ITP survival analysis: 17-a-estradiol
This compound had a significant effect on survival: males p = 0.0025
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
17aE2 effect on survival,
females, test site = All
Log-rank test
chisq = 0.0067
p = 0.9349
Wang-Allison test
odds ratio = 1.1542
p = 0.7247
Quantiles
17aE2
Control
% difference
25% died before day:
782
778
+1 %
Median lifespan (days)
902
881
+2 %
75% died before day:
998
988
+1 %
90% died before day:
1068
1066
0 %
Max lifespan observed (days)
1167
1229
Number of mice at start
133
242
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
17aE2 effect on survival,
males, test site = All
Log-rank test
chisq = 9.1525
p = 0.0025
Wang-Allison test
odds ratio = 1.7538
p = 0.0927
Quantiles
17aE2
Control
% difference
25% died before day:
743
616
+21 %
Median lifespan (days)
892
807
+11 %
75% died before day:
1013
973
+4 %
90% died before day:
1148
1094
+5 %
Max lifespan observed (days)
1361
1338
Number of mice at start
143
295
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
17aE2 effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.1184
p = 0.7308
Wang-Allison test
odds ratio = 1.5648
p = 0.5337
Quantiles
17aE2
Control
% difference
25% died before day:
776
768
+1 %
Median lifespan (days)
886
894
-1 %
75% died before day:
1036
976
+6 %
90% died before day:
1107
1051
+5 %
Max lifespan observed (days)
1166
1197
Number of mice at start
48
60
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
17aE2 effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.2186
p = 0.6401
Wang-Allison test
odds ratio = 1.5509
p = 0.4162
Quantiles
17aE2
Control
% difference
25% died before day:
568
606
-6 %
Median lifespan (days)
828
807
+3 %
75% died before day:
989
941
+5 %
90% died before day:
1079
1061
+2 %
Max lifespan observed (days)
1246
1338
Number of mice at start
53
101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
17aE2 effect on survival,
females, test site = UM
Log-rank test
chisq = 1.0472
p = 0.3061
Wang-Allison test
odds ratio = 0.5547
p = 0.5467
Quantiles
17aE2
Control
% difference
25% died before day:
810
797
+2 %
Median lifespan (days)
909
886
+3 %
75% died before day:
971
1008
-4 %
90% died before day:
1006
1088
-8 %
Max lifespan observed (days)
1167
1229
Number of mice at start
42
90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
17aE2 effect on survival,
males, test site = UM
Log-rank test
chisq = 2.0596
p = 0.1513
Wang-Allison test
odds ratio = 1.6666
p = 0.378
Quantiles
17aE2
Control
% difference
25% died before day:
831
742
+12 %
Median lifespan (days)
949
925
+3 %
75% died before day:
1145
1077
+6 %
90% died before day:
1187
1151
+3 %
Max lifespan observed (days)
1361
1325
Number of mice at start
45
95
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
17aE2 effect on survival,
females, test site = UT
Log-rank test
chisq = 0.2541
p = 0.6142
Wang-Allison test
odds ratio = 1.6956
p = 0.3733
Quantiles
17aE2
Control
% difference
25% died before day:
782
750
+4 %
Median lifespan (days)
903
866
+4 %
75% died before day:
1014
994
+2 %
90% died before day:
1079
1062
+2 %
Max lifespan observed (days)
1130
1213
Number of mice at start
43
92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
17aE2 effect on survival,
males, test site = UT
Log-rank test
chisq = 11.2529
p = 0.0008
Wang-Allison test
odds ratio = 2.0837
p = 0.2378
Quantiles
17aE2
Control
% difference
25% died before day:
771
497
+55 %
Median lifespan (days)
900
704
+28 %
75% died before day:
964
903
+7 %
90% died before day:
1110
1013
+10 %
Max lifespan observed (days)
1213
1133
Number of mice at start
45
99
Animal censor events are denoted by + marks in the plot
See our
ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions