MPD: JaxKOMP-EAP genotype: Fam124b<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Fam124b^em1(IMPC)J/Mmjax -/- Gene Fam124b

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-0.12931	1.6952	-0.30880	0.984	0.940
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-2.8834	2.2865	-0.63976	0.708	0.222
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	7.7155	3.1326	1.1521	0.218	0.0225
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	6.2103	5.0512	0.85818	0.625	0.233
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	3.4360	3.5289	0.52022	0.690	0.342
body composition	body length	0.026540	0.060769	0.59427	0.858	0.692
body composition	body weight (at time of DXA)	-0.63938	1.6497	-0.38672	0.856	0.724
body composition	bone area, whole body scan, head excluded	-0.099109	0.14964	-0.21602	0.772	0.555
body composition	bone mineral content of whole body scan, head excluded	0.0017762	0.016311	0.23843	0.971	0.920
body composition	bone mineral content to body weight ratio	-0.000047613	0.00040012	0.084748	0.965	0.913
body composition	bone mineral density of whole body scan, head excluded	0.00087429	0.0012537	0.98244	0.769	0.536
body composition	fat tissue mass of whole body scan, head excluded	-0.30753	0.34926	-0.57329	0.684	0.443
body composition	fat tissue mass to body weight ratio	-0.010294	0.011158	-0.43223	0.654	0.424
body composition	lean tissue mass of whole body scan, head excluded	0.66292	0.76898	1.1153	0.730	0.452
body composition	lean tissue mass to body weight ratio	0.016565	0.010586	0.81849	0.467	0.216
body composition	percent fat, whole body scan, head excluded	-1.0907	1.0527	-0.50228	0.620	0.376
body composition	ratio of soft-tissue attenuation coefficients	0.0013663	0.0011682	0.56824	0.573	0.327
body composition	tissue area	-0.039013	0.59740	0.053329	0.986	0.952
body composition	total tissue mass, whole body scan, head excluded	0.48545	0.90862	0.80370	0.804	0.630
clinical blood chemistry	alanine transaminase (plasma ALT)	7.3001	21.206	0.56334	0.927	0.763
clinical blood chemistry	albumin (plasma Alb)	0.087320	0.81639	0.18643	0.980	0.925
clinical blood chemistry	alkaline phosphatase (plasma ALP)	7.3427	8.0582	0.75546	0.688	0.458
clinical blood chemistry	aspartate transaminase (plasma AST)	-1.1632	31.277	-0.049643	0.992	0.974
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.47994	0.16996	-1.3873	0.480	0.106
clinical blood chemistry	blood urea nitrogen (BUN)	0.81930	1.0613	0.28844	0.745	0.521
clinical blood chemistry	calcium (plasma Ca)	-0.12537	0.082075	-0.54227	0.496	0.266
clinical blood chemistry	creatinine (plasma)	0.033550	0.086531	0.89037	0.854	0.736
clinical blood chemistry	glucose (plasma GLU, no fast)	-16.752	26.712	-0.34903	0.765	0.595
clinical blood chemistry	HDL cholesterol (plasma HDL)	0.85796	4.1664	-0.12145	0.954	0.856
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.038556	0.0081941	1.7603	0.268	0.0423
clinical blood chemistry	phosphorus (plasma phosphate)	0.34385	0.92681	0.47228	0.882	0.746
clinical blood chemistry	total bilirubin (plasma TBIL)	0.0053378	0.0076881	0.35507	0.811	0.559
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-2.9568	5.0026	-0.75669	0.840	0.614
clinical blood chemistry	total protein (plasma TP)	-1.2563	1.6218	-1.0522	0.740	0.520
clinical blood chemistry	triglyceride (plasma TG, no fast)	10.670	14.508	0.78857	0.772	0.539
ERG v2.0	left eye a-wave amplitude (Photopic)	-3.6652	3.6899	-1.0690	0.727	0.425
ERG v2.0	left eye a-wave amplitude (Scotopic)	10.185	19.780	0.16324	0.867	0.658
ERG v2.0	left eye a-wave implicit timing (Photopic)	0.18256	2.2804	0.28763	0.992	0.943
ERG v2.0	left eye a-wave implicit timing (Scotopic)	0.23375	1.1697	0.26130	0.965	0.860
ERG v2.0	left eye b-wave amplitude (Photopic)	7.0260	20.131	0.40076	0.922	0.760
