Harrill2 animal documentation

Drug study: Survey of kidney injury due to DB289 treatment in females of 34 inbred strains of mice   (2012)

Harrill A

See also: Harrill2 protocol


Harrill1 Animal Documentation

Acclimation & testing periods

Vendor Mice 6-8 wks of age were obtained from The Jackson Laboratory (JAX®, Bar Harbor, ME) or Charles River (CD-1)
Ages
11-13 wks old at the time of testing
Feed
NIH-07 diet (Zeigler Brothers, Gardners, PA) given ad libitum, except during an 18 h period of fasting prior to necropsy
Water
Provided ad libitum
Temperature
18-26°C
Humidity
30-70%
Housing
Housed in polycarbonate cages; vehicle-treated mice housed 5/cage; DB289 treated mice housed 4/cage within the same strain
Bedding
Sani-Chips, irradiated hardwood bedding (P.J. Murphy Forest Products Corp., Montville, NJ)
Photoperiod
Automatic light controls set to provide fluorescent lighting for an approximate 12 h photo period (approximately 0700-1900h for light phase)
Health status
Care of mice followed institutional guidelines under a protocol approved by The Hamner Institutional Animal Care and Use Committee