MPD: Data set: Project1133

Zhang G, Deighan A, Raj A, Robinson L, Donato HJ, Garland G, Leland M, Martin-McNulty B, Kolumam GA, Riegler J, Freund A, Wright KM, Churchill GA. Intermittent fasting and caloric restriction interact with genetics to shape physiological health in mice. Genetics. pii: iyab157. doi: 10.1093/genetics/iyab157. PubMed 34791228 FullText

Project1133 downloads
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Ontology terms mapped to Project1133 measures:

MA:0000009 adipose tissue
MA:0000072 heart
MA:0000085 heart interventricular septum
MA:0000092 heart left ventricle
MA:0000167 central nervous system
MA:0000615 forelimb muscle
MA:0000692 limb muscle
MA:0001459 bone
MP:0001256 abnormal body length
MP:0001392 abnormal locomotor behavior
MP:0001486 abnormal startle reflex
MP:0001515 abnormal grip strength
MP:0001516 abnormal motor coordination/balance
MP:0001627 abnormal cardiac output
MP:0001629 abnormal heart rate
MP:0002332 abnormal exercise endurance
MP:0003795 abnormal bone structure
MP:0003921 abnormal heart left ventricle morphology
MP:0003956 abnormal body size
MP:0005378 growth/size/body region phenotype
MP:0005457 abnormal percent body fat/body weight
MP:0010119 abnormal bone mineral density
MP:0010122 abnormal bone mineral content
MP:0012321 abnormal total tissue mass
MP:0020136 abnormal interventricular septum thickness
VT:0001256 body length
VT:0001259 body mass
VT:0001392 locomotor behavior trait
VT:0001516 motor coordination/balance trait
VT:0002332 exercise endurance trait
VT:0004262 physical strength trait
VT:0005007 bone mineral mass
VT:0005452 adipose amount
VT:0007031 heart left ventricle mass
VT:0007075 heart left ventricle wall thickness
VT:0007086 heart ventricle septum thickness
VT:0010003 bone morphology trait
VT:0010080 skeletal muscle physiology trait
VT:0010482 body fat mass
VT:0010486 cardiac output trait
VT:0010725 startle reflex trait
VT:0010758 heart left ventricle end-diastolic diameter
VT:0010759 heart left ventricle end-systolic diameter
VT:0100005 body size trait
VT:2000009 heart pumping trait

Investigators	Gary A Churchill The Jackson Laboratory, Bar Harbor, ME Kevin M Wright Calico Labs, South San Francisco, CA Samuel Widmayer
Participants	Zhang G, Deighan A, Raj A, Robinson L, Donato HJ, Garland G, Leland M, Martin-McNulty B, Kolumam GA, Riegler J, Freund A
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	JAX Nathan Shock Aging Center
Acknowledgements	Natalie Telis, J. Graham Ruby, Nick van Bruggen and David Botstein
Funding Provided By	Calico Life Sciences LLC
Project type	Phenotype strain survey data set
MPD identifiers	Project1133 MPD:1133
Data changelog	This project has not yet been released.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Dietary interventions can dramatically affect physiological health and organismal lifespan. The degree to which organismal health is improved depends upon genotype and the severity of dietary intervention, but neither the effects of these factors, nor their interaction, have been quantified in an outbred population. Moreover, it is not well understood what physiological changes occur shortly after dietary change and how these may affect the health of an adult population. In this article, we investigated the effect of 6-month exposure of either caloric restriction (CR) or intermittent fasting (IF) on a broad range of physiological traits in 960 1-year old Diversity Outbred mice.

Experimental groups in this study:
• Ad libitum (AL) • Fast 1 day/wk (1D) • Fast 2 consecutive days/wk (2D) • 20% caloric restriction (20) • 40% caloric restriction (40)

Procedures conducted:

• acoustic startle test
• echocardiography
• DXA
• rotarod
• running wheel monitoring

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Project1133:1	Project1133	acoustic startle test	various diets 3	slope of curve [Z-score] AS_SLOP 116208 diet: AL 1D 2D 20 40	DO population	f	46 wks	N=130

Project1133:6	Project1133	acoustic startle test	various diets 3	total hearing ability, area under the curve [Z-score] AS_TAUC 116213 diet: AL 1D 2D 20 40	DO population	f	46 wks	N=130

Project1133:11	Project1133	acoustic startle test	various diets 3	median inflection point for sound level [Z-score] AS_XINF 116218 diet: AL 1D 2D 20 40	DO population	f	46 wks	N=130

Project1133:16	Project1133	acoustic startle test	various diets 3	median inflection point for startle response [Z-score] AS_YINF 116223 diet: AL 1D 2D 20 40	DO population	f	46 wks	N=130

Project1133:21	Project1133	DXA	various diets 3	total bone area [Z-score] DX_BARE 116228 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=129

Project1133:26	Project1133	DXA	various diets 3	body weight [Z-score] DX_BODY 116233 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=129

Project1133:31	Project1133	DXA	various diets 3	bone mineral content [Z-score] DX_BOMC 116238 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=129

