Chesler1: High-throughput pain-related behavioral phenotyping in 61 BXD recombinant inbred strains of mice (2010)

Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ. High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains. Genes Brain Behav. 2010 Mar 1;9(2):129-59. Epub 2009 Sep 22.   PubMed 19958391     FullText

Chesler1 downloads
• Download Chesler1 project data set     one row per animal, one column per trait
• Download Chesler1 strain means, SD, N, etc.     one row per strain/sex/measure
• Chesler1 supplementary data
Participants Elissa J Chesler       The Jackson Laboratory Bar Harbor, ME
Vivek M Philip       The Jackson Laboratory Bar Harbor, ME
William R Lariviere       University of Pittsburgh School of Medicine Pittsburgh, PA
With: Spence JS
ContactElissa J Chesler     Lab web site
AcknowledgementsFunding provided by NIH DA020677, AA13509, AA13499, AA16662, DA021198; Office of Biological and Environmental Research; US Department of Energy
Project type Phenotype strain survey data set
MPD identifiersChesler1     MPD:348
Data changelog No updates/corrections.       Initial release date: 09/2010.
Formatted citation
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Summary of procedures that were conducted
• nociception assay Tail clip, Von Frey, Hargreaves, tail withdrawal, hot plate.
Mice: BXD   61 strains   ♀♂   age 7-15wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Chesler1 34801 nociception assay (none) latency of nociception to mechanical pressure on the tail   [s]  TC BXD 60 both 7-15wks N=7
    Chesler1 34810 nociception assay (none) mean sensory threshold eliciting withdrawal response from both hindfeet, Von Frey test days 1 and 2   [mN]  VF BXD 60 both 7-15wks N=7
    Chesler1 34819 nociception assay (none) mean latency of both hindpaws to withdraw, Hargreaves test trials 1-3   [s]  mean_HT BXD 60 both 7-15wks N=6
    Chesler1 34823 nociception assay (none) mean latency of tail withdrawal to thermal stimulation (trials 1, 2, 3)   [s]  mean_TW BXD 60 both 7-15wks N=7
    Chesler1 34829 nociception assay (none) mean latency of nociceptive response to hot plate (transformed)   [s]  mean_logN_HP BXD 60 both 7-15wks N=6
    All boxes