ITP survival analysis:   17-a-estradiol

Intervention:   17-a-estradiol     non-feminizing steroid, anti-aging
Trial code: 17aE2 Dose: 4.8 ppm initiated at age: 10 mo Sex: both Cohort: C2009
This compound had a significant effect on survival:   males p = 0.0025

Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
17aE2 effect on survival, females, test site = All
Log-rank test chisq = 0.0067 p = 0.9349
Wang-Allison test odds ratio = 1.1542 p = 0.7247
Quantiles 17aE2 Control % difference
25% died before day: 782 778 +1 %
Median lifespan (days) 902 881 +2 %
75% died before day: 998 988 +1 %
90% died before day: 1068 1066 0 %
Max lifespan observed (days) 1167 1229
Number of mice at start 133 242
Animal censor events are denoted by + marks in the plot
All test sites combined – male
17aE2 effect on survival, males, test site = All
Log-rank test chisq = 9.1525 p = 0.0025
Wang-Allison test odds ratio = 1.7538 p = 0.0927
Quantiles 17aE2 Control % difference
25% died before day: 743 616 +21 %
Median lifespan (days) 892 807 +11 %
75% died before day: 1013 973 +4 %
90% died before day: 1148 1094 +5 %
Max lifespan observed (days) 1361 1338
Number of mice at start 143 295
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
17aE2 effect on survival, females, test site = TJL
Log-rank test chisq = 0.1184 p = 0.7308
Wang-Allison test odds ratio = 1.5648 p = 0.5337
Quantiles 17aE2 Control % difference
25% died before day: 776 768 +1 %
Median lifespan (days) 886 894 -1 %
75% died before day: 1036 976 +6 %
90% died before day: 1107 1051 +5 %
Max lifespan observed (days) 1166 1197
Number of mice at start 48 60
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
17aE2 effect on survival, males, test site = TJL
Log-rank test chisq = 0.2186 p = 0.6401
Wang-Allison test odds ratio = 1.5509 p = 0.4162
Quantiles 17aE2 Control % difference
25% died before day: 568 606 -6 %
Median lifespan (days) 828 807 +3 %
75% died before day: 989 941 +5 %
90% died before day: 1079 1061 +2 %
Max lifespan observed (days) 1246 1338
Number of mice at start 53 101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
17aE2 effect on survival, females, test site = UM
Log-rank test chisq = 1.0472 p = 0.3061
Wang-Allison test odds ratio = 0.5547 p = 0.5467
Quantiles 17aE2 Control % difference
25% died before day: 810 797 +2 %
Median lifespan (days) 909 886 +3 %
75% died before day: 971 1008 -4 %
90% died before day: 1006 1088 -8 %
Max lifespan observed (days) 1167 1229
Number of mice at start 42 90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
17aE2 effect on survival, males, test site = UM
Log-rank test chisq = 2.0596 p = 0.1513
Wang-Allison test odds ratio = 1.6666 p = 0.378
Quantiles 17aE2 Control % difference
25% died before day: 831 742 +12 %
Median lifespan (days) 949 925 +3 %
75% died before day: 1145 1077 +6 %
90% died before day: 1187 1151 +3 %
Max lifespan observed (days) 1361 1325
Number of mice at start 45 95
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
17aE2 effect on survival, females, test site = UT
Log-rank test chisq = 0.2541 p = 0.6142
Wang-Allison test odds ratio = 1.6956 p = 0.3733
Quantiles 17aE2 Control % difference
25% died before day: 782 750 +4 %
Median lifespan (days) 903 866 +4 %
75% died before day: 1014 994 +2 %
90% died before day: 1079 1062 +2 %
Max lifespan observed (days) 1130 1213
Number of mice at start 43 92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
17aE2 effect on survival, males, test site = UT
Log-rank test chisq = 11.2529 p = 0.0008
Wang-Allison test odds ratio = 2.0837 p = 0.2378
Quantiles 17aE2 Control % difference
25% died before day: 771 497 +55 %
Median lifespan (days) 900 704 +28 %
75% died before day: 964 903 +7 %
90% died before day: 1110 1013 +10 %
Max lifespan observed (days) 1213 1133
Number of mice at start 45 99
Animal censor events are denoted by + marks in the plot


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Statistical definitions