ITP phenotypes:   body composition     acarbose

Trial code: ACA_mid Dose: 1000 ppm   initiated at age: 4 mo Sex: f Cohort: C2013
Trial code: ACA_mid Dose: 1000 ppm   initiated at age: 4 mo Sex: m Cohort: C2013
The plots below show the means with ± SEM error bars





Body mass — Females

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 6709.1112 6709.1112 99.6858 < 0.0001
time 4 1734.6914 433.6728 6.4436 0.0001
group:time 4 1322.6188 330.6547 4.913 0.0008
Residuals 298 20056.1678 67.3026 NA NA


Means

group time mean SE
ACA_mid time_m12 33.1344 0.782
ACA_mid time_m16 34.3687 0.9267
ACA_mid time_m20 35.14 1.1325
ACA_mid time_m22 35.0714 1.0254
ACA_mid time_m8 34.4281 1.0567
Control time_m12 42.6375 1.5259
Control time_m16 45.0375 1.878
Control time_m20 48.0233 2.3251
Control time_m22 47.7036 2.0837
Control time_m8 36.0469 1.3415


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 -1.6188 2.051 298 -0.7893 0.4306
ACA_mid - Control time_m12 -9.5031 2.051 298 -4.6335 < 0.0001
ACA_mid - Control time_m16 -10.6688 2.051 298 -5.2018 < 0.0001
ACA_mid - Control time_m20 -12.8833 2.1182 298 -6.0822 < 0.0001
ACA_mid - Control time_m22 -12.6321 2.1926 298 -5.7614 < 0.0001




Fat mass — Females

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 6264.2998 6264.2998 146.1234 < 0.0001
time 4 608.2122 152.053 3.5468 0.0076
group:time 4 1339.6411 334.9103 7.8122 < 0.0001
Residuals 298 12775.2367 42.8699 NA NA


Means

group time mean SE
ACA_mid time_m12 9.055 0.6325
ACA_mid time_m16 9.7653 0.703
ACA_mid time_m20 10.1723 0.8535
ACA_mid time_m22 9.1339 0.7991
ACA_mid time_m8 11.6197 0.8673
Control time_m12 18.3969 1.2107
Control time_m16 20.2797 1.4631
Control time_m20 22.1177 1.8197
Control time_m22 21.8829 1.7648
Control time_m8 12.8166 1.1055


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 -1.1969 1.6369 298 -0.7312 0.4652
ACA_mid - Control time_m12 -9.3419 1.6369 298 -5.7071 < 0.0001
ACA_mid - Control time_m16 -10.5144 1.6369 298 -6.4234 < 0.0001
ACA_mid - Control time_m20 -11.9453 1.6906 298 -7.0659 < 0.0001
ACA_mid - Control time_m22 -12.7489 1.7499 298 -7.2855 < 0.0001




Fat percent — Females

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 13254.8286 13254.8286 147.1337 < 0.0001
time 4 267.7994 66.9499 0.7432 0.5632
group:time 4 2963.5217 740.8804 8.2241 < 0.0001
Residuals 298 26845.9139 90.087 NA NA


Means

group time mean SE
ACA_mid time_m12 26.5127 1.3081
ACA_mid time_m16 27.4737 1.3284
ACA_mid time_m20 27.5671 1.6375
ACA_mid time_m22 25.0219 1.5027
ACA_mid time_m8 32.339 1.6868
Control time_m12 41.6066 1.591
Control time_m16 43.1165 1.6863
Control time_m20 43.4646 2.1352
Control time_m22 43.6211 2.2016
Control time_m8 33.5654 1.8979


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 -1.2264 2.3729 298 -0.5168 0.6057
ACA_mid - Control time_m12 -15.0939 2.3729 298 -6.3611 < 0.0001
ACA_mid - Control time_m16 -15.6428 2.3729 298 -6.5924 < 0.0001
ACA_mid - Control time_m20 -15.8975 2.4507 298 -6.487 < 0.0001
ACA_mid - Control time_m22 -18.5992 2.5367 298 -7.3321 < 0.0001




Lean mass — Females

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 26.6388 26.6388 5.8425 0.0162
time 4 199.4684 49.8671 10.9371 < 0.0001
group:time 4 6.5915 1.6479 0.3614 0.836
Residuals 298 1358.7135 4.5594 NA NA


Means

group time mean SE
ACA_mid time_m12 22.5053 0.2539
ACA_mid time_m16 22.63 0.2977
ACA_mid time_m20 23.3557 0.3706
ACA_mid time_m22 23.7589 0.3462
ACA_mid time_m8 21.6881 0.2998
Control time_m12 22.9703 0.3825
Control time_m16 23.3416 0.4794
Control time_m20 24.446 0.5341
Control time_m22 24.2239 0.5002
Control time_m8 21.9131 0.3129


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 -0.225 0.5338 298 -0.4215 0.6737
ACA_mid - Control time_m12 -0.465 0.5338 298 -0.8711 0.3844
ACA_mid - Control time_m16 -0.7116 0.5338 298 -1.333 0.1836
ACA_mid - Control time_m20 -1.0903 0.5513 298 -1.9776 0.0489
ACA_mid - Control time_m22 -0.465 0.5707 298 -0.8148 0.4158




Lean percent — Females

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 10123.8888 10123.8888 129.5302 < 0.0001
time 4 459.433 114.8583 1.4696 0.2114
group:time 4 2027.0505 506.7626 6.4838 0.0001
Residuals 298 23291.2369 78.1585 NA NA


Means

group time mean SE
ACA_mid time_m12 68.7 1.2297
ACA_mid time_m16 66.7309 1.2316
ACA_mid time_m20 67.6814 1.4245
ACA_mid time_m22 68.6533 1.3662
ACA_mid time_m8 64.2959 1.5364
Control time_m12 55.3632 1.525
Control time_m16 53.7103 1.6545
Control time_m20 53.4272 2.0337
Control time_m22 52.8359 2.0033
Control time_m8 62.6746 1.7716


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 1.6213 2.2102 298 0.7336 0.4638
ACA_mid - Control time_m12 13.3368 2.2102 298 6.0342 < 0.0001
ACA_mid - Control time_m16 13.0206 2.2102 298 5.8912 < 0.0001
ACA_mid - Control time_m20 14.2542 2.2827 298 6.2445 < 0.0001
ACA_mid - Control time_m22 15.8173 2.3628 298 6.6944 < 0.0001




Free water mass — Females

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 0.0231 0.0231 0.6354 0.426
time 4 0.9831 0.2458 6.7469 < 0.0001
group:time 4 0.2192 0.0548 1.5046 0.2008
Residuals 298 10.8558 0.0364 NA NA


Means

group time mean SE
ACA_mid time_m12 0.1259 0.0187
ACA_mid time_m16 0.1912 0.0269
ACA_mid time_m20 0.192 0.027
ACA_mid time_m22 0.3364 0.0778
ACA_mid time_m8 0.1291 0.0212
Control time_m12 0.1575 0.0243
Control time_m16 0.1416 0.0148
Control time_m20 0.235 0.0388
Control time_m22 0.2307 0.0459
Control time_m8 0.1159 0.0207


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 0.0131 0.0477 298 0.2751 0.7835
ACA_mid - Control time_m12 -0.0316 0.0477 298 -0.6615 0.5088
ACA_mid - Control time_m16 0.0497 0.0477 298 1.0413 0.2986
ACA_mid - Control time_m20 -0.043 0.0493 298 -0.8726 0.3836
ACA_mid - Control time_m22 0.1057 0.051 298 2.0724 0.0391




Free water percent — Females

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 2.2321 2.2321 8.4324 0.004
time 4 5.6033 1.4008 5.292 0.0004
group:time 4 2.3882 0.597 2.2555 0.0632
Residuals 298 78.8821 0.2647 NA NA


Means

group time mean SE
ACA_mid time_m12 0.3871 0.0575
ACA_mid time_m16 0.5429 0.0697
ACA_mid time_m20 0.5832 0.0969
ACA_mid time_m22 0.9868 0.2346
ACA_mid time_m8 0.3664 0.0527
Control time_m12 0.3714 0.0531
Control time_m16 0.306 0.0257
Control time_m20 0.4631 0.0617
Control time_m22 0.4869 0.0942
Control time_m8 0.3496 0.0694


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 0.0168 0.1286 298 0.1307 0.8961
ACA_mid - Control time_m12 0.0157 0.1286 298 0.1222 0.9028
ACA_mid - Control time_m16 0.2369 0.1286 298 1.8415 0.0665
ACA_mid - Control time_m20 0.1201 0.1328 298 0.9043 0.3665
ACA_mid - Control time_m22 0.4998 0.1375 298 3.635 0.0003




