Project measure / variable:   Jaxpheno3   ALT16

ID, description, units MPD:22816   ALT16   alanine transaminase (plasma ALT)   [IU/L]  at age 16wks  
Data set, strains Jaxpheno3   inbred   8 strains     sex: both     age: 16wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Jaxpheno3 - alanine transaminase (plasma ALT) at age 16wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means47.0   IU/L 57.4   IU/L
Median of the strain means44.2   IU/L 51.1   IU/L
SD of the strain means± 12.2 ± 25.8
Coefficient of variation (CV)0.259 0.450
Min–max range of strain means32.4   –   64.9   IU/L 30.0   –   97.9   IU/L
Mean sample size per strain16.2   mice 16.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 5682.3671 5682.3671 2.5038 0.1149
strain 7 47460.7569 6780.1081 2.9875 0.005
sex:strain 7 43828.377 6261.1967 2.7588 0.0089
Residuals 245 556029.6714 2269.5089


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6D2F1/J f 59.5 26.4   10 8.35 0.444 34.0, 114.0 1.02
B6D2F1/J m 55.3 39.8   10 12.6 0.721 23.0, 156.0 -0.08
BALB/cByJ f 57.5 40.3   20 9.01 0.7 24.0, 166.0 0.86
BALB/cByJ m 81.7 77.4   20 17.3 0.948 30.0, 306.0 0.94
C3H/HeJ f 44.7 32.4   10 10.3 0.725 24.0, 135.0 -0.19
C3H/HeJ m 97.9 118.0   10 37.4 1.21 27.0, 373.0 1.57
C57BL/6J f 39.9 30.8   30 5.63 0.774 25.0, 197.0 -0.59
C57BL/6J m 79.0 74.6   30 13.6 0.945 36.0, 394.0 0.84
CBA/J f 33.9 4.51   10 1.43 0.133 28.0, 40.0 -1.08
CBA/J m 30.0 11.9   20 2.67 0.398 17.0, 69.0 -1.06
DBA/2J f 32.4 10.8   10 3.4 0.332 23.0, 59.0 -1.2
DBA/2J m 30.2 10.9   10 3.46 0.362 18.0, 54.0 -1.05
NOD.CB17-Prkdcscid/J f 43.6 3.69   10 1.17 0.0846 39.0, 51.0 -0.28
NOD.CB17-Prkdcscid/J m 46.9 12.1   10 3.83 0.258 31.0, 68.0 -0.41
NOD/ShiLtJ f 64.9 44.4   30 8.1 0.684 5.0, 181.0 1.47
NOD/ShiLtJ m 38.2 12.7   21 2.78 0.334 23.0, 78.0 -0.74


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6D2F1/J f 59.5 15.0649 89.1732 29.8268
B6D2F1/J m 55.3 15.0649 84.9732 25.6268
BALB/cByJ f 57.55 10.6525 78.5321 36.5679
BALB/cByJ m 81.65 10.6525 102.6321 60.6679
C3H/HeJ f 44.7 15.0649 74.3732 15.0268
C3H/HeJ m 97.9 15.0649 127.5732 68.2268
C57BL/6J f 39.8667 8.6977 56.9985 22.7348
C57BL/6J m 78.9667 8.6977 96.0985 61.8348
CBA/J f 33.9 15.0649 63.5732 4.2268
CBA/J m 30.0 10.6525 50.9821 9.0179
DBA/2J f 32.4 15.0649 62.0732 2.7268
DBA/2J m 30.2 15.0649 59.8732 0.5268
NOD.CB17-Prkdcscid/J f 43.6 15.0649 73.2732 13.9268
NOD.CB17-Prkdcscid/J m 46.9 15.0649 76.5732 17.2268
NOD/ShiLtJ f 64.9 8.6977 82.0318 47.7682
NOD/ShiLtJ m 38.1905 10.3958 58.6669 17.714


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6D2F1/J both 57.4 10.6525 78.3821 36.4179
BALB/cByJ both 69.6 7.5324 84.4366 54.7634
C3H/HeJ both 71.3 10.6525 92.2821 50.3179
C57BL/6J both 59.4167 6.1502 71.5307 47.3026
CBA/J both 31.95 9.2253 50.1211 13.7789
DBA/2J both 31.3 10.6525 52.2821 10.3179
NOD.CB17-Prkdcscid/J both 45.25 10.6525 66.2321 24.2679
NOD/ShiLtJ both 51.5452 6.7772 64.8943 38.1962




  GWAS USING LINEAR MIXED MODELS