MPD: JaxKOMP-EAP genotype: Fam171a1<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Fam171a1^em1(IMPC)J/Mmjax -/- Gene Fam171a1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-2.6141	1.5942	-0.99069	0.629	0.200
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-4.5112	4.6405	-0.94025	0.813	0.403
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	0.62923	5.5030	-0.037644	0.975	0.916
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-6.1364	4.4921	-1.0465	0.651	0.265
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-2.2727	4.4206	-0.38804	0.860	0.643
body composition	body length	-0.26068	0.054554	-1.8552	0.00216	0.0000508
body composition	body weight (at time of DXA)	-0.90467	0.72347	-0.57053	0.437	0.221
body composition	bone area, whole body scan, head excluded	-0.66871	0.15575	-1.9684	0.00564	0.000190
body composition	bone mineral content of whole body scan, head excluded	-0.050068	0.012610	-1.9977	0.0127	0.000455
body composition	bone mineral content to body weight ratio	-0.0017969	0.00044622	-1.7998	0.00931	0.000391
body composition	bone mineral density of whole body scan, head excluded	-0.0012670	0.00068810	-1.2647	0.296	0.0762
body composition	fat tissue mass of whole body scan, head excluded	1.7997	0.52517	2.1779	0.0303	0.00191
body composition	fat tissue mass to body weight ratio	0.064380	0.019871	2.2082	0.0351	0.00308
body composition	lean tissue mass of whole body scan, head excluded	-1.4514	0.58131	-2.3775	0.149	0.0187
body composition	lean tissue mass to body weight ratio	-0.042459	0.016569	-1.9682	0.116	0.0161
body composition	percent fat, whole body scan, head excluded	5.7234	1.8652	2.2406	0.0472	0.00474
body composition	ratio of soft-tissue attenuation coefficients	-0.0065454	0.0021284	-2.2747	0.0461	0.00466
body composition	tissue area	-0.54079	0.33546	-1.4773	0.381	0.118
body composition	total tissue mass, whole body scan, head excluded	0.48105	0.46120	0.79618	0.559	0.306
clinical blood chemistry	alanine transaminase (plasma ALT)	-45.943	18.138	-2.4397	0.237	0.0180
clinical blood chemistry	albumin (plasma Alb)	-0.31525	0.55115	-0.39656	0.828	0.572
clinical blood chemistry	alkaline phosphatase (plasma ALP)	1.8042	4.1293	-0.21635	0.827	0.666
clinical blood chemistry	aspartate transaminase (plasma AST)	-21.142	14.385	-0.97348	0.468	0.154
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	1.0124	0.23980	2.2988	0.0332	0.000301
clinical blood chemistry	blood urea nitrogen (BUN)	5.3133	1.3831	1.9671	0.0177	0.000744
clinical blood chemistry	calcium (plasma Ca)	-0.31696	0.075831	-1.7743	0.00818	0.000334
clinical blood chemistry	creatinine (plasma)	0.034563	0.021447	0.92742	0.330	0.120
clinical blood chemistry	glucose (plasma GLU, no fast)	-35.393	12.178	-0.92168	0.0440	0.00775
clinical blood chemistry	HDL cholesterol (plasma HDL)	-1.8213	2.4008	-0.72379	0.736	0.455
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.0015709	0.0099047	-0.053403	0.969	0.875
clinical blood chemistry	phosphorus (plasma phosphate)	0.53421	0.42645	0.74555	0.503	0.222
clinical blood chemistry	total bilirubin (plasma TBIL)	0.015904	0.0053164	1.0170	0.0877	0.00616
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-1.8323	3.3645	-0.55881	0.832	0.591
clinical blood chemistry	total protein (plasma TP)	-0.68036	0.71663	-0.60786	0.619	0.352
clinical blood chemistry	triglyceride (plasma TG, no fast)	64.780	30.684	2.4363	0.221	0.0449
ERG v2.0	left eye a-wave amplitude (Photopic)	3.2281	1.6841	1.0308	0.465	0.0875
ERG v2.0	left eye a-wave amplitude (Scotopic)	49.708	20.447	1.4898	0.319	0.0379
