MPD: JaxKOMP-EAP genotype: Tmem33<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Tmem33^em1(IMPC)J/Mmjax -/- Gene Tmem33

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

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Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	7.1269	4.7412	1.5055	0.588	0.161
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	7.9757	4.6074	1.4463	0.562	0.109
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	12.079	5.3473	1.6037	0.302	0.0433
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	10.765	2.8850	1.4620	0.0638	0.00287
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	5.9091	5.6894	0.91290	0.678	0.319
body composition	body length	-0.40651	0.28747	-2.2732	0.554	0.252
body composition	body weight (at time of DXA)	-1.0532	0.78155	-0.65958	0.488	0.271
body composition	bone area, whole body scan, head excluded	0.090433	0.57647	0.57329	0.951	0.885
body composition	bone mineral content of whole body scan, head excluded	0.0096466	0.039430	0.70742	0.926	0.823
body composition	bone mineral content to body weight ratio	0.000066656	0.0016482	0.24828	0.987	0.970
body composition	bone mineral density of whole body scan, head excluded	0.00032213	0.00081301	0.36225	0.871	0.718
body composition	fat tissue mass of whole body scan, head excluded	-0.72903	1.0952	-1.3724	0.767	0.553
body composition	fat tissue mass to body weight ratio	-0.026322	0.036387	-1.1813	0.735	0.522
body composition	lean tissue mass of whole body scan, head excluded	1.0268	0.60463	1.6707	0.496	0.188
body composition	lean tissue mass to body weight ratio	0.032647	0.037737	1.5929	0.687	0.451
body composition	percent fat, whole body scan, head excluded	-2.6554	3.5538	-1.2650	0.725	0.509
body composition	ratio of soft-tissue attenuation coefficients	0.0029157	0.0039326	1.2516	0.731	0.512
body composition	tissue area	-0.94845	0.58278	-2.2751	0.486	0.202
body composition	total tissue mass, whole body scan, head excluded	0.42390	0.27575	0.66765	0.462	0.222
clinical blood chemistry	alanine transaminase (plasma ALT)	1.0319	1.9703	0.082988	0.869	0.608
clinical blood chemistry	albumin (plasma Alb)	0.34043	0.35155	0.51526	0.657	0.347
clinical blood chemistry	alkaline phosphatase (plasma ALP)	3.0103	2.8777	0.0021255	0.562	0.311
clinical blood chemistry	aspartate transaminase (plasma AST)	-13.038	6.9206	-0.63583	0.359	0.0779
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.47499	0.14987	-1.3763	0.140	0.00595
clinical blood chemistry	blood urea nitrogen (BUN)	3.9699	1.6004	1.4993	0.141	0.0246
clinical blood chemistry	calcium (plasma Ca)	-0.0042686	0.10858	0.33082	0.980	0.969
clinical blood chemistry	creatinine (plasma)	0.023793	0.010969	0.71019	0.198	0.0466
clinical blood chemistry	glucose (plasma GLU, no fast)	-37.523	14.285	-0.98235	0.0805	0.0191
clinical blood chemistry	HDL cholesterol (plasma HDL)	-0.0014289	5.2607	-0.32816	1.00	1.00
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.020885	0.013388	-1.2595	0.460	0.138
clinical blood chemistry	phosphorus (plasma phosphate)	-1.0539	0.67600	-1.5431	0.391	0.140
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.0034233	0.011953	-0.26274	0.919	0.778
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	5.4692	7.7134	0.70652	0.767	0.489
clinical blood chemistry	total protein (plasma TP)	0.82016	0.63720	0.55712	0.498	0.216
clinical blood chemistry	triglyceride (plasma TG, no fast)	-0.073582	12.213	0.20897	0.999	0.995
ERG v2.0	left eye a-wave amplitude (Photopic)	-0.39762	2.5188	-0.049493	0.946	0.877
ERG v2.0	left eye a-wave amplitude (Scotopic)	-6.4820	21.159	-0.35728	0.910	0.764
ERG v2.0	left eye a-wave implicit timing (Photopic)	-0.48338	1.5207	-0.091025	0.965	0.755
ERG v2.0	left eye a-wave implicit timing (Scotopic)	-1.7585	1.1961	-1.4426	0.636	0.162
ERG v2.0	left eye b-wave amplitude (Photopic)	10.327	11.363	0.63364	0.772	0.379
ERG v2.0	left eye b-wave amplitude (Scotopic)	-10.626	38.007	-0.030305	0.924	0.784
ERG v2.0	left eye b-wave implicit timing (Photopic)	5.5932	2.6527	1.1190	0.305	0.0522
ERG v2.0	left eye b-wave implicit timing (Scotopic)	-5.7183	7.2599	-0.45911	0.777	0.443
ERG v2.0	left eye c-wave amplitude (Scotopic)	13.449	31.199	0.47335	0.855	0.673
ERG v2.0	left eye c-wave implicit timing (Scotopic)	102.56	60.702	0.82760	0.542	0.113
ERG v2.0	left eye FO-like wave amplitude (Scotopic)	-56.212	47.932	-0.90770	0.632	0.260
ERG v2.0	left eye FO-like wave implicit timing (Scotopic)	388.46	103.57	1.4261	0.109	0.00215
