Benoist1: Survey of regulatory T cells (Treg) of the thymus and spleen in males of 33 inbred strains of mice (2007)

Feuerer M, Jiang W, Holler PD, Satpathy A, Campbell C, Bogue M, Mathis D, Benoist C. Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18181-6. Epub 2007 Nov 8.   PubMed 17991775     FullText


         
An investigation of strain differences in the production of regulatory T cells in thymus and spleen using flow cytometry.

Procedures conducted:
• immune cell quantification  Regulatory T cells (Treg), thymus, spleen.

Benoist1 downloads
• Download Benoist1 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators Christophe Benoist       Harvard Medical School,  Boston, MA
Diane Mathis       Harvard Medical School,  Boston, MA
Ansuman Satpathy       Washington University School of Medicine,  St. Louis, MO
Markus Feuerer       Harvard Medical School,  Boston, MA
Participants Jiang W, Holler P, Campbell C
ContactChristophe Benoist     Christophe_Benoist@hms.harvard.edu     Lab web site
AcknowledgementsFunding provided by NIH DK60027; German Research Foundation; Juvenile Diabetes Research Foundation 4-2004-368

Mice provided by the Mouse Phenome Project Collaborations Program, The Jackson Laboratory.

Acknowledgements: Technical assistance by Roser L, Hyatt E, Hattori K, LaVecchio J, Buruzala G.
Project type Phenotype strain survey data set
MPD identifiersBenoist1     MPD:258
Data changelog 1 update/correction.       Initial release date: 11/2008.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Mice: inbred   33 strains   ♂   age 5-6wks   1 experimental group

Sort/
Pick
Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
    Benoist1 immune cell quantification (none) percentage of thymic CD4 Treg cells that are CD25hi   [%]  Treg_thy_CD25   25801 inbred 33 m 5-6wks N=3
    Benoist1 immune cell quantification (none) percentage of thymic CD4 Treg cells that are Foxp3+   [%]  Treg_thy_Foxp3   25802 inbred 10 m 5-6wks N=3
    Benoist1 immune cell quantification (none) percentage of splenic CD4 Treg cells that are CD25hi   [%]  Treg_spl_CD25   25803 inbred 31 m 5-6wks N=3
    Benoist1 immune cell quantification (none) percentage of splenic CD4 Treg cells that are Foxp3+   [%]  Treg_spl_Foxp3   25804 inbred 10 m 5-6wks N=3
    All boxes