Total water mass — Females

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 13.1247 13.1247 3.6046 0.0586
time 4 494.2207 123.5552 33.933 < 0.0001
group:time 4 15.5586 3.8896 1.0682 0.3724
Residuals 298 1085.0629 3.6412 NA NA


Means

group time mean SE
ACA_mid time_m12 17.3784 0.2218
ACA_mid time_m16 17.5553 0.3042
ACA_mid time_m20 17.9497 0.3123
ACA_mid time_m22 20.4829 0.3009
ACA_mid time_m8 16.7753 0.2653
Control time_m12 17.5225 0.3334
Control time_m16 17.9403 0.4158
Control time_m20 19.2523 0.4669
Control time_m22 20.6518 0.4634
Control time_m8 16.8641 0.2971


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 -0.0887 0.477 298 -0.186 0.8525
ACA_mid - Control time_m12 -0.1441 0.477 298 -0.302 0.7629
ACA_mid - Control time_m16 -0.385 0.477 298 -0.8071 0.4203
ACA_mid - Control time_m20 -1.3027 0.4927 298 -2.644 0.0086
ACA_mid - Control time_m22 -0.1689 0.51 298 -0.3312 0.7407




Total water percent — Females

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 6658.7558 6658.7558 114.1172 < 0.0001
time 4 1162.4486 290.6122 4.9805 0.0007
group:time 4 1340.7681 335.192 5.7445 0.0002
Residuals 298 17388.3507 58.3502 NA NA


Means

group time mean SE
ACA_mid time_m12 53.1387 1.1577
ACA_mid time_m16 51.732 1.0633
ACA_mid time_m20 52.1561 1.3804
ACA_mid time_m22 59.219 1.2462
ACA_mid time_m8 49.8184 1.3677
Control time_m12 42.2181 1.2058
Control time_m16 41.3249 1.3869
Control time_m20 42.1103 1.7004
Control time_m22 45.0711 1.7958
Control time_m8 48.1904 1.4005


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 1.6279 1.9097 298 0.8525 0.3946
ACA_mid - Control time_m12 10.9206 1.9097 298 5.7185 < 0.0001
ACA_mid - Control time_m16 10.4071 1.9097 298 5.4497 < 0.0001
ACA_mid - Control time_m20 10.0459 1.9723 298 5.0934 < 0.0001
ACA_mid - Control time_m22 14.1478 2.0415 298 6.93 < 0.0001










Body mass — Males

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 2987.3459 2987.3459 75.5897 < 0.0001
time 4 129.9114 32.4778 0.8218 0.5123
group:time 4 122.5051 30.6263 0.7749 0.5424
Residuals 254 10038.2139 39.5205 NA NA


Means

group time mean SE
ACA_mid time_m12 39.5844 1.1208
ACA_mid time_m16 41.025 1.2002
ACA_mid time_m20 40.7437 1.1753
ACA_mid time_m22 38.3567 1.1099
ACA_mid time_m8 41.1788 1.0399
Control time_m12 47.2435 1.0778
Control time_m16 48.1421 1.3498
Control time_m20 47.7882 1.864
Control time_m22 47.125 1.5608
Control time_m8 45.8567 1.0927


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 -4.6779 1.5859 254 -2.9497 0.0035
ACA_mid - Control time_m12 -7.6591 1.7185 254 -4.4568 < 0.0001
ACA_mid - Control time_m16 -7.1171 1.8207 254 -3.9089 0.0001
ACA_mid - Control time_m20 -7.0445 1.8867 254 -3.7337 0.0002
ACA_mid - Control time_m22 -8.7683 1.9461 254 -4.5055 < 0.0001




Fat mass — Males

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 1164.6079 1164.6079 74.565 < 0.0001
time 4 192.0676 48.0169 3.0743 0.0169
group:time 4 119.2634 29.8159 1.909 0.1094
Residuals 254 3967.1501 15.6187 NA NA


Means

group time mean SE
ACA_mid time_m12 8.7859 0.7606
ACA_mid time_m16 9.9356 0.7927
ACA_mid time_m20 9.3653 0.7735
ACA_mid time_m22 6.8467 0.7516
ACA_mid time_m8 10.9794 0.7683
Control time_m12 13.5157 0.4369
Control time_m16 13.8368 0.6197
Control time_m20 14.2071 1.1311
Control time_m22 13.1056 1.1041
Control time_m8 13.1357 0.4713


