MPD: JaxKOMP-EAP genotype: Hps5<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Hps5^em1(IMPC)J/Mmjax -/- Gene Hps5

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	1.8079	4.3405	0.30729	0.908	0.698
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	0.36703	9.4636	0.092945	0.990	0.971
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	2.3253	8.1094	0.31547	0.934	0.789
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	2.2917	4.1639	0.25684	0.847	0.611
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-0.73904	8.1200	-0.13924	0.979	0.932
body composition	body length	-0.16635	0.091314	-1.4014	0.296	0.0835
body composition	body weight (at time of DXA)	0.30371	1.0602	0.34731	0.888	0.777
body composition	bone area, whole body scan, head excluded	-0.50349	0.16784	-1.5981	0.0665	0.00708
body composition	bone mineral content of whole body scan, head excluded	-0.026492	0.013468	-1.2121	0.250	0.0632
body composition	bone mineral content to body weight ratio	-0.00030068	0.00071633	-0.21462	0.839	0.679
body composition	bone mineral density of whole body scan, head excluded	-0.00032639	0.00090974	-0.32313	0.872	0.724
body composition	fat tissue mass of whole body scan, head excluded	0.94356	0.55477	1.3282	0.310	0.104
body composition	fat tissue mass to body weight ratio	0.027286	0.017471	1.1517	0.336	0.134
body composition	lean tissue mass of whole body scan, head excluded	-0.64775	0.30294	-1.3654	0.233	0.0450
body composition	lean tissue mass to body weight ratio	-0.018826	0.018567	-1.0300	0.582	0.323
body composition	percent fat, whole body scan, head excluded	2.4494	1.6814	1.1333	0.381	0.161
body composition	ratio of soft-tissue attenuation coefficients	-0.0035806	0.0017742	-1.4183	0.210	0.0572
body composition	tissue area	-0.92537	0.29561	-2.2077	0.0648	0.00527
body composition	total tissue mass, whole body scan, head excluded	-0.10061	0.49402	-0.46241	0.924	0.841
clinical blood chemistry	alanine transaminase (plasma ALT)	-14.875	5.1340	-1.1371	0.143	0.00645
clinical blood chemistry	albumin (plasma Alb)	-0.16265	0.35054	-0.19224	0.859	0.646
clinical blood chemistry	alkaline phosphatase (plasma ALP)	2.1591	3.1671	-0.15722	0.722	0.500
clinical blood chemistry	aspartate transaminase (plasma AST)	-26.949	10.183	-1.1840	0.136	0.0120
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.029024	0.19093	-0.055384	0.967	0.880
clinical blood chemistry	blood urea nitrogen (BUN)	1.2170	1.2720	0.44968	0.620	0.345
clinical blood chemistry	calcium (plasma Ca)	-0.083309	0.064258	-0.24631	0.435	0.203
clinical blood chemistry	creatinine (plasma)	0.043164	0.015637	1.1801	0.0693	0.00902
clinical blood chemistry	glucose (plasma GLU, no fast)	-29.037	11.929	-0.73632	0.0839	0.0202
clinical blood chemistry	HDL cholesterol (plasma HDL)	-1.1332	3.0138	-0.61047	0.890	0.709
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.021024	0.010402	-1.2722	0.295	0.0508
clinical blood chemistry	phosphorus (plasma phosphate)	0.47138	0.36333	0.65980	0.481	0.203
clinical blood chemistry	total bilirubin (plasma TBIL)	0.0066422	0.0058800	0.45368	0.616	0.266
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	1.0315	4.1806	-0.050495	0.929	0.807
clinical blood chemistry	total protein (plasma TP)	-0.59733	0.52839	-0.51590	0.544	0.266
clinical blood chemistry	triglyceride (plasma TG, no fast)	16.002	24.486	1.0238	0.755	0.518
ERG v2.0	left eye a-wave amplitude (Photopic)	0.42301	1.9841	0.18241	0.935	0.833
ERG v2.0	left eye a-wave amplitude (Scotopic)	6.0983	20.893	0.030305	0.916	0.773
ERG v2.0	left eye a-wave implicit timing (Photopic)	-1.2778	1.5990	-0.51494	0.862	0.433
ERG v2.0	left eye a-wave implicit timing (Scotopic)	-1.4379	0.65451	-1.2053	0.403	0.0394
ERG v2.0	left eye b-wave amplitude (Photopic)	2.9166	6.3483	0.043990	0.907	0.650
ERG v2.0	left eye b-wave amplitude (Scotopic)	-4.9838	57.410	0.035817	0.998	0.932
ERG v2.0	left eye b-wave implicit timing (Photopic)	2.1326	3.3382	0.59382	0.780	0.530
ERG v2.0	left eye b-wave implicit timing (Scotopic)	-3.9760	5.3163	-0.32226	0.778	0.463
ERG v2.0	left eye c-wave amplitude (Scotopic)	-0.22338	39.325	0.24994	0.998	0.996
ERG v2.0	left eye c-wave implicit timing (Scotopic)	-64.501	51.010	-0.66075	0.644	0.219
ERG v2.0	left eye FO-like wave amplitude (Scotopic)	11.890	47.826	-0.12677	0.895	0.806
ERG v2.0	left eye FO-like wave implicit timing (Scotopic)	90.660	224.13	0.48374	0.906	0.690
ERG v2.0	right eye a-wave amplitude (Photopic)	3.1908	1.4891	1.0886	0.391	0.0440
ERG v2.0	right eye a-wave amplitude (Scotopic)	43.257	18.931	1.3279	0.377	0.0323
ERG v2.0	right eye a-wave implicit timing (Photopic)	0.26467	1.0930	0.10763	0.951	0.811
ERG v2.0	right eye a-wave implicit timing (Scotopic)	-2.3966	0.66307	-1.9360	0.0497	0.00154
ERG v2.0	right eye b-wave amplitude (Photopic)	4.3924	4.4382	0.17124	0.683	0.334
ERG v2.0	right eye b-wave amplitude (Scotopic)	-89.087	46.798	-1.2402	0.476	0.0701
ERG v2.0	right eye b-wave implicit timing (Photopic)	-3.8464	1.8091	-0.74522	0.302	0.0455
ERG v2.0	right eye b-wave implicit timing (Scotopic)	-11.257	4.0639	-1.1087	0.188	0.0112
ERG v2.0	right eye c-wave amplitude (Scotopic)	-37.067	22.944	-0.54214	0.540	0.120
ERG v2.0	right eye c-wave implicit timing (Scotopic)	97.944	38.122	0.92293	0.306	0.0175
ERG v2.0	right eye FO-like wave amplitude (Scotopic)	82.518	31.123	1.0123	0.230	0.0146
ERG v2.0	right eye FO-like wave implicit timing (Scotopic)	434.16	180.13	1.5998	0.441	0.0252
glucose tolerance test	amount glucose injected	-1.9904	2.2163	-0.22815	0.734	0.377
glucose tolerance test	plasma glucose, 0min	-7.4043	4.5134	-0.92728	0.280	0.112
glucose tolerance test	plasma glucose, 15min	-80.538	20.574	-1.9954	0.0220	0.000483
glucose tolerance test	plasma glucose, 30min	-82.739	20.895	-2.1906	0.0181	0.000426
glucose tolerance test	plasma glucose, 60min	-43.702	13.160	-1.6307	0.0576	0.00237
glucose tolerance test	plasma glucose, 120min	-2.8295	9.0813	-0.33130	0.915	0.758
grip strength	body weight (at time of grip strength test)	0.042143	0.57102	0.25065	0.967	0.942
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-15.131	6.6039	-0.79733	0.113	0.0300
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.67170	0.30598	-0.79135	0.141	0.0373
grip strength	forelimb and hindlimb grip strength by trial, trial1	-19.966	8.0855	-1.0716	0.133	0.0201
grip strength	forelimb and hindlimb grip strength by trial, trial2	-6.4862	9.2085	-0.17222	0.720	0.487
grip strength	forelimb and hindlimb grip strength by trial, trial3	-20.531	8.2926	-1.0665	0.124	0.0199
grip strength	forelimb grip strength (mean of trials), average	0.42771	2.4561	0.34203	0.949	0.863
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.11198	0.13256	0.52740	0.670	0.406
grip strength	forelimb grip strength by trial, trial1	-2.5559	3.9562	-0.024691	0.802	0.524
grip strength	forelimb grip strength by trial, trial2	1.5853	3.2536	0.38548	0.859	0.630
grip strength	forelimb grip strength by trial, trial3	1.9988	4.1478	0.48775	0.846	0.634
heart weight	heart weight, normalized to body weight	0.090082	0.14373	-0.11715	0.718	0.534
heart weight	heart weight, weight	6.2719	3.2245	0.44163	0.204	0.0588
hematology	basophil differential (percent of total WBC)	-0.0078788	0.030925	-0.092104	0.950	0.800
hematology	eosinophil differential (percent of total WBC)	0.67265	0.22534	1.6924	0.139	0.00507
hematology	hematocrit (HCT)	0.79783	0.60427	0.54522	0.486	0.195
hematology	lymphocyte differential (percent of total WBC)	-0.82147	1.3473	-0.38665	0.746	0.546
hematology	mean corpuscular hemoglobin (CHr)	0.12603	0.061411	0.97222	0.176	0.0477
hematology	mean platelet volume (MPV)	0.22313	0.054419	1.0603	0.00335	0.000233
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.11838	0.14999	-0.27320	0.760	0.435
hematology	mean RBC corpuscular volume (MCV)	0.61585	0.22498	1.0437	0.0574	0.00967
hematology	measured hemoglobin (mHGB)	0.18709	0.18068	0.24235	0.614	0.308
hematology	monocyte differential (percent of total WBC)	0.15216	0.39800	0.70658	0.895	0.704
hematology	neutrophil differential (percent of total WBC)	0.074470	1.0393	0.056066	0.972	0.943
hematology	platelet count (PLT; units per volume x 10³)	-107.05	42.128	-1.2433	0.179	0.0156
hematology	RBC corpuscular distribution width (RDW)	-0.34840	0.17628	-1.2812	0.234	0.0558
hematology	red blood cell count (RBC; per volume x 10⁶)	0.045917	0.13321	-0.13864	0.880	0.732
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-14.855	14.279	-0.55859	0.689	0.305
hematology	reticulocyte differential (percent of total RBC)	-0.15366	0.14169	-0.45771	0.654	0.285
hematology	white blood cell count (WBC; units per volume x 10³)	-3.0113	0.81359	-1.7342	0.00970	0.000714
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-1.4386	1.5417	-1.3863	0.758	0.359
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.0096386	0.71553	0.12949	0.993	0.989
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.41190	0.56989	-0.61883	0.864	0.476
