Project measure / variable:   GMC13   QTc_dispersion

ID, description, units MPD:56222   QTc_dispersion   QTc dispersion, calculated as rate-corrected QT dispersion   [ms]  
Data set, strains GMC13   inbred   6 strains     sex: both     age: 14-15wks
Procedure ECG
Ontology mappings

  STRAIN COMPARISON PLOT
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GMC13 - QTc dispersion, calculated as rate-corrected QT dispersion



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested6 strains6 strains
Mean of the strain means22.8   ms 22.5   ms
Median of the strain means22.3   ms 22.5   ms
SD of the strain means± 2.53 ± 1.48
Coefficient of variation (CV)0.111 0.0659
Min–max range of strain means19.9   –   27.3   ms 20.9   –   24.5   ms
Mean sample size per strain15.3   mice 14.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 3.9588 3.9588 0.0386 0.8446
strain 5 385.7895 77.1579 0.7514 0.5861
sex:strain 5 272.6873 54.5375 0.5311 0.7525
Residuals 166 17045.3299 102.6827


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 22.9 6.5   16 1.62 0.284 8.0, 36.0 0.06
129S1/SvImJ m 21.7 7.21   16 1.8 0.333 8.0, 32.0 -0.55
A/J f 27.3 12.7   16 3.18 0.466 14.0, 61.1 1.8
A/J m 23.3 12.8   16 3.21 0.551 1.0, 56.0 0.53
C57BL/6J f 21.4 5.32   16 1.33 0.249 13.3, 36.0 -0.53
C57BL/6J m 20.9 8.49   16 2.12 0.407 1.0, 35.0 -1.09
NOD/ShiLtJ f 21.7 5.38   12 1.55 0.248 14.0, 28.0 -0.41
NOD/ShiLtJ m 21.1 6.92   12 2.0 0.328 1.0, 27.0 -0.95
NZO/HlLtJ f 19.9 8.52   17 2.07 0.427 1.0, 34.0 -1.13
NZO/HlLtJ m 24.5 14.6   11 4.39 0.596 10.0, 58.0 1.34
PWK/PhJ f 23.3 14.0   15 3.63 0.604 8.0, 66.3 0.22
PWK/PhJ m 23.6 13.0   15 3.34 0.548 8.0, 64.4 0.73


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 22.8937 2.5333 27.8954 17.8921
129S1/SvImJ m 21.6625 2.5333 26.6642 16.6608
A/J f 27.2625 2.5333 32.2642 22.2608
A/J m 23.3062 2.5333 28.3079 18.3046
C57BL/6J f 21.3562 2.5333 26.3579 16.3546
C57BL/6J m 20.8687 2.5333 25.8704 15.8671
NOD/ShiLtJ f 21.6667 2.9252 27.4421 15.8912
NOD/ShiLtJ m 21.0833 2.9252 26.8588 15.3079
NZO/HlLtJ f 19.9412 2.4577 24.7935 15.0888
NZO/HlLtJ m 24.4545 3.0553 30.4868 18.4223
PWK/PhJ f 23.2533 2.6164 28.419 18.0876
PWK/PhJ m 23.6333 2.6164 28.799 18.4676


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 22.2781 1.7913 25.8148 18.7414
A/J both 25.2844 1.7913 28.8211 21.7477
C57BL/6J both 21.1125 1.7913 24.6492 17.5758
NOD/ShiLtJ both 21.375 2.0684 25.4588 17.2912
NZO/HlLtJ both 22.1979 1.9605 26.0687 18.327
PWK/PhJ both 23.4433 1.8501 27.096 19.7906




GWAS analysis not available: At least 12 strains are required