Project measure / variable:   Jaxpheno3   CK16

ID, description, units MPD:22818   CK16   creatine kinase (plasma CK)   [IU/L]  at age 16wks  
Data set, strains Jaxpheno3   inbred   8 strains     sex: both     age: 16wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Jaxpheno3 - creatine kinase (plasma CK) at age 16wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means699   IU/L 457   IU/L
Median of the strain means696   IU/L 494   IU/L
SD of the strain means± 305 ± 169
Coefficient of variation (CV)0.436 0.370
Min–max range of strain means289   –   1251   IU/L 110   –   607   IU/L
Mean sample size per strain16.2   mice 16.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1092372.9929 1092372.9929 6.4471 0.0117
strain 7 5404185.3378 772026.4768 4.5564 0.0001
sex:strain 7 5536392.2144 790913.1735 4.6679 0.0001
Residuals 245 41512115.5929 169437.2065


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6D2F1/J f 1251.0 851.0   10 269.0 0.68 320.0, 3406.0 1.81
B6D2F1/J m 433.0 195.0   10 61.8 0.451 194.0, 745.0 -0.14
BALB/cByJ f 609.0 416.0   20 93.0 0.683 80.0, 1242.0 -0.29
BALB/cByJ m 443.0 230.0   20 51.4 0.519 80.0, 890.0 -0.08
C3H/HeJ f 867.0 608.0   10 192.0 0.702 93.0, 2128.0 0.55
C3H/HeJ m 339.0 390.0   10 123.0 1.15 58.0, 1080.0 -0.7
C57BL/6J f 358.0 314.0   30 57.3 0.878 91.0, 1437.0 -1.12
C57BL/6J m 601.0 270.0   30 49.3 0.449 91.0, 1217.0 0.85
CBA/J f 761.0 307.0   10 97.1 0.403 190.0, 1328.0 0.2
CBA/J m 577.0 645.0   20 144.0 1.12 55.0, 2185.0 0.71
DBA/2J f 289.0 110.0   10 34.8 0.381 92.0, 465.0 -1.35
DBA/2J m 110.0 83.5   10 26.4 0.762 23.0, 312.0 -2.05
NOD.CB17-Prkdcscid/J f 824.0 475.0   10 150.0 0.576 304.0, 1867.0 0.41
NOD.CB17-Prkdcscid/J m 546.0 331.0   10 105.0 0.606 245.0, 1096.0 0.53
NOD/ShiLtJ f 631.0 494.0   30 90.3 0.783 69.0, 1948.0 -0.22
NOD/ShiLtJ m 607.0 288.0   21 62.8 0.474 153.0, 1131.0 0.89


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6D2F1/J f 1251.4 130.168 1507.7912 995.0088
B6D2F1/J m 433.1 130.168 689.4912 176.7088
BALB/cByJ f 608.7 92.0427 789.996 427.404
BALB/cByJ m 442.9 92.0427 624.196 261.604
C3H/HeJ f 866.7 130.168 1123.0912 610.3088
C3H/HeJ m 339.4 130.168 595.7912 83.0088
C57BL/6J f 357.8667 75.1526 505.8942 209.8391
C57BL/6J m 600.9 75.1526 748.9275 452.8725
CBA/J f 760.8 130.168 1017.1912 504.4088
CBA/J m 576.55 92.0427 757.846 395.254
DBA/2J f 288.9 130.168 545.2912 32.5088
DBA/2J m 109.6 130.168 365.9912 0.0
NOD.CB17-Prkdcscid/J f 824.1 130.168 1080.4912 567.7088
NOD.CB17-Prkdcscid/J m 546.3 130.168 802.6912 289.9088
NOD/ShiLtJ f 631.3667 75.1526 779.3942 483.3391
NOD/ShiLtJ m 607.0952 89.8245 784.022 430.1685


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6D2F1/J both 842.25 92.0427 1023.546 660.954
BALB/cByJ both 525.8 65.084 653.9956 397.6044
C3H/HeJ both 603.05 92.0427 784.346 421.754
C57BL/6J both 479.3833 53.1409 584.0546 374.7121
CBA/J both 668.675 79.7113 825.6819 511.6681
DBA/2J both 199.25 92.0427 380.546 17.954
NOD.CB17-Prkdcscid/J both 685.2 92.0427 866.496 503.904
NOD/ShiLtJ both 619.231 58.5584 734.5731 503.8888




  GWAS USING LINEAR MIXED MODELS