Phenotype measure:   Korstanje1   ACR_M12


  STRAIN COMPARISON PLOT
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Korstanje1 - albumin-creatinine ratio (urine ACR) at age 12mo



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested30 strains30 strains
Mean of the strain means82.7   mg/g 35.6   mg/g
Median of the strain means34.7   mg/g 14.8   mg/g
SD of the strain means± 129 ± 59.1
Coefficient of variation (CV)1.56 1.66
Min–max range of strain means0   –   484   mg/g 0   –   294   mg/g
Mean sample size per strain7.5   mice 7.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 212651.8725 212651.8725 6.7331 0.0098
strain 29 2171843.5671 74891.1575 2.3712 0.0001
sex:strain 29 2339299.3769 80665.4958 2.5541 < 0.0001
Residuals 388 12254273.746 31583.1798


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 170.0 434.0   8 154.0 2.55 0.68
129S1/SvImJ m 12.4 15.3   8 5.4 1.23 -0.39
A/J f 65.4 121.0   8 42.8 1.85 -0.13
A/J m 58.6 63.8   8 22.6 1.09 0.39
BALB/cByJ f 0.0 0.0   8 0.0 0.0 -0.64
BALB/cByJ m 0.0 0.0   8 0.0 0.0 -0.6
BTBR T+ Itpr3tf/J f 57.8 155.0   8 54.8 2.68 -0.19
BTBR T+ Itpr3tf/J m 0.0 0.0   8 0.0 0.0 -0.6
BUB/BnJ f 480.0 607.0   8 214.0 1.27 3.09
BUB/BnJ m 16.7 15.7   6 6.39 0.939 -0.32
C3H/HeJ f 110.0 67.0   8 23.7 0.611 33.0, 227.0 0.21
C3H/HeJ m 7.25 9.11   8 3.22 1.26 -0.48
C57BL/10J f 0.875 2.47   8 0.875 2.83 -0.64
C57BL/10J m 4.75 5.68   8 2.01 1.19 -0.52
C57BL/6J f 5.12 14.5   8 5.12 2.83 -0.6
C57BL/6J m 13.2 28.5   8 10.1 2.15 -0.38
C57BLKS/J f 21.6 33.6   7 12.7 1.56 -0.47
C57BLKS/J m 19.6 51.8   7 19.6 2.65 -0.27
C57BR/cdJ f 0.0 0.0   7 0.0 0.0 -0.64
C57BR/cdJ m 0.0 0.0   8 0.0 0.0 -0.6
C57L/J f 8.88 25.1   8 8.88 2.83 -0.57
C57L/J m 22.6 50.4   8 17.8 2.23 -0.22
CAST/EiJ f 7.43 9.85   7 3.72 1.33 -0.58
CAST/EiJ m 87.3 70.3   7 26.6 0.805 10.0, 209.0 0.88
CBA/J f 0.0 0.0   7 0.0 0.0 -0.64
CBA/J m 24.3 16.7   7 6.3 0.687 -0.19
DBA/2J f 98.2 225.0   6 91.9 2.29 0.12
DBA/2J m 9.6 14.0   5 6.28 1.46 -0.44
FVB/NJ f 4.0 10.6   7 4.0 2.65 -0.61
FVB/NJ m 16.9 28.4   8 10.0 1.68 -0.32
KK/HlJ f 484.0 655.0   7 248.0 1.35 3.12
KK/HlJ m 53.1 65.3   8 23.1 1.23 9.0, 206.0 0.3
LP/J f 3.5 9.9   8 3.5 2.83 -0.62
LP/J m 0.0 0.0   8 0.0 0.0 -0.6
MRL/MpJ f 144.0 316.0   7 119.0 2.19 0.48
MRL/MpJ m 5.38 15.2   8 5.38 2.83 -0.51
NOD.B10Sn-H2b/J f 0.0 0.0   7 0.0 0.0 -0.64
NOD.B10Sn-H2b/J m 294.0 548.0   10 173.0 1.86 4.38
NON/ShiLtJ f 303.0 344.0   8 122.0 1.14 1.71
NON/ShiLtJ m 24.0 18.8   8 6.64 0.783 -0.2
NZO/HlLtJ f 35.0 59.4   7 22.5 1.7 -0.37
NZO/HlLtJ m 135.0 201.0   6 82.2 1.5 1.68
NZW/LacJ f 18.6 35.3   8 12.5 1.9 -0.5
NZW/LacJ m 10.1 14.0   8 4.95 1.38 -0.43
P/J f 65.0 117.0   7 44.1 1.8 -0.14
P/J m 0.75 1.5   4 0.75 2.0 -0.59
PL/J f 15.1 40.1   7 15.1 2.65 -0.53
PL/J m 2.17 3.37   6 1.38 1.56 -0.57
PWD/PhJ f 0.0 0.0   8 0.0 0.0 -0.64
PWD/PhJ m 99.4 132.0   8 46.6 1.33 1.08
RIIIS/J f 45.1 103.0   8 36.3 2.28 -0.29
RIIIS/J m 12.8 13.8   8 4.89 1.09 -0.39
SJL/J f 175.0 205.0   5 91.8 1.17 0.72
SJL/J m 4.25 6.2   8 2.19 1.46 -0.53
SM/J f 83.9 173.0   8 61.2 2.06 0.01
SM/J m 48.2 40.6   9 13.5 0.842 0.21
SWR/J f 44.4 25.0   8 8.85 0.564 -0.3
SWR/J m 16.5 14.8   6 6.06 0.9 -0.32
WSB/EiJ f 34.4 30.4   7 11.5 0.882 -0.38
WSB/EiJ m 67.9 31.8   8 11.2 0.468 32.0, 113.0 0.55


