Project measure / variable:   Jaxpheno3   CK8

ID, description, units MPD:22817   CK8   creatine kinase (plasma CK)   [IU/L]  at age 8wks  
Data set, strains Jaxpheno3   inbred   11 strains     sex: both     age: 8wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Jaxpheno3 - creatine kinase (plasma CK) at age 8wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested11 strains11 strains
Mean of the strain means973   IU/L 894   IU/L
Median of the strain means841   IU/L 827   IU/L
SD of the strain means± 372 ± 343
Coefficient of variation (CV)0.383 0.384
Min–max range of strain means498   –   1609   IU/L 428   –   1331   IU/L
Mean sample size per strain15.8   mice 17.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 924477.8545 924477.8545 3.0358 0.0823
strain 10 16973994.3199 1697399.432 5.5739 < 0.0001
sex:strain 10 21345806.9065 2134580.6907 7.0096 < 0.0001
Residuals 376 114501244.8185 304524.5873


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6.129P2-Apoetm1Unc/J f 841.0 415.0   10 131.0 0.494 394.0, 1820.0 -0.35
B6.129P2-Apoetm1Unc/J m 447.0 391.0   10 124.0 0.874 134.0, 1481.0 -1.3
B6D2F1/J f 1609.0 962.0   10 304.0 0.598 447.0, 3040.0 1.71
B6D2F1/J m 1091.0 822.0   10 260.0 0.753 409.0, 3329.0 0.57
BALB/cByJ f 1111.0 651.0   20 146.0 0.586 199.0, 2652.0 0.37
BALB/cByJ m 545.0 250.0   20 56.0 0.459 166.0, 1065.0 -1.02
BALB/cJ f 768.0 492.0   20 110.0 0.641 111.0, 1889.0 -0.55
BALB/cJ m 428.0 287.0   22 61.1 0.67 105.0, 1054.0 -1.36
C3H/HeJ f 1317.0 491.0   10 155.0 0.373 445.0, 2359.0 0.93
C3H/HeJ m 1081.0 683.0   10 216.0 0.632 468.0, 2546.0 0.54
C57BL/6J f 720.0 545.0   30 99.5 0.757 173.0, 2150.0 -0.68
C57BL/6J m 799.0 611.0   52 84.7 0.765 97.0, 3045.0 -0.28
CBA/J f 650.0 477.0   21 104.0 0.733 102.0, 1777.0 -0.87
CBA/J m 827.0 450.0   30 82.2 0.544 226.0, 1861.0 -0.2
DBA/2J f 1504.0 813.0   21 177.0 0.541 427.0, 2982.0 1.43
DBA/2J m 698.0 477.0   20 107.0 0.683 150.0, 1658.0 -0.57
FVB/NJ f 498.0 270.0   10 85.4 0.542 192.0, 1042.0 -1.28
FVB/NJ m 1325.0 627.0   12 181.0 0.473 492.0, 2432.0 1.26
NOD.CB17-Prkdcscid/J f 1029.0 578.0   10 183.0 0.562 197.0, 2250.0 0.15
NOD.CB17-Prkdcscid/J m 1331.0 536.0   10 169.0 0.403 625.0, 2151.0 1.27
NOD/ShiLtJ f 651.0 337.0   20 75.4 0.518 179.0, 1235.0 -0.86
NOD/ShiLtJ m 1264.0 601.0   20 134.0 0.475 473.0, 2423.0 1.08


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6.129P2-Apoetm1Unc/J f 840.7 174.5063 1183.8306 497.5694
B6.129P2-Apoetm1Unc/J m 446.8 174.5063 789.9306 103.6694
B6D2F1/J f 1609.3 174.5063 1952.4306 1266.1694
B6D2F1/J m 1091.2 174.5063 1434.3306 748.0694
BALB/cByJ f 1111.25 123.3946 1353.88 868.62
BALB/cByJ m 544.95 123.3946 787.58 302.32
BALB/cJ f 767.9 123.3946 1010.53 525.27
BALB/cJ m 427.6818 117.6521 659.0204 196.3432
C3H/HeJ f 1317.3 174.5063 1660.4306 974.1694
C3H/HeJ m 1080.7 174.5063 1423.8306 737.5694
C57BL/6J f 719.8333 100.7513 917.9399 521.7268
C57BL/6J m 798.8846 76.5261 949.3573 648.4119
CBA/J f 650.3333 120.4208 887.116 413.5507
CBA/J m 827.4333 100.7513 1025.5399 629.3268
DBA/2J f 1503.5238 120.4208 1740.3064 1266.7412
DBA/2J m 698.2 123.3946 940.83 455.57
FVB/NJ f 498.2 174.5063 841.3306 155.0694
FVB/NJ m 1324.75 159.3018 1637.984 1011.516
NOD.CB17-Prkdcscid/J f 1029.0 174.5063 1372.1306 685.8694
NOD.CB17-Prkdcscid/J m 1331.0 174.5063 1674.1306 987.8694
NOD/ShiLtJ f 651.2 123.3946 893.83 408.57
NOD/ShiLtJ m 1263.95 123.3946 1506.58 1021.32


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6.129P2-Apoetm1Unc/J both 643.75 123.3946 886.38 401.12
B6D2F1/J both 1350.25 123.3946 1592.88 1107.62
BALB/cByJ both 828.1 87.2532 999.6653 656.5347
BALB/cJ both 597.7909 85.2471 765.4117 430.1702
C3H/HeJ both 1199.0 123.3946 1441.63 956.37
C57BL/6J both 759.359 63.2595 883.7457 634.9722
CBA/J both 738.8833 78.5048 893.2467 584.52
DBA/2J both 1100.8619 86.2082 1270.3725 931.3513
FVB/NJ both 911.475 118.1413 1143.7755 679.1745
NOD.CB17-Prkdcscid/J both 1180.0 123.3946 1422.63 937.37
NOD/ShiLtJ both 957.575 87.2532 1129.1403 786.0097




  GWAS USING LINEAR MIXED MODELS