ERG v2.0	left eye b-wave amplitude (Scotopic)	-3.3698	61.026	0.046844	0.998	0.961
ERG v2.0	left eye b-wave implicit timing (Photopic)	-1.5985	2.2959	-0.19920	0.804	0.558
ERG v2.0	left eye b-wave implicit timing (Scotopic)	-8.3258	7.7459	-0.77294	0.756	0.395
ERG v2.0	left eye c-wave amplitude (Scotopic)	-39.619	47.300	-0.49188	0.795	0.490
ERG v2.0	left eye c-wave implicit timing (Scotopic)	-51.500	27.081	-0.54214	0.633	0.198
ERG v2.0	left eye FO-like wave amplitude (Scotopic)	64.988	66.403	0.68836	0.737	0.431
ERG v2.0	left eye FO-like wave implicit timing (Scotopic)	-166.24	141.11	-0.48374	0.838	0.360
ERG v2.0	right eye a-wave amplitude (Photopic)	0.56123	2.8844	0.26699	0.979	0.864
ERG v2.0	right eye a-wave amplitude (Scotopic)	13.455	29.587	0.24994	0.942	0.694
ERG v2.0	right eye a-wave implicit timing (Photopic)	0.31730	3.3871	0.13538	0.996	0.934
ERG v2.0	right eye a-wave implicit timing (Scotopic)	-1.1042	0.67669	-0.91302	0.679	0.244
ERG v2.0	right eye b-wave amplitude (Photopic)	-7.9036	28.711	-0.84319	0.956	0.809
ERG v2.0	right eye b-wave amplitude (Scotopic)	-57.729	96.066	-0.76717	0.933	0.609
ERG v2.0	right eye b-wave implicit timing (Photopic)	-4.4015	4.7061	-0.81989	0.746	0.448
ERG v2.0	right eye b-wave implicit timing (Scotopic)	-16.807	6.6361	-1.5998	0.614	0.127
ERG v2.0	right eye c-wave amplitude (Scotopic)	-46.169	55.084	-0.74522	0.842	0.490
ERG v2.0	right eye c-wave implicit timing (Scotopic)	-37.823	66.778	-0.25904	0.867	0.628
ERG v2.0	right eye FO-like wave amplitude (Scotopic)	64.159	63.470	0.76717	0.797	0.418
ERG v2.0	right eye FO-like wave implicit timing (Scotopic)	-12.439	119.83	0.14897	0.985	0.927
glucose tolerance test	amount glucose injected	-9.6196	13.073	-1.8864	0.830	0.538
glucose tolerance test	plasma glucose, 0min	20.119	16.991	1.6103	0.586	0.358
glucose tolerance test	plasma glucose, 15min	48.398	55.092	1.4017	0.764	0.472
glucose tolerance test	plasma glucose, 30min	48.353	79.703	1.4916	0.828	0.606
glucose tolerance test	plasma glucose, 60min	45.244	53.421	1.7446	0.776	0.486
glucose tolerance test	plasma glucose, 120min	32.517	24.255	1.8632	0.617	0.312
grip strength	body weight (at time of grip strength test)	0.81107	0.99546	0.96050	0.617	0.425
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-30.969	7.2894	-1.8226	0.00646	0.000434
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.1258	0.35342	-1.3938	0.0372	0.00487
grip strength	forelimb and hindlimb grip strength by trial, trial1	-43.702	11.633	-2.3106	0.0245	0.00134
grip strength	forelimb and hindlimb grip strength by trial, trial2	-17.814	9.1067	-0.87990	0.235	0.0653
grip strength	forelimb and hindlimb grip strength by trial, trial3	-26.753	9.9136	-1.4252	0.0989	0.0138
grip strength	forelimb grip strength (mean of trials), average	-7.4145	4.7284	-0.67905	0.359	0.133
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.36221	0.46011	-0.68272	0.703	0.441
grip strength	forelimb grip strength by trial, trial1	-9.3354	5.7908	-0.80333	0.414	0.123
grip strength	forelimb grip strength by trial, trial2	-3.3547	5.8921	-0.14427	0.833	0.576
grip strength	forelimb grip strength by trial, trial3	-13.869	6.8771	-1.1638	0.278	0.0581
hematology	basophil differential (percent of total WBC)	-0.042810	0.027080	-0.63788	0.690	0.255
hematology	calculated hemoglobin (cHGB)	-0.66446	0.16507	-1.8253	0.256	0.0565
hematology	eosinophil differential (percent of total WBC)	-0.30372	0.18366	-0.74712	0.628	0.240
hematology	hematocrit (HCT)	0.41697	0.92765	0.076613	0.852	0.697
hematology	hemoglobin concentration distribution width (HDW)	-0.095928	0.079758	-2.1634	0.655	0.352
hematology	large unstained cells (percent of total WBC)	-0.11246	0.24007	-0.75698	0.876	0.686
hematology	lymphocyte differential (percent of total WBC)	1.0041	0.68762	0.37782	0.538	0.282
hematology	mean corpuscular hemoglobin (CHr)	-0.029819	0.18288	-0.22376	0.944	0.885
hematology	mean platelet volume (MPV)	0.46917	0.22128	1.6795	0.366	0.168
hematology	mean RBC corpuscular hemoglobin (MCH)	0.22048	0.074743	0.82878	0.406	0.0983
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.56689	0.24655	-0.95222	0.494	0.148
hematology	mean RBC corpuscular volume (MCV)	1.4786	0.32684	2.0283	0.164	0.0455
hematology	measured hemoglobin (mHGB)	-0.11228	0.34597	-0.51485	0.897	0.776
hematology	monocyte differential (percent of total WBC)	-0.25316	0.15009	-0.62138	0.593	0.234
hematology	neutrophil differential (percent of total WBC)	-0.89161	0.69548	-0.41032	0.568	0.328
hematology	platelet count (PLT; units per volume x 10³)	55.261	56.334	0.77862	0.749	0.430
hematology	RBC corpuscular distribution width (RDW)	0.055068	0.10489	0.20075	0.820	0.652
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-1.0678	0.71617	-2.2634	0.532	0.274
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.31716	0.13250	-1.4647	0.391	0.139
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-30.699	11.609	-1.1695	0.485	0.118
hematology	reticulocyte differential (percent of total RBC)	-0.15873	0.16306	-0.48278	0.752	0.433
hematology	white blood cell count (WBC; units per volume x 10³)	-0.16500	0.92984	0.068391	0.930	0.876
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.82519	1.0910	0.82253	0.814	0.455
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.86091	0.57879	1.4806	0.678	0.146
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.054089	0.67581	0.016036	0.978	0.937
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.11152	0.89607	0.19621	0.975	0.902
holeboard	number of hole pokes by individual hole number, 20 min test, 5	1.2072	0.77840	1.7698	0.643	0.130
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.34713	0.30265	0.92692	0.834	0.259
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.63900	0.31242	1.4748	0.630	0.0489
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.32176	0.99204	0.67714	0.960	0.748
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.0013351	0.42690	0.11171	1.00	0.998
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.75372	0.35408	1.6792	0.582	0.0408
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.66468	0.30361	1.4268	0.582	0.0358
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.20047	0.60586	0.45741	0.952	0.743
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.43959	0.63112	0.51822	0.816	0.491
holeboard	number of hole pokes by individual hole number, 20 min test, 14	1.0588	0.52601	1.5787	0.415	0.0523
holeboard	number of hole pokes by individual hole number, 20 min test, 15	1.2309	0.60662	1.7386	0.465	0.0503
holeboard	number of hole pokes by individual hole number, 20 min test, 16	1.1307	0.94741	0.99103	0.660	0.241
holeboard	total number of hole pokes, 20 min test	9.6129	4.6811	1.2839	0.247	0.0480
light / dark	latency to enter dark zone, 20 min test	4.1813	45.869	-0.035160	0.976	0.928
light / dark	number of transitions between light and dark zones, 20 min test	-8.8665	9.1600	-0.79959	0.647	0.340
light / dark	percentage of total time in dark zone, 20 min test	0.13762	3.4663	0.14791	0.989	0.969
light / dark	percentage of total time in light zone, 20 min test	-0.13762	3.4663	-0.15474	0.988	0.969
light / dark	time mobile in dark zone, 20 min test	5.6109	15.577	0.28503	0.885	0.721
light / dark	time mobile in light zone, 20 min test	0.56744	11.164	-0.20559	0.979	0.960
light / dark	time spent in dark zone, 20 min test	-2.4465	43.355	0.16707	0.989	0.955
light / dark	time spent in light zone, 20 min test	2.4465	43.355	-0.16707	0.989	0.955
open field	average speed in center of arena, 20 min test	-0.24055	0.37930	-0.51533	0.802	0.529
open field	average speed in periphery of arena, 20 min test	0.056727	0.13967	-0.29349	0.831	0.686
open field	distance traveled habituation ratio, 20 min test	-3.1098	6.8747	-0.21718	0.858	0.653
open field	distance traveled in center of arena, 20 min test	137.60	90.300	0.51533	0.359	0.134
open field	distance traveled in periphery of arena, 20 min test	-87.712	151.93	-0.77353	0.759	0.566
open field	distance traveled slope, 20 min test	-5.4372	6.1268	-0.44452	0.688	0.379
open field	distance traveled, 20 min test, 1st 5min	-12.118	72.319	-0.44897	0.943	0.868
open field	distance traveled, 20 min test, 2nd 5min	88.081	49.351	0.48944	0.256	0.0806
open field	distance traveled, 20 min test, 3rd 5min	6.6990	45.131	-0.34435	0.955	0.883
open field	distance traveled, 20 min test, 4th 5min	-33.143	49.946	-0.83475	0.735	0.510
open field	number of clockwise revolution episodes, 20 min test	-1.1186	1.3468	-1.1078	0.748	0.410
open field	number of counter-clockwise revolution episodes, 20 min test	1.5054	1.0392	0.38164	0.424	0.154
open field	number of rears in 5 min bins, 20 min test, 1st 5min	0.50584	2.0060	-0.068563	0.917	0.802
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-1.5592	2.2428	-0.75020	0.729	0.490
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-3.6901	2.1054	-1.1644	0.295	0.0860
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-4.9145	2.5182	-1.3885	0.256	0.0568
open field	percentage of total time in center of arena, 20 min test	9.1379	3.1164	1.6788	0.0940	0.00519
open field	percentage of total time in center of arena, slope, 20 min test	-2.4545	1.7603	-1.1513	0.635	0.170
open field	percentage of total time in center, habituation ratio, 20 min test	-2.4926	1.8570	-1.1358	0.663	0.186
open field	percentage of total time in corners of arena, 20 min test	-4.1963	3.8148	-0.46536	0.585	0.277
open field	percentage of total time in corners, habituation ratio, 20 min test	2.4206	1.8381	0.79729	0.690	0.194
open field	percentage of total time in corners, slope, 20 min test	2.5804	1.8136	0.88528	0.646	0.161
open field	permanence time in center of arena, 20 min test	109.67	37.396	1.6843	0.0938	0.00518
open field	permanence time in corners of arena, 20 min test	-50.356	45.778	-0.46536	0.585	0.277
open field	permanence time in periphery of arena, 20 min test	-109.65	37.395	-1.6843	0.0940	0.00519
open field	total distance traveled, 20 min test	46.955	188.21	-0.34577	0.900	0.804
open field	total number of rears, 20 min test	-9.7007	7.6699	-1.0388	0.454	0.212
open field	whole arena average speed, 20 min test	0.039571	0.15692	-0.34577	0.900	0.802
open field	whole arena resting time, 20 min test	-15.759	17.360	0.096144	0.570	0.369
open field	whole arena time spent mobile, 20 min test	15.593	17.344	0.13805	0.584	0.373
open field	whole arena time spent vertical, 20 min test	-19.492	6.9630	-1.5594	0.0832	0.00741
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-1.7665	1.4347	-0.54531	0.548	0.232
startle / PPI	average baseline movement during background noise	-1.2986	2.1002	-0.87771	0.901	0.541
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.14938	0.068714	1.1939	0.276	0.0383
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.14772	0.066994	1.3299	0.273	0.0358
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	6.2452	7.6611	0.72323	0.879	0.422
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	14.833	7.5984	1.4894	0.368	0.0614
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	13.681	6.5961	1.3104	0.246	0.0474
startle / PPI	average startle response to full pulse (120 dB)	-109.55	46.343	-1.5424	0.122	0.0253
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-103.99	43.605	-1.4207	0.109	0.0241
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-115.44	42.221	-1.7226	0.0643	0.0107
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-100.49	37.126	-1.7675	0.0705	0.0114
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.22457	1.5840	0.23113	0.981	0.888
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	2.5530	1.2574	1.3071	0.508	0.0523
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	3.8981	2.2178	1.2908	0.501	0.0897
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.066577	0.087987	0.65396	0.900	0.456
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.17645	0.088176	1.4318	0.320	0.0552
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.20014	0.079921	1.3405	0.122	0.0184
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-108.47	46.956	-1.5154	0.129	0.0285
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-104.74	44.141	-1.4285	0.111	0.0247
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-118.91	42.444	-1.7478	0.0580	0.00912
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-104.66	37.854	-1.8781	0.0642	0.00996
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.051709	0.098629	0.47471	0.930	0.604
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.18894	0.088313	1.4166	0.278	0.0413
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.20791	0.078075	1.3134	0.0979	0.0127
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-409.75	170.29	-1.5952	0.112	0.0230
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-390.21	156.87	-1.4851	0.0915	0.0191
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-454.87	148.42	-1.8541	0.0362	0.00478
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-391.87	133.33	-1.9479	0.0467	0.00653
startle / PPI	maximum baseline movement during background noise	-2.0069	4.8445	-0.54006	0.936	0.682
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	4.9913	8.9503	0.52714	0.938	0.582
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	15.890	7.6937	1.4018	0.320	0.0483
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	15.860	6.7140	1.3238	0.164	0.0254
startle / PPI	maximum startle response to full pulse (120 dB)	-411.54	169.09	-1.6103	0.107	0.0216
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-390.36	155.72	-1.5066	0.0892	0.0183
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-444.28	147.70	-1.8164	0.0391	0.00551
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-384.09	131.37	-1.9118	0.0487	0.00678
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-0.020697	4.0200	0.11585	1.00	0.996
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	6.0184	5.1793	1.3760	0.751	0.255
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	7.0840	5.7942	0.96333	0.616	0.232

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	16.0 %	0.0808
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	9.0 %	0.0996
eye morphology	bulging eye	females	16.0 %	0.0626
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	9.0 %	0.0809
eye morphology	cornea	females	16.0 %	0.0877
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	9.0 %	0.113
eye morphology	cornea opacity	females	28.0 %	0.0276
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	15.0 %	0.0458
eye morphology	cornea vascularization	females	31.0 %	0.00944
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	17.0 %	0.0155
eye morphology	corneal deposits	females	16.0 %	0.110
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	9.0 %	0.148
eye morphology	corneal mineralization	females	16.0 %	0.117
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	9.0 %	0.142
eye morphology	corneal scleralization	females	16.0 %	0.111
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	9.0 %	0.142
eye morphology	corneal ulcer	females	16.0 %	0.0842
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	9.0 %	0.108
eye morphology	eye closure	females	16.0 %	0.0624
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	9.0 %	0.0807
eye morphology	eye hemorrhage or blood presence	females	16.0 %	0.0893
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	9.0 %	0.114
eye morphology	eyelid morphology	females	16.0 %	0.0687
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	9.0 %	0.0863
eye morphology	eyes (present, absent)	females	17.0 %	0.00688
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	9.0 %	0.00645
eye morphology	fusion between cornea and lens	females	15.0 %	0.205
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	7.0 %	0.269
eye morphology	iris pigmentation	females	16.0 %	0.0781
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	8.0 %	0.155
eye morphology	iris transillumination	females	16.0 %	0.0635
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	9.0 %	0.136
eye morphology	irispupil	females	29.0 %	0.0217
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	15.0 %	0.0405
eye morphology	lacrimation	females	16.0 %	0.132
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	8.0 %	0.255
eye morphology	lens	females	15.0 %	0.240
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	8.0 %	0.380
eye morphology	lens opacity	females	15.0 %	0.312
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	7.0 %	0.421
eye morphology	narrow eye opening	females	31.0 %	0.00771
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	17.0 %	0.0145
eye morphology	optic disc	females	15.0 %	0.231
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	7.0 %	0.308
eye morphology	persistence of hyaloid vascular system	females	20.0 %	0.166
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	0.295
eye morphology	pupil dilation	females	16.0 %	0.0803
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	8.0 %	0.169
eye morphology	pupil light response	females	16.0 %	0.0825
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	8.0 %	0.169
eye morphology	pupil position	females	29.0 %	0.0244
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	14.0 %	0.0466
eye morphology	pupil shape	females	16.0 %	0.0916
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	8.0 %	0.178
eye morphology	retina	females	15.0 %	0.280
eye morphology	retina	males	14.0 %	0.580
eye morphology	retina	both	7.0 %	0.343
eye morphology	retinal blood vessels	females	15.0 %	0.213
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	7.0 %	0.279
eye morphology	retinal blood vessels pattern	females	15.0 %	0.257
eye morphology	retinal blood vessels pattern	males	2.0 %	1.00
eye morphology	retinal blood vessels pattern	both	7.0 %	0.332
eye morphology	retinal blood vessels structure	females	15.0 %	0.220
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	7.0 %	0.291
eye morphology	retinal pigmentation	females	15.0 %	0.282
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	7.0 %	0.502
eye morphology	retinal structure	females	15.0 %	0.222
eye morphology	retinal structure	males	2.0 %	1.00
eye morphology	retinal structure	both	7.0 %	0.296
eye morphology	synechia	females	15.0 %	0.209
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	7.0 %	0.273
eye morphology	vitreous	females	15.0 %	0.211
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	7.0 %	0.275
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	12.0 %	0.0175
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	6.0 %	0.0234
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	24.0 %	0.00126
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	12.0 %	0.00316
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	24.0 %	0.00365
SHIRPA	coat hair distribution abdomen	both	12.0 %	0.00512
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	16.0 %	0.154
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	5.0 %	0.327
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	12.0 %	0.0436
SHIRPA	snout size	both	6.0 %	0.0575
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Fam124b^em1(IMPC)J/Mmjax -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.