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 170.5 62.8323 294.0344 46.9656
129S1/SvImJ m 12.375 62.8323 135.9094 -111.1594
A/J f 65.375 62.8323 188.9094 -58.1594
A/J m 58.625 62.8323 182.1594 -64.9094
BALB/cByJ f 0.0 62.8323 123.5344 -123.5344
BALB/cByJ m 0.0 62.8323 123.5344 -123.5344
BTBR T+ Itpr3tf/J f 57.75 62.8323 181.2844 -65.7844
BTBR T+ Itpr3tf/J m 0.0 62.8323 123.5344 -123.5344
BUB/BnJ f 479.5 62.8323 603.0344 355.9656
BUB/BnJ m 16.6667 72.5525 159.3119 -125.9786
C3H/HeJ f 109.75 62.8323 233.2844 -13.7844
C3H/HeJ m 7.25 62.8323 130.7844 -116.2844
C57BL/10J f 0.875 62.8323 124.4094 -122.6594
C57BL/10J m 4.75 62.8323 128.2844 -118.7844
C57BL/6J f 5.125 62.8323 128.6594 -118.4094
C57BL/6J m 13.25 62.8323 136.7844 -110.2844
C57BLKS/J f 21.5714 67.1706 153.6352 -110.4924
C57BLKS/J m 19.5714 67.1706 151.6352 -112.4924
C57BR/cdJ f 0.0 67.1706 132.0638 -132.0638
C57BR/cdJ m 0.0 62.8323 123.5344 -123.5344
C57L/J f 8.875 62.8323 132.4094 -114.6594
C57L/J m 22.625 62.8323 146.1594 -100.9094
CAST/EiJ f 7.4286 67.1706 139.4924 -124.6352
CAST/EiJ m 87.2857 67.1706 219.3495 -44.7781
CBA/J f 0.0 67.1706 132.0638 -132.0638
CBA/J m 24.2857 67.1706 156.3495 -107.7781
DBA/2J f 98.1667 72.5525 240.8119 -44.4786
DBA/2J m 9.6 79.4773 165.86 -146.66
FVB/NJ f 4.0 67.1706 136.0638 -128.0638
FVB/NJ m 16.875 62.8323 140.4094 -106.6594
KK/HlJ f 484.2857 67.1706 616.3495 352.2219
KK/HlJ m 53.125 62.8323 176.6594 -70.4094
LP/J f 3.5 62.8323 127.0344 -120.0344
LP/J m 0.0 62.8323 123.5344 -123.5344
MRL/MpJ f 143.8571 67.1706 275.921 11.7933
MRL/MpJ m 5.375 62.8323 128.9094 -118.1594
NOD.B10Sn-H2b/J f 0.0 67.1706 132.0638 -132.0638
NOD.B10Sn-H2b/J m 294.5 56.1989 404.9925 184.0075
NON/ShiLtJ f 302.875 62.8323 426.4094 179.3406
NON/ShiLtJ m 24.0 62.8323 147.5344 -99.5344
NZO/HlLtJ f 35.0 67.1706 167.0638 -97.0638
NZO/HlLtJ m 134.6667 72.5525 277.3119 -7.9786
NZW/LacJ f 18.625 62.8323 142.1594 -104.9094
NZW/LacJ m 10.125 62.8323 133.6594 -113.4094
P/J f 65.0 67.1706 197.0638 -67.0638
P/J m 0.75 88.8583 175.454 -173.954
PL/J f 15.1429 67.1706 147.2067 -116.921
PL/J m 2.1667 72.5525 144.8119 -140.4786
PWD/PhJ f 0.0 62.8323 123.5344 -123.5344
PWD/PhJ m 99.375 62.8323 222.9094 -24.1594
RIIIS/J f 45.125 62.8323 168.6594 -78.4094
RIIIS/J m 12.75 62.8323 136.2844 -110.7844
SJL/J f 175.2 79.4773 331.46 18.94
SJL/J m 4.25 62.8323 127.7844 -119.2844
SM/J f 83.875 62.8323 207.4094 -39.6594
SM/J m 48.2222 59.2389 164.6916 -68.2471
SWR/J f 44.375 62.8323 167.9094 -79.1594
SWR/J m 16.5 72.5525 159.1452 -126.1452
WSB/EiJ f 34.4286 67.1706 166.4924 -97.6352
WSB/EiJ m 67.875 62.8323 191.4094 -55.6594


