ITP survival analysis: acarbose
Intervention:
acarbose
a-glucosidase inhibitor, anti-aging
Trial code: ACA_lo
Dose: 400 ppm
initiated at age: 8 mo
Sex: both
Cohort: C2013
Trial code: ACA_mid
Dose: 1000 ppm
initiated at age: 8 mo
Sex: both
Cohort: C2013
Trial code: ACA_hi
Dose: 2500 ppm
initiated at age: 8 mo
Sex: both
Cohort: C2013
This compound had a significant effect on survival: 400 ppm females p = 0.033; 400 ppm males p < 0.0001; 1000 ppm females p = 0.0027; 1000 ppm males p < 0.0001; 2500 ppm females p = 0.0061; 2500 ppm males p < 0.0001
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
ACA_lo effect on survival,
females, test site = All
Log-rank test
chisq = 4.5452
p = 0.033
Wang-Allison test
odds ratio = 1.3409
p = 0.3975
Quantiles
ACA_lo
Control
% difference
25% died before day:
759
751
+1 %
Median lifespan (days)
887
889
0 %
75% died before day:
1042
976
+7 %
90% died before day:
1123
1097
+2 %
Max lifespan observed (days)
1274
1263
Number of mice at start
139
287
Animal censor events are denoted by + marks in the plot
ACA_mid effect on survival,
females, test site = All
Log-rank test
chisq = 8.9906
p = 0.0027
Wang-Allison test
odds ratio = 2.4334
p = 0.0065
Quantiles
ACA_mid
Control
% difference
25% died before day:
785
751
+5 %
Median lifespan (days)
932
889
+5 %
75% died before day:
1060
976
+9 %
90% died before day:
1125
1097
+3 %
Max lifespan observed (days)
1263
1263
Number of mice at start
142
287
Animal censor events are denoted by + marks in the plot
ACA_hi effect on survival,
females, test site = All
Log-rank test
chisq = 7.5225
p = 0.0061
Wang-Allison test
odds ratio = 1.6647
p = 0.1321
Quantiles
ACA_hi
Control
% difference
25% died before day:
808
751
+8 %
Median lifespan (days)
922
889
+4 %
75% died before day:
1038
976
+6 %
90% died before day:
1125
1097
+3 %
Max lifespan observed (days)
1540
1263
Number of mice at start
152
287
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
ACA_lo effect on survival,
males, test site = All
Log-rank test
chisq = 21.8612
p < 0.0001
Wang-Allison test
odds ratio = 2.9188
p = 0.0011
Quantiles
ACA_lo
Control
% difference
25% died before day:
774
641
+21 %
Median lifespan (days)
918
830
+11 %
75% died before day:
1076
968
+11 %
90% died before day:
1211
1089
+11 %
Max lifespan observed (days)
1376
1294
Number of mice at start
147
273
Animal censor events are denoted by + marks in the plot
ACA_mid effect on survival,
males, test site = All
Log-rank test
chisq = 33.6935
p < 0.0001
Wang-Allison test
odds ratio = 3.0259
p = 0.0008
Quantiles
ACA_mid
Control
% difference
25% died before day:
823
641
+28 %
Median lifespan (days)
975
830
+17 %
75% died before day:
1107
968
+14 %
90% died before day:
1210
1089
+11 %
Max lifespan observed (days)
1418
1294
Number of mice at start
161
273
Animal censor events are denoted by + marks in the plot
ACA_hi effect on survival,
males, test site = All
Log-rank test
chisq = 32.7321
p < 0.0001
Wang-Allison test
odds ratio = 3.4654
p < 0.0001
Quantiles
ACA_hi
Control
% difference
25% died before day:
837
641
+31 %
Median lifespan (days)
964
830
+16 %
75% died before day:
1083
968
+12 %
90% died before day:
1181
1089
+8 %
Max lifespan observed (days)
1329
1294
Number of mice at start
163
273
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
ACA_lo effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.6181
p = 0.4317
Wang-Allison test
odds ratio = 0.7041
p = 0.7736
Quantiles
ACA_lo
Control
% difference
25% died before day:
788
773
+2 %
Median lifespan (days)
887
890
0 %
75% died before day:
1026
984
+4 %
90% died before day:
1085
1104
-2 %
Max lifespan observed (days)
1274
1263
Number of mice at start
48
96
Animal censor events are denoted by + marks in the plot
ACA_mid effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.9709
p = 0.3245
Wang-Allison test
odds ratio = 1.3778
p = 0.5725
Quantiles
ACA_mid
Control
% difference
25% died before day:
760
773
-2 %
Median lifespan (days)
934
890
+5 %
75% died before day:
1042
984
+6 %
90% died before day:
1130
1104
+2 %
Max lifespan observed (days)
1226
1263
Number of mice at start
48
96
Animal censor events are denoted by + marks in the plot
ACA_hi effect on survival,
females, test site = TJL
Log-rank test
chisq = 2.3535
p = 0.125
Wang-Allison test
odds ratio = 1.586
p = 0.5504
Quantiles
ACA_hi
Control
% difference
25% died before day:
819
773
+6 %
Median lifespan (days)
938
890
+5 %
75% died before day:
1050
984
+7 %
90% died before day:
1141
1104
+3 %
Max lifespan observed (days)
1242
1263
Number of mice at start
48
96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
ACA_lo effect on survival,
males, test site = TJL
Log-rank test
chisq = 10.8226
p = 0.001
Wang-Allison test
odds ratio = 4.6203
p = 0.0118
Quantiles
ACA_lo
Control
% difference
25% died before day:
769
578
+33 %
Median lifespan (days)
880
802
+10 %
75% died before day:
1076
939
+15 %
90% died before day:
1248
1037
+20 %
Max lifespan observed (days)
1302
1294
Number of mice at start
45
96
Animal censor events are denoted by + marks in the plot
ACA_mid effect on survival,
males, test site = TJL
Log-rank test
chisq = 17.1751
p < 0.0001
Wang-Allison test
odds ratio = 5.9449
p = 0.0029
Quantiles
ACA_mid
Control
% difference
25% died before day:
784
578
+36 %
Median lifespan (days)
967
802
+21 %
75% died before day:
1081
939
+15 %
90% died before day:
1171
1037
+13 %
Max lifespan observed (days)
1302
1294
Number of mice at start
53
96
Animal censor events are denoted by + marks in the plot
ACA_hi effect on survival,
males, test site = TJL
Log-rank test
chisq = 15.5548
p < 0.0001
Wang-Allison test
odds ratio = 4.2862
p = 0.0101
Quantiles
ACA_hi
Control
% difference
25% died before day:
816
578
+41 %
Median lifespan (days)
960
802
+20 %
75% died before day:
1108
939
+18 %
90% died before day:
1192
1037
+15 %
Max lifespan observed (days)
1323
1294
Number of mice at start
52
96
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
ACA_lo effect on survival,
females, test site = UM
Log-rank test
chisq = 0.4756
p = 0.4904
Wang-Allison test
odds ratio = 1.7556
p = 0.3657
Quantiles
ACA_lo
Control
% difference
25% died before day:
729
757
-4 %
Median lifespan (days)
871
870
0 %
75% died before day:
1023
979
+4 %
90% died before day:
1139
1097
+4 %
Max lifespan observed (days)
1212
1218
Number of mice at start
43
95
Animal censor events are denoted by + marks in the plot
ACA_mid effect on survival,
females, test site = UM
Log-rank test
chisq = 3.5101
p = 0.061
Wang-Allison test
odds ratio = 3.0603
p = 0.0681
Quantiles
ACA_mid
Control
% difference
25% died before day:
775
757
+2 %
Median lifespan (days)
890
870
+2 %
75% died before day:
1056
979
+8 %
90% died before day:
1152
1097
+5 %
Max lifespan observed (days)
1263
1218
Number of mice at start
46
95
Animal censor events are denoted by + marks in the plot
ACA_hi effect on survival,
females, test site = UM
Log-rank test
chisq = 0.9838
p = 0.3213
Wang-Allison test
odds ratio = 0.9049
p = 1.0
Quantiles
ACA_hi
Control
% difference
25% died before day:
738
757
-3 %
Median lifespan (days)
931
870
+7 %
75% died before day:
1042
979
+6 %
90% died before day:
1074
1097
-2 %
Max lifespan observed (days)
1221
1218
Number of mice at start
52
95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
ACA_lo effect on survival,
males, test site = UM
Log-rank test
chisq = 1.6032
p = 0.2054
Wang-Allison test
odds ratio = 1.9522
p = 0.3675
Quantiles
ACA_lo
Control
% difference
25% died before day:
738
743
-1 %
Median lifespan (days)
924
912
+1 %
75% died before day:
1104
1079
+2 %
90% died before day:
