Rusyn7: Toxicokinetics and toxicodynamics of tetrachloroethylene in males of 45 Collaborative Cross strains of mice (2016)

Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap AH, Wade T, Sweet S, Chiu WA, Threadgill DW, Rusyn I. Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population. Environ Health Perspect. 2017 May 30;125(5):057006. doi: 10.1289/EHP788.   PubMed 28572074  

Luo YS, Cichocki JA, Hsieh NH, Lewis L, Wright FA, Threadgill DW, Chiu WA, Rusyn I. Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene. Environ Health Perspect. 2019 Jun;127(6):67011. doi: 10.1289/EHP5105. Epub 2019 Jun 27.   PubMed 31246107     FullText


     
Male mice from 45 strains of the Collaborative Cross were orally administered a single dose of tetrachloroethylene (percholorethylene, PERC) or vehicle and euthanized at various time points to generate population-level concentration-time profiles for PERC and its primary oxidative metabolite trichloroacetate (TCA) across multiple tissues. Toxicodynamic phenotyping included study of the expression of CYPs and dysregulation of hepatic lipid metabolism. Update: TCVG, TCVC, NAcTCVC in kidney, liver, and serum have been added to the dataset. Update: Kidney gene expression and KIM1 protein levels have been added to the dataset.

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Investigators Joseph A Cichocki       Texas A&M University,  College Station, TX
Ivan Rusyn       Texas A&M University,  College Station, TX
Participants Furuya S, Venkatratnam A, McDonald TJ, Knap AH, Wade T, Sweet S, Chui WA, Threadgill DW
ContactIvan Rusyn     IRusyn@cvm.tamu.edu     Lab web site
Project type Phenotype archive study
MPD identifiersRusyn7     MPD:590
Data changelog 2 updates/corrections.       Initial release date: 05/2017.
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Protocol       Animal documentation