Project measure / variable:   GMC13   QTc

ID, description, units MPD:56217   QTc   duration of QTc interval, calculated by dividing QT interval by square root of preceeding RR interval   [ms]  
Data set, strains GMC13   inbred   6 strains     sex: both     age: 14-15wks
Procedure ECG
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  STRAIN COMPARISON PLOT
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GMC13 - duration of QTc interval, calculated by dividing QT interval by square root of preceeding RR interval



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested6 strains6 strains
Mean of the strain means44.0   ms 44.0   ms
Median of the strain means44.2   ms 44.1   ms
SD of the strain means± 1.09 ± 1.90
Coefficient of variation (CV)0.0247 0.0432
Min–max range of strain means42.2   –   45.3   ms 41.5   –   47.1   ms
Mean sample size per strain15.3   mice 14.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.0829 0.0829 0.0066 0.9352
strain 5 168.0877 33.6175 2.6886 0.023
sex:strain 5 148.202 29.6404 2.3706 0.0415
Residuals 166 2075.583 12.5035


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 45.3 3.12   16 0.781 0.0689 40.0, 50.0 1.18
129S1/SvImJ m 44.6 3.48   16 0.87 0.0781 38.5, 51.0 0.3
A/J f 44.5 5.12   16 1.28 0.115 36.0, 55.0 0.44
A/J m 44.4 4.83   16 1.21 0.109 36.0, 52.0 0.19
C57BL/6J f 42.2 2.67   16 0.667 0.0631 39.0, 48.0 -1.67
C57BL/6J m 43.9 2.25   16 0.564 0.0513 40.0, 48.0 -0.07
NOD/ShiLtJ f 44.7 3.31   12 0.956 0.0742 41.0, 50.0 0.63
NOD/ShiLtJ m 42.7 3.11   12 0.899 0.073 38.0, 50.0 -0.7
NZO/HlLtJ f 43.9 3.56   17 0.864 0.0812 38.0, 50.0 -0.11
NZO/HlLtJ m 47.1 2.7   11 0.814 0.0573 43.0, 52.0 1.61
PWK/PhJ f 43.5 3.26   15 0.841 0.0749 37.0, 50.0 -0.47
PWK/PhJ m 41.5 3.48   15 0.9 0.0839 37.0, 48.0 -1.33


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 45.3 0.884 47.0453 43.5547
129S1/SvImJ m 44.5812 0.884 46.3266 42.8359
A/J f 44.5187 0.884 46.2641 42.7734
A/J m 44.4187 0.884 46.1641 42.6734
C57BL/6J f 42.2437 0.884 43.9891 40.4984
C57BL/6J m 43.95 0.884 45.6953 42.2047
NOD/ShiLtJ f 44.6667 1.0208 46.682 42.6513
NOD/ShiLtJ m 42.6667 1.0208 44.682 40.6513
NZO/HlLtJ f 43.9059 0.8576 45.5991 42.2126
NZO/HlLtJ m 47.0909 1.0662 49.1959 44.9859
PWK/PhJ f 43.4933 0.913 45.2959 41.6907
PWK/PhJ m 41.5267 0.913 43.3293 39.7241


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 44.9406 0.6251 46.1748 43.7065
A/J both 44.4687 0.6251 45.7029 43.2346
C57BL/6J both 43.0969 0.6251 44.331 41.8627
NOD/ShiLtJ both 43.6667 0.7218 45.0917 42.2416
NZO/HlLtJ both 45.4984 0.6841 46.8491 44.1477
PWK/PhJ both 42.51 0.6456 43.7846 41.2354




  GWAS USING LINEAR MIXED MODELS