MPD: JaxKOMP-EAP genotype: Ces5a<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Ces5a^em1(IMPC)J/Mmjax -/- Gene Ces5a

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

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Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-1.1504	3.2741	-0.61247	0.923	0.732
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-9.4386	4.6421	-1.6473	0.475	0.0669
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-5.7602	4.2323	-1.3128	0.557	0.201
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-5.9457e-10	3.9274	-0.11354	1.00	1.00
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-2.5641	3.0983	-0.43689	0.745	0.425
body composition	body length	-0.081748	0.049346	-0.73299	0.355	0.110
body composition	body weight (at time of DXA)	-1.0581	0.62140	-0.66297	0.266	0.101
body composition	bone area, whole body scan, head excluded	-0.42882	0.14153	-1.3551	0.0564	0.00562
body composition	bone mineral content of whole body scan, head excluded	-0.040203	0.011328	-1.7048	0.0276	0.00156
body composition	bone mineral content to body weight ratio	-0.0017827	0.00052502	-1.7663	0.0294	0.00229
body composition	bone mineral density of whole body scan, head excluded	-0.0023662	0.00074553	-2.0851	0.0580	0.00396
body composition	fat tissue mass of whole body scan, head excluded	2.3538	0.57977	2.4818	0.0113	0.000425
body composition	fat tissue mass to body weight ratio	0.066878	0.018741	2.2755	0.0222	0.00149
body composition	lean tissue mass of whole body scan, head excluded	-1.0134	0.42694	-1.8735	0.175	0.0256
body composition	lean tissue mass to body weight ratio	-0.049802	0.017932	-2.0973	0.0903	0.0102
body composition	percent fat, whole body scan, head excluded	5.9947	1.7647	2.3338	0.0313	0.00228
body composition	ratio of soft-tissue attenuation coefficients	-0.0066629	0.0019614	-2.3126	0.0308	0.00228
body composition	tissue area	1.1515	0.26776	2.7192	0.00910	0.000228
body composition	total tissue mass, whole body scan, head excluded	1.4443	0.34020	2.4264	0.00606	0.000263
clinical blood chemistry	alanine transaminase (plasma ALT)	-1.7153	2.6973	-0.19175	0.821	0.530
clinical blood chemistry	albumin (plasma Alb)	0.22567	0.42377	0.36284	0.842	0.599
clinical blood chemistry	alkaline phosphatase (plasma ALP)	3.0281	3.8462	0.0035424	0.675	0.438
clinical blood chemistry	aspartate transaminase (plasma AST)	-6.0182	6.3264	-0.30376	0.667	0.350
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.096246	0.15248	-0.30560	0.836	0.533
clinical blood chemistry	blood urea nitrogen (BUN)	-0.89722	1.0546	-0.39793	0.667	0.402
clinical blood chemistry	calcium (plasma Ca)	0.074952	0.059690	0.85918	0.449	0.220
clinical blood chemistry	creatinine (plasma)	-0.0054770	0.014109	-0.0030643	0.833	0.701
clinical blood chemistry	glucose (plasma GLU, no fast)	13.132	16.834	0.79569	0.643	0.442
clinical blood chemistry	HDL cholesterol (plasma HDL)	-0.35275	2.5179	-0.41781	0.963	0.890
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.012281	0.0073546	-0.81594	0.408	0.106
clinical blood chemistry	phosphorus (plasma phosphate)	0.34183	0.50128	0.46751	0.754	0.501
clinical blood chemistry	total bilirubin (plasma TBIL)	0.0093378	0.0045471	0.58702	0.260	0.0495
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	1.3916	3.7508	0.013507	0.894	0.714
clinical blood chemistry	total protein (plasma TP)	-0.60790	0.58420	-0.52735	0.586	0.307
clinical blood chemistry	triglyceride (plasma TG, no fast)	2.1869	12.701	0.34434	0.940	0.865
ERG v2.0	left eye a-wave amplitude (Photopic)	-1.9997	1.5389	-0.57426	0.625	0.213
ERG v2.0	left eye a-wave amplitude (Scotopic)	-17.479	23.747	-0.68664	0.783	0.473
ERG v2.0	left eye a-wave implicit timing (Photopic)	1.6891	1.5129	1.0109	0.786	0.281
ERG v2.0	left eye a-wave implicit timing (Scotopic)	2.0451	1.0973	1.6844	0.519	0.0821
ERG v2.0	left eye b-wave amplitude (Photopic)	10.660	4.0706	0.67449	0.210	0.0194
ERG v2.0	left eye b-wave amplitude (Scotopic)	6.8500	46.453	0.25335	0.975	0.885
ERG v2.0	left eye b-wave implicit timing (Photopic)	0.31250	1.8202	0.25562	0.965	0.866
ERG v2.0	left eye b-wave implicit timing (Scotopic)	9.9415	10.383	1.0294	0.723	0.354
ERG v2.0	left eye c-wave amplitude (Scotopic)	10.656	44.271	0.40672	0.893	0.813
