Dietrich1: Bacillus anthracis lethal toxin susceptibility in females of 50 strains of mice (1998)

Dietrich WF   With: Watters JW, Boyden ED, Roberts JE, Ballard JD, Dewar K, Lehoczky J, Boyartchuk V

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• Download Dietrich1 strain means, SD, N, etc.     one row per strain/sex/measure
Participants William F Dietrich       Harvard Medical School Boston, MA
With: Watters JW, Boyden ED, Roberts JE, Ballard JD, Dewar K, Lehoczky J, Boyartchuk V
ContactWilliam F Dietrich     Lab web site
AcknowledgementsFunding provided by Howard Hughes Medical Institute; NIH AI22021, AI43321
Project type Phenotype strain survey data set
MPD identifiersDietrich1     MPD:15
Data changelog 3 updates/corrections.       Initial release date: 12/2001.
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"Resistant" is defined as cells that show greater than 90% viability when incubated 4 hr with lethal factor (LF; 10 micrograms/milliliter) and protective antigen (PA; 1 microgram/milliliter). "Susceptible" is defined as cells that show less than 10% viability under the same conditions.

Summary of procedures that were conducted
• in vitro assay Bacillus anthracis lethal toxin (anthrax) susceptibility.
Mice: inbred   50 strains   ♀   age 6-8wks*   1 cohort

References   (chronological)

1.   Roberts JE, Watters JW, Ballard JD, Dietrich WF. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11. Mol Microbiol. 1998 Jul;29(2):581-91.   PubMed 9720874  

2.   Watters JW, Dietrich WF. Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11. Genomics. 2001 Apr 15;73(2):223-31.   PubMed 11318612  

3.   Watters JW, Dewar K, Lehoczky J, Boyartchuk V, Dietrich WF. Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor. Curr Biol. 2001 Oct 2;11(19):1503-11.   PubMed 11591317  

4.   Boyden ED, Dietrich WF. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet. 2006 Feb;38(2):240-4. Epub 2006 Jan 22.   PubMed 16429160