MPD: JaxKOMP-EAP genotype: Cpa5<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Cpa5^em1(IMPC)J/Mmjax -/- Gene Cpa5

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-0.85010	3.5564	-0.52605	0.949	0.815
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-1.6748	6.9512	-0.35218	0.949	0.814
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	2.6316	5.2453	0.38188	0.871	0.625
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-7.7576	3.1783	-1.2883	0.240	0.0311
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-6.7554	4.4453	-1.0109	0.532	0.154
body composition	body length	0.071376	0.10869	1.1427	0.775	0.520
body composition	body weight (at time of DXA)	4.0691	0.98565	2.6684	0.00677	0.000571
body composition	bone area, whole body scan, head excluded	0.38409	0.22576	1.7535	0.333	0.106
body composition	bone mineral content of whole body scan, head excluded	0.016339	0.017812	1.0634	0.654	0.371
body composition	bone mineral content to body weight ratio	-0.00049339	0.00049305	-0.45180	0.601	0.330
body composition	bone mineral density of whole body scan, head excluded	0.00022488	0.00092672	0.26606	0.918	0.811
body composition	fat tissue mass of whole body scan, head excluded	-0.43199	0.68043	-0.79618	0.756	0.533
body composition	fat tissue mass to body weight ratio	0.0061143	0.018809	0.34678	0.881	0.749
body composition	lean tissue mass of whole body scan, head excluded	0.13233	0.70546	0.11906	0.943	0.853
body composition	lean tissue mass to body weight ratio	-0.017907	0.018638	-0.97802	0.605	0.349
body composition	percent fat, whole body scan, head excluded	0.84926	1.7866	0.47765	0.814	0.640
body composition	ratio of soft-tissue attenuation coefficients	-0.00094517	0.0019853	-0.48031	0.814	0.639
body composition	tissue area	0.81422	0.31057	2.1096	0.134	0.0173
body composition	total tissue mass, whole body scan, head excluded	0.22612	0.43858	0.28364	0.791	0.612
clinical blood chemistry	alanine transaminase (plasma ALT)	-8.8427	4.7180	-0.75358	0.421	0.0764
clinical blood chemistry	albumin (plasma Alb)	0.55063	0.35335	0.80875	0.446	0.136
clinical blood chemistry	alkaline phosphatase (plasma ALP)	1.6323	3.3618	-0.25423	0.809	0.633
clinical blood chemistry	aspartate transaminase (plasma AST)	-16.923	8.0394	-0.78942	0.290	0.0488
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.11666	0.15647	-0.36416	0.809	0.465
clinical blood chemistry	blood urea nitrogen (BUN)	1.0841	1.6114	0.39793	0.737	0.509
clinical blood chemistry	calcium (plasma Ca)	-0.28706	0.079348	-1.6348	0.0242	0.00197
clinical blood chemistry	creatinine (plasma)	-0.024631	0.027782	-0.45552	0.627	0.386
clinical blood chemistry	glucose (plasma GLU, no fast)	-3.8829	16.482	0.13683	0.900	0.816
clinical blood chemistry	HDL cholesterol (plasma HDL)	7.0972	2.6017	1.2716	0.126	0.0134
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.029165	0.0075274	1.4008	0.0349	0.00111
clinical blood chemistry	phosphorus (plasma phosphate)	-0.89436	0.30217	-1.3964	0.0837	0.00805
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.041634	0.016560	-2.2255	0.177	0.0211
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	6.8832	3.4708	0.90748	0.269	0.0620
clinical blood chemistry	total protein (plasma TP)	0.63453	0.39948	0.42187	0.413	0.129
clinical blood chemistry	triglyceride (plasma TG, no fast)	-6.7101	14.999	-0.15080	0.843	0.660
glucose tolerance test	amount glucose injected	-1.1197	2.3972	0.021314	0.880	0.643
glucose tolerance test	plasma glucose, 0min	1.7158	4.6535	-0.057687	0.850	0.714
glucose tolerance test	plasma glucose, 15min	17.053	24.342	0.60623	0.776	0.488
glucose tolerance test	plasma glucose, 30min	50.936	22.183	1.5528	0.184	0.0276
glucose tolerance test	plasma glucose, 60min	25.286	15.657	1.0893	0.393	0.115
glucose tolerance test	plasma glucose, 120min	9.1786	6.3837	0.49750	0.470	0.159
grip strength	body weight (at time of grip strength test)	1.4262	0.63379	1.4461	0.104	0.0308
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-5.4795	6.5351	-0.16338	0.614	0.408
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.22460	0.29559	-0.11791	0.651	0.453
grip strength	forelimb and hindlimb grip strength by trial, trial1	2.0955	7.8393	0.37299	0.921	0.791
grip strength	forelimb and hindlimb grip strength by trial, trial2	-13.331	7.5292	-0.61110	0.275	0.0856
grip strength	forelimb and hindlimb grip strength by trial, trial3	-5.2029	8.8065	-0.14721	0.776	0.559
grip strength	forelimb grip strength (mean of trials), average	-7.0481	4.2748	-0.63224	0.327	0.108
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.22623	0.20516	-0.34357	0.555	0.278
grip strength	forelimb grip strength by trial, trial1	2.5189	5.2436	0.54585	0.854	0.634
grip strength	forelimb grip strength by trial, trial2	-6.6116	5.1856	-0.50418	0.537	0.211
grip strength	forelimb grip strength by trial, trial3	-16.796	5.9257	-1.4132	0.0957	0.00767
heart weight	heart weight, normalized to body weight	0.058711	0.20017	-0.24081	0.876	0.772
