Project measure / variable:   GMC12   cardiac_output

ID, description, units MPD:56125   cardiac_output   cardiac output, volume of blood pumped by the heart per min   [mL/min]  
Data set, strains GMC12   inbred w/CC8   8 strains     sex: both     age: 14-15wks
Procedure echocardiography
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  STRAIN COMPARISON PLOT
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GMC12 - cardiac output, volume of blood pumped by the heart per min



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means10.7   mL/min 14.0   mL/min
Median of the strain means9.15   mL/min 12.4   mL/min
SD of the strain means± 4.05 ± 5.49
Coefficient of variation (CV)0.378 0.391
Min–max range of strain means6.46   –   19.1   mL/min 6.71   –   24.8   mL/min
Mean sample size per strain12.9   mice 12.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 601.6338 601.6338 50.2115 < 0.0001
strain 7 3855.742 550.8203 45.9707 < 0.0001
sex:strain 7 287.0443 41.0063 3.4223 0.0018
Residuals 188 2252.613 11.982


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 7.86 3.12   12 0.902 0.398 4.54, 13.0 -0.71
129S1/SvImJ m 6.71 1.97   12 0.568 0.293 3.81, 11.0 -1.33
A/J f 8.7 2.88   11 0.869 0.331 3.59, 14.5 -0.5
A/J m 11.8 3.59   12 1.04 0.305 5.11, 19.9 -0.41
C57BL/6J f 12.0 3.07   12 0.887 0.257 7.87, 16.7 0.32
C57BL/6J m 16.9 2.96   12 0.855 0.176 11.1, 21.0 0.52
CAST/EiJ f 9.61 3.61   13 1.0 0.376 5.37, 19.9 -0.27
CAST/EiJ m 10.4 1.83   10 0.578 0.176 6.8, 13.2 -0.66
NOD/ShiLtJ f 13.4 3.48   14 0.931 0.261 9.8, 20.3 0.66
NOD/ShiLtJ m 17.0 3.72   12 1.07 0.219 12.8, 24.7 0.54
NZO/HlLtJ f 19.1 2.99   13 0.828 0.157 15.4, 24.2 2.07
NZO/HlLtJ m 24.8 6.72   13 1.86 0.271 11.7, 36.7 1.96
PWK/PhJ f 6.46 2.27   15 0.586 0.351 3.14, 10.4 -1.05
PWK/PhJ m 12.9 3.92   18 0.925 0.305 5.93, 20.1 -0.21
WSB/EiJ f 8.64 3.95   13 1.1 0.457 4.71, 16.9 -0.51
WSB/EiJ m 11.8 0.979   12 0.283 0.0829 9.75, 13.1 -0.41


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 7.8552 0.9992 9.8264 5.8841
129S1/SvImJ m 6.7111 0.9992 8.6823 4.7399
A/J f 8.7021 1.0437 10.7609 6.6433
A/J m 11.7687 0.9992 13.7398 9.7975
C57BL/6J f 11.97 0.9992 13.9412 9.9988
C57BL/6J m 16.8729 0.9992 18.8441 14.9017
CAST/EiJ f 9.6119 0.96 11.5058 7.7181
CAST/EiJ m 10.4091 1.0946 12.5684 8.2498
NOD/ShiLtJ f 13.3657 0.9251 15.1907 11.5408
NOD/ShiLtJ m 16.9961 0.9992 18.9673 15.0249
NZO/HlLtJ f 19.0771 0.96 20.9709 17.1832
NZO/HlLtJ m 24.8103 0.96 26.7042 22.9165
PWK/PhJ f 6.4566 0.8938 8.2197 4.6935
PWK/PhJ m 12.8861 0.8159 14.4955 11.2766
WSB/EiJ f 8.6446 0.96 10.5385 6.7508
WSB/EiJ m 11.806 0.9992 13.7772 9.8348


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 7.2832 0.7066 8.677 5.8893
A/J both 10.2354 0.7225 11.6605 8.8102
C57BL/6J both 14.4215 0.7066 15.8153 13.0276
CAST/EiJ both 10.0105 0.728 11.4466 8.5744
NOD/ShiLtJ both 15.1809 0.6809 16.524 13.8378
NZO/HlLtJ both 21.9437 0.6789 23.2828 20.6045
PWK/PhJ both 9.6713 0.6051 10.8649 8.4777
WSB/EiJ both 10.2253 0.6929 11.5921 8.8585




  GWAS USING LINEAR MIXED MODELS