio = 1.2925 p = 0.7679
Quantiles ACA_hi Control % difference
25% died before day: 861 743 +16 %
Median lifespan (days) 975 912 +7 %
75% died before day: 1083 1079 0 %
90% died before day: 1165 1158 +1 %
Max lifespan observed (days) 1329 1268
Number of mice at start 51 75
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
ACA_lo effect on survival, females, test site = UT
Log-rank test chisq = 4.7897 p = 0.0286
Wang-Allison test odds ratio = 1.8693 p = 0.2594
Quantiles ACA_lo Control % difference
25% died before day: 765 741 +3 %
Median lifespan (days) 923 897 +3 %
75% died before day: 1066 973 +10 %
90% died before day: 1123 1096 +2 %
Max lifespan observed (days) 1250 1190
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
ACA_mid effect on survival, females, test site = UT
Log-rank test chisq = 5.4202 p = 0.0199
Wang-Allison test odds ratio = 3.4281 p = 0.0389
Quantiles ACA_mid Control % difference
25% died before day: 822 741 +11 %
Median lifespan (days) 950 897 +6 %
75% died before day: 1085 973 +12 %
90% died before day: 1118 1096 +2 %
Max lifespan observed (days) 1223 1190
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
ACA_hi effect on survival, females, test site = UT
Log-rank test chisq = 4.9536 p = 0.026
Wang-Allison test odds ratio = 3.1131 p = 0.0455
Quantiles ACA_hi Control % difference
25% died before day: 815 741 +10 %
Median lifespan (days) 917 897 +2 %
75% died before day: 1022 973 +5 %
90% died before day: 1150 1096 +5 %
Max lifespan observed (days) 1540 1190
Number of mice at start 52 96
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
ACA_lo effect on survival, males, test site = UT
Log-rank test chisq = 11.674 p = 0.0006
Wang-Allison test odds ratio = 2.6954 p = 0.0927
Quantiles ACA_lo Control % difference
25% died before day: 778 623 +25 %
Median lifespan (days) 919 807 +14 %
75% died before day: 1041 938 +11 %
90% died before day: 1139 1066 +7 %
Max lifespan observed (days) 1242 1204
Number of mice at start 54 102
Animal censor events are denoted by + marks in the plot
ACA_mid effect on survival, males, test site = UT
Log-rank test chisq = 9.7401 p = 0.0018
Wang-Allison test odds ratio = 2.6954 p = 0.0927
Quantiles ACA_mid Control % difference
25% died before day: 782 623 +26 %
Median lifespan (days) 914 807 +13 %
75% died before day: 1025 938 +9 %
90% died before day: 1210 1066 +14 %
Max lifespan observed (days) 1257 1204
Number of mice at start 54 102
Animal censor events are denoted by + marks in the plot
ACA_hi effect on survival, males, test site = UT
Log-rank test chisq = 20.5789 p < 0.0001
Wang-Allison test odds ratio = 6.6913 p = 0.0008
Quantiles ACA_hi Control % difference
25% died before day: 834 623 +34 %
Median lifespan (days) 956 807 +18 %
75% died before day: 1089 938 +16 %
90% died before day: 1158 1066 +9 %
Max lifespan observed (days) 1322 1204
Number of mice at start 60 102
Animal censor events are denoted by + marks in the plot


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Statistical definitions