ITP survival analysis: acarbose
This compound had a significant effect on survival: males p < 0.0001; females p = 0.0048
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
ACA effect on survival,
females, test site = All
Log-rank test
chisq = 7.9499
p = 0.0048
Wang-Allison test
odds ratio = 3.351
p = 0.0006
Quantiles
ACA
Control
% difference
25% died before day:
806
778
+4 %
Median lifespan (days)
916
881
+4 %
75% died before day:
1048
988
+6 %
90% died before day:
1152
1066
+8 %
Max lifespan observed (days)
1250
1229
Number of mice at start
132
242
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
ACA effect on survival,
males, test site = All
Log-rank test
chisq = 46.1754
p < 0.0001
Wang-Allison test
odds ratio = 4.8433
p < 0.0001
Quantiles
ACA
Control
% difference
25% died before day:
832
616
+35 %
Median lifespan (days)
982
807
+22 %
75% died before day:
1130
973
+16 %
90% died before day:
1214
1094
+11 %
Max lifespan observed (days)
1423
1338
Number of mice at start
150
295
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
ACA effect on survival,
females, test site = TJL
Log-rank test
chisq = 1.18
p = 0.2774
Wang-Allison test
odds ratio = 6.5821
p = 0.0108
Quantiles
ACA
Control
% difference
25% died before day:
716
768
-7 %
Median lifespan (days)
911
894
+2 %
75% died before day:
1055
976
+8 %
90% died before day:
1159
1051
+10 %
Max lifespan observed (days)
1240
1197
Number of mice at start
48
60
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
ACA effect on survival,
males, test site = TJL
Log-rank test
chisq = 12.6549
p = 0.0004
Wang-Allison test
odds ratio = 2.6671
p = 0.0933
Quantiles
ACA
Control
% difference
25% died before day:
840
606
+39 %
Median lifespan (days)
974
807
+21 %
75% died before day:
1127
941
+20 %
90% died before day:
1212
1061
+14 %
Max lifespan observed (days)
1315
1338
Number of mice at start
54
101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
ACA effect on survival,
females, test site = UM
Log-rank test
chisq = 2.4586
p = 0.1169
Wang-Allison test
odds ratio = 2.2897
p = 0.1442
Quantiles
ACA
Control
% difference
25% died before day:
825
797
+4 %
Median lifespan (days)
949
886
+7 %
75% died before day:
1027
1008
+2 %
90% died before day:
1152
1088
+6 %
Max lifespan observed (days)
1250
1229
Number of mice at start
43
90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
ACA effect on survival,
males, test site = UM
Log-rank test
chisq = 3.7812
p = 0.0518
Wang-Allison test
odds ratio = 3.3902
p = 0.0394
Quantiles
ACA
Control
% difference
25% died before day:
825
742
+11 %
Median lifespan (days)
992
925
+7 %
75% died before day:
1164
1077
+8 %
90% died before day:
1221
1151
+6 %
Max lifespan observed (days)
1423
1325
Number of mice at start
48
95
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
ACA effect on survival,
females, test site = UT
Log-rank test
chisq = 4.7403
p = 0.0295
Wang-Allison test
odds ratio = 3.4375
p = 0.0332
Quantiles
ACA
Control
% difference
25% died before day:
820
750
+9 %
Median lifespan (days)
920
866
+6 %
75% died before day:
1053
994
+6 %
90% died before day:
1147
1062
+8 %
Max lifespan observed (days)
1223
1213
Number of mice at start
41
92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
ACA effect on survival,
males, test site = UT
Log-rank test
chisq = 41.1884
p < 0.0001
Wang-Allison test
odds ratio = 17.6209
p < 0.0001
Quantiles
ACA
Control
% difference
25% died before day:
823
497
+66 %
Median lifespan (days)
993
704
+41 %
75% died before day:
1126
903
+25 %
90% died before day:
1167
1013
+15 %
Max lifespan observed (days)
1348
1133
Number of mice at start
48
99
Animal censor events are denoted by + marks in the plot
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ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions