Project measure / variable:   Johnson4   ABR_8kHz

ID, description, units MPD:42602   ABR_8kHz   auditory brainstem response (ABR) threshold, sound pressure level   [dB]  8 kHZ tone stimulus  
Data set, strains Johnson4   B6.PWD consomic w/par   28 strains     sex: both     age: 49-63wks
Procedure ABR test
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  STRAIN COMPARISON PLOT
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Johnson4 - auditory brainstem response (ABR) threshold, sound pressure level 8 kHZ tone stimulus



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested28 strains28 strains
Mean of the strain means71.6   dB 65.2   dB
Median of the strain means72.9   dB 65.3   dB
SD of the strain means± 11.2 ± 10.9
Coefficient of variation (CV)0.156 0.167
Min–max range of strain means42.3   –   88.0   dB 41.1   –   85.6   dB
Mean sample size per strain8.4   mice 8.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 3875.7873 3875.7873 32.2274 < 0.0001
strain 27 51621.2843 1911.8994 15.8975 < 0.0001
sex:strain 27 3655.229 135.3789 1.1257 0.3053
Residuals 400 48105.5393 120.2638


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6.PWD-Chr1 f 70.0 12.2   6 5.0 0.175 60.0, 90.0 -0.14
B6.PWD-Chr1 m 66.1 6.97   9 2.32 0.105 55.0, 75.0 0.09
B6.PWD-Chr10.1 f 61.5 15.8   10 5.0 0.257 30.0, 80.0 -0.91
B6.PWD-Chr10.1 m 58.1 10.7   8 3.77 0.184 40.0, 70.0 -0.65
B6.PWD-Chr10.2 f 43.9 11.1   9 3.71 0.253 30.0, 70.0 -2.48
B6.PWD-Chr10.2 m 41.1 7.41   9 2.47 0.18 35.0, 60.0 -2.22
B6.PWD-Chr10.3 f 70.0 14.1   9 4.71 0.202 45.0, 90.0 -0.14
B6.PWD-Chr10.3 m 60.0 11.2   7 4.23 0.186 40.0, 75.0 -0.48
B6.PWD-Chr11.1 f 73.1 11.6   8 4.11 0.159 50.0, 85.0 0.13
B6.PWD-Chr11.1 m 74.4 11.8   8 4.17 0.158 50.0, 85.0 0.85
B6.PWD-Chr11.2 f 71.0 15.6   5 6.96 0.219 45.0, 85.0 -0.05
B6.PWD-Chr11.2 m 76.7 7.91   9 2.64 0.103 65.0, 85.0 1.06
B6.PWD-Chr11.3 f 81.7 5.16   6 2.11 0.0632 75.0, 90.0 0.9
B6.PWD-Chr11.3 m 76.0 11.3   10 3.56 0.148 60.0, 100.0 1.0
B6.PWD-Chr12 f 78.6 12.1   7 4.59 0.155 55.0, 90.0 0.63
B6.PWD-Chr12 m 69.4 8.46   9 2.82 0.122 60.0, 80.0 0.39
B6.PWD-Chr13 f 82.5 7.58   6 3.1 0.0919 75.0, 95.0 0.98
B6.PWD-Chr13 m 72.5 8.86   8 3.13 0.122 55.0, 85.0 0.68
B6.PWD-Chr14 f 83.5 7.09   10 2.24 0.0849 70.0, 95.0 1.07
B6.PWD-Chr14 m 72.1 15.0   7 5.65 0.207 50.0, 85.0 0.64
B6.PWD-Chr15 f 77.2 11.8   9 3.92 0.152 60.0, 100.0 0.5
B6.PWD-Chr15 m 60.6 10.5   8 3.71 0.173 50.0, 80.0 -0.42
B6.PWD-Chr16 f 88.0 11.1   10 3.51 0.126 70.0, 100.0 1.47
B6.PWD-Chr16 m 78.8 6.41   8 2.27 0.0814 70.0, 85.0 1.26
B6.PWD-Chr17 f 67.1 15.5   7 5.86 0.231 45.0, 85.0 -0.4
B6.PWD-Chr17 m 62.9 9.06   7 3.43 0.144 50.0, 75.0 -0.21
B6.PWD-Chr18 f 53.1 12.8   8 4.53 0.241 35.0, 75.0 -1.66
B6.PWD-Chr18 m 45.7 6.73   7 2.54 0.147 35.0, 55.0 -1.79
B6.PWD-Chr19 f 82.5 14.4   8 5.09 0.174 60.0, 100.0 0.98
B6.PWD-Chr19 m 66.1 10.5   9 3.51 0.159 50.0, 80.0 0.09
B6.PWD-Chr2 f 87.9 7.56   7 2.86 0.086 80.0, 100.0 1.46
B6.PWD-Chr2 m 84.2 14.3   6 5.83 0.17 60.0, 100.0 1.75
B6.PWD-Chr3 f 66.2 14.1   8 4.98 0.213 40.0, 85.0 -0.49
B6.PWD-Chr3 m 65.0 11.9   7 4.5 0.183 45.0, 80.0 -0.02
B6.PWD-Chr5 f 79.0 13.3   10 4.2 0.168 50.0, 95.0 0.66
B6.PWD-Chr5 m 85.6 11.2   8 3.95 0.13 70.0, 100.0 1.88
B6.PWD-Chr6 f 72.8 11.5   9 3.83 0.158 55.0, 90.0 0.11
B6.PWD-Chr6 m 57.5 14.4   8 5.09 0.25 40.0, 85.0 -0.71
B6.PWD-Chr8 f 65.0 9.13   10 2.89 0.14 50.0, 80.0 -0.59
B6.PWD-Chr8 m 58.5 13.3   10 4.22 0.228 45.0, 85.0 -0.61
B6.PWD-Chr9 f 73.0 8.23   10 2.6 0.113 60.0, 85.0 0.12
B6.PWD-Chr9 m 64.4 10.2   8 3.59 0.158 50.0, 75.0 -0.07
B6.PWD-ChrX.1 f 73.1 10.3   8 3.65 0.141 60.0, 90.0 0.13
B6.PWD-ChrX.1 m 68.8 11.9   8 4.2 0.173 55.0, 90.0 0.34
B6.PWD-ChrX.2 f 75.9 9.17   11 2.76 0.121 60.0, 90.0 0.38
B6.PWD-ChrX.2 m 63.0 7.53   10 2.38 0.119 50.0, 75.0 -0.2
B6.PWD-ChrX.3 f 71.5 13.8   10 4.35 0.192 45.0, 90.0 -0.01
B6.PWD-ChrX.3 m 65.7 15.7   7 5.92 0.238 45.0, 85.0 0.05
B6.PWD-ChrY f 72.1 13.8   7 5.22 0.191 55.0, 90.0 0.04
B6.PWD-ChrY m 64.3 7.87   7 2.97 0.122 55.0, 75.0 -0.08
B6.PWD-mt f 73.8 5.18   8 1.83 0.0702 65.0, 80.0 0.2
B6.PWD-mt m 66.2 7.91   8 2.8 0.119 55.0, 80.0 0.1
C57BL/6J f 68.8 14.1   8 4.98 0.205 50.0, 90.0 -0.25
C57BL/6J m 58.8 2.5   4 1.25 0.0426 55.0, 60.0 -0.59
PWD/PhJ f 42.3 3.44   11 1.04 0.0813 35.0, 45.0 -2.63
PWD/PhJ m 42.1 6.36   7 2.4 0.151 35.0, 50.0 -2.13


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6.PWD-Chr1 f 70.0 4.477 78.8015 61.1985
B6.PWD-Chr1 m 66.1111 3.6555 73.2975 58.9247
B6.PWD-Chr10.1 f 61.5 3.4679 68.3176 54.6824
B6.PWD-Chr10.1 m 58.125 3.8772 65.7473 50.5027
B6.PWD-Chr10.2 f 43.8889 3.6555 51.0753 36.7025
B6.PWD-Chr10.2 m 41.1111 3.6555 48.2975 33.9247
B6.PWD-Chr10.3 f 70.0 3.6555 77.1864 62.8136
B6.PWD-Chr10.3 m 60.0 4.1449 68.1486 51.8514
B6.PWD-Chr11.1 f 73.125 3.8772 80.7473 65.5027
B6.PWD-Chr11.1 m 74.375 3.8772 81.9973 66.7527
B6.PWD-Chr11.2 f 71.0 4.9044 80.6415 61.3585
B6.PWD-Chr11.2 m 76.6667 3.6555 83.8531 69.4803
B6.PWD-Chr11.3 f 81.6667 4.477 90.4682 72.8652
B6.PWD-Chr11.3 m 76.0 3.4679 82.8176 69.1824
B6.PWD-Chr12 f 78.5714 4.1449 86.72 70.4228
B6.PWD-Chr12 m 69.4444 3.6555 76.6308 62.2581
B6.PWD-Chr13 f 82.5 4.477 91.3015 73.6985
B6.PWD-Chr13 m 72.5 3.8772 80.1223 64.8777
B6.PWD-Chr14 f 83.5 3.4679 90.3176 76.6824
B6.PWD-Chr14 m 72.1429 4.1449 80.2915 63.9943
B6.PWD-Chr15 f 77.2222 3.6555 84.4086 70.0358
B6.PWD-Chr15 m 60.625 3.8772 68.2473 53.0027
B6.PWD-Chr16 f 88.0 3.4679 94.8176 81.1824
B6.PWD-Chr16 m 78.75 3.8772 86.3723 71.1277
B6.PWD-Chr17 f 67.1429 4.1449 75.2915 58.9943
B6.PWD-Chr17 m 62.8571 4.1449 71.0057 54.7085
B6.PWD-Chr18 f 53.125 3.8772 60.7473 45.5027
B6.PWD-Chr18 m 45.7143 4.1449 53.8629 37.5657
B6.PWD-Chr19 f 82.5 3.8772 90.1223 74.8777
B6.PWD-Chr19 m 66.1111 3.6555 73.2975 58.9247
B6.PWD-Chr2 f 87.8571 4.1449 96.0057 79.7085
B6.PWD-Chr2 m 84.1667 4.477 92.9682 75.3652
B6.PWD-Chr3 f 66.25 3.8772 73.8723 58.6277
B6.PWD-Chr3 m 65.0 4.1449 73.1486 56.8514
B6.PWD-Chr5 f 79.0 3.4679 85.8176 72.1824
B6.PWD-Chr5 m 85.625 3.8772 93.2473 78.0027
B6.PWD-Chr6 f 72.7778 3.6555 79.9642 65.5914
B6.PWD-Chr6 m 57.5 3.8772 65.1223 49.8777
B6.PWD-Chr8 f 65.0 3.4679 71.8176 58.1824
B6.PWD-Chr8 m 58.5 3.4679 65.3176 51.6824
B6.PWD-Chr9 f 73.0 3.4679 79.8176 66.1824
B6.PWD-Chr9 m 64.375 3.8772 71.9973 56.7527
B6.PWD-ChrX.1 f 73.125 3.8772 80.7473 65.5027
B6.PWD-ChrX.1 m 68.75 3.8772 76.3723 61.1277
B6.PWD-ChrX.2 f 75.9091 3.3065 82.4094 69.4088
B6.PWD-ChrX.2 m 63.0 3.4679 69.8176 56.1824
B6.PWD-ChrX.3 f 71.5 3.4679 78.3176 64.6824
B6.PWD-ChrX.3 m 65.7143 4.1449 73.8629 57.5657
B6.PWD-ChrY f 72.1429 4.1449 80.2915 63.9943
B6.PWD-ChrY m 64.2857 4.1449 72.4343 56.1371
B6.PWD-mt f 73.75 3.8772 81.3723 66.1277
B6.PWD-mt m 66.25 3.8772 73.8723 58.6277
C57BL/6J f 68.75 3.8772 76.3723 61.1277
C57BL/6J m 58.75 5.4832 69.5296 47.9704
PWD/PhJ f 42.2727 3.3065 48.7731 35.7724
PWD/PhJ m 42.1429 4.1449 50.2915 33.9943


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6.PWD-Chr1 both 68.0556 2.8899 73.7369 62.3742
B6.PWD-Chr10.1 both 59.8125 2.6009 64.9257 54.6993
B6.PWD-Chr10.2 both 42.5 2.5848 47.5815 37.4185
B6.PWD-Chr10.3 both 65.0 2.7633 70.4324 59.5676
B6.PWD-Chr11.1 both 73.75 2.7416 79.1398 68.3602
B6.PWD-Chr11.2 both 73.8333 3.0584 79.8459 67.8208
B6.PWD-Chr11.3 both 78.8333 2.8315 84.3999 73.2668
B6.PWD-Chr12 both 74.0079 2.7633 79.4403 68.5755
B6.PWD-Chr13 both 77.5 2.9613 83.3216 71.6784
B6.PWD-Chr14 both 77.8214 2.7022 83.1337 72.5092
B6.PWD-Chr15 both 68.9236 2.6644 74.1615 63.6857
B6.PWD-Chr16 both 83.375 2.6009 88.4882 78.2618
B6.PWD-Chr17 both 65.0 2.9309 70.7619 59.2381
B6.PWD-Chr18 both 49.4196 2.8378 54.9986 43.8407
B6.PWD-Chr19 both 74.3056 2.6644 79.5435 69.0676
B6.PWD-Chr2 both 86.0119 3.0506 92.0091 80.0147
B6.PWD-Chr3 both 65.625 2.8378 71.204 60.046
B6.PWD-Chr5 both 82.3125 2.6009 87.4257 77.1993
B6.PWD-Chr6 both 65.1389 2.6644 70.3768 59.901
B6.PWD-Chr8 both 61.75 2.4522 66.5708 56.9292
B6.PWD-Chr9 both 68.6875 2.6009 73.8007 63.5743
B6.PWD-ChrX.1 both 70.9375 2.7416 76.3273 65.5477
B6.PWD-ChrX.2 both 69.4545 2.3958 74.1645 64.7446
B6.PWD-ChrX.3 both 68.6071 2.7022 73.9194 63.2949
B6.PWD-ChrY both 68.2143 2.9309 73.9762 62.4524
B6.PWD-mt both 70.0 2.7416 75.3898 64.6102
C57BL/6J both 63.75 3.3578 70.3511 57.1489
PWD/PhJ both 42.2078 2.6511 47.4197 36.9959




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA