Phenotype measure:   Korstanje1   ACR_M24


  STRAIN COMPARISON PLOT
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Korstanje1 - albumin-creatinine ratio (urine ACR) at age 24mo



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested24 strains24 strains
Mean of the strain means250   mg/g 191   mg/g
Median of the strain means94.8   mg/g 125   mg/g
SD of the strain means± 412 ± 234
Coefficient of variation (CV)1.65 1.23
Min–max range of strain means0   –   1875   mg/g 1.00   –   889   mg/g
Mean sample size per strain7.2   mice 6.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 178981.3361 178981.3361 0.7327 0.3928
strain 22 17964897.1721 816586.2351 3.3428 < 0.0001
sex:strain 22 14256138.6018 648006.3001 2.6527 0.0001
Residuals 274 66933255.4869 244281.9543


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 291.0 383.0   8 135.0 1.32 0.1
129S1/SvImJ m 143.0 118.0   6 48.3 0.826 7.0, 284.0 -0.2
A/J f 185.0 205.0   9 68.2 1.11 -0.16
A/J m 527.0 217.0   4 109.0 0.413 222.0, 697.0 1.44
BALB/cByJ f 0.0 0.0   7 0.0 0.0 -0.61
BALB/cByJ m 43.7 95.5   7 36.1 2.18 -0.63
BTBR T+ Itpr3tf/J m 8.6 19.2   5 8.6 2.24 -0.78
BUB/BnJ f 941.0 1046.0   6 427.0 1.11 1.68
BUB/BnJ m 35.3 37.4   6 15.3 1.06 -0.67
C3H/HeJ f 207.0 344.0   10 109.0 1.66 -0.1
C3H/HeJ m 44.6 57.3   8 20.2 1.28 -0.63
C57BL/10J f 62.7 33.7   9 11.2 0.538 -0.45
C57BL/10J m 168.0 109.0   9 36.4 0.65 29.0, 376.0 -0.1
C57BL/6J f 31.8 65.6   6 26.8 2.06 -0.53
C57BL/6J m 1.0 2.45   6 1.0 2.45 -0.81
C57BLKS/J f 28.2 49.3   8 17.4 1.74 -0.54
C57BLKS/J m 211.0 365.0   9 122.0 1.73 33.0, 1170.0 0.09
C57BR/cdJ f 32.0 44.8   6 18.3 1.4 -0.53
C57BR/cdJ m 22.6 58.0   7 21.9 2.57 -0.72
C57L/J f 39.0 58.2   6 23.8 1.49 -0.51
C57L/J m 112.0 119.0   7 45.2 1.06 -0.34
CBA/J f 51.1 90.0   8 31.8 1.76 -0.48
CBA/J m 28.6 26.2   7 9.92 0.918 -0.69
DBA/2J f 12.5 26.3   6 10.7 2.1 -0.58
DBA/2J m 71.3 58.2   6 23.7 0.815 -0.51
FVB/NJ f 61.9 159.0   8 56.2 2.57 -0.46
FVB/NJ m 318.0 241.0   7 91.0 0.756 78.0, 654.0 0.54
LP/J f 69.5 107.0   8 37.8 1.54 -0.44
LP/J m 4.29 11.3   7 4.29 2.65 -0.8
NOD.B10Sn-H2b/J f 38.6 56.8   5 25.4 1.47 -0.51
NOD.B10Sn-H2b/J m 22.0 16.4   6 6.69 0.745 -0.72
NON/ShiLtJ f 593.0 470.0   9 157.0 0.794 7.0, 1210.0 0.83
NON/ShiLtJ m 167.0 334.0   6 136.0 2.0 7.0, 848.0 -0.1
NZW/LacJ f 95.1 119.0   7 44.8 1.25 7.0, 286.0 -0.37
NZW/LacJ m 889.0 1376.0   6 562.0 1.55 15.0, 3110.0 2.98
P/J f 100.0 99.9   7 37.8 0.995 -0.36
PWD/PhJ f 484.0 389.0   7 147.0 0.803 164.0, 1290.0 0.57
PWD/PhJ m 479.0 547.0   8 194.0 1.14 125.0, 1730.0 1.23
RIIIS/J f 94.5 72.1   6 29.5 0.763 20.0, 197.0 -0.38
RIIIS/J m 154.0 55.9   6 22.8 0.362 96.0, 243.0 -0.16
SJL/J f 1875.0 2738.0   6 1118.0 1.46 3.94
SJL/J m 71.5 65.5   4 32.8 0.917 -0.51
SM/J f 117.0 234.0   6 95.4 2.0 -0.32
SM/J m 221.0 257.0   7 97.0 1.16 0.13
SWR/J f 176.0 198.0   8 69.9 1.13 -0.18
SWR/J m 138.0 322.0   7 122.0 2.32 -0.23
WSB/EiJ f 407.0 440.0   7 166.0 1.08 48.0, 1280.0 0.38
WSB/EiJ m 703.0 470.0   8 166.0 0.668 74.0, 1280.0 2.19


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 290.875 174.7434 634.8852 -53.1352
129S1/SvImJ m 143.1667 201.7763 540.3954 -254.0621
A/J f 184.8889 164.7496 509.2248 -139.447
A/J m 526.75 247.1244 1013.2539 40.2461
BALB/cByJ f 0.0 186.8085 367.7624 -367.7624
BALB/cByJ m 43.7143 186.8085 411.4767 -324.0481
BUB/BnJ f 940.8333 201.7763 1338.0621 543.6046
BUB/BnJ m 35.3333 201.7763 432.5621 -361.8954
C3H/HeJ f 206.9 156.2952 514.5921 -100.7921
C3H/HeJ m 44.625 174.7434 388.6352 -299.3852
C57BL/10J f 62.6667 164.7496 387.0026 -261.6693
C57BL/10J m 167.8889 164.7496 492.2248 -156.447
C57BL/6J f 31.8333 201.7763 429.0621 -365.3954
C57BL/6J m 1.0 201.7763 398.2288 -396.2288
C57BLKS/J f 28.25 174.7434 372.2602 -315.7602
C57BLKS/J m 211.2222 164.7496 535.5582 -113.1137
C57BR/cdJ f 32.0 201.7763 429.2288 -365.2288
C57BR/cdJ m 22.5714 186.8085 390.3338 -345.191
C57L/J f 39.0 201.7763 436.2288 -358.2288
C57L/J m 112.2857 186.8085 480.0481 -255.4767
CBA/J f 51.125 174.7434 395.1352 -292.8852
CBA/J m 28.5714 186.8085 396.3338 -339.191
DBA/2J f 12.5 201.7763 409.7288 -384.7288
DBA/2J m 71.3333 201.7763 468.5621 -325.8954
FVB/NJ f 61.875 174.7434 405.8852 -282.1352
FVB/NJ m 318.1429 186.8085 685.9052 -49.6195
LP/J f 69.5 174.7434 413.5102 -274.5102
LP/J m 4.2857 186.8085 372.0481 -363.4767
NOD.B10Sn-H2b/J f 38.6 221.0348 473.7423 -396.5423
NOD.B10Sn-H2b/J m 22.0 201.7763 419.2288 -375.2288
NON/ShiLtJ f 592.6667 164.7496 917.0026 268.3307
NON/ShiLtJ m 166.8333 201.7763 564.0621 -230.3954
NZW/LacJ f 95.1429 186.8085 462.9052 -272.6195
NZW/LacJ m 888.8333 201.7763 1286.0621 491.6046
PWD/PhJ f 484.1429 186.8085 851.9052 116.3805
PWD/PhJ m 479.25 174.7434 823.2602 135.2398
RIIIS/J f 94.5 201.7763 491.7288 -302.7288
RIIIS/J m 154.5 201.7763 551.7288 -242.7288
SJL/J f 1874.6667 201.7763 2271.8954 1477.4379
SJL/J m 71.5 247.1244 558.0039 -415.0039
SM/J f 116.6667 201.7763 513.8954 -280.5621
SM/J m 221.2857 186.8085 589.0481 -146.4767
SWR/J f 175.625 174.7434 519.6352 -168.3852
SWR/J m 138.4286 186.8085 506.191 -229.3338
WSB/EiJ f 407.0 186.8085 774.7624 39.2376
WSB/EiJ m 703.25 174.7434 1047.2602 359.2398


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 217.0208 133.4625 479.763 -45.7213
A/J both 355.8194 148.5033 648.1719 63.467
BALB/cByJ both 21.8571 132.0936 281.9044 -238.1901
BUB/BnJ both 488.0833 142.6774 768.9665 207.2002
C3H/HeJ both 125.7625 117.2214 356.5316 -105.0066
C57BL/10J both 115.2778 116.4956 344.6179 -114.0624
C57BL/6J both 16.4167 142.6774 297.2998 -264.4665
C57BLKS/J both 119.7361 120.0809 356.1345 -116.6623
C57BR/cdJ both 27.2857 137.4873 297.9515 -243.3801
C57L/J both 75.6429 137.4873 346.3086 -195.0229
CBA/J both 39.8482 127.899 291.6379 -211.9415
DBA/2J both 41.9167 142.6774 322.7998 -238.9665
FVB/NJ both 190.0089 127.899 441.7986 -61.7808
LP/J both 36.8929 127.899 288.6826 -214.8968
NOD.B10Sn-H2b/J both 30.3 149.6413 324.8927 -264.2927
NON/ShiLtJ both 379.75 130.246 636.1601 123.3399
NZW/LacJ both 491.9881 137.4873 762.6539 221.3223
PWD/PhJ both 481.6964 127.899 733.4861 229.9067
RIIIS/J both 124.5 142.6774 405.3832 -156.3832
SJL/J both 973.0833 159.5181 1287.1203 659.0464
SM/J both 168.9762 137.4873 439.642 -101.6896
SWR/J both 157.0268 127.899 408.8165 -94.7629
WSB/EiJ both 555.125 127.899 806.9147 303.3353




  GWAS USING LINEAR MIXED MODELS