ERG v2.0	left eye a-wave implicit timing (Photopic)	-1.3750	0.95637	-0.55949	0.743	0.184
ERG v2.0	left eye a-wave implicit timing (Scotopic)	-1.6328	0.73606	-1.3147	0.403	0.0537
ERG v2.0	left eye b-wave amplitude (Photopic)	-5.0553	5.9706	-0.61361	0.795	0.419
ERG v2.0	left eye b-wave amplitude (Scotopic)	-129.48	52.280	-1.7306	0.302	0.0352
ERG v2.0	left eye b-wave implicit timing (Photopic)	-5.5234	4.2817	-1.0787	0.594	0.229
ERG v2.0	left eye b-wave implicit timing (Scotopic)	-20.766	7.0318	-1.8098	0.236	0.0161
ERG v2.0	left eye c-wave amplitude (Scotopic)	-67.417	34.402	-1.1190	0.422	0.0817
ERG v2.0	left eye c-wave implicit timing (Scotopic)	20.031	90.466	0.14897	0.961	0.830
ERG v2.0	left eye FO-like wave amplitude (Scotopic)	83.203	41.444	0.95001	0.448	0.0756
ERG v2.0	left eye FO-like wave implicit timing (Scotopic)	427.44	231.52	1.5603	0.556	0.0979
ERG v2.0	right eye a-wave amplitude (Photopic)	4.4044	1.7335	1.4272	0.349	0.0317
ERG v2.0	right eye a-wave amplitude (Scotopic)	50.270	16.857	1.5253	0.257	0.0175
ERG v2.0	right eye a-wave implicit timing (Photopic)	-2.5391	1.9888	-1.2389	0.774	0.234
ERG v2.0	right eye a-wave implicit timing (Scotopic)	0.18773	0.64931	0.18322	0.932	0.780
ERG v2.0	right eye b-wave amplitude (Photopic)	-7.9352	5.5917	-0.85106	0.623	0.194
ERG v2.0	right eye b-wave amplitude (Scotopic)	-159.72	46.256	-1.9752	0.170	0.00866
ERG v2.0	right eye b-wave implicit timing (Photopic)	-1.3594	1.1763	-0.15453	0.651	0.278
ERG v2.0	right eye b-wave implicit timing (Scotopic)	-7.0508	8.4323	-0.62694	0.824	0.425
ERG v2.0	right eye c-wave amplitude (Scotopic)	-121.15	31.403	-2.1609	0.148	0.00482
ERG v2.0	right eye c-wave implicit timing (Scotopic)	139.08	280.66	1.1384	0.867	0.632
ERG v2.0	right eye FO-like wave amplitude (Scotopic)	124.83	33.355	1.5803	0.109	0.00461
ERG v2.0	right eye FO-like wave implicit timing (Scotopic)	-349.66	301.21	-1.0690	0.801	0.276
glucose tolerance test	amount glucose injected	0.45230	2.8803	0.50384	0.958	0.876
glucose tolerance test	plasma glucose, 0min	11.397	5.5847	0.91261	0.166	0.0508
glucose tolerance test	plasma glucose, 15min	-19.283	26.708	-0.41222	0.767	0.476
glucose tolerance test	plasma glucose, 30min	7.9726	22.934	0.36338	0.892	0.731
glucose tolerance test	plasma glucose, 60min	16.987	17.627	0.78842	0.673	0.344
glucose tolerance test	plasma glucose, 120min	30.291	8.4902	1.7770	0.0434	0.00137
grip strength	body weight (at time of grip strength test)	-1.9416	0.71595	-1.4138	0.0575	0.0134
grip strength	forelimb and hindlimb grip strength (mean of trials), average	4.1286	8.3417	0.53242	0.788	0.626
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.28731	0.36455	0.61285	0.643	0.440
grip strength	forelimb and hindlimb grip strength by trial, trial1	7.7875	7.0018	0.77753	0.578	0.279
grip strength	forelimb and hindlimb grip strength by trial, trial2	2.4500	8.2322	0.37767	0.890	0.769
grip strength	forelimb and hindlimb grip strength by trial, trial3	-7.1335	13.072	-0.26596	0.799	0.591
grip strength	forelimb grip strength (mean of trials), average	-0.45833	4.1260	0.20326	0.969	0.913
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.21888	0.24609	-0.32667	0.653	0.385
grip strength	forelimb grip strength by trial, trial1	-2.9625	6.7274	-0.082874	0.863	0.664
grip strength	forelimb grip strength by trial, trial2	-0.92500	6.6508	0.12083	0.957	0.891
grip strength	forelimb grip strength by trial, trial3	-1.6137	7.1308	0.094539	0.929	0.823
heart weight	heart weight, normalized to body weight	0.14869	0.14701	0.092695	0.537	0.320
heart weight	heart weight, weight	-1.2759	4.2163	-0.53451	0.869	0.764
hematology	basophil differential (percent of total WBC)	-0.17041	0.17023	-1.7770	0.733	0.326
hematology	eosinophil differential (percent of total WBC)	-0.18584	0.21428	-0.45638	0.766	0.394
hematology	hematocrit (HCT)	0.61299	0.54487	0.31828	0.570	0.271
hematology	lymphocyte differential (percent of total WBC)	4.2371	1.8649	1.3931	0.166	0.0316
hematology	mean corpuscular hemoglobin (CHr)	-0.069565	0.089320	-0.56433	0.680	0.443
hematology	mean platelet volume (MPV)	-0.064524	0.047915	-0.62326	0.397	0.190
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.25229	0.14484	-0.52126	0.407	0.0934
hematology	mean RBC corpuscular volume (MCV)	0.24290	0.28457	0.46599	0.629	0.401
hematology	measured hemoglobin (mHGB)	0.037689	0.18866	-0.14339	0.933	0.843
hematology	monocyte differential (percent of total WBC)	-1.0610	0.43198	-1.7467	0.227	0.0210
hematology	neutrophil differential (percent of total WBC)	-2.7929	1.3924	-1.0921	0.224	0.0554
hematology	platelet count (PLT; units per volume x 10³)	-28.618	47.691	-0.33992	0.820	0.554
hematology	RBC corpuscular distribution width (RDW)	-0.077398	0.15793	-0.27549	0.805	0.628
hematology	red blood cell count (RBC; per volume x 10⁶)	0.061879	0.12777	-0.073953	0.812	0.632
hematology	reticulocyte count (Retic; units per volume x 10⁹)	0.52727	14.934	0.11356	0.992	0.972
hematology	reticulocyte differential (percent of total RBC)	-0.040696	0.13318	0.050154	0.907	0.762
hematology	white blood cell count (WBC; units per volume x 10³)	-3.5504	1.1430	-1.9873	0.0340	0.00454
holeboard	number of hole pokes by individual hole number, 20 min test, 1	1.1833	0.97607	1.0922	0.705	0.232
holeboard	number of hole pokes by individual hole number, 20 min test, 2	1.8112	0.66068	2.3759	0.357	0.00910
holeboard	number of hole pokes by individual hole number, 20 min test, 3	1.0375	0.60662	1.5725	0.633	0.0948
holeboard	number of hole pokes by individual hole number, 20 min test, 4	2.3833	0.83948	1.9851	0.229	0.00701
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.11667	0.63175	-0.088734	0.970	0.854
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.84583	0.39673	1.7235	0.554	0.0390
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.21178	0.38293	0.57333	0.943	0.583
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.78596	0.50628	1.3689	0.685	0.128
holeboard	number of hole pokes by individual hole number, 20 min test, 9	1.3880	0.43602	1.9848	0.165	0.00278
holeboard	number of hole pokes by individual hole number, 20 min test, 10	1.0042	0.42294	2.0352	0.581	0.0223
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.94583	0.38896	1.8761	0.496	0.0195
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.074465	0.74084	0.22453	0.980	0.920
holeboard	number of hole pokes by individual hole number, 20 min test, 13	2.1542	0.93853	1.8967	0.377	0.0269
holeboard	number of hole pokes by individual hole number, 20 min test, 14	2.4839	0.77787	2.7099	0.214	0.00274
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.75342	0.61777	1.2210	0.676	0.230
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.66103	1.2584	0.61530	0.890	0.602
holeboard	total number of hole pokes, 20 min test	16.017	5.0424	1.9282	0.0555	0.00283
light / dark	latency to enter dark zone, 20 min test	-77.816	34.230	-1.5380	0.328	0.0283
light / dark	number of transitions between light and dark zones, 20 min test	8.2417	4.8127	0.85480	0.371	0.0944
light / dark	percentage of total time in dark zone, 20 min test	9.1264	5.0873	1.7708	0.402	0.0802
light / dark	percentage of total time in light zone, 20 min test	-9.1267	5.0874	-1.7708	0.399	0.0802