1243
1158
+7 %
Max lifespan observed (days)
1376
1268
Number of mice at start
48
75
Animal censor events are denoted by + marks in the plot
ACA_mid effect on survival,
males, test site = UM
Log-rank test
chisq = 7.6099
p = 0.0058
Wang-Allison test
odds ratio = 1.7054
p = 0.3869
Quantiles
ACA_mid
Control
% difference
25% died before day:
906
743
+22 %
Median lifespan (days)
1032
912
+13 %
75% died before day:
1157
1079
+7 %
90% died before day:
1241
1158
+7 %
Max lifespan observed (days)
1418
1268
Number of mice at start
54
75
Animal censor events are denoted by + marks in the plot
ACA_hi effect on survival,
males, test site = UM
Log-rank test
chisq = 1.5632
p = 0.2112
Wang-Allison test
odds ratio = 1.2925
p = 0.7679
Quantiles
ACA_hi
Control
% difference
25% died before day:
861
743
+16 %
Median lifespan (days)
975
912
+7 %
75% died before day:
1083
1079
0 %
90% died before day:
1165
1158
+1 %
Max lifespan observed (days)
1329
1268
Number of mice at start
51
75
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
ACA_lo effect on survival,
females, test site = UT
Log-rank test
chisq = 4.7897
p = 0.0286
Wang-Allison test
odds ratio = 1.8693
p = 0.2594
Quantiles
ACA_lo
Control
% difference
25% died before day:
765
741
+3 %
Median lifespan (days)
923
897
+3 %
75% died before day:
1066
973
+10 %
90% died before day:
1123
1096
+2 %
Max lifespan observed (days)
1250
1190
Number of mice at start
48
96
Animal censor events are denoted by + marks in the plot
ACA_mid effect on survival,
females, test site = UT
Log-rank test
chisq = 5.4202
p = 0.0199
Wang-Allison test
odds ratio = 3.4281
p = 0.0389
Quantiles
ACA_mid
Control
% difference
25% died before day:
822
741
+11 %
Median lifespan (days)
950
897
+6 %
75% died before day:
1085
973
+12 %
90% died before day:
1118
1096
+2 %
Max lifespan observed (days)
1223
1190
Number of mice at start
48
96
Animal censor events are denoted by + marks in the plot
ACA_hi effect on survival,
females, test site = UT
Log-rank test
chisq = 4.9536
p = 0.026
Wang-Allison test
odds ratio = 3.1131
p = 0.0455
Quantiles
ACA_hi
Control
% difference
25% died before day:
815
741
+10 %
Median lifespan (days)
917
897
+2 %
75% died before day:
1022
973
+5 %
90% died before day:
1150
1096
+5 %
Max lifespan observed (days)
1540
1190
Number of mice at start
52
96
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
ACA_lo effect on survival,
males, test site = UT
Log-rank test
chisq = 11.674
p = 0.0006
Wang-Allison test
odds ratio = 2.6954
p = 0.0927
Quantiles
ACA_lo
Control
% difference
25% died before day:
778
623
+25 %
Median lifespan (days)
919
807
+14 %
75% died before day:
1041
938
+11 %
90% died before day:
1139
1066
+7 %
Max lifespan observed (days)
1242
1204
Number of mice at start
54
102
Animal censor events are denoted by + marks in the plot
ACA_mid effect on survival,
males, test site = UT
Log-rank test
chisq = 9.7401
p = 0.0018
Wang-Allison test
odds ratio = 2.6954
p = 0.0927
Quantiles
ACA_mid
Control
% difference
25% died before day:
782
623
+26 %
Median lifespan (days)
914
807
+13 %
75% died before day:
1025
938
+9 %
90% died before day:
1210
1066
+14 %
Max lifespan observed (days)
1257
1204
Number of mice at start
54
102
Animal censor events are denoted by + marks in the plot
ACA_hi effect on survival,
males, test site = UT
Log-rank test
chisq = 20.5789
p < 0.0001
Wang-Allison test
odds ratio = 6.6913
p = 0.0008
Quantiles
ACA_hi
Control
% difference
25% died before day:
834
623
+34 %
Median lifespan (days)
956
807
+18 %
75% died before day:
1089
938
+16 %
90% died before day:
1158
1066
+9 %
Max lifespan observed (days)
1322
1204
Number of mice at start
60
102
Animal censor events are denoted by + marks in the plot
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Statistical definitions