Mogil1: Investigation of basal nociception in males of 12 inbred strains of mice (2002)

References   (chronological)

1.   Mogil JS, Wilson SG, Bon K, Lee SE, Chung K, Raber P, Pieper JO, Hain HS, Belknap JK, Hubert L, Elmer GI, Chung JM, Devor M. Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception. Pain. 1999 Mar;80(1-2):67-82.   PubMed 10204719  

2.   Mogil JS, Wilson SG, Bon K, Lee SE, Chung K, Raber P, Pieper JO, Hain HS, Belknap JK, Hubert L, Elmer GI, Chung JM, Devor M. Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis. Pain. 1999 Mar;80(1-2):83-93.   PubMed 10204720  

3.   Lariviere WR, Wilson SG, Laughlin TM, Kokayeff A, West EE, Adhikari SM, Wan Y, Mogil JS. Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity. Pain. 2002 May;97(1-2):75-86.   PubMed 12031781  


           
Notes
For each strain/sex/measurement the following summary data were submitted: mean measurement value, N (usually a range such as "6-8"), and standard error of the measurement value.

Dec 2008: In order to use these data more effectively with MPD tools, where N was supplied as a range the lower N value is retained in the MPD database.


Mogil1 downloads
• Download Mogil1 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators Jeffrey S Mogil       McGill University,  Montreal, Quebec CANADA
Marshall Devor       Hebrew University of Jerusalem,  Jerusalem ISRAEL
William R Lariviere       University of Pittsburgh School of Medicine,  Pittsburgh, PA
Participants Wilson SG, Bon K, Lee SE, Chung K, Raber P, Pieper JO, Hain HS, Belknap JK, Hubert L, Elmer GI, Chung JM, Laughlin TM, Kokayeff A, West EE, Adhikari SM, Wan Y
ContactJeffrey S Mogil     jeffrey.mogil@mcgill.ca     Lab web site
AcknowledgementsFunding provided by NIH DA11394, DA11888, NS35057, NS31680, NS11255, DE12735; and by Fritz Thyssen Stiftung Foundation and the Hebrew University Center for Research on Pain, Fonds pour la Formation de Chercheurs et l'Aide a la Recherche of Quebec.
Project type Phenotype strain survey data set
MPD identifiersMogil1     MPD:22
Data changelog 2 updates/corrections.       Initial release date: 02/2001.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Procedures conducted:
• nociception assay  Battery of tests for mechanical, chemical, thermal nociception.

Mice: inbred   12 strains   ♂   age 6-18wks   2 experimental groups

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Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
    Mogil1 nociception assay (none) latency of nociceptive response, (53°C) hot plate test   [s]  HP   2201 inbred 11 m 6-18wks N=8
    Mogil1 nociception assay (none) latency of heated hindpaw withdrawal, Hargreaves test   [s]  HT   2202 inbred 11 m 6-18wks N=6
    Mogil1 nociception assay (none) latency of tail withdrawal, 49°C heat stimulation   [s]  TW_HOT1   2203 inbred 11 m 6-18wks N=10
    Mogil1 nociception assay (none) median 50% foot withdrawal threshold, Von Frey test   [mN]  VF   2204 inbred 11 m 6-18wks N=7
    Mogil1 nociception assay (none) number of abdominal constrictions induced with acetic acid (i.p.), 20 min   [n]  AC_AA   2205 inbred 11 m 6-18wks N=6
    Mogil1 nociception assay (none) number of abdominal constrictions induced with magnesium sulfate (i.p.), 5 min   [n]  AC_MS   2206 inbred 11 m 6-18wks N=6
    Mogil1 nociception assay (none) percent hypersensitivity threshold to carrageenan-induced thermal hyperalgesia, treated and heated hindpaw withdrawal   [%]  CAR_HT   2207 inbred 11 m 6-18wks N=6
    Mogil1 nociception assay (none) duration of nociceptive response to acute inflammation (early phase), 0-10 min post-formalin (s.q.) injection   [s]  F_early   2208 inbred 11 m 6-18wks N=7
    Mogil1 nociception assay (none) duration of nociceptive response to subacute/chronic inflammation (late phase), 10-60 min post-formalin (s.q.) injection   [s]  F_late   2209 inbred 11 m 6-18wks N=7
    Mogil1 nociception assay (none) autotomy (neuropathy) score (1-11) following hindlimb denervation   [score]  AUT   2210 inbred 11 m 6-18wks N=9
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