Rusyn8: Trichloroethylene exposure in males of 45 Collaborative Cross strains of mice (2017)

Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar W, Konganti K, Threadgill DW, Gillespie KM, Aylor DL, Wright FA, Chiu WA, Rusyn I. Editor's Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism. Toxicol Sci. 2017 Jul 1;158(1):48-62. doi: 10.1093/toxsci/kfx065.   PubMed 28369613  

Rusyn8 downloads
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Investigators Ivan Rusyn       Texas A&M University,  College Station, TX
Abhishek Venkatratnam       University of North Carolina,  Chapel Hill, NC
ContactIvan Rusyn     Lab web site
Project type QTL Archive data set
MPD identifiersRusyn8     MPD:595
Data changelog No updates/corrections.       Initial release date: 05/2017.
Measures taken at baseline, 24, 80, 240, and 800 mg/kg trichloroethylene (TCE). Measured phenotypes include liver trichloroacetic acid (TCA) levels; liver gene expression, protein levels and enzyme activity; body weight and liver, kidney, and brain weight. See downloadable Excel file for details.

QTL data set parameters:
Cross typeCollaborative Cross
Population size 0 ♀     225 ♂

For information on measured phenotypes please see the Excel file.

Project / data set:   Rusyn8     a.k.a. Rusyn_2017

QTL file list not available on this MPD instance.