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 91.4375 44.4291 178.7895 4.0855
A/J both 62.0 44.4291 149.352 -25.352
BALB/cByJ both 0.0 44.4291 87.352 -87.352
BTBR T+ Itpr3tf/J both 28.875 44.4291 116.227 -58.477
BUB/BnJ both 248.0833 47.989 342.4343 153.7324
C3H/HeJ both 58.5 44.4291 145.852 -28.852
C57BL/10J both 2.8125 44.4291 90.1645 -84.5395
C57BL/6J both 9.1875 44.4291 96.5395 -78.1645
C57BLKS/J both 20.5714 47.4968 113.9546 -72.8118
C57BR/cdJ both 0.0 45.9885 90.4179 -90.4179
C57L/J both 15.75 44.4291 103.102 -71.602
CAST/EiJ both 47.3571 47.4968 140.7404 -46.0261
CBA/J both 12.1429 47.4968 105.5261 -81.2404
DBA/2J both 53.8833 53.8064 159.6719 -51.9052
FVB/NJ both 10.4375 45.9885 100.8554 -79.9804
KK/HlJ both 268.7054 45.9885 359.1233 178.2874
LP/J both 1.75 44.4291 89.102 -85.602
MRL/MpJ both 74.6161 45.9885 165.034 -15.8018
NOD.B10Sn-H2b/J both 147.25 43.7898 233.3451 61.1549
NON/ShiLtJ both 163.4375 44.4291 250.7895 76.0855
NZO/HlLtJ both 84.8333 49.4362 182.0297 -12.363
NZW/LacJ both 14.375 44.4291 101.727 -72.977
P/J both 32.875 55.6949 142.3765 -76.6265
PL/J both 8.6548 49.4362 105.8511 -88.5416
PWD/PhJ both 49.6875 44.4291 137.0395 -37.6645
RIIIS/J both 28.9375 44.4291 116.2895 -58.4145
SJL/J both 89.725 50.657 189.3216 -9.8716
SM/J both 66.0486 43.1774 150.9395 -18.8423
SWR/J both 30.4375 47.989 124.7884 -63.9134
WSB/EiJ both 51.1518 45.9885 141.5697 -39.2661




  GWAS USING LINEAR MIXED MODELS