heart weight	heart weight, weight	5.3111	5.7923	0.31243	0.580	0.368
hematology	basophil differential (percent of total WBC)	0.068449	0.044020	0.98585	0.567	0.135
hematology	eosinophil differential (percent of total WBC)	0.38171	0.26931	1.1401	0.563	0.171
hematology	hematocrit (HCT)	1.1413	0.48363	0.95369	0.188	0.0280
hematology	lymphocyte differential (percent of total WBC)	-1.0686	1.1385	-0.49823	0.605	0.359
hematology	mean corpuscular hemoglobin (CHr)	0.024706	0.082422	0.24080	0.889	0.767
hematology	mean platelet volume (MPV)	0.11783	0.061617	0.57726	0.207	0.0696
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.28591	0.17154	0.63126	0.435	0.110
hematology	mean RBC corpuscular volume (MCV)	-0.32028	0.21786	-0.58368	0.350	0.156
hematology	measured hemoglobin (mHGB)	0.48126	0.14018	1.0178	0.0532	0.00250
hematology	monocyte differential (percent of total WBC)	-0.19874	0.40298	-0.45991	0.859	0.627
hematology	neutrophil differential (percent of total WBC)	0.82043	0.78328	0.45232	0.551	0.307
hematology	platelet count (PLT; units per volume x 10³)	-33.007	71.319	-0.39402	0.865	0.648
hematology	RBC corpuscular distribution width (RDW)	0.17044	0.16804	0.58466	0.579	0.322
hematology	red blood cell count (RBC; per volume x 10⁶)	0.32470	0.12765	1.0815	0.138	0.0189
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-35.657	20.361	-1.3416	0.447	0.0952
hematology	reticulocyte differential (percent of total RBC)	-0.46426	0.21001	-1.5777	0.315	0.0389
hematology	white blood cell count (WBC; units per volume x 10³)	-0.76455	0.55027	-0.36903	0.376	0.179
holeboard	number of hole pokes by individual hole number, 20 min test, 1	1.3643	0.89975	1.2314	0.643	0.140
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.33266	0.56023	0.63941	0.887	0.557
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.40000	0.59715	0.74229	0.880	0.508
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.47161	1.0093	-0.40311	0.894	0.644
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.38571	0.60283	0.72462	0.880	0.527
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.19139	0.44237	-0.52401	0.945	0.668
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.50087	0.46711	1.2750	0.837	0.293
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.53571	0.56671	1.0157	0.807	0.352
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.52143	0.55854	1.0040	0.814	0.358
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.60000	0.41946	1.4168	0.746	0.163
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.013889	0.40344	0.047313	0.993	0.973
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.50000	0.50550	0.89625	0.768	0.331
holeboard	number of hole pokes by individual hole number, 20 min test, 13	1.9357	0.94667	1.6874	0.396	0.0500
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.10000	0.53422	-0.084442	0.973	0.853
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.93571	0.56377	1.4045	0.570	0.108
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.29525	0.87512	0.29785	0.933	0.738
holeboard	total number of hole pokes, 20 min test	8.1571	5.8460	1.1175	0.453	0.174
light / dark	latency to enter dark zone, 20 min test	102.68	44.602	1.5790	0.327	0.0269
light / dark	number of transitions between light and dark zones, 20 min test	-6.1118	4.0984	-0.50311	0.444	0.144
light / dark	percentage of total time in dark zone, 20 min test	-3.3085	5.9016	-0.47871	0.837	0.578
light / dark	percentage of total time in light zone, 20 min test	3.3085	5.9016	0.47568	0.836	0.578
light / dark	time mobile in dark zone, 20 min test	-12.886	6.2055	-0.88439	0.219	0.0447
light / dark	time mobile in light zone, 20 min test	4.2874	5.2213	0.039218	0.673	0.417
light / dark	time spent in dark zone, 20 min test	-113.23	64.018	-1.3848	0.444	0.0850
light / dark	time spent in light zone, 20 min test	113.23	64.018	1.3848	0.444	0.0850
open field	average speed in center of arena, 20 min test	-0.13926	0.39733	-0.35434	0.903	0.728
open field	average speed in periphery of arena, 20 min test	-0.057267	0.20233	-0.74134	0.878	0.779
open field	distance traveled habituation ratio, 20 min test	-7.3396	7.2849	-0.61134	0.639	0.320
open field	distance traveled in center of arena, 20 min test	6.8795	139.15	-0.34150	0.978	0.961
open field	distance traveled in periphery of arena, 20 min test	-110.42	205.93	-0.88528	0.775	0.595
open field	distance traveled slope, 20 min test	-7.7928	7.1999	-0.68421	0.613	0.286
open field	distance traveled, 20 min test, 1st 5min	15.083	84.132	-0.20894	0.941	0.859
open field	distance traveled, 20 min test, 2nd 5min	-9.3792	84.620	-0.60649	0.957	0.912
open field	distance traveled, 20 min test, 3rd 5min	-52.631	77.055	-1.0343	0.721	0.499
open field	distance traveled, 20 min test, 4th 5min	-51.083	75.359	-1.0458	0.729	0.502
open field	number of clockwise revolution episodes, 20 min test	1.3122	1.3856	0.35955	0.700	0.349
open field	number of counter-clockwise revolution episodes, 20 min test	-2.2655	1.8476	-1.7244	0.512	0.227
open field	number of rears in 5 min bins, 20 min test, 1st 5min	3.8318	2.5784	0.84392	0.390	0.145
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	1.8347	4.2155	0.11234	0.840	0.666
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	5.5277	3.7767	0.96137	0.410	0.151
open field	number of rears in 5 min bins, 20 min test, 4th 5min	2.8857	3.5446	0.30754	0.688	0.421
open field	percentage of total time in center of arena, 20 min test	-1.9262	4.2596	-0.67407	0.868	0.654
open field	percentage of total time in center of arena, slope, 20 min test	-6.0315	2.3708	-2.4592	0.319	0.0150
open field	percentage of total time in center, habituation ratio, 20 min test	-5.7877	2.4268	-2.4592	0.332	0.0220
open field	percentage of total time in corners of arena, 20 min test	5.0026	3.7417	1.1995	0.498	0.189
open field	percentage of total time in corners, habituation ratio, 20 min test	2.3630	1.5705	0.77172	0.626	0.140
open field	percentage of total time in corners, slope, 20 min test	2.6301	1.5987	0.90938	0.593	0.108
open field	permanence time in center of arena, 20 min test	-23.121	51.117	-0.67238	0.869	0.654
open field	permanence time in corners of arena, 20 min test	60.021	44.905	1.1995	0.498	0.189
open field	permanence time in periphery of arena, 20 min test	23.122	51.116	0.67238	0.869	0.654
open field	total distance traveled, 20 min test	-95.396	290.29	-0.77716	0.869	0.744
open field	total number of rears, 20 min test	13.161	12.071	0.55876	0.539	0.282
open field	whole arena average speed, 20 min test	-0.080440	0.24177	-0.78080	0.868	0.741
open field	whole arena resting time, 20 min test	24.190	43.158	1.2276	0.742	0.578
open field	whole arena time spent mobile, 20 min test	-3.8370	6.9984	-0.72029	0.751	0.587
open field	whole arena time spent vertical, 20 min test	8.2442	7.2449	0.52918	0.566	0.262
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	1.4221	1.4557	0.77065	0.640	0.336
startle / PPI	average baseline movement during background noise	0.16992	1.5232	0.21819	0.995	0.912
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.045875	0.096445	0.32288	0.840	0.639
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.023609	0.081578	0.15704	0.904	0.775
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	9.7899	10.670	1.1174	0.879	0.368
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-5.5989	8.0570	-0.57773	0.787	0.494
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-1.5549	8.2467	-0.26436	0.941	0.852
startle / PPI	average startle response to full pulse (120 dB)	123.11	44.309	1.8541	0.0695	0.0107
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	114.90	44.687	1.7675	0.0863	0.0171
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	119.97	38.543	1.8781	0.0373	0.00490
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	65.222	33.433	1.4093	0.216	0.0639
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	1.0118	1.9155	0.71778	0.913	0.602
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	3.7408	1.6404	1.6984	0.444	0.0322
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	7.1717	2.4784	2.0288	0.196	0.00819
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.11884	0.11599	1.1575	0.869	0.316
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.044649	0.083065	-0.46745	0.838	0.596
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.054940	0.086462	0.28270	0.758	0.532
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	123.01	44.919	1.8541	0.0734	0.0117
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	114.01	45.656	1.7743	0.0954	0.0201
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	116.34	39.160	1.8541	0.0472	0.00684
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	58.655	32.653	1.3689	0.251	0.0862
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.14584	0.13158	1.2908	0.853	0.279
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.036684	0.095923	-0.36397	0.871	0.706
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.10279	0.096666	0.57231	0.569	0.299
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	471.31	162.07	1.9206	0.0547	0.00792
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	438.77	167.58	1.8091	0.0799	0.0154
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	437.34	143.46	1.8620	0.0408	0.00570
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	208.65	112.92	1.3271	0.231	0.0781
startle / PPI	maximum baseline movement during background noise	0.85482	3.3236	0.36450	0.960	0.799
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	12.610	12.026	1.3137	0.888	0.305
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-4.9701	9.1929	-0.50791	0.832	0.594
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	9.1016	9.5821	0.71416	0.641	0.353
startle / PPI	maximum startle response to full pulse (120 dB)	471.95	161.00	1.9296	0.0526	0.00750
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	439.95	165.80	1.8164	0.0751	0.0142
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	448.62	142.17	1.8947	0.0339	0.00442
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	226.12	114.72	1.3980	0.203	0.0614
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	1.6160	4.7855	0.57939	0.948	0.739
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	11.531	3.7005	2.0179	0.257	0.00486
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	19.396	6.4865	2.1124	0.141	0.00654

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	11.0 %	0.323
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	5.0 %	0.387
eye morphology	cornea vascularization	females	13.0 %	0.167
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	7.0 %	0.208
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.0
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.0
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.0
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.00
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.00
eye morphology	fusion between cornea and lens	females	4.0 %	1.0
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.0
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.0
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.0
eye morphology	lacrimation	females	3.0 %	1.00
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.00
eye morphology	lens	females	10.0 %	1.0
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	9.0 %	1.00
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	6.0 %	1.00
eye morphology	lens opacity	both	7.0 %	1.00
eye morphology	narrow eye opening	females	2.0 %	1.00
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.0
eye morphology	optic disc	males	2.0 %	1.00
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	15.0 %	0.239
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	6.0 %	0.344
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.00
eye morphology	pupil dilation	both	2.0 %	1.00
eye morphology	pupil light response	females	2.0 %	1.0
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.0
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.0
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	23.0 %	0.174
eye morphology	retina	both	10.0 %	0.432
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.00
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.00
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.0
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.00
eye morphology	retinal structure	females	4.0 %	1.0
eye morphology	retinal structure	males	2.0 %	1.00
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.00
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.0
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.0
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.0
SHIRPA	body length	both	0.0 %	1.0
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.0
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.00
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	14.0 %	0.0405
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	7.0 %	0.0786
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.00
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.0
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.0
SHIRPA	contact righting	both	5.0 %	1.0
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.0
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.00
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.0
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.0
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.0
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.0
SHIRPA	head morphology	both	0.0 %	1.00
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.0
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.0
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.0
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.0
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.618
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.0
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.0
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.00
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.0
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.00
SHIRPA	tail elevation	females	1.0 %	1.0
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.0
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.0
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.0
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.00
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.0
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.00
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	27.0 %	0.00707
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	14.0 %	0.0104
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.0
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Cpa5^em1(IMPC)J/Mmjax -/- with genotype: