Project measure / variable:   GMC14   retinal_thickness_L

ID, description, units MPD:56351   retinal_thickness_L   retinal thickness, optical coherence tomography   [µm]  left eye  
Data set, strains GMC14   inbred w/CC8   8 strains     sex: both     age: 15-17wks
Procedure computed tomography
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  STRAIN COMPARISON PLOT
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GMC14 - retinal thickness, optical coherence tomography left eye



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means232   µm 233   µm
Median of the strain means228   µm 226   µm
SD of the strain means± 10.3 ± 10.4
Coefficient of variation (CV)0.0444 0.0447
Min–max range of strain means218   –   248   µm 223   –   249   µm
Mean sample size per strain13.1   mice 12.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 50.6897 50.6897 0.3775 0.5397
strain 7 20311.4621 2901.6374 21.609 < 0.0001
sex:strain 7 337.806 48.258 0.3594 0.9247
Residuals 187 25110.1605 134.2789


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 238.0 9.75   15 2.52 0.041 220.0, 255.0 0.58
129S1/SvImJ m 239.0 8.86   16 2.21 0.037 224.0, 255.0 0.61
A/J f 244.0 17.4   16 4.34 0.071 204.0, 280.0 1.17
A/J m 246.0 14.6   15 3.78 0.0596 213.0, 276.0 1.29
C57BL/6J f 248.0 9.68   16 2.42 0.0391 232.0, 266.0 1.55
C57BL/6J m 249.0 17.0   15 4.38 0.0683 228.0, 301.0 1.57
CAST/EiJ f 228.0 4.03   18 0.95 0.0177 222.0, 235.0 -0.39
CAST/EiJ m 225.0 8.98   14 2.4 0.0399 214.0, 243.0 -0.73
NOD/ShiLtJ f 218.0 14.4   18 3.41 0.0662 189.0, 248.0 -1.36
NOD/ShiLtJ m 223.0 12.9   16 3.22 0.0577 194.0, 245.0 -0.93
NZO/HlLtJ f 229.0 8.53   16 2.13 0.0372 216.0, 243.0 -0.29
NZO/HlLtJ m 227.0 8.53   16 2.13 0.0376 208.0, 243.0 -0.54
PWK/PhJ f 225.0 1.53   3 0.882 0.0068 223.0, 226.0 -0.68
PWK/PhJ m 226.0 4.95   2   3.5 0.0219 223.0, 230.0 -0.64
WSB/EiJ f 226.0 1.53   3 0.882 0.00675 225.0, 228.0 -0.58
WSB/EiJ m 226.0 4.5   4 2.25 0.0199 222.0, 232.0 -0.64


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 237.9333 2.992 243.8357 232.031
129S1/SvImJ m 239.3125 2.897 245.0274 233.5976
A/J f 244.3125 2.897 250.0274 238.5976
A/J m 245.7333 2.992 251.6357 239.831
C57BL/6J f 247.9375 2.897 253.6524 242.2226
C57BL/6J m 248.5333 2.992 254.4357 242.631
CAST/EiJ f 227.6667 2.7313 233.0548 222.2786
CAST/EiJ m 225.4286 3.097 231.5381 219.319
NOD/ShiLtJ f 218.2222 2.7313 223.6103 212.8341
NOD/ShiLtJ m 223.4375 2.897 229.1524 217.7226
NZO/HlLtJ f 229.4375 2.897 235.1524 223.7226
NZO/HlLtJ m 226.875 2.897 232.5899 221.1601
PWK/PhJ f 224.6667 6.6903 237.8648 211.4686
PWK/PhJ m 226.5 8.1939 242.6643 210.3357
WSB/EiJ f 226.3333 6.6903 239.5314 213.1352
WSB/EiJ m 225.75 5.7939 237.1799 214.3201


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 238.6229 2.0823 242.7308 234.515
A/J both 245.0229 2.0823 249.1308 240.915
C57BL/6J both 248.2354 2.0823 252.3433 244.1275
CAST/EiJ both 226.5476 2.0647 230.6206 222.4746
NOD/ShiLtJ both 220.8299 1.9908 224.7571 216.9026
NZO/HlLtJ both 228.1563 2.0485 232.1973 224.1152
PWK/PhJ both 225.5833 5.2891 236.0173 215.1493
WSB/EiJ both 226.0417 4.4252 234.7714 217.3119




  GWAS USING LINEAR MIXED MODELS