Project1133:36	Project1133	DXA	various diets 3	bone mineral density [Z-score] DX_BOMD 116243 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=129

Project1133:41	Project1133	DXA	various diets 3	percent fat mass [Z-score] DX_PFAT 116248 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=129

Project1133:46	Project1133	DXA	various diets 3	body length [Z-score] DX_SIZE 116258 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=129

Project1133:51	Project1133	DXA	(none)	total body area [Z-score] DX_TARE 116263 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=129

Project1133:56	Project1133	DXA	various diets 3	total tissue mass [Z-score] DX_TTME 116268 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=129

Project1133:61	Project1133	echocardiography	various diets 3	cardiac output [Z-score] EC_COUT 116273 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=123

Project1133:66	Project1133	echocardiography	various diets 3	ejection fraction [Z-score] EC_EFRA 116278 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=123

Project1133:71	Project1133	echocardiography	various diets 3	heart rate [Z-score] EC_HRAT 116283 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=123

Project1133:76	Project1133	echocardiography	various diets 3	interventricular septum thickness - diastole [Z-score] EC_IVSD 116288 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=123

Project1133:81	Project1133	echocardiography	various diets 3	interventricular septum thickness - systole [Z-score] EC_IVSS 116293 diet AL 1D 2D 20 40	DO population	f	45 wks	N=123

Project1133:86	Project1133	echocardiography	various diets 3	left ventricular inner diameter - diastole [Z-score] EC_LVID 116298 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=123

Project1133:91	Project1133	echocardiography	various diets 3	left ventricular inner diameter - systole [Z-score] EC_LVIS 116303 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=123

Project1133:96	Project1133	echocardiography	various diets 3	left ventricular mass [Z-score] EC_LVMA 116308 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=123

Project1133:101	Project1133	echocardiography	various diets 3	left ventricular posterior wall thickness - diastole [Z-score] EC_LVPD 116313 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=123

Project1133:106	Project1133	echocardiography	various diets 3	left ventricular posterior wall thickness - systole [Z-score] EC_LVPS 116318 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=123

Project1133:111	Project1133	echocardiography	various diets 3	stroke volume [Z-score] EC_STRO 116323 diet: AL 1D 2D 20 40	DO population	f	45 wks	N=123

Project1133:116	Project1133	grip strength	various diets 3	all-paws force - 3 trial average [Z-score] GS_APAW 116328 diet: AL 1D 2D 20 40	DO population	f	44 wks	N=130

Project1133:121	Project1133	grip strength	various diets 3	forepaws force - 3 trial average [Z-score] GS_FORE 116333 AL 1D 2D 20 40	DO population	f	44 wks	N=130

Project1133:126	Project1133	rotarod	various diets 3	latency to fall - trial 1 [Z-score] RR_FIRS 116338 diet: AL 1D 2D 20 40	DO population	f	43 wks	N=116

Project1133:131	Project1133	rotarod	various diets 3	latency to fall - slope for trials 1, 2, 3 [Z-score] RR_SLOP 116343 diet: AL 1D 2D 20 40	DO population	f	43 wks	N=116

Project1133:136	Project1133	rotarod	various diets 3	latency to fall - average of trials 2 3 [Z-score] RR_TAVG 116348 diet: AL 1D 2D 20 40	DO population	f	43 wks	N=116

Project1133:141	Project1133	running wheel monitoring	various diets 3	average distance - day [Z-score] WR_DDAY 116353 diet: AL 1D 2D 20 40	DO population	f	47 wks	N=125

Project1133:146	Project1133	running wheel monitoring	various diets 3	total distance [Z-score] WR_DIST 116358 AL 1D 2D 20 40	DO population	f	47 wks	N=129

Project1133:151	Project1133	running wheel monitoring	various diets 3	average distance - night [Z-score] WR_DNIG 116363 diet: AL 1D 2D 20 40	DO population	f	47 wks	N=129

Project1133:156	Project1133	running wheel monitoring	various diets 3	maximum distance in 30 min - day [Z-score] WR_MDAY 116368 diet: AL 1D 2D 20 40	DO population	f	47 wks	N=128

Project1133:161	Project1133	running wheel monitoring	various diets 3	maximum distance in 30 min - night [Z-score] WR_MNIG 116373 AL 1D 2D 20 40	DO population	f	47 wks	N=130

Project1133:166	Project1133	running wheel monitoring	various diets 3	maximum running speed in 30 min [Z-score] WR_MSPE 116378 diet: AL 1D 2D 20 40	DO population	f	47 wks	N=129

Project1133:171	Project1133	running wheel monitoring	various diets 3	time running - day [Z-score] WR_TDAY 116383 diet: AL 1D 2D 20 40	DO population	f	47 wks	N=128

Project1133:176	Project1133	running wheel monitoring	various diets 3	time running - night [Z-score] WR_TNIG 116388 diet: AL 1D 2D 20 40	DO population	f	47 wks	N=130

Project1133: Aging Diet Intervention Study Year1 (2022) [Pending]

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