MPD: JaxKOMP-EAP genotype: Exoc3l4<sup>em1(IMPC)J</sup>/Mmjax -/+

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	3.7175	2.1354	0.82937	0.740	0.332
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	5.1250	3.2912	1.0495	0.789	0.363
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	1.5951	3.5998	0.18063	0.904	0.734
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-0.44568	3.9779	-0.20049	0.977	0.929
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	0.11545	12.464	-0.019628	0.997	0.994
body composition	body length	-0.028413	0.052949	-0.14264	0.807	0.597
body composition	body weight (at time of DXA)	0.10313	0.54410	0.18457	0.937	0.851
body composition	bone area, whole body scan, head excluded	0.055481	0.21159	0.40985	0.911	0.795
body composition	bone mineral content of whole body scan, head excluded	0.000095000	0.017780	0.14247	0.998	0.996
body composition	bone mineral content to body weight ratio	0.00013529	0.00066984	0.33376	0.936	0.842
body composition	bone mineral density of whole body scan, head excluded	-0.00029875	0.00089347	-0.28166	0.878	0.741
body composition	fat tissue mass of whole body scan, head excluded	0.25310	0.58130	0.43223	0.833	0.668
body composition	fat tissue mass to body weight ratio	0.0068168	0.017986	0.38767	0.860	0.708
body composition	lean tissue mass of whole body scan, head excluded	-0.20130	0.44052	-0.58783	0.860	0.652
body composition	lean tissue mass to body weight ratio	-0.0060817	0.014235	-0.38422	0.845	0.673
body composition	percent fat, whole body scan, head excluded	0.65245	1.7073	0.38033	0.865	0.706
body composition	ratio of soft-tissue attenuation coefficients	-0.00072439	0.0018974	-0.37973	0.865	0.706
body composition	tissue area	0.084235	0.17159	0.49514	0.856	0.628
body composition	total tissue mass, whole body scan, head excluded	0.051799	0.26204	-0.10395	0.926	0.845
glucose tolerance test	amount glucose injected	1.2484	3.2415	0.71785	0.908	0.704
glucose tolerance test	plasma glucose, 0min	-2.8000	5.7151	-0.51937	0.798	0.629
glucose tolerance test	plasma glucose, 15min	-47.487	16.825	-1.1836	0.110	0.00992
glucose tolerance test	plasma glucose, 30min	-88.719	13.204	-2.3114	0.000382	0.00000120
glucose tolerance test	plasma glucose, 60min	-27.500	10.065	-1.0385	0.144	0.0122
glucose tolerance test	plasma glucose, 120min	-9.4152	11.739	-0.77723	0.698	0.431
heart weight	heart weight, normalized to body weight	-0.58826	0.25401	-2.2980	0.129	0.0298
heart weight	heart weight, weight	3.0309	5.1485	0.023650	0.734	0.562
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-1.3125	1.2997	-1.2533	0.739	0.323
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-1.4125	1.2529	-1.9172	0.775	0.271
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.75	0.84216	1.1927	0.826	0.382
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.47500	1.2419	0.54681	0.914	0.706
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.81250	0.87389	-1.2278	0.805	0.362
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.74657	0.37165	-1.9734	0.579	0.0570
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.125	0.33195	-0.37814	0.971	0.710
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.80000	0.86124	-1.2065	0.807	0.363
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-1.4125	0.85287	-2.1237	0.557	0.111
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.7625	0.43582	-2.1073	0.691	0.0935
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.8875	0.46332	-2.2122	0.650	0.0679
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.28510	0.53916	-0.41107	0.903	0.602
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.51250	1.2634	-0.42026	0.915	0.689
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.46250	0.97548	0.80890	0.882	0.640
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.275	0.56239	-0.35839	0.896	0.629
holeboard	number of hole pokes by individual hole number, 20 min test, 16	1.1103e-15	1.2415	0.026993	1.00	1.00
holeboard	total number of hole pokes, 20 min test	-7.5625	6.5005	-1.0077	0.553	0.257
light / dark	latency to enter dark zone, 20 min test	-48.16	41.514	-1.0048	0.673	0.258
light / dark	number of transitions between light and dark zones, 20 min test	0.45000	13.158	0.15885	0.986	0.973
light / dark	percentage of total time in dark zone, 20 min test	5.4110	4.1603	1.1290	0.583	0.206
light / dark	percentage of total time in light zone, 20 min test	-5.4110	4.1603	-1.1316	0.583	0.206
light / dark	time mobile in dark zone, 20 min test	18.969	13.671	0.92304	0.473	0.179
light / dark	time mobile in light zone, 20 min test	-8.8712	15.164	-0.87841	0.784	0.564
light / dark	time spent in dark zone, 20 min test	85.259	54.946	1.4789	0.550	0.134
light / dark	time spent in light zone, 20 min test	-85.259	54.946	-1.4789	0.550	0.134
open field	average speed in center of arena, 20 min test	0.92288	0.49412	1.4359	0.354	0.0746
open field	average speed in periphery of arena, 20 min test	0.22823	0.16286	0.35720	0.378	0.174
open field	distance traveled habituation ratio, 20 min test	-11.305	11.543	-0.96350	0.653	0.338
open field	distance traveled in center of arena, 20 min test	-16.004	140.11	-0.48189	0.953	0.910
open field	distance traveled in periphery of arena, 20 min test	336.07	150.40	0.85007	0.151	0.0359
open field	distance traveled slope, 20 min test	-11.408	10.884	-1.0027	0.628	0.305
open field	distance traveled, 20 min test, 1st 5min	159.24	89.987	0.88528	0.274	0.0901
open field	distance traveled, 20 min test, 2nd 5min	76.063	67.797	0.35863	0.511	0.273
open field	distance traveled, 20 min test, 3rd 5min	34.864	60.555	-0.046336	0.775	0.571
open field	distance traveled, 20 min test, 4th 5min	57.463	69.643	0.17203	0.651	0.418
open field	number of clockwise revolution episodes, 20 min test	3.075	1.4183	1.2173	0.251	0.0408
open field	number of counter-clockwise revolution episodes, 20 min test	2.4375	1.5106	0.85007	0.384	0.120