ERG v2.0	left eye c-wave implicit timing (Scotopic)	-5.3882	57.719	-0.11016	0.981	0.927
ERG v2.0	left eye FO-like wave amplitude (Scotopic)	-26.918	63.774	-0.54852	0.854	0.679
ERG v2.0	left eye FO-like wave implicit timing (Scotopic)	140.95	134.35	0.69363	0.831	0.311
ERG v2.0	right eye a-wave amplitude (Photopic)	-4.8175	2.8042	-1.2766	0.561	0.106
ERG v2.0	right eye a-wave amplitude (Scotopic)	-53.831	15.795	-1.8399	0.105	0.00360
ERG v2.0	right eye a-wave implicit timing (Photopic)	1.8487	1.7032	1.0109	0.839	0.295
ERG v2.0	right eye a-wave implicit timing (Scotopic)	1.0018	0.74346	0.86386	0.623	0.198
ERG v2.0	right eye b-wave amplitude (Photopic)	9.5626	5.7778	0.64714	0.552	0.119
ERG v2.0	right eye b-wave amplitude (Scotopic)	77.230	27.157	1.3830	0.200	0.0123
ERG v2.0	right eye b-wave implicit timing (Photopic)	4.5092	3.4648	1.2402	0.583	0.213
ERG v2.0	right eye b-wave implicit timing (Scotopic)	25.873	7.4847	2.2215	0.107	0.00352
ERG v2.0	right eye c-wave amplitude (Scotopic)	86.356	28.602	1.7076	0.212	0.00863
ERG v2.0	right eye c-wave implicit timing (Scotopic)	20.486	32.320	0.31647	0.847	0.536
ERG v2.0	right eye FO-like wave amplitude (Scotopic)	-138.11	40.149	-1.8108	0.0976	0.00365
ERG v2.0	right eye FO-like wave implicit timing (Scotopic)	97.208	239.72	0.52314	0.923	0.690
glucose tolerance test	amount glucose injected	-3.5586	4.4007	-0.66374	0.759	0.428
glucose tolerance test	plasma glucose, 0min	12.284	4.8295	0.98809	0.0856	0.0185
glucose tolerance test	plasma glucose, 15min	24.064	21.374	0.80350	0.602	0.272
glucose tolerance test	plasma glucose, 30min	23.346	27.674	0.81493	0.717	0.408
glucose tolerance test	plasma glucose, 60min	16.193	28.302	0.76063	0.828	0.573
glucose tolerance test	plasma glucose, 120min	23.336	7.1466	1.4017	0.0718	0.00370
grip strength	body weight (at time of grip strength test)	-1.5350	0.45383	-1.0932	0.0157	0.00228
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-16.912	6.6584	-0.90587	0.0792	0.0174
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.52459	0.36736	-0.58505	0.351	0.166
grip strength	forelimb and hindlimb grip strength by trial, trial1	-15.700	7.6593	-0.78937	0.232	0.0510
grip strength	forelimb and hindlimb grip strength by trial, trial2	-11.327	8.7363	-0.46822	0.453	0.206
grip strength	forelimb and hindlimb grip strength by trial, trial3	-18.911	7.7107	-0.96897	0.129	0.0212
grip strength	forelimb grip strength (mean of trials), average	1.0875	3.7438	0.42807	0.902	0.774
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.15637	0.22345	0.65008	0.745	0.491
grip strength	forelimb grip strength by trial, trial1	1.2952	5.6890	0.41537	0.926	0.822
grip strength	forelimb grip strength by trial, trial2	1.4168	5.4962	0.36367	0.930	0.799
grip strength	forelimb grip strength by trial, trial3	0.81897	5.7113	0.35128	0.958	0.887
heart weight	heart weight, normalized to body weight	-0.22146	0.12777	-1.3081	0.252	0.0927
heart weight	heart weight, weight	-14.862	3.7546	-2.2445	0.00755	0.000394
hematology	basophil differential (percent of total WBC)	-0.040462	0.034218	-0.60459	0.687	0.247
hematology	eosinophil differential (percent of total WBC)	0.33276	0.33386	0.99284	0.714	0.327
hematology	hematocrit (HCT)	0.61008	0.47588	0.31110	0.503	0.210
hematology	lymphocyte differential (percent of total WBC)	1.1296	1.2095	0.41777	0.605	0.358
hematology	mean corpuscular hemoglobin (CHr)	-0.0094369	0.066693	-0.056024	0.944	0.889
hematology	mean platelet volume (MPV)	-0.0055937	0.042713	-0.23046	0.954	0.897
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.29073	0.14743	0.64301	0.335	0.0589
hematology	mean RBC corpuscular volume (MCV)	-0.26374	0.24677	-0.48435	0.525	0.294
hematology	measured hemoglobin (mHGB)	0.33398	0.14812	0.65107	0.212	0.0322
hematology	monocyte differential (percent of total WBC)	-0.85519	0.29635	-1.5459	0.142	0.00744
hematology	neutrophil differential (percent of total WBC)	-0.43047	0.93770	-0.20647	0.813	0.650
hematology	platelet count (PLT; units per volume x 10³)	31.014	53.268	0.48128	0.825	0.565
hematology	RBC corpuscular distribution width (RDW)	0.029616	0.13433	0.10641	0.914	0.827
hematology	red blood cell count (RBC; per volume x 10⁶)	0.19282	0.11674	0.49882	0.348	0.110
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-17.288	20.175	-0.66804	0.753	0.399
hematology	reticulocyte differential (percent of total RBC)	-0.22252	0.19604	-0.75716	0.637	0.266
hematology	white blood cell count (WBC; units per volume x 10³)	-0.53750	0.71483	-0.20368	0.648	0.458
light / dark	latency to enter dark zone, 20 min test	-49.066	44.694	-1.0252	0.689	0.285
light / dark	number of transitions between light and dark zones, 20 min test	-1.9961	4.2478	-0.074429	0.845	0.643
light / dark	percentage of total time in dark zone, 20 min test	-4.4194	4.6585	-0.67025	0.688	0.353
light / dark	percentage of total time in light zone, 20 min test	4.4194	4.6585	0.66856	0.688	0.353
light / dark	time mobile in dark zone, 20 min test	-0.66833	3.6352	-0.14927	0.946	0.856
light / dark	time mobile in light zone, 20 min test	3.3556	3.6203	-0.025691	0.630	0.364
light / dark	time spent in dark zone, 20 min test	-26.075	55.887	-0.18905	0.889	0.646
light / dark	time spent in light zone, 20 min test	26.075	55.887	0.18905	0.889	0.646
open field	average speed in center of arena, 20 min test	1.3120	0.56808	1.9133	0.240	0.0302
open field	average speed in periphery of arena, 20 min test	0.65831	0.17760	1.6363	0.0122	0.00110
open field	distance traveled habituation ratio, 20 min test	-4.1258	7.3715	-0.30613	0.810	0.581
open field	distance traveled in center of arena, 20 min test	209.66	124.37	0.92781	0.308	0.105
open field	distance traveled in periphery of arena, 20 min test	635.43	210.12	1.6519	0.0499	0.00604
open field	distance traveled slope, 20 min test	-2.6707	7.9807	-0.17884	0.906	0.741
open field	distance traveled, 20 min test, 1st 5min	250.50	78.862	1.4746	0.0343	0.00407
open field	distance traveled, 20 min test, 2nd 5min	260.82	80.105	1.8284	0.0336	0.00335
open field	distance traveled, 20 min test, 3rd 5min	238.91	74.539	1.7487	0.0366	0.00393
open field	distance traveled, 20 min test, 4th 5min	169.30	65.217	1.2626	0.0942	0.0162
open field	number of clockwise revolution episodes, 20 min test	5.0203	1.9527	1.8354	0.147	0.0168
open field	number of counter-clockwise revolution episodes, 20 min test	3.3917	1.4192	1.3245	0.179	0.0254
open field	number of rears in 5 min bins, 20 min test, 1st 5min	3.2119	2.2058	0.68889	0.410	0.158
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	6.8414	3.7622	1.3343	0.309	0.0815
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	6.9062	3.4924	1.2449	0.243	0.0596
open field	number of rears in 5 min bins, 20 min test, 4th 5min	7.3170	3.1372	1.2507	0.180	0.0284
open field	percentage of total time in center of arena, 20 min test	-3.5664	4.5945	-1.1056	0.734	0.446
open field	percentage of total time in center of arena, slope, 20 min test	3.2548	2.6235	1.8503	0.691	0.227
open field	percentage of total time in center, habituation ratio, 20 min test	2.6999	2.5198	1.5824	0.766	0.295
open field	percentage of total time in corners of arena, 20 min test	0.26613	4.6609	0.35720	0.980	0.955
open field	percentage of total time in corners, habituation ratio, 20 min test	0.071943	2.8198	-0.26140	0.996	0.980
open field	percentage of total time in corners, slope, 20 min test	-0.32532	2.6878	-0.41946	0.969	0.905
open field	permanence time in center of arena, 20 min test	-42.807	55.133	-1.1056	0.734	0.445
open field	permanence time in corners of arena, 20 min test	3.1818	55.927	0.35720	0.980	0.955
open field	permanence time in periphery of arena, 20 min test	42.805	55.133	1.1032	0.734	0.445
open field	total distance traveled, 20 min test	874.50	261.62	1.6679	0.0233	0.00282
open field	total number of rears, 20 min test	25.024	10.435	1.2960	0.131	0.0246
open field	whole arena average speed, 20 min test	0.72781	0.21838	1.6625	0.0237	0.00289
open field	whole arena resting time, 20 min test	-54.956	38.437	-0.91141	0.347	0.166
open field	whole arena time spent mobile, 20 min test	18.084	5.1486	0.22131	0.0164	0.00179
open field	whole arena time spent vertical, 20 min test	6.0185	6.7320	0.37299	0.678	0.380
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	0.65480	0.95648	0.45511	0.756	0.500
startle / PPI	average baseline movement during background noise	-0.24311	1.3448	-0.094718	0.986	0.858
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.0069562	0.083666	-0.15545	0.972	0.934
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.024877	0.078072	0.17126	0.903	0.752
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.42151	9.9150	0.11162	0.995	0.966
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	6.7357	6.9601	0.62815	0.681	0.340
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	1.0341	7.0530	0.0063051	0.954	0.884
startle / PPI	average startle response to full pulse (120 dB)	9.0526	46.966	0.42203	0.942	0.848
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-17.605	49.378	-0.17818	0.866	0.724
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-16.556	41.310	-0.16823	0.817	0.691
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-9.4509	34.886	-0.044150	0.881	0.788
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	1.5753	1.4798	0.96110	0.785	0.294
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.41965	1.3379	0.29203	0.956	0.756
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	0.97536	2.3519	0.29349	0.913	0.681
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.0091288	0.11539	0.12291	0.991	0.937
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.066286	0.077448	0.46745	0.706	0.398
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.00078389	0.082556	-0.17472	0.995	0.992
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	9.1668	46.912	0.42510	0.940	0.846
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-20.234	49.333	-0.21963	0.846	0.684
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-17.154	41.233	-0.18245	0.810	0.680
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-10.426	34.483	-0.056776	0.864	0.764
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.061241	0.12924	-0.52392	0.936	0.638
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.035714	0.079340	0.16761	0.851	0.655
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.0046584	0.085118	-0.15341	0.985	0.957
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	35.565	172.25	0.40068	0.935	0.838
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-29.424	174.07	0.0077063	0.931	0.867
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-32.104	150.91	0.0063051	0.902	0.833
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-31.506	127.50	-0.0063051	0.892	0.806
startle / PPI	maximum baseline movement during background noise	-0.33013	2.8944	0.031531	0.980	0.910
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-5.6752	11.527	-0.53197	0.938	0.625
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	4.5393	7.3661	0.31404	0.808	0.542
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.47332	7.8022	-0.11726	0.981	0.952
startle / PPI	maximum startle response to full pulse (120 dB)	35.368	172.05	0.39462	0.936	0.838
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-25.359	173.85	0.042748	0.943	0.885
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-31.733	151.12	0.0049040	0.901	0.835
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-26.179	128.48	0.021719	0.915	0.840
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	4.6022	3.8676	1.2141	0.727	0.242
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	0.37092	3.3819	0.13845	0.991	0.913
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	5.3267	5.8937	0.72506	0.738	0.372

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	12.0 %	0.116
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	6.0 %	0.140
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.0
eye morphology	corneal scleralization	females	11.0 %	0.220
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	6.0 %	0.277
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.0
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	11.0 %	0.264
eye morphology	fusion between cornea and lens	males	27.0 %	0.0117
eye morphology	fusion between cornea and lens	both	18.0 %	0.0112
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	12.0 %	0.0969
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	6.0 %	0.285
eye morphology	lacrimation	females	11.0 %	0.172
eye morphology	lacrimation	males	28.0 %	0.00710
eye morphology	lacrimation	both	19.0 %	0.00490
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	11.0 %	0.397
eye morphology	lens opacity	males	27.0 %	0.0237
eye morphology	lens opacity	both	18.0 %	0.0348
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	11.0 %	0.295
eye morphology	optic disc	males	27.0 %	0.0152
eye morphology	optic disc	both	18.0 %	0.0165
eye morphology	persistence of hyaloid vascular system	females	11.0 %	0.429
eye morphology	persistence of hyaloid vascular system	males	27.0 %	0.0240
eye morphology	persistence of hyaloid vascular system	both	18.0 %	0.0435
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.00
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	12.0 %	0.213
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	6.0 %	0.303
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	11.0 %	0.365
eye morphology	retina	males	27.0 %	0.0356
eye morphology	retina	both	18.0 %	0.0430
eye morphology	retinal blood vessels	females	11.0 %	0.273
eye morphology	retinal blood vessels	males	27.0 %	0.0125
eye morphology	retinal blood vessels	both	18.0 %	0.0102
eye morphology	retinal blood vessels pattern	females	20.0 %	0.0347
eye morphology	retinal blood vessels pattern	males	27.0 %	0.0136
eye morphology	retinal blood vessels pattern	both	23.0 %	0.00158
eye morphology	retinal blood vessels structure	females	11.0 %	0.282
eye morphology	retinal blood vessels structure	males	27.0 %	0.00906
eye morphology	retinal blood vessels structure	both	18.0 %	0.0143
eye morphology	retinal pigmentation	females	11.0 %	0.380
eye morphology	retinal pigmentation	males	27.0 %	0.0325
eye morphology	retinal pigmentation	both	18.0 %	0.0457
eye morphology	retinal structure	females	11.0 %	0.284
eye morphology	retinal structure	males	27.0 %	0.0120
eye morphology	retinal structure	both	18.0 %	0.0150
eye morphology	synechia	females	11.0 %	0.268
eye morphology	synechia	males	27.0 %	0.0120
eye morphology	synechia	both	18.0 %	0.00893
eye morphology	vitreous	females	11.0 %	0.271
eye morphology	vitreous	males	27.0 %	0.00732
eye morphology	vitreous	both	18.0 %	0.0118
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.00
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.0
SHIRPA	body length	both	0.0 %	1.0
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.00
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.00
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.00
SHIRPA	coat color abdomen	both	4.0 %	1.00
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.0
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.0
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.00
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.0
SHIRPA	coat color pattern back	both	0.0 %	1.00
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.00
SHIRPA	coat color pattern head	both	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.00
SHIRPA	coat hair distribution head	females	24.0 %	0.00185
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	13.0 %	0.00474
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.00
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.0
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.00
SHIRPA	genitalia size	both	0.0 %	1.00
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.0
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.00
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.00
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.00
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.00
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.00
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	4.0 %	0.524
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	1.0 %	1.0
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.0
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.0
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.0
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.00
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.00
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.00
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.0
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	12.0 %	0.0876
SHIRPA	transfer arousal	males	28.0 %	0.00150
SHIRPA	transfer arousal	both	19.0 %	0.000312
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.00
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.00
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.0
SHIRPA	vocalization	males	2.0 %	1.00
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Ces5a^em1(IMPC)J/Mmjax -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.