MPD: Data set: Nelson1

Nelson1: Effects of dietary restriction on body composition and lifespan: life extension and life shortening in 44 ILSXISS recombinant inbred strains of mice (2010)

Liao CY, Rikke BA, Johnson TE, Diaz V, Nelson JF. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell. 2010 Feb;9(1):92-5. Epub 2009 Oct 30. PubMed 19878144

Liao CY, Rikke BA, Johnson TE, Gelfond JA, Diaz V, Nelson JF. Fat maintenance is a predictor of the murine lifespan response to dietary restriction. Aging Cell. 2011 Aug;10(4):629-39. doi: 10.1111/j.1474-9726.2011.00702.x. Epub 2011 Apr 25. PubMed 21388497

Nelson1 downloads
• Download Nelson1 project data set animal data, as uploaded
• Download Nelson1 animal data matrix with factor-related expansion applied as necessary
• Download Nelson1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Nelson1 measures:

MA:0000009 adipose tissue
MP:0001259 abnormal body weight
MP:0003959 abnormal lean body mass
MP:0005452 abnormal adipose tissue amount
MP:0005457 abnormal percent body fat/body weight
MP:0020148 abnormal sensitivity to induced morbidity/mortality
VT:0001259 body mass
VT:0001661 total life span
VT:0005452 adipose amount
VT:0010482 body fat mass
VT:0010483 body lean mass

Investigators	James F Nelson University of Texas Health Science Center, San Antonio, TX Thomas E Johnson University of Colorado, Boulder, CO
Participants	Liao C-Y, Rikke BA, Gelfond J, Diaz V
Contact	James F Nelson nelsonj@uthscsa.edu Lab web site
Acknowledgements	Funding provided by NIH AG024354; Ellison Medical Foundation; Glenn Foundation
Project type	Phenotype strain survey data set
MPD identifiers	Nelson1 MPD:341
Data changelog	1 update/correction. Initial release date: 07/2010.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Two cohorts: 1) control mice fed ad libitum, and 2) test mice subjected to 40% dietary restriction (60% of ad libitum diet). Dietary restriction started at 2-5 mo of age. All mice from both cohorts were weighed and assessed for body composition at 15-17 mo of age. Lifespan data was collected.

Procedures conducted:

• body weight		Restricted diet vs. ad libitum diet.
• NMR		Body mass, fat mass, lean mass. Restricted diet vs. ad libitum diet.
• colony observation		Life span comparison. Restricted diet vs. ad libitum diet.

Mice: ILSXISS 44 strains ♀♂ age max lifespan 2 experimental groups

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Nelson1:1	Nelson1	body weight	restricted diet	body weight [g] bw 34101 control DR diet	ILSXISS	44	both	65-74wks	N=4

Nelson1:3	Nelson1	NMR	restricted diet	lean tissue mass, head included (NMR) [g] lean 34103 control DR diet	ILSXISS	44	both	65-74wks	N=4

Nelson1:5	Nelson1	NMR	restricted diet	fat tissue mass, head included (NMR) [g] fat 34105 control DR diet	ILSXISS	44	both	65-74wks	N=4

Nelson1:7	Nelson1	NMR	restricted diet	percent fat, whole body with head (NMR) [%] pct_fat 34107 control DR diet	ILSXISS	44	both	65-74wks	N=4

Nelson1:9	Nelson1	colony observation	restricted diet	lifespan [d] lifespan 34109 control DR diet	ILSXISS	44	both	varies	N=5

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