ITP survival analysis:   acarbose

Intervention:   acarbose     a-glucosidase inhibitor, anti-aging
Trial code: ACA Dose: 1000 ppm initiated at age: 4 mo Sex: both Cohort: C2009
This compound had a significant effect on survival:   males p < 0.0001; females p = 0.0048

Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
ACA effect on survival, females, test site = All
Log-rank test chisq = 7.9499 p = 0.0048
Wang-Allison test odds ratio = 3.351 p = 0.0006
Quantiles ACA Control % difference
25% died before day: 806 778 +4 %
Median lifespan (days) 916 881 +4 %
75% died before day: 1048 988 +6 %
90% died before day: 1152 1066 +8 %
Max lifespan observed (days) 1250 1229
Number of mice at start 132 242
Animal censor events are denoted by + marks in the plot
All test sites combined – male
ACA effect on survival, males, test site = All
Log-rank test chisq = 46.1754 p < 0.0001
Wang-Allison test odds ratio = 4.8433 p < 0.0001
Quantiles ACA Control % difference
25% died before day: 832 616 +35 %
Median lifespan (days) 982 807 +22 %
75% died before day: 1130 973 +16 %
90% died before day: 1214 1094 +11 %
Max lifespan observed (days) 1423 1338
Number of mice at start 150 295
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
ACA effect on survival, females, test site = TJL
Log-rank test chisq = 1.18 p = 0.2774
Wang-Allison test odds ratio = 6.5821 p = 0.0108
Quantiles ACA Control % difference
25% died before day: 716 768 -7 %
Median lifespan (days) 911 894 +2 %
75% died before day: 1055 976 +8 %
90% died before day: 1159 1051 +10 %
Max lifespan observed (days) 1240 1197
Number of mice at start 48 60
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
ACA effect on survival, males, test site = TJL
Log-rank test chisq = 12.6549 p = 0.0004
Wang-Allison test odds ratio = 2.6671 p = 0.0933
Quantiles ACA Control % difference
25% died before day: 840 606 +39 %
Median lifespan (days) 974 807 +21 %
75% died before day: 1127 941 +20 %
90% died before day: 1212 1061 +14 %
Max lifespan observed (days) 1315 1338
Number of mice at start 54 101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
ACA effect on survival, females, test site = UM
Log-rank test chisq = 2.4586 p = 0.1169
Wang-Allison test odds ratio = 2.2897 p = 0.1442
Quantiles ACA Control % difference
25% died before day: 825 797 +4 %
Median lifespan (days) 949 886 +7 %
75% died before day: 1027 1008 +2 %
90% died before day: 1152 1088 +6 %
Max lifespan observed (days) 1250 1229
Number of mice at start 43 90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
ACA effect on survival, males, test site = UM
Log-rank test chisq = 3.7812 p = 0.0518
Wang-Allison test odds ratio = 3.3902 p = 0.0394
Quantiles ACA Control % difference
25% died before day: 825 742 +11 %
Median lifespan (days) 992 925 +7 %
75% died before day: 1164 1077 +8 %
90% died before day: 1221 1151 +6 %
Max lifespan observed (days) 1423 1325
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
ACA effect on survival, females, test site = UT
Log-rank test chisq = 4.7403 p = 0.0295
Wang-Allison test odds ratio = 3.4375 p = 0.0332
Quantiles ACA Control % difference
25% died before day: 820 750 +9 %
Median lifespan (days) 920 866 +6 %
75% died before day: 1053 994 +6 %
90% died before day: 1147 1062 +8 %
Max lifespan observed (days) 1223 1213
Number of mice at start 41 92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
ACA effect on survival, males, test site = UT
Log-rank test chisq = 41.1884 p < 0.0001
Wang-Allison test odds ratio = 17.6209 p < 0.0001
Quantiles ACA Control % difference
25% died before day: 823 497 +66 %
Median lifespan (days) 993 704 +41 %
75% died before day: 1126 903 +25 %
90% died before day: 1167 1013 +15 %
Max lifespan observed (days) 1348 1133
Number of mice at start 48 99
Animal censor events are denoted by + marks in the plot


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Statistical definitions