ERG v2.0	right eye a-wave amplitude (Photopic)	0.93931	1.8452	0.39481	0.907	0.619
ERG v2.0	right eye a-wave amplitude (Scotopic)	40.789	21.835	1.2168	0.483	0.0828
ERG v2.0	right eye a-wave implicit timing (Photopic)	0.54979	1.6024	0.26474	0.941	0.736
ERG v2.0	right eye a-wave implicit timing (Scotopic)	1.4018	1.2735	1.1914	0.691	0.290
ERG v2.0	right eye b-wave amplitude (Photopic)	-8.0419	9.2384	-0.85898	0.737	0.398
ERG v2.0	right eye b-wave amplitude (Scotopic)	-79.450	51.590	-1.0787	0.633	0.146
ERG v2.0	right eye b-wave implicit timing (Photopic)	3.5760	4.2283	1.0497	0.723	0.411
ERG v2.0	right eye b-wave implicit timing (Scotopic)	15.788	8.0983	1.5614	0.543	0.0716
ERG v2.0	right eye c-wave amplitude (Scotopic)	-36.725	35.373	-0.52945	0.714	0.317
ERG v2.0	right eye c-wave implicit timing (Scotopic)	29.848	76.978	0.42268	0.890	0.704
ERG v2.0	right eye FO-like wave amplitude (Scotopic)	55.251	53.282	0.62694	0.718	0.317
ERG v2.0	right eye FO-like wave implicit timing (Scotopic)	39.481	176.40	0.34186	0.969	0.826
glucose tolerance test	amount glucose injected	-0.94640	2.5278	0.065359	0.911	0.711
glucose tolerance test	plasma glucose, 0min	15.439	4.5438	1.2710	0.0199	0.00220
glucose tolerance test	plasma glucose, 15min	-21.223	23.505	-0.46360	0.696	0.375
glucose tolerance test	plasma glucose, 30min	-8.2024	18.642	-0.11971	0.858	0.664
glucose tolerance test	plasma glucose, 60min	9.5489	12.682	0.51153	0.757	0.459
glucose tolerance test	plasma glucose, 120min	9.4455	8.7721	0.52094	0.599	0.292
grip strength	body weight (at time of grip strength test)	-0.020739	0.45264	0.19710	0.980	0.964
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-14.797	6.4834	-0.77360	0.116	0.0309
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.62952	0.30993	-0.72930	0.174	0.0522
grip strength	forelimb and hindlimb grip strength by trial, trial1	-10.663	7.9588	-0.49595	0.471	0.191
grip strength	forelimb and hindlimb grip strength by trial, trial2	-18.323	7.3849	-0.91025	0.118	0.0199
grip strength	forelimb and hindlimb grip strength by trial, trial3	-14.826	7.7695	-0.76385	0.261	0.0675
grip strength	forelimb grip strength (mean of trials), average	-11.427	3.4993	-1.0978	0.0347	0.00306
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.51611	0.16554	-1.0462	0.0496	0.00430
grip strength	forelimb grip strength by trial, trial1	-15.377	4.3424	-1.3862	0.0439	0.00153
grip strength	forelimb grip strength by trial, trial2	-2.8128	5.0159	-0.090163	0.835	0.580
grip strength	forelimb grip strength by trial, trial3	-15.621	5.4274	-1.3037	0.0957	0.00773
heart weight	heart weight, normalized to body weight	-0.10724	0.15821	-0.86104	0.695	0.505
heart weight	heart weight, weight	-9.7380	5.4556	-1.6130	0.251	0.0887
hematology	basophil differential (percent of total WBC)	0.029031	0.025714	0.46819	0.706	0.277
hematology	eosinophil differential (percent of total WBC)	-0.35706	0.25973	-0.88449	0.582	0.188
hematology	hematocrit (HCT)	0.019075	0.66653	-0.35298	0.988	0.978
hematology	lymphocyte differential (percent of total WBC)	0.0031915	0.93549	-0.047855	0.997	0.997
hematology	mean corpuscular hemoglobin (CHr)	-0.21809	0.072176	-1.5678	0.0483	0.00811
hematology	mean platelet volume (MPV)	0.0081911	0.18721	-0.13556	0.983	0.966
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.27872	0.17197	-0.56733	0.457	0.125
hematology	mean RBC corpuscular volume (MCV)	-0.46277	0.22513	-0.83734	0.185	0.0565
hematology	measured hemoglobin (mHGB)	-0.11514	0.22035	-0.52424	0.810	0.609
hematology	monocyte differential (percent of total WBC)	-0.20711	0.31621	-0.48435	0.797	0.522
hematology	neutrophil differential (percent of total WBC)	-0.15851	0.75836	-0.054697	0.918	0.837
hematology	platelet count (PLT; units per volume x 10³)	-33.340	131.89	-0.40438	0.929	0.804
hematology	RBC corpuscular distribution width (RDW)	0.21978	0.31367	0.78963	0.719	0.494
hematology	red blood cell count (RBC; per volume x 10⁶)	0.11893	0.15248	0.18438	0.691	0.448
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-14.759	16.134	-0.55378	0.739	0.374
hematology	reticulocyte differential (percent of total RBC)	-0.11723	0.12890	-0.29218	0.719	0.377
hematology	white blood cell count (WBC; units per volume x 10³)	-1.4078	1.3965	-0.78232	0.541	0.329
light / dark	latency to enter dark zone, 20 min test	104.68	34.129	1.6029	0.130	0.00422
light / dark	number of transitions between light and dark zones, 20 min test	-10.042	5.1308	-0.92719	0.296	0.0586
light / dark	percentage of total time in dark zone, 20 min test	-3.2513	3.7288	-0.46059	0.708	0.389
light / dark	percentage of total time in light zone, 20 min test	3.2513	3.7288	0.45759	0.707	0.389
light / dark	time mobile in dark zone, 20 min test	-4.1680	7.1909	-0.39101	0.806	0.566
light / dark	time mobile in light zone, 20 min test	0.56622	6.6537	-0.20697	0.967	0.933
light / dark	time spent in dark zone, 20 min test	-115.12	43.607	-1.4172	0.190	0.0124
light / dark	time spent in light zone, 20 min test	115.12	43.607	1.4172	0.190	0.0124
open field	average speed in center of arena, 20 min test	0.82699	0.39196	1.2806	0.279	0.0417
open field	average speed in periphery of arena, 20 min test	0.55551	0.16197	1.4136	0.0155	0.00150
open field	distance traveled habituation ratio, 20 min test	0.28573	9.0501	0.059781	0.991	0.975
open field	distance traveled in center of arena, 20 min test	77.630	83.336	0.16113	0.613	0.358
open field	distance traveled in periphery of arena, 20 min test	614.44	183.72	1.6312	0.0220	0.00190
open field	distance traveled slope, 20 min test	-0.53606	8.5312	-0.0033565	0.992	0.950
open field	distance traveled, 20 min test, 1st 5min	187.57	89.000	1.0716	0.173	0.0419
open field	distance traveled, 20 min test, 2nd 5min	170.49	56.783	1.2655	0.0421	0.00478
open field	distance traveled, 20 min test, 3rd 5min	146.05	50.416	1.0764	0.0491	0.00630
open field	distance traveled, 20 min test, 4th 5min	183.26	63.173	1.3609	0.0493	0.00623
open field	number of clockwise revolution episodes, 20 min test	3.6010	1.3797	1.4133	0.129	0.0130
open field	number of counter-clockwise revolution episodes, 20 min test	1.7326	1.2573	0.52301	0.455	0.176
open field	number of rears in 5 min bins, 20 min test, 1st 5min	3.0949	2.0894	0.64858	0.392	0.147
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	3.6927	3.3725	0.60166	0.566	0.281
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	5.6061	3.5844	0.98073	0.375	0.127
open field	number of rears in 5 min bins, 20 min test, 4th 5min	3.8125	3.3894	0.49550	0.542	0.268
open field	percentage of total time in center of arena, 20 min test	-3.8154	3.4922	-1.1671	0.600	0.282
open field	percentage of total time in center of arena, slope, 20 min test	1.4790	1.5765	0.94866	0.794	0.354
open field	percentage of total time in center, habituation ratio, 20 min test	1.6652	1.6864	1.0094	0.788	0.330
open field	percentage of total time in corners of arena, 20 min test	-1.5187	4.3735	0.016783	0.895	0.730
open field	percentage of total time in corners, habituation ratio, 20 min test	-0.25234	2.0351	-0.41507	0.988	0.902
open field	percentage of total time in corners, slope, 20 min test	0.067824	1.9253	-0.23095	0.995	0.972
open field	permanence time in center of arena, 20 min test	-45.788	41.907	-1.1671	0.601	0.282
open field	permanence time in corners of arena, 20 min test	-18.216	52.481	0.016783	0.896	0.730
open field	permanence time in periphery of arena, 20 min test	45.781	41.903	1.1644	0.600	0.282
open field	total distance traveled, 20 min test	687.94	209.83	1.3054	0.0204	0.00228
open field	total number of rears, 20 min test	15.891	10.597	0.74488	0.364	0.142
open field	whole arena average speed, 20 min test	0.57308	0.17475	1.3054	0.0203	0.00227
open field	whole arena resting time, 20 min test	-98.445	34.172	-1.7549	0.0405	0.00664
open field	whole arena time spent mobile, 20 min test	24.055	11.227	0.39176	0.138	0.0390
open field	whole arena time spent vertical, 20 min test	10.928	7.2122	0.74310	0.417	0.138
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-3.3750	1.4830	-1.2555	0.204	0.0310
startle / PPI	average baseline movement during background noise	1.6402	1.5706	1.0183	0.803	0.303
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.033705	0.075067	0.19815	0.851	0.656
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.076883	0.065683	0.68465	0.598	0.249
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-1.0146	7.2531	-0.070816	0.994	0.890
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	1.2836	8.5999	0.098941	0.962	0.882
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	7.6132	6.6690	0.68375	0.559	0.261
startle / PPI	average startle response to full pulse (120 dB)	-84.277	32.759	-1.1996	0.0829	0.0142
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-83.827	34.243	-1.1825	0.0937	0.0192
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-66.806	29.068	-1.0567	0.116	0.0273
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-60.871	25.503	-1.1332	0.107	0.0222
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	1.3862	1.3806	0.87977	0.800	0.322
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	3.1526	1.6453	1.5333	0.542	0.0631
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	0.069712	1.5840	-0.14270	0.992	0.965
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.0070796	0.086677	0.10598	0.991	0.935
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.10300	0.11125	0.80500	0.680	0.361
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.12600	0.078644	0.78808	0.334	0.118
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-86.151	32.996	-1.2141	0.0780	0.0130
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-85.169	34.667	-1.1825	0.0925	0.0188
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-69.799	29.341	-1.0890	0.104	0.0226
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-60.720	25.757	-1.1070	0.113	0.0238
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.057558	0.10087	-0.49679	0.928	0.572
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.064495	0.11238	0.43381	0.799	0.570
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.11156	0.083159	0.63969	0.444	0.188
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-329.38	122.62	-1.3238	0.0668	0.0108
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-319.35	132.67	-1.2593	0.0976	0.0212
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-257.31	117.19	-1.1122	0.137	0.0345
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-226.62	98.193	-1.1253	0.119	0.0267
startle / PPI	maximum baseline movement during background noise	2.2684	3.4756	0.71055	0.856	0.518
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-4.4332	8.5536	-0.40676	0.938	0.607
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.83788	9.5348	-0.0077063	0.978	0.930
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	7.7278	7.6253	0.59437	0.604	0.317
startle / PPI	maximum startle response to full pulse (120 dB)	-326.54	122.23	-1.3038	0.0688	0.0112
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-317.53	132.03	-1.2500	0.0976	0.0213
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-251.22	116.70	-1.0815	0.146	0.0379
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-226.96	97.723	-1.1253	0.118	0.0258
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	1.9992	3.2460	0.67669	0.868	0.542
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	6.5329	3.7367	1.4442	0.582	0.0887
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-0.092147	3.9184	-0.19244	0.994	0.981

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	21.0 %	0.0142
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	10.0 %	0.0269
eye morphology	cornea opacity	females	9.0 %	0.359
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	4.0 %	0.428
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	11.0 %	0.316
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	5.0 %	0.467
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.0
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	11.0 %	0.230
eye morphology	pupil position	both	5.0 %	0.461
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	0.457
eye morphology	retina	males	10.0 %	0.482
eye morphology	retina	both	4.0 %	0.477
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	12.0 %	0.0440
SHIRPA	activity body position	males	12.0 %	0.0627
SHIRPA	activity body position	both	12.0 %	0.00672
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	12.0 %	0.00301
SHIRPA	body position	males	12.0 %	0.0492
SHIRPA	body position	both	12.0 %	0.000206
SHIRPA	body thickness	females	12.0 %	0.0517
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	6.0 %	0.0796
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	36.0 %	0.0000894
SHIRPA	coat hair distribution abdomen	both	18.0 %	0.000167
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	12.0 %	0.0433
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	6.0 %	0.0603
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	12.0 %	0.0117
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	6.0 %	0.0176
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.624
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	12.0 %	0.0876
SHIRPA	transfer arousal	males	12.0 %	0.0653
SHIRPA	transfer arousal	both	12.0 %	0.00606
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.0
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Tmem33^em1(IMPC)J/Mmjax -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.