light / dark	time mobile in dark zone, 20 min test	10.357	5.1666	0.51697	0.242	0.0516
light / dark	time mobile in light zone, 20 min test	-6.4878	4.4369	-0.73604	0.388	0.151
light / dark	time spent in dark zone, 20 min test	151.34	57.770	2.1534	0.190	0.0123
light / dark	time spent in light zone, 20 min test	-151.34	57.769	-2.1534	0.190	0.0123
open field	average speed in center of arena, 20 min test	0.55246	0.35926	0.86364	0.449	0.132
open field	average speed in periphery of arena, 20 min test	0.047083	0.14151	-0.33866	0.858	0.741
open field	distance traveled habituation ratio, 20 min test	-7.2793	8.2947	-0.60488	0.697	0.385
open field	distance traveled in center of arena, 20 min test	112.06	103.88	0.40776	0.541	0.287
open field	distance traveled in periphery of arena, 20 min test	77.672	162.00	-0.12045	0.804	0.634
open field	distance traveled slope, 20 min test	-7.6704	7.9895	-0.66902	0.661	0.343
open field	distance traveled, 20 min test, 1st 5min	103.14	56.259	0.48641	0.243	0.0740
open field	distance traveled, 20 min test, 2nd 5min	41.270	58.696	-0.027527	0.709	0.486
open field	distance traveled, 20 min test, 3rd 5min	7.7165	62.220	-0.33581	0.966	0.902
open field	distance traveled, 20 min test, 4th 5min	37.618	64.127	-0.024841	0.764	0.561
open field	number of clockwise revolution episodes, 20 min test	0.50833	1.4575	-0.10767	0.904	0.729
open field	number of counter-clockwise revolution episodes, 20 min test	2.6139	1.2160	0.94236	0.216	0.0375
open field	number of rears in 5 min bins, 20 min test, 1st 5min	5.0083	2.1115	1.1458	0.139	0.0225
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	4.0583	3.3815	0.71855	0.533	0.237
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	0.28862	3.5251	-0.25030	0.965	0.935
open field	number of rears in 5 min bins, 20 min test, 4th 5min	4.6389	3.3180	0.68591	0.440	0.170
open field	percentage of total time in center of arena, 20 min test	-2.0970	3.4573	-0.72203	0.811	0.548
open field	percentage of total time in center of arena, slope, 20 min test	0.28376	1.7612	0.27392	0.965	0.873
open field	percentage of total time in center, habituation ratio, 20 min test	-0.22152	1.8011	0.0046991	0.973	0.903
open field	percentage of total time in corners of arena, 20 min test	2.1244	3.0386	0.68761	0.754	0.488
open field	percentage of total time in corners, habituation ratio, 20 min test	1.7876	1.8640	0.53382	0.806	0.343
open field	percentage of total time in corners, slope, 20 min test	1.3898	1.8917	0.36580	0.873	0.467
open field	permanence time in center of arena, 20 min test	-25.145	41.488	-0.72203	0.811	0.548
open field	permanence time in corners of arena, 20 min test	25.480	36.464	0.68931	0.755	0.489
open field	permanence time in periphery of arena, 20 min test	25.139	41.488	0.72203	0.811	0.548
open field	total distance traveled, 20 min test	189.74	196.56	0.086706	0.563	0.340
open field	total number of rears, 20 min test	13.444	10.427	0.58246	0.444	0.204
open field	whole arena average speed, 20 min test	0.15863	0.16385	0.084011	0.562	0.339
open field	whole arena resting time, 20 min test	-67.065	21.270	-1.1832	0.0224	0.00302
open field	whole arena time spent mobile, 20 min test	9.3676	4.6759	-0.097492	0.167	0.0518
open field	whole arena time spent vertical, 20 min test	7.4700	7.2950	0.46836	0.616	0.312
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-4.0275	1.3524	-1.5029	0.0972	0.00743
startle / PPI	average baseline movement during background noise	-0.16983	1.7198	-0.051164	0.995	0.922
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.067562	0.060782	-0.72506	0.637	0.274
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.11465	0.057201	-1.2047	0.316	0.0528
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	5.6542	7.6001	0.66791	0.887	0.462
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-12.717	6.5798	-1.2844	0.368	0.0614
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-16.501	6.3675	-1.5952	0.129	0.0138
startle / PPI	average startle response to full pulse (120 dB)	159.09	42.788	2.0399	0.00969	0.000721
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	148.55	41.766	1.9669	0.0135	0.00113
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	123.15	40.845	1.8863	0.0371	0.00483
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	117.75	32.302	1.9032	0.0136	0.000883
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-1.2546	1.0061	-0.85124	0.747	0.221
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-2.9798	1.7674	-1.7743	0.591	0.101
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-1.3041	2.2705	-0.88391	0.870	0.569
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.070384	0.095236	0.71597	0.900	0.465
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.17099	0.074406	-1.5017	0.250	0.0276
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.23595	0.079833	-1.9030	0.0602	0.00555
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	160.22	43.615	2.0399	0.0107	0.000816
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	149.21	41.906	1.9767	0.0137	0.00112
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	126.96	41.220	1.8947	0.0326	0.00408
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	89.544	27.128	1.7949	0.0225	0.00222
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.14456	0.10234	1.2717	0.804	0.167
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.12731	0.083326	-1.0711	0.464	0.136
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.21952	0.078529	-1.6981	0.0756	0.00836
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	602.90	161.95	2.1256	0.00956	0.000711
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	535.39	155.92	2.0073	0.0172	0.00158
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	460.61	157.92	1.9032	0.0426	0.00622
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	346.99	99.213	1.8020	0.0160	0.00130
startle / PPI	maximum baseline movement during background noise	-1.5648	3.8715	-0.42356	0.937	0.689
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	12.864	8.7370	1.3374	0.859	0.150
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-9.6418	7.6748	-0.93259	0.588	0.217
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-15.463	6.7610	-1.4936	0.175	0.0284
startle / PPI	maximum startle response to full pulse (120 dB)	598.90	159.80	2.1256	0.00905	0.000663
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	533.41	155.49	2.0073	0.0170	0.00160
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	452.18	156.51	1.9032	0.0449	0.00668
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	341.80	98.292	1.8091	0.0165	0.00137
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-2.4837	2.6346	-0.68198	0.791	0.352
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-5.7357	4.7931	-1.5110	0.731	0.239
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-4.9182	5.1365	-1.2229	0.711	0.345

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	37.0 %	0.000112
eye morphology	anterior chamber depth	males	25.0 %	0.000858
eye morphology	anterior chamber depth	both	31.0 %	4.34e-7
eye morphology	bulging eye	females	37.0 %	0.0000517
eye morphology	bulging eye	males	25.0 %	0.000705
eye morphology	bulging eye	both	31.0 %	1.48e-7
eye morphology	cornea	females	37.0 %	0.000320
eye morphology	cornea	males	25.0 %	0.00211
eye morphology	cornea	both	31.0 %	0.00000201
eye morphology	cornea opacity	females	37.0 %	0.000438
eye morphology	cornea opacity	males	25.0 %	0.00196
eye morphology	cornea opacity	both	31.0 %	0.00000325
eye morphology	cornea vascularization	females	37.0 %	0.000268
eye morphology	cornea vascularization	males	25.0 %	0.00160
eye morphology	cornea vascularization	both	31.0 %	0.00000170
eye morphology	corneal deposits	females	37.0 %	0.000296
eye morphology	corneal deposits	males	25.0 %	0.00208
eye morphology	corneal deposits	both	31.0 %	0.00000146
eye morphology	corneal mineralization	females	48.0 %	0.0000101
eye morphology	corneal mineralization	males	25.0 %	0.00164
eye morphology	corneal mineralization	both	36.0 %	8.80e-8
eye morphology	corneal scleralization	females	37.0 %	0.000360
eye morphology	corneal scleralization	males	25.0 %	0.00248
eye morphology	corneal scleralization	both	31.0 %	0.00000255
eye morphology	corneal ulcer	females	37.0 %	0.000216
eye morphology	corneal ulcer	males	25.0 %	0.00118
eye morphology	corneal ulcer	both	31.0 %	0.00000133
eye morphology	eye closure	females	37.0 %	0.0000512
eye morphology	eye closure	males	25.0 %	0.000700
eye morphology	eye closure	both	31.0 %	1.95e-7
eye morphology	eye hemorrhage or blood presence	females	37.0 %	0.000205
eye morphology	eye hemorrhage or blood presence	males	25.0 %	0.00131
eye morphology	eye hemorrhage or blood presence	both	31.0 %	0.00000143
eye morphology	eyelid morphology	females	37.0 %	0.0000890
eye morphology	eyelid morphology	males	25.0 %	0.000700
eye morphology	eyelid morphology	both	31.0 %	3.75e-7
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	37.0 %	0.000264
eye morphology	iris pigmentation	males	25.0 %	0.00192
eye morphology	iris pigmentation	both	31.0 %	0.00000222
eye morphology	iris transillumination	females	37.0 %	0.000101
eye morphology	iris transillumination	males	25.0 %	0.00145
eye morphology	iris transillumination	both	31.0 %	3.64e-7
eye morphology	irispupil	females	37.0 %	0.000463
eye morphology	irispupil	males	25.0 %	0.00342
eye morphology	irispupil	both	31.0 %	0.00000355
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	9.0 %	0.531
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	3.0 %	0.703
eye morphology	narrow eye opening	females	37.0 %	0.000230
eye morphology	narrow eye opening	males	25.0 %	0.00117
eye morphology	narrow eye opening	both	31.0 %	0.00000126
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	37.0 %	0.000206
eye morphology	pupil dilation	males	25.0 %	0.00305
eye morphology	pupil dilation	both	31.0 %	0.00000197
eye morphology	pupil light response	females	37.0 %	0.000261
eye morphology	pupil light response	males	25.0 %	0.00246
eye morphology	pupil light response	both	31.0 %	0.00000153
eye morphology	pupil position	females	37.0 %	0.000654
eye morphology	pupil position	males	25.0 %	0.00359
eye morphology	pupil position	both	31.0 %	0.00000527
eye morphology	pupil shape	females	37.0 %	0.000438
eye morphology	pupil shape	males	25.0 %	0.00313
eye morphology	pupil shape	both	31.0 %	0.00000391
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.0
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	12.0 %	0.0461
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	6.0 %	0.0959
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	7.0 %	0.375
SHIRPA	limb grasp	both	1.0 %	1.0
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Fam171a1^em1(IMPC)J/Mmjax -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.