holeboard	number of hole pokes by individual hole number, 20 min test, 4	1.7880	1.9999	1.6400	0.786	0.380
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.13304	0.76537	-0.11079	0.970	0.863
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.10482	0.43949	0.32975	0.969	0.813
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.43023	0.35506	1.0822	0.808	0.237
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.25388	0.60233	0.55663	0.937	0.677
holeboard	number of hole pokes by individual hole number, 20 min test, 9	1.8545	0.63687	2.3756	0.255	0.00728
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.12651	0.33568	0.41408	0.951	0.709
holeboard	number of hole pokes by individual hole number, 20 min test, 11	1.1940	1.2276	2.2530	0.823	0.340
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.53582	1.0223	0.95316	0.903	0.605
holeboard	number of hole pokes by individual hole number, 20 min test, 13	3.9988	1.5208	2.5088	0.353	0.0142
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.18675	0.82718	0.39278	0.959	0.823
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.090682	0.78392	-0.042183	0.973	0.909
holeboard	number of hole pokes by individual hole number, 20 min test, 16	1.8676	1.3328	1.5614	0.588	0.173
holeboard	total number of hole pokes, 20 min test	14.833	7.8697	1.8208	0.293	0.0707
light / dark	latency to enter dark zone, 20 min test	19.828	28.108	0.28222	0.829	0.484
light / dark	number of transitions between light and dark zones, 20 min test	15.111	4.5902	1.4246	0.0452	0.00183
light / dark	percentage of total time in dark zone, 20 min test	-3.9533	4.6871	-0.59752	0.718	0.403
light / dark	percentage of total time in light zone, 20 min test	3.9533	4.6871	0.59429	0.716	0.403
light / dark	time mobile in dark zone, 20 min test	1.6912	3.9699	0.020282	0.857	0.672
light / dark	time mobile in light zone, 20 min test	6.6944	4.1791	0.20421	0.336	0.115
light / dark	time spent in dark zone, 20 min test	-55.219	51.979	-0.60724	0.698	0.293
light / dark	time spent in light zone, 20 min test	55.217	51.979	0.60724	0.698	0.293
open field	average speed in center of arena, 20 min test	0.90166	0.30094	1.3850	0.0802	0.00421
open field	average speed in periphery of arena, 20 min test	0.73506	0.13884	1.7740	0.0000991	0.00000255
open field	distance traveled habituation ratio, 20 min test	-11.610	9.7878	-0.98508	0.563	0.241
open field	distance traveled in center of arena, 20 min test	255.74	114.93	1.1724	0.145	0.0305
open field	distance traveled in periphery of arena, 20 min test	723.75	145.22	1.8006	0.000275	0.00000756
open field	distance traveled slope, 20 min test	-12.504	9.2315	-1.0861	0.503	0.182
open field	distance traveled, 20 min test, 1st 5min	272.84	81.360	1.5967	0.0196	0.00151
open field	distance traveled, 20 min test, 2nd 5min	285.02	58.761	1.8888	0.000415	0.0000120
open field	distance traveled, 20 min test, 3rd 5min	220.44	48.704	1.6519	0.00123	0.0000362
open field	distance traveled, 20 min test, 4th 5min	186.77	51.469	1.3921	0.00992	0.000659
open field	number of clockwise revolution episodes, 20 min test	4.5008	1.5572	1.6676	0.0803	0.00564
open field	number of counter-clockwise revolution episodes, 20 min test	2.4557	1.2516	0.85780	0.255	0.0553
open field	number of rears in 5 min bins, 20 min test, 1st 5min	7.0537	2.3229	1.6569	0.0523	0.00376
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	10.856	2.3584	1.9851	0.00149	0.0000279
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	13.443	2.3363	2.2147	0.0000714	4.97e-7
open field	number of rears in 5 min bins, 20 min test, 4th 5min	11.187	2.5332	1.8888	0.00367	0.0000524
open field	percentage of total time in center of arena, 20 min test	0.20017	3.4079	-0.14076	0.986	0.953
open field	percentage of total time in center of arena, slope, 20 min test	-3.6942	1.8524	-1.7244	0.441	0.0515
open field	percentage of total time in center, habituation ratio, 20 min test	-3.7397	1.9459	-1.6625	0.464	0.0602
open field	percentage of total time in corners of arena, 20 min test	-2.4650	3.3870	-0.13941	0.744	0.470
open field	percentage of total time in corners, habituation ratio, 20 min test	3.4657	2.0280	1.2079	0.552	0.0935
open field	percentage of total time in corners, slope, 20 min test	3.8540	1.9172	1.4359	0.482	0.0497
open field	permanence time in center of arena, 20 min test	2.4054	40.895	-0.13941	0.985	0.953
open field	permanence time in corners of arena, 20 min test	-29.586	40.644	-0.13941	0.744	0.470
open field	permanence time in periphery of arena, 20 min test	-2.4102	40.895	0.13941	0.986	0.953
open field	total distance traveled, 20 min test	936.16	186.57	1.7549	0.000224	0.00000673
open field	total number of rears, 20 min test	42.540	7.2050	2.1168	0.0000416	2.90e-7
open field	whole arena average speed, 20 min test	0.78085	0.15547	1.7549	0.000220	0.00000661
open field	whole arena resting time, 20 min test	-99.405	17.971	-1.7805	0.0000447	0.00000110
open field	whole arena time spent mobile, 20 min test	14.590	3.3718	0.098842	0.00148	0.0000723
open field	whole arena time spent vertical, 20 min test	21.693	4.8267	1.4666	0.00260	0.0000403
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	3.2489	1.1327	1.4717	0.0997	0.00792
startle / PPI	average baseline movement during background noise	-0.27073	1.1901	-0.12432	0.971	0.821
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.036983	0.069323	-0.43432	0.822	0.596
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.027569	0.068953	-0.33510	0.878	0.691
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	1.3282	7.8521	0.21389	0.992	0.866
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-5.6973	6.4084	-0.58936	0.715	0.379
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-5.9685	5.9065	-0.66441	0.616	0.317
startle / PPI	average startle response to full pulse (120 dB)	60.931	33.417	1.2624	0.233	0.0746
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	56.855	34.161	1.1548	0.287	0.103
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	66.292	31.234	1.3171	0.151	0.0391
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	51.033	26.087	1.2349	0.196	0.0564
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.97153	1.2141	0.69798	0.837	0.428
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.8846	1.5579	-1.2876	0.741	0.232
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	1.1242	1.4503	0.35106	0.798	0.442
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.055631	0.092288	0.56783	0.922	0.550
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.063907	0.072075	-0.60015	0.695	0.380
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.057548	0.067896	-0.61919	0.661	0.401
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	61.225	33.416	1.2655	0.224	0.0733
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	56.269	34.219	1.1466	0.294	0.107
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	68.177	31.170	1.3442	0.134	0.0337
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	49.946	25.808	1.2349	0.197	0.0590
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.040249	0.089571	0.39310	0.938	0.655
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.075545	0.079764	-0.65873	0.669	0.348
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.069381	0.067060	-0.70292	0.570	0.306
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	243.65	124.38	1.2908	0.193	0.0561
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	215.42	131.96	1.1713	0.299	0.109
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	257.29	119.35	1.3689	0.141	0.0363
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	195.67	100.19	1.2973	0.193	0.0568
startle / PPI	maximum baseline movement during background noise	-1.2250	2.6999	-0.29935	0.920	0.652
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	1.0815	8.2762	0.16254	0.999	0.897
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-7.1920	7.2983	-0.69441	0.680	0.329
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-6.8352	6.0294	-0.74525	0.556	0.263
startle / PPI	maximum startle response to full pulse (120 dB)	242.43	124.00	1.2908	0.196	0.0565
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	216.01	131.66	1.1741	0.295	0.108
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	253.00	119.10	1.3477	0.148	0.0389
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	198.20	100.52	1.2941	0.190	0.0545
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	1.6451	2.7414	0.58603	0.877	0.551
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-3.6729	3.9328	-1.0325	0.797	0.355
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	2.5872	3.3437	0.31109	0.789	0.443

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	19.0 %	0.00552
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	11.0 %	0.0190
eye morphology	bulging eye	females	19.0 %	0.00504
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	11.0 %	0.0114
