ITP survival analysis: 4-OH-a-phenyl-N-tert-butyl nitrone
Intervention:
4-OH-a-phenyl-N-tert-butyl nitrone
anti-oxidant
Trial code: 4-OH-PBN
Dose: 315 ppm
initiated at age: 4 mo
Sex: both
Cohort: C2004
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
4-OH-PBN effect on survival,
females, test site = All
Log-rank test
chisq = 0.4712
p = 0.4924
Wang-Allison test
odds ratio = 1.0587
p = 0.8624
Quantiles
4-OH-PBN
Control
% difference
25% died before day:
741
739
0 %
Median lifespan (days)
850
888
-4 %
75% died before day:
970
988
-2 %
90% died before day:
1077
1072
0 %
Max lifespan observed (days)
1206
1212
Number of mice at start
133
271
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
4-OH-PBN effect on survival,
males, test site = All
Log-rank test
chisq = 0.6507
p = 0.4199
Wang-Allison test
odds ratio = 1.0341
p = 1.0
Quantiles
4-OH-PBN
Control
% difference
25% died before day:
617
612
+1 %
Median lifespan (days)
808
784
+3 %
75% died before day:
939
912
+3 %
90% died before day:
1037
1048
-1 %
Max lifespan observed (days)
1332
1305
Number of mice at start
165
350
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
4-OH-PBN effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.1638
p = 0.6857
Wang-Allison test
odds ratio = 1.0718
p = 1.0
Quantiles
4-OH-PBN
Control
% difference
25% died before day:
729
738
-1 %
Median lifespan (days)
875
858
+2 %
75% died before day:
976
969
+1 %
90% died before day:
1055
1050
0 %
Max lifespan observed (days)
1119
1212
Number of mice at start
48
93
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
4-OH-PBN effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.805
p = 0.3696
Wang-Allison test
odds ratio = 0.8145
p = 0.7955
Quantiles
4-OH-PBN
Control
% difference
25% died before day:
491
553
-11 %
Median lifespan (days)
704
757
-7 %
75% died before day:
896
875
+2 %
90% died before day:
961
967
-1 %
Max lifespan observed (days)
1077
1216
Number of mice at start
58
125
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
4-OH-PBN effect on survival,
females, test site = UM
Log-rank test
chisq = 0.5149
p = 0.473
Wang-Allison test
odds ratio = 0.6972
p = 0.7505
Quantiles
4-OH-PBN
Control
% difference
25% died before day:
741
772
-4 %
Median lifespan (days)
827
916
-10 %
75% died before day:
984
1005
-2 %
90% died before day:
1092
1111
-2 %
Max lifespan observed (days)
1135
1210
Number of mice at start
38
82
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
4-OH-PBN effect on survival,
males, test site = UM
Log-rank test
chisq = 0.0432
p = 0.8353
Wang-Allison test
odds ratio = 1.016
p = 1.0
Quantiles
4-OH-PBN
Control
% difference
25% died before day:
756
727
+4 %
Median lifespan (days)
879
864
+2 %
75% died before day:
1002
995
+1 %
90% died before day:
1128
1121
+1 %
Max lifespan observed (days)
1243
1305
Number of mice at start
57
106
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
4-OH-PBN effect on survival,
females, test site = UT
Log-rank test
chisq = 0.0111
p = 0.916
Wang-Allison test
odds ratio = 1.4111
p = 0.5678
Quantiles
4-OH-PBN
Control
% difference
25% died before day:
757
744
+2 %
Median lifespan (days)
844
880
-4 %
75% died before day:
951
994
-4 %
90% died before day:
1111
1076
+3 %
Max lifespan observed (days)
1206
1188
Number of mice at start
47
96
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
4-OH-PBN effect on survival,
males, test site = UT
Log-rank test
chisq = 4.2839
p = 0.0385
Wang-Allison test
odds ratio = 1.3365
p = 0.5838
Quantiles
4-OH-PBN
Control
% difference
25% died before day:
621
592
+5 %
Median lifespan (days)
808
739
+9 %
75% died before day:
969
877
+10 %
90% died before day:
1039
988
+5 %
Max lifespan observed (days)
1332
1132
Number of mice at start
50
119
Animal censor events are denoted by + marks in the plot
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Statistical definitions