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 -2.1563 0.997 254 -2.1629 0.0315
ACA_mid - Control time_m12 -4.7297 1.0804 254 -4.3779 < 0.0001
ACA_mid - Control time_m16 -3.9012 1.1446 254 -3.4084 0.0008
ACA_mid - Control time_m20 -4.8417 1.1861 254 -4.0821 0.0001
ACA_mid - Control time_m22 -6.259 1.2234 254 -5.1159 < 0.0001




Fat percent — Males

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 2820.3863 2820.3863 67.2864 < 0.0001
time 4 984.4255 246.1064 5.8714 0.0002
group:time 4 443.1591 110.7898 2.6431 0.0342
Residuals 253 10604.7801 41.9161 NA NA


Means

group time mean SE
ACA_mid time_m12 21.2493 1.3155
ACA_mid time_m16 23.2821 1.222
ACA_mid time_m20 22.0438 1.2432
ACA_mid time_m22 16.8643 1.3807
ACA_mid time_m8 25.8327 1.4564
Control time_m12 28.6192 0.6752
Control time_m16 28.6203 0.8449
Control time_m20 30.3636 1.112
Control time_m22 27.1954 1.8036
Control time_m8 28.5189 0.697


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 -2.6861 1.6332 253 -1.6447 0.1013
ACA_mid - Control time_m12 -7.3699 1.7698 253 -4.1642 < 0.0001
ACA_mid - Control time_m16 -5.3382 1.8751 253 -2.8469 < 0.0001
ACA_mid - Control time_m20 -8.3198 1.9823 253 -4.197 < 0.0001
ACA_mid - Control time_m22 -10.3312 2.0042 253 -5.1547 < 0.0001




Lean mass — Males

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 425.5973 425.5973 42.6581 < 0.0001
time 4 22.0643 5.5161 0.5529 0.6971
group:time 4 8.6557 2.1639 0.2169 0.9289
Residuals 254 2534.1402 9.9769 NA NA


Means

group time mean SE
ACA_mid time_m12 29.1659 0.4695
ACA_mid time_m16 29.4959 0.4783
ACA_mid time_m20 29.5891 0.4631
ACA_mid time_m22 29.6943 0.499
ACA_mid time_m8 29.0861 0.4959
Control time_m12 32.1526 0.7904
Control time_m16 32.6953 0.8647
Control time_m20 31.8824 0.8754
Control time_m22 32.1894 0.7749
Control time_m8 31.3903 0.7389


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 -2.3043 0.7968 254 -2.8919 0.0042
ACA_mid - Control time_m12 -2.9867 0.8635 254 -3.459 0.0006
ACA_mid - Control time_m16 -3.1993 0.9148 254 -3.4973 0.0006
ACA_mid - Control time_m20 -2.2933 0.948 254 -2.4191 0.0163
ACA_mid - Control time_m22 -2.495 0.9778 254 -2.5516 0.0113




Lean percent — Males

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 2148.5238 2148.5238 50.939 < 0.0001
time 4 554.0209 138.5052 3.2838 0.012
group:time 4 285.2177 71.3044 1.6905 0.1526
Residuals 254 10713.3121 42.1784 NA NA


Means

group time mean SE
ACA_mid time_m12 74.5977 1.3021
ACA_mid time_m16 72.8139 1.2061
ACA_mid time_m20 73.5552 1.2396
ACA_mid time_m22 78.2873 1.2431
ACA_mid time_m8 71.5062 1.4878
Control time_m12 68.0595 0.646
Control time_m16 68.0727 0.8612
Control time_m20 67.5164 1.6719
Control time_m22 68.9026 1.7482
Control time_m8 68.5921 0.6976


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 2.9141 1.6383 254 1.7787 0.0765
ACA_mid - Control time_m12 6.5383 1.7754 254 3.6828 0.0003
ACA_mid - Control time_m16 4.7412 1.881 254 2.5206 0.0123
ACA_mid - Control time_m20 6.0387 1.9491 254 3.0982 0.0022
ACA_mid - Control time_m22 9.3846 2.0105 254 4.6678 < 0.0001




Free water — Males

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 0.0616 0.0616 6.8633 0.0093
time 4 0.0115 0.0029 0.3203 0.8642
group:time 4 0.0667 0.0167 1.856 0.1187
Residuals 254 2.2806 0.009 NA NA


