Nelson1: Effects of dietary restriction on body composition and lifespan: life extension and life shortening in 44 ILSXISS recombinant inbred strains of mice (2010)

Liao CY, Rikke BA, Johnson TE, Diaz V, Nelson JF. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell. 2010 Feb;9(1):92-5. Epub 2009 Oct 30.   PubMed 19878144  

Liao CY, Rikke BA, Johnson TE, Gelfond JA, Diaz V, Nelson JF. Fat maintenance is a predictor of the murine lifespan response to dietary restriction. Aging Cell. 2011 Aug;10(4):629-39. doi: 10.1111/j.1474-9726.2011.00702.x. Epub 2011 Apr 25.   PubMed 21388497  

Nelson1 downloads
• Download Nelson1 project data set     animal data, as uploaded
• Download Nelson1 animal data matrix     with factor-related expansion applied as necessary
• Download Nelson1 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators James F Nelson       University of Texas Health Science Center,  San Antonio, TX
Thomas E Johnson       University of Colorado,  Boulder, CO
Participants Liao C-Y, Rikke BA, Gelfond J, Diaz V
ContactJames F Nelson     Lab web site
AcknowledgementsFunding provided by NIH AG024354; Ellison Medical Foundation; Glenn Foundation
Project type Phenotype strain survey data set
MPD identifiersNelson1     MPD:341
Data changelog 1 update/correction.       Initial release date: 07/2010.
Formatted citation
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Two cohorts: 1) control mice fed ad libitum, and 2) test mice subjected to 40% dietary restriction (60% of ad libitum diet). Dietary restriction started at 2-5 mo of age. All mice from both cohorts were weighed and assessed for body composition at 15-17 mo of age. Lifespan data was collected.

Procedures conducted:
• body weight  Restricted diet vs. ad libitum diet.
• NMR  Body mass, fat mass, lean mass. Restricted diet vs. ad libitum diet.
• colony observation  Life span comparison. Restricted diet vs. ad libitum diet.

Mice: ILSXISS   44 strains   ♀♂   age max lifespan   2 experimental groups