ITP survival analysis: acarbose
This compound had a significant effect on survival: males p < 0.0001
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
ACA effect on survival,
females, test site = All
Log-rank test
chisq = 3.2299
p = 0.0723
Wang-Allison test
odds ratio = 1.9159
p = 0.0579
Quantiles
ACA
Control
% difference
25% died before day:
772
770
0 %
Median lifespan (days)
903
877
+3 %
75% died before day:
1022
1006
+2 %
90% died before day:
1166
1100
+6 %
Max lifespan observed (days)
1365
1301
Number of mice at start
136
279
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
ACA effect on survival,
males, test site = All
Log-rank test
chisq = 16.1801
p < 0.0001
Wang-Allison test
odds ratio = 3.3119
p = 0.0003
Quantiles
ACA
Control
% difference
25% died before day:
682
620
+10 %
Median lifespan (days)
877
816
+7 %
75% died before day:
1042
960
+9 %
90% died before day:
1183
1055
+12 %
Max lifespan observed (days)
1306
1260
Number of mice at start
148
284
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
ACA effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.4052
p = 0.5244
Wang-Allison test
odds ratio = 1.8693
p = 0.2594
Quantiles
ACA
Control
% difference
25% died before day:
776
801
-3 %
Median lifespan (days)
882
924
-5 %
75% died before day:
1030
1014
+2 %
90% died before day:
1240
1092
+14 %
Max lifespan observed (days)
1365
1301
Number of mice at start
48
96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
ACA effect on survival,
males, test site = TJL
Log-rank test
chisq = 8.9223
p = 0.0028
Wang-Allison test
odds ratio = 3.6481
p = 0.0231
Quantiles
ACA
Control
% difference
25% died before day:
756
624
+21 %
Median lifespan (days)
876
844
+4 %
75% died before day:
1044
960
+9 %
90% died before day:
1170
1006
+16 %
Max lifespan observed (days)
1303
1163
Number of mice at start
53
101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
ACA effect on survival,
females, test site = UM
Log-rank test
chisq = 1.868
p = 0.1717
Wang-Allison test
odds ratio = 2.2285
p = 0.227
Quantiles
ACA
Control
% difference
25% died before day:
768
745
+3 %
Median lifespan (days)
904
843
+7 %
75% died before day:
1021
988
+3 %
90% died before day:
1133
1084
+5 %
Max lifespan observed (days)
1261
1243
Number of mice at start
44
90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
ACA effect on survival,
males, test site = UM
Log-rank test
chisq = 6.9285
p = 0.0085
Wang-Allison test
odds ratio = 4.2781
p = 0.0239
Quantiles
ACA
Control
% difference
25% died before day:
747
719
+4 %
Median lifespan (days)
957
872
+10 %
75% died before day:
1070
1022
+5 %
90% died before day:
1191
1111
+7 %
Max lifespan observed (days)
1306
1204
Number of mice at start
44
84
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
ACA effect on survival,
females, test site = UT
Log-rank test
chisq = 1.2376
p = 0.2659
Wang-Allison test
odds ratio = 1.6709
p = 0.3771
Quantiles
ACA
Control
% difference
25% died before day:
800
738
+8 %
Median lifespan (days)
912
873
+4 %
75% died before day:
1018
1008
+1 %
90% died before day:
1160
1116
+4 %
Max lifespan observed (days)
1243
1255
Number of mice at start
44
93
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
ACA effect on survival,
males, test site = UT
Log-rank test
chisq = 1.8773
p = 0.1706
Wang-Allison test
odds ratio = 2.4293
p = 0.1481
Quantiles
ACA
Control
% difference
25% died before day:
500
577
-13 %
Median lifespan (days)
792
751
+5 %
75% died before day:
951
886
+7 %
90% died before day:
1133
994
+14 %
Max lifespan observed (days)
1285
1260
Number of mice at start
51
99
Animal censor events are denoted by + marks in the plot
See our
ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions