The JAX Diversity Outbred (DO) population
is a new mouse resource derived from partially inbred Collaborative Cross strains. Each animal has a high degree of heterozygosity and carries a unique combination of alleles. The phenotypic diversity of DO mouse is striking and divergent from the founder strains. It is an ideal resource of high-resolution genetic mapping. In this publication, the authors used DO mice to map the cholesterol trait to a very narrow region on chromosome 3. The result demonstrated the DO mice, comparing with the traditional QTL resource, was not only a high-density, low-cost genotyping platform, but also a powerful model system closely reflects the genetic mechanisms of human disease. For detailed protocols, see Svenson et al 2011.