open field	number of rears in 5 min bins, 20 min test, 1st 5min	3.6179	3.0260	0.79321	0.509	0.245
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	3.2375	3.1400	0.48641	0.599	0.313
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-2.3875	4.4818	-0.85200	0.793	0.599
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-2.8375	4.7155	-0.93194	0.763	0.553
open field	percentage of total time in center of arena, 20 min test	-6.6969	5.8916	-1.8213	0.590	0.267
open field	percentage of total time in center of arena, slope, 20 min test	2.1515	2.1702	1.3149	0.781	0.332
open field	percentage of total time in center, habituation ratio, 20 min test	2.3261	2.2901	1.3781	0.786	0.320
open field	percentage of total time in corners of arena, 20 min test	1.5491	5.6698	0.57769	0.920	0.787
open field	percentage of total time in corners, habituation ratio, 20 min test	-0.58250	2.6447	-0.55719	0.966	0.828
open field	percentage of total time in corners, slope, 20 min test	-0.99575	2.5719	-0.78810	0.933	0.702
open field	permanence time in center of arena, 20 min test	-80.357	70.696	-1.8213	0.591	0.267
open field	permanence time in corners of arena, 20 min test	18.591	68.032	0.57769	0.920	0.787
open field	permanence time in periphery of arena, 20 min test	80.350	70.699	1.8213	0.591	0.267
open field	total distance traveled, 20 min test	331.90	228.99	0.46536	0.348	0.161
open field	total number of rears, 20 min test	0.96714	13.302	-0.27671	0.977	0.943
open field	whole arena average speed, 20 min test	0.27588	0.19082	0.46387	0.351	0.162
open field	whole arena resting time, 20 min test	-34.102	22.232	-0.38308	0.306	0.139
open field	whole arena time spent mobile, 20 min test	34.195	22.242	0.64404	0.311	0.138
open field	whole arena time spent vertical, 20 min test	1.3829	11.469	0.00067130	0.964	0.905
startle / PPI	average baseline movement during background noise	-2.3057	2.4713	-1.5110	0.829	0.361
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.16539	0.087963	1.3477	0.365	0.0728
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.13227	0.080981	1.1875	0.437	0.116
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	9.5756	10.935	1.0840	0.879	0.391
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	7.8422	7.3412	0.73603	0.658	0.296
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	13.965	7.8667	1.3339	0.330	0.0891
startle / PPI	average startle response to full pulse (120 dB)	-68.683	44.201	-1.0066	0.335	0.134
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-87.594	46.245	-1.2289	0.223	0.0709
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-75.685	44.626	-1.1797	0.284	0.103
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-82.077	38.330	-1.5066	0.167	0.0431
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.19583	2.6294	-0.069412	0.989	0.941
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	2.4167	2.2869	1.2319	0.814	0.302
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-0.46063	2.2903	-0.42970	0.963	0.842
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.13279	0.11531	1.3071	0.852	0.262
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.11645	0.080147	0.89772	0.500	0.160
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.15474	0.093208	0.99464	0.324	0.110
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-66.198	43.773	-0.95225	0.352	0.144
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-87.398	45.872	-1.2141	0.220	0.0693
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-78.102	44.177	-1.1967	0.254	0.0903
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-81.475	38.101	-1.4685	0.167	0.0433
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.16937	0.13111	1.5110	0.826	0.210
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.15556	0.081784	1.1223	0.346	0.0698
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.17837	0.098616	1.0811	0.277	0.0836
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-208.69	148.92	-0.84522	0.394	0.174
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-323.71	156.01	-1.2781	0.171	0.0494
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-284.92	150.19	-1.2200	0.218	0.0705
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-304.70	137.48	-1.5066	0.147	0.0368
startle / PPI	maximum baseline movement during background noise	-7.0167	6.0007	-1.7811	0.737	0.254
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	14.095	12.624	1.5110	0.884	0.276
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	12.649	7.7746	1.1018	0.455	0.117
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	17.012	8.7204	1.4363	0.271	0.0634
startle / PPI	maximum startle response to full pulse (120 dB)	-215.70	149.66	-0.86135	0.378	0.163
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-326.58	157.15	-1.2781	0.171	0.0490
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-282.52	151.80	-1.2200	0.227	0.0756
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-305.64	137.24	-1.5287	0.145	0.0360
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-2.8687	5.6196	-0.79424	0.910	0.615
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	2.6583	5.8368	0.72323	0.928	0.653
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-0.48179	5.4475	-0.27744	0.985	0.930

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	9.0 %	0.359
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	4.0 %	0.428
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	12.0 %	0.103
eye morphology	corneal mineralization	males	12.0 %	0.0257
eye morphology	corneal mineralization	both	12.0 %	0.00512
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	19.0 %	0.0555
eye morphology	lens opacity	both	5.0 %	0.287
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.0
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	7.0 %	0.610
eye morphology	retina	both	7.0 %	0.801
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00