Project measure / variable:   GMC07   latency_2

ID, description, units MPD:55612   latency_2   latency of nociceptive response to hot plate   [s]  reaction2  
Data set, strains GMC07   inbred w/CC8   8 strains     sex: both     age: 11-12wks
Procedure nociception assay
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  STRAIN COMPARISON PLOT
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GMC07 - latency of nociceptive response to hot plate reaction2



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means22.2   s 22.7   s
Median of the strain means22.9   s 23.5   s
SD of the strain means± 4.38 ± 4.91
Coefficient of variation (CV)0.198 0.216
Min–max range of strain means15.6   –   27.6   s 13.8   –   29.0   s
Mean sample size per strain17.5   mice 16.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 19.0041 19.0041 0.5996 0.4394
strain 7 4897.8678 699.6954 22.0749 < 0.0001
sex:strain 7 293.7446 41.9635 1.3239 0.2391
Residuals 259 8209.3571 31.6964


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 27.6 4.35   16 1.09 0.158 16.5, 30.0 1.24
129S1/SvImJ m 29.0 2.8   16 0.699 0.0964 19.7, 30.0 1.28
A/J f 23.6 7.9   16 1.98 0.335 9.5, 30.0 0.33
A/J m 21.6 8.12   16 2.03 0.376 6.4, 30.0 -0.22
C57BL/6J f 17.1 3.29   16 0.822 0.193 9.8, 23.0 -1.16
C57BL/6J m 18.2 3.85   16 0.963 0.211 13.9, 25.7 -0.92
CAST/EiJ f 23.6 5.63   19 1.29 0.238 15.4, 30.0 0.33
CAST/EiJ m 22.4 7.32   17 1.78 0.327 11.3, 30.0 -0.06
NOD/ShiLtJ f 22.1 5.45   18 1.28 0.246 13.8, 30.0 -0.02
NOD/ShiLtJ m 24.8 5.17   16 1.29 0.209 14.5, 30.0 0.43
NZO/HlLtJ f 15.6 5.58   17 1.35 0.358 8.8, 25.7 -1.5
NZO/HlLtJ m 13.8 3.97   17 0.963 0.287 8.4, 19.4 -1.81
PWK/PhJ f 27.5 4.05   20 0.906 0.147 17.2, 30.0 1.22
PWK/PhJ m 27.2 4.26   21 0.929 0.156 16.2, 30.0 0.92
WSB/EiJ f 20.3 8.35   18 1.97 0.412 8.9, 30.0 -0.43
WSB/EiJ m 24.6 6.08   16 1.52 0.247 10.0, 30.0 0.39


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 27.6063 1.4075 30.3778 24.8347
129S1/SvImJ m 28.9938 1.4075 31.7653 26.2222
A/J f 23.5563 1.4075 26.3278 20.7847
A/J m 21.5938 1.4075 24.3653 18.8222
C57BL/6J f 17.0625 1.4075 19.8341 14.2909
C57BL/6J m 18.225 1.4075 20.9966 15.4534
CAST/EiJ f 23.5947 1.2916 26.1381 21.0514
CAST/EiJ m 22.4118 1.3655 25.1006 19.7229
NOD/ShiLtJ f 22.1389 1.327 24.752 19.5258
NOD/ShiLtJ m 24.7688 1.4075 27.5403 21.9972
NZO/HlLtJ f 15.5941 1.3655 18.2829 12.9053
NZO/HlLtJ m 13.8471 1.3655 16.5359 11.1582
PWK/PhJ f 27.525 1.2589 30.004 25.046
PWK/PhJ m 27.2238 1.2286 29.643 24.8046
WSB/EiJ f 20.2722 1.327 22.8853 17.6592
WSB/EiJ m 24.5688 1.4075 27.3403 21.7972


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 28.3 0.9952 30.2598 26.3402
A/J both 22.575 0.9952 24.5348 20.6152
C57BL/6J both 17.6438 0.9952 19.6036 15.6839
CAST/EiJ both 23.0033 0.9398 24.8538 21.1527
NOD/ShiLtJ both 23.4538 0.9672 25.3584 21.5492
NZO/HlLtJ both 14.7206 0.9655 16.6219 12.8193
PWK/PhJ both 27.3744 0.8795 29.1063 25.6425
WSB/EiJ both 22.4205 0.9672 24.3251 20.5159




  GWAS USING LINEAR MIXED MODELS