Rusyn7: Toxicokinetics and toxicodynamics of tetrachloroethylene in males of 45 Collaborative Cross strains of mice (2016)

Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap AH, Wade T, Sweet S, Chiu WA, Threadgill DW, Rusyn I. Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population. Environ Health Perspect. 2017 May 30;125(5):057006. doi: 10.1289/EHP788.   PubMed 28572074  

Male mice from 45 strains of the Collaborative Cross were orally administered a single dose of tetrachloroethylene (percholorethylene, PERC) or vehicle and euthanized at various time points to generate population-level concentration-time profiles for PERC and its primary oxidative metabolite trichloroacetate (TCA) across multiple tissues. Toxicodynamic phenotyping included study of the expression of CYPs and dysregulation of hepatic lipid metabolism. Update: TCVG, TCVC, NAcTCVC in kidney, liver, and serum have been added to the dataset. Update: Kidney gene expression and KIM1 protein levels have been added to the dataset.

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Participants Joseph A Cichocki       Texas A&M University,  College Station, TX
Ivan Rusyn       Texas A&M University,  College Station, TX
With: Furuya S, Venkatratnam A, McDonald TJ, Knap AH, Wade T, Sweet S, Chui WA, Threadgill DW
ContactIvan Rusyn     Lab web site
Project type Phenotype archive study
MPD identifiersRusyn7     MPD:590
Data changelog 2 updates/corrections.       Initial release date: 05/2017.
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Protocol       Animal documentation