Project measure / variable:   GMC12   stroke_vol

ID, description, units MPD:56124   stroke_vol   stroke volume, volume of blood pumped from one ventricle of the heart with each beat   [µL]  
Data set, strains GMC12   inbred w/CC8   8 strains     sex: both     age: 14-15wks
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  STRAIN COMPARISON PLOT
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GMC12 - stroke volume, volume of blood pumped from one ventricle of the heart with each beat



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means18.3   µL 22.0   µL
Median of the strain means15.0   µL 19.1   µL
SD of the strain means± 7.82 ± 9.61
Coefficient of variation (CV)0.427 0.436
Min–max range of strain means11.8   –   31.3   µL 13.0   –   40.2   µL
Mean sample size per strain17.1   mice 16.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1105.6296 1105.6296 20.1141 < 0.0001
strain 7 17925.9959 2560.8566 46.5883 < 0.0001
sex:strain 7 338.0368 48.291 0.8785 0.524
Residuals 252 13851.8989 54.9679


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 11.8 4.68   16 1.17 0.397 5.72, 20.2 -0.83
129S1/SvImJ m 15.0 6.97   16 1.74 0.465 8.82, 34.1 -0.73
A/J f 11.8 4.97   15 1.28 0.423 4.92, 20.2 -0.83
A/J m 15.8 8.03   16 2.01 0.509 3.81, 35.2 -0.65
C57BL/6J f 22.0 8.18   16 2.05 0.372 11.6, 38.5 0.47
C57BL/6J m 24.1 11.1   16 2.77 0.459 11.3, 55.5 0.22
CAST/EiJ f 12.1 7.0   19 1.6 0.577 4.88, 37.2 -0.8
CAST/EiJ m 14.4 4.22   14 1.13 0.293 8.04, 21.5 -0.79
NOD/ShiLtJ f 17.9 5.15   18 1.21 0.287 12.0, 27.0 -0.05
NOD/ShiLtJ m 22.5 5.59   16 1.4 0.248 11.9, 33.4 0.05
NZO/HlLtJ f 31.3 7.83   17 1.9 0.25 24.1, 55.1 1.66
NZO/HlLtJ m 40.2 12.0   17 2.92 0.3 19.5, 65.8 1.89
PWK/PhJ f 27.5 7.57   19 1.74 0.275 16.6, 43.7 1.17
PWK/PhJ m 31.2 8.76   20 1.96 0.281 19.5, 51.2 0.95
WSB/EiJ f 12.2 5.73   17 1.39 0.472 4.84, 24.6 -0.78
WSB/EiJ m 13.0 4.39   16 1.1 0.339 5.48, 17.6 -0.94


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 11.7781 1.8535 15.4285 8.1278
129S1/SvImJ m 15.0006 1.8535 18.651 11.3503
A/J f 11.7507 1.9143 15.5207 7.9806
A/J m 15.7512 1.8535 19.4016 12.1009
C57BL/6J f 21.9756 1.8535 25.626 18.3253
C57BL/6J m 24.1419 1.8535 27.7922 20.4915
CAST/EiJ f 12.1153 1.7009 15.465 8.7655
CAST/EiJ m 14.4014 1.9815 18.3038 10.4991
NOD/ShiLtJ f 17.9433 1.7475 21.3849 14.5018
NOD/ShiLtJ m 22.4806 1.8535 26.131 18.8303
NZO/HlLtJ f 31.3165 1.7982 34.8578 27.7751
NZO/HlLtJ m 40.1676 1.7982 43.709 36.6263
PWK/PhJ f 27.5395 1.7009 30.8893 24.1897
PWK/PhJ m 31.167 1.6578 34.432 27.902
WSB/EiJ f 12.1541 1.7982 15.6955 8.6128
WSB/EiJ m 12.9594 1.8535 16.6097 9.309


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 13.3894 1.3106 15.9706 10.8082
A/J both 13.751 1.3323 16.3748 11.1271
C57BL/6J both 23.0587 1.3106 25.6399 20.4776
CAST/EiJ both 13.2583 1.3057 15.8298 10.6869
NOD/ShiLtJ both 20.212 1.2737 22.7204 17.7035
NZO/HlLtJ both 35.7421 1.2715 38.2462 33.2379
PWK/PhJ both 29.3532 1.1876 31.6921 27.0144
WSB/EiJ both 12.5567 1.2912 15.0997 10.0138




  GWAS USING LINEAR MIXED MODELS