Schoenrock1: Perinatal nutrition effects on anxiety- and depression-related behaviors in females of F1 hybrids (RIX) of Collaborative Cross strains of mice (2018)

Schoenrock SA, Oreper D, Farrington J, McMullan RC, Ervin R, Miller DR, Pardo-Manuel de Villena F, Valdar W, Tarantino LM. Perinatal nutrition interacts with genetic background to alter behavior in a parent-of-origin-dependent manner in adult Collaborative Cross mice. Genes Brain Behav. 2017 Nov 10. doi: 10.1111/gbb.12438. [Epub ahead of print]   PubMed 29125223  


       
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Participants Sarah E Schoenrock       University of North Carolina Chapel Hill, NC
Lisa M Tarantino       University of North Carolina Chapel Hill, NC
With: Oreper D, Farrington J, McMullan RC, Ervin R, Miller DR, Pardo-Manuel de Villena F, Valdar W
ContactLisa M Tarantino     lisat@med.unc.edu     Lab web site
AcknowledgementsFunding provided by NIH MH100241; Pharmaceutical Research and Manufacturers of America Foundation
Project type Phenotype strain survey data set
MPD identifiersSchoenrock1     MPD:612
Data changelog No updates/corrections.       Initial release date: 04/2018.
Formatted citation
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Female mice from selected Collaborative Cross (CC) strains were administered experimental diets: protein-deficient, vitamin D-deficient, methyl donor-enriched or standard (control) diet for 5 wks. These CC females were then crossed to a male from a different CC strain to produce reciprocal F1 hybrid females comprising distinct genetic backgrounds. The diet was administered throughout the gestation period until weaning. The adult F1 females were then tested at 8-9 wks of age in the open field, light/dark, stress-induced hyperthermia, forced swim and restraint stress assays.

Summary of procedures that were conducted
• body weight Body weight at weaning and time of test. Comparison of 4 diets.
• open field test Locomotor activity, anxiety-related behavior. 10 min test. Comparison of 4 diets.
• light-dark box Anxiety-related behavior. 10 min test. Comparison of 4 diets.
• body temperature Temperature before and after stress. Comparison of 4 diets.
• forced swim test Immobility time. 6 min test. Comparison of 4 diets.
• hormone quantification Serum corticosterone at baseline and 10 mins after stress. Comparison of 4 diets.
Mice: CC RIX   18 strains   ♀   age 8-9 wks   4 cohorts