Means

group time mean SE
ACA_mid time_m12 0.1272 0.0146
ACA_mid time_m16 0.1397 0.0134
ACA_mid time_m20 0.1312 0.0096
ACA_mid time_m22 0.1247 0.0119
ACA_mid time_m8 0.1161 0.0177
Control time_m12 0.1509 0.0288
Control time_m16 0.1168 0.0188
Control time_m20 0.1647 0.0194
Control time_m22 0.1531 0.0179
Control time_m8 0.1917 0.0268


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 -0.0756 0.0239 254 -3.163 0.0018
ACA_mid - Control time_m12 -0.0237 0.0259 254 -0.9143 0.3614
ACA_mid - Control time_m16 0.0228 0.0274 254 0.8324 0.4059
ACA_mid - Control time_m20 -0.0335 0.0284 254 -1.1764 0.2405
ACA_mid - Control time_m22 -0.0285 0.0293 254 -0.9702 0.3329




Free water percent — Males

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 0.0097 0.0097 0.2211 0.6386
time 4 0.0304 0.0076 0.1727 0.9522
group:time 4 0.3992 0.0998 2.2666 0.0625
Residuals 254 11.1829 0.044 NA NA


Means

group time mean SE
ACA_mid time_m12 0.3335 0.0381
ACA_mid time_m16 0.3475 0.0333
ACA_mid time_m20 0.324 0.0232
ACA_mid time_m22 0.3307 0.0302
ACA_mid time_m8 0.2766 0.0386
Control time_m12 0.314 0.056
Control time_m16 0.2374 0.0362
Control time_m20 0.3593 0.0541
Control time_m22 0.3275 0.0378
Control time_m8 0.4014 0.0544


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 -0.1248 0.0529 254 -2.3573 0.0192
ACA_mid - Control time_m12 0.0196 0.0574 254 0.341 0.7334
ACA_mid - Control time_m16 0.11 0.0608 254 1.8106 0.0714
ACA_mid - Control time_m20 -0.0353 0.063 254 -0.5602 0.5759
ACA_mid - Control time_m22 0.0033 0.065 254 0.0507 0.9596




Total water — Males

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 269.2188 269.2188 40.2102 < 0.0001
time 4 282.4415 70.6104 10.5463 < 0.0001
group:time 4 7.1804 1.7951 0.2681 0.8983
Residuals 254 1700.6037 6.6953 NA NA


Means

group time mean SE
ACA_mid time_m12 21.9197 0.4064
ACA_mid time_m16 22.295 0.4272
ACA_mid time_m20 22.7831 0.41
ACA_mid time_m22 24.8853 0.4005
ACA_mid time_m8 22.2288 0.3629
Control time_m12 24.6061 0.6422
Control time_m16 24.5358 0.7332
Control time_m20 25.0047 0.6889
Control time_m22 27.1738 0.6727
Control time_m8 23.93 0.5674


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 -1.7012 0.6527 254 -2.6063 0.0097
ACA_mid - Control time_m12 -2.6864 0.7073 254 -3.7979 0.0002
ACA_mid - Control time_m16 -2.2408 0.7494 254 -2.9901 0.0031
ACA_mid - Control time_m20 -2.2216 0.7766 254 -2.8607 0.0046
ACA_mid - Control time_m22 -2.2884 0.801 254 -2.8569 0.0046




Total water percent — Males

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 1229.0207 1229.0207 37.8916 < 0.0001
time 4 2911.3208 727.8302 22.4396 < 0.0001
group:time 4 168.6155 42.1539 1.2996 0.2707
Residuals 254 8238.5249 32.4351 NA NA


Means

group time mean SE
ACA_mid time_m12 56.0242 1.0397
ACA_mid time_m16 54.9335 0.8797
ACA_mid time_m20 56.6285 1.0822
ACA_mid time_m22 65.6553 1.0957
ACA_mid time_m8 54.7718 1.2983
Control time_m12 52.0736 0.6229
Control time_m16 51.0425 0.8041
Control time_m20 53.1535 1.812
Control time_m22 58.1825 1.5674
Control time_m8 52.3618 0.7674


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_mid - Control time_m8 2.41 1.4367 254 1.6775 0.0947
ACA_mid - Control time_m12 3.9507 1.5569 254 2.5376 0.0118
ACA_mid - Control time_m16 3.891 1.6495 254 2.359 0.0191
ACA_mid - Control time_m20 3.475 1.7093 254 2.033 0.0431
ACA_mid - Control time_m22 7.4728 1.7631 254 4.2385 < 0.0001










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