eye morphology	cornea	females	19.0 %	0.0153
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	11.0 %	0.0336
eye morphology	cornea opacity	females	25.0 %	0.00633
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	13.0 %	0.0144
eye morphology	cornea vascularization	females	19.0 %	0.0109
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	11.0 %	0.0309
eye morphology	corneal deposits	females	19.0 %	0.0152
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	11.0 %	0.0278
eye morphology	corneal mineralization	females	19.0 %	0.0148
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	11.0 %	0.0313
eye morphology	corneal scleralization	females	19.0 %	0.0156
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	11.0 %	0.0319
eye morphology	corneal ulcer	females	19.0 %	0.00904
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	11.0 %	0.0208
eye morphology	eye closure	females	19.0 %	0.00501
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	11.0 %	0.00837
eye morphology	eye hemorrhage or blood presence	females	19.0 %	0.0101
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	11.0 %	0.0194
eye morphology	eyelid morphology	females	19.0 %	0.00604
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	11.0 %	0.00956
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.0
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	78.0 %	5.45e-17
eye morphology	iris pigmentation	males	100.0 %	1.75e-21
eye morphology	iris pigmentation	both	87.0 %	9.42e-37
eye morphology	iris transillumination	females	40.0 %	2.14e-9
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	22.0 %	3.54e-9
eye morphology	irispupil	females	19.0 %	0.0151
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	11.0 %	0.0400
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.0
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	7.0 %	1.00
eye morphology	narrow eye opening	females	28.0 %	0.00141
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	15.0 %	0.00404
eye morphology	optic disc	females	4.0 %	1.0
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	4.0 %	0.769
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	4.0 %	0.827
eye morphology	pupil dilation	females	19.0 %	0.0126
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	11.0 %	0.0282
eye morphology	pupil light response	females	19.0 %	0.0137
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	11.0 %	0.0302
eye morphology	pupil position	females	26.0 %	0.00582
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	13.0 %	0.0168
eye morphology	pupil shape	females	27.0 %	0.00271
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	14.0 %	0.00925
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.0
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.0
eye morphology	retinal blood vessels structure	females	4.0 %	1.0
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.0
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.0
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.0
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	47.0 %	0.0000131
SHIRPA	coat color abdomen	males	46.0 %	0.000115
SHIRPA	coat color abdomen	both	46.0 %	4.01e-9
SHIRPA	coat color back	females	50.0 %	2.53e-11
SHIRPA	coat color back	males	50.0 %	2.21e-9
SHIRPA	coat color back	both	50.0 %	1.05e-19
SHIRPA	coat color head	females	50.0 %	1.21e-12
SHIRPA	coat color head	males	50.0 %	2.21e-9
SHIRPA	coat color head	both	50.0 %	8.67e-21
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.00
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.00
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	0.624
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.0
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.0
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.636
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.0
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.0
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.00
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.0
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	50.0 %	1.22e-12
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	50.0 %	6.56e-11
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	50.0 %	1.01e-22
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.00
SHIRPA	vocalization	females	2.0 %	1.0
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Hps5^em1(IMPC)J/Mmjax -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.