Svenson6: High-resolution genetic mapping in diversity outbred (DO) mouse population (2012) [Pending]

Svenson KL   With: Gatti DM, Valdar W, Welsh CE, Cheng R, Chesler EJ, Palmer AA, McMillan L, Churchill GA

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Investigators Karen L Svenson       The Jackson Laboratory,  Bar Harbor, ME
Participants Gatti DM, Valdar W, Welsh CE, Cheng R, Chesler EJ, Palmer AA, McMillan L, Churchill GA
ContactKaren L Svenson
Affiliated CenterQTL Archive
AcknowledgementsThis work was supported by The Jackson Laboratory and National Institutes of Health (NIH) grants GM076468 and GM070683 to G.A.C., and by NIH grants R01DA021336, R21DA024845, and R01MH079103 and a Grant from the Schweppe Foundation to A.A.P.
Project type QTL Archive data set
MPD identifiersSvenson6     MPD:277
Data changelog This project has not yet been released.
The JAX Diversity Outbred (DO) population is a new mouse resource derived from partially inbred Collaborative Cross strains. Each animal has a high degree of heterozygosity and carries a unique combination of alleles. The phenotypic diversity of DO mouse is striking and divergent from the founder strains. It is an ideal resource of high-resolution genetic mapping. In this publication, the authors used DO mice to map the cholesterol trait to a very narrow region on chromosome 3. The result demonstrated the DO mice, comparing with the traditional QTL resource, was not only a high-density, low-cost genotyping platform, but also a powerful model system closely reflects the genetic mechanisms of human disease. For detailed protocols, see Svenson et al 2011.

QTL data set parameters:
Progenitor strains CC8 founder strains    
Cross typeDiversity Outbred
Population size 75 ♀     75 ♂

For information on measured phenotypes please see the Excel file.

Project / data set:   Svenson6     a.k.a. Svenson_2012
Excel file:   Data_Description_DO_Svenson2012.xlsx
CSV file:   Svenson2012_geno.csv
CSV file:   Svenson2012_pheno.csv
Large zipped data set: