MPD: JaxKOMP-EAP genotype: Ier5l<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Ier5l^em1(IMPC)J/Mmjax -/- Gene Ier5l

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

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Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-1.7788	3.6390	-0.77959	0.892	0.632
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-11.017	4.9521	-1.7898	0.386	0.0419
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-2.6651	4.6772	-0.75376	0.844	0.577
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	3.1751	3.6456	0.41943	0.742	0.398
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	7.1667	6.0464	1.0989	0.642	0.256
body composition	body length	-0.053531	0.059425	-0.42521	0.661	0.372
body composition	body weight (at time of DXA)	-0.33460	0.88857	-0.18041	0.848	0.708
body composition	bone area, whole body scan, head excluded	-0.78183	0.14728	-2.2241	0.000349	0.00000266
body composition	bone mineral content of whole body scan, head excluded	-0.041029	0.011503	-1.7535	0.0186	0.000819
body composition	bone mineral content to body weight ratio	-0.0018651	0.00050684	-1.8428	0.0121	0.000580
body composition	bone mineral density of whole body scan, head excluded	-0.00043446	0.00062411	-0.45282	0.749	0.490
body composition	fat tissue mass of whole body scan, head excluded	0.62808	0.34719	0.93522	0.261	0.0766
body composition	fat tissue mass to body weight ratio	0.022819	0.012230	0.99841	0.221	0.0681
body composition	lean tissue mass of whole body scan, head excluded	0.42757	0.33265	0.73219	0.508	0.205
body composition	lean tissue mass to body weight ratio	0.010993	0.013127	0.53619	0.648	0.406
body composition	percent fat, whole body scan, head excluded	1.6442	1.1389	0.82271	0.374	0.155
body composition	ratio of soft-tissue attenuation coefficients	-0.0020812	0.0012557	-0.91072	0.291	0.104
body composition	tissue area	-0.29537	0.21942	-0.80669	0.468	0.184
body composition	total tissue mass, whole body scan, head excluded	1.0003	0.25261	1.6598	0.00578	0.000242
clinical blood chemistry	alanine transaminase (plasma ALT)	-5.0091	5.4577	-0.48051	0.710	0.362
clinical blood chemistry	albumin (plasma Alb)	-0.98831	0.38839	-1.2216	0.139	0.0134
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-1.6442	3.4849	-0.82319	0.812	0.639
clinical blood chemistry	aspartate transaminase (plasma AST)	-20.810	7.5661	-0.94208	0.106	0.00779
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.29155	0.13951	-0.91080	0.335	0.0407
clinical blood chemistry	blood urea nitrogen (BUN)	4.4782	1.1039	1.6876	0.00581	0.000140
clinical blood chemistry	calcium (plasma Ca)	-0.12083	0.073041	-0.49992	0.288	0.103
clinical blood chemistry	creatinine (plasma)	0.00050586	0.020955	0.11774	0.990	0.981
clinical blood chemistry	glucose (plasma GLU, no fast)	16.684	10.119	0.93708	0.261	0.104
clinical blood chemistry	HDL cholesterol (plasma HDL)	4.7061	2.8596	0.76492	0.354	0.105
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.0070101	0.0088313	0.25982	0.731	0.430
clinical blood chemistry	phosphorus (plasma phosphate)	-0.18990	0.34564	-0.36339	0.801	0.585
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.013708	0.0082820	-1.0004	0.383	0.103
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	4.4217	3.9905	0.55218	0.589	0.272
clinical blood chemistry	total protein (plasma TP)	-1.3960	0.54642	-1.1298	0.119	0.0131
clinical blood chemistry	triglyceride (plasma TG, no fast)	-4.7611	19.991	-0.034344	0.917	0.813
glucose tolerance test	amount glucose injected	-1.6467	1.8886	-0.13447	0.741	0.386
glucose tolerance test	plasma glucose, 0min	8.4352	4.5138	0.64125	0.197	0.0657
glucose tolerance test	plasma glucose, 15min	-20.311	17.501	-0.43777	0.581	0.250
glucose tolerance test	plasma glucose, 30min	-34.535	16.714	-0.94430	0.243	0.0424
glucose tolerance test	plasma glucose, 60min	-19.800	13.394	-0.72089	0.444	0.144
glucose tolerance test	plasma glucose, 120min	9.7406	7.5222	0.54467	0.509	0.200
grip strength	body weight (at time of grip strength test)	-1.6250	0.47863	-1.1877	0.00935	0.00116
grip strength	forelimb and hindlimb grip strength (mean of trials), average	1.6695	5.6812	0.35592	0.883	0.770
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.00057649	0.27719	0.20177	0.999	0.998
grip strength	forelimb and hindlimb grip strength by trial, trial1	-1.9768	7.2291	0.085789	0.919	0.785
grip strength	forelimb and hindlimb grip strength by trial, trial2	7.2432	6.8190	0.72363	0.546	0.292
grip strength	forelimb and hindlimb grip strength by trial, trial3	-2.5787	7.5316	0.031956	0.886	0.733
grip strength	forelimb grip strength (mean of trials), average	-5.8520	3.9776	-0.47959	0.375	0.146
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.33110	0.19042	-0.60063	0.288	0.0867
grip strength	forelimb grip strength by trial, trial1	-0.23964	4.9633	0.25995	0.984	0.962
grip strength	forelimb grip strength by trial, trial2	-9.5560	4.4801	-0.81948	0.231	0.0366
grip strength	forelimb grip strength by trial, trial3	-7.7602	5.2728	-0.59889	0.432	0.146
heart weight	heart weight, normalized to body weight	0.27868	0.12482	0.51281	0.126	0.0287
heart weight	heart weight, weight	9.2559	3.9139	0.84355	0.106	0.0207
hematology	basophil differential (percent of total WBC)	-0.015572	0.055561	-0.23553	0.940	0.780
hematology	eosinophil differential (percent of total WBC)	-0.20242	0.25623	-0.49466	0.789	0.432
hematology	hematocrit (HCT)	1.2776	0.54469	1.0773	0.162	0.0219
hematology	lymphocyte differential (percent of total WBC)	1.4618	1.2071	0.51533	0.486	0.230
hematology	mean corpuscular hemoglobin (CHr)	0.11643	0.065619	0.90770	0.248	0.0805
hematology	mean platelet volume (MPV)	-0.079840	0.076402	-0.71776	0.529	0.300
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.026951	0.14063	-0.047959	0.949	0.849
hematology	mean RBC corpuscular volume (MCV)	0.44778	0.20527	0.79164	0.133	0.0326
hematology	measured hemoglobin (mHGB)	0.36633	0.16095	0.75255	0.199	0.0260
hematology	monocyte differential (percent of total WBC)	0.019967	0.27075	0.27685	0.978	0.941
hematology	neutrophil differential (percent of total WBC)	-1.2806	1.0358	-0.58531	0.471	0.221
hematology	platelet count (PLT; units per volume x 10³)	-185.11	48.779	-1.9403	0.0145	0.000317
hematology	RBC corpuscular distribution width (RDW)	0.35693	0.13222	1.1336	0.0872	0.00878
hematology	red blood cell count (RBC; per volume x 10⁶)	0.17911	0.13482	0.44529	0.451	0.188
hematology	reticulocyte count (Retic; units per volume x 10⁹)	40.158	17.723	1.5525	0.278	0.0267
hematology	reticulocyte differential (percent of total RBC)	0.33404	0.16901	1.4172	0.345	0.0522
hematology	white blood cell count (WBC; units per volume x 10³)	0.36104	0.52800	0.42823	0.679	0.496
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.74290	0.80700	-0.68993	0.758	0.360
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.69606	0.50587	-0.96607	0.697	0.172
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.61741	0.52335	-0.96339	0.745	0.241
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.36682	0.67513	-0.26907	0.879	0.588
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.77864	0.47916	-1.1689	0.622	0.108
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.26908	0.30120	0.75172	0.881	0.374
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.21934	0.28371	0.59943	0.902	0.441
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.50148	0.42771	-0.73122	0.757	0.244
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.19809	0.50866	0.44498	0.941	0.698
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.016547	0.33375	0.032142	0.992	0.961
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.10452	0.31928	0.30888	0.950	0.744
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-1.0632	0.48121	-1.5729	0.351	0.0296
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.88226	0.71278	-0.78802	0.647	0.219
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.60405	0.45731	-0.85906	0.625	0.190
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.57006	0.44905	-0.82776	0.667	0.207
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.68763	0.65186	-0.55917	0.704	0.294
holeboard	total number of hole pokes, 20 min test	-7.1381	4.3273	-0.93472	0.353	0.102
light / dark	latency to enter dark zone, 20 min test	-86.397	43.416	-1.6754	0.417	0.0492
light / dark	number of transitions between light and dark zones, 20 min test	-11.621	6.4202	-1.0554	0.332	0.0732
light / dark	percentage of total time in dark zone, 20 min test	0.45285	4.4700	0.20283	0.977	0.920
light / dark	percentage of total time in light zone, 20 min test	-0.45291	4.4701	-0.20974	0.976	0.919
light / dark	time mobile in dark zone, 20 min test	-12.321	9.0681	-0.84703	0.470	0.177
light / dark	time mobile in light zone, 20 min test	7.3854	8.4152	0.24442	0.642	0.382
light / dark	time spent in dark zone, 20 min test	69.632	56.709	1.2828	0.643	0.222
light / dark	time spent in light zone, 20 min test	-69.633	56.709	-1.2828	0.643	0.222
open field	average speed in center of arena, 20 min test	1.0137	0.54586	1.5731	0.340	0.0661
open field	average speed in periphery of arena, 20 min test	-0.29788	0.13126	-1.5919	0.106	0.0253
open field	distance traveled habituation ratio, 20 min test	-3.4943	6.4222	-0.25446	0.811	0.588
open field	distance traveled in center of arena, 20 min test	-246.44	98.598	-1.8731	0.0920	0.0140
open field	distance traveled in periphery of arena, 20 min test	-291.43	144.91	-1.6162	0.185	0.0469
open field	distance traveled slope, 20 min test	-5.6692	6.0187	-0.46986	0.667	0.348
open field	distance traveled, 20 min test, 1st 5min	-54.385	63.571	-0.77898	0.639	0.394
open field	distance traveled, 20 min test, 2nd 5min	-143.68	48.702	-2.0252	0.0370	0.00393
open field	distance traveled, 20 min test, 3rd 5min	-231.05	54.686	-2.4878	0.00153	0.0000517
open field	distance traveled, 20 min test, 4th 5min	-93.261	50.427	-1.4907	0.236	0.0672
open field	number of clockwise revolution episodes, 20 min test	-2.6372	1.1597	-1.9301	0.188	0.0250
open field	number of counter-clockwise revolution episodes, 20 min test	-1.8561	1.2153	-1.4434	0.390	0.130
open field	number of rears in 5 min bins, 20 min test, 1st 5min	5.7828	2.3220	1.3373	0.110	0.0144
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	6.1564	3.1111	1.2079	0.233	0.0505
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	3.9954	3.1156	0.62924	0.477	0.203
open field	number of rears in 5 min bins, 20 min test, 4th 5min	0.44840	3.3188	-0.26418	0.947	0.893
open field	percentage of total time in center of arena, 20 min test	-2.3687	2.9123	-0.77716	0.717	0.418
open field	percentage of total time in center of arena, slope, 20 min test	-3.1547	1.1467	-1.4706	0.229	0.00700
open field	percentage of total time in center, habituation ratio, 20 min test	-2.6900	1.1847	-1.2191	0.356	0.0252
open field	percentage of total time in corners of arena, 20 min test	4.2757	3.4912	1.0740	0.538	0.223
open field	percentage of total time in corners, habituation ratio, 20 min test	0.38981	1.5067	-0.10289	0.963	0.796
open field	percentage of total time in corners, slope, 20 min test	0.73376	1.4014	0.066508	0.911	0.602
open field	permanence time in center of arena, 20 min test	-28.410	34.946	-0.77716	0.717	0.418
open field	permanence time in corners of arena, 20 min test	51.306	41.894	1.0740	0.538	0.223
open field	permanence time in periphery of arena, 20 min test	28.400	34.948	0.77898	0.717	0.418
open field	total distance traveled, 20 min test	-428.03	177.84	-1.6064	0.0821	0.0179
open field	total number of rears, 20 min test	16.587	10.184	0.79177	0.307	0.106
open field	whole arena average speed, 20 min test	-0.35621	0.14820	-1.6064	0.0827	0.0180
open field	whole arena resting time, 20 min test	59.426	22.840	2.0688	0.0558	0.0106
open field	whole arena time spent mobile, 20 min test	-0.87614	11.809	-0.57136	0.971	0.941
open field	whole arena time spent vertical, 20 min test	10.603	8.4120	0.71162	0.519	0.210
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-1.6782	1.5755	-0.50639	0.598	0.290
startle / PPI	average baseline movement during background noise	0.24803	2.0245	0.26146	0.993	0.903
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.011762	0.075586	0.0021017	0.950	0.877
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.021387	0.068307	0.13578	0.904	0.755
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	17.138	8.6037	2.0628	0.784	0.0509
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-5.7674	7.5619	-0.59604	0.747	0.449
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-3.6550	6.4805	-0.47785	0.827	0.575
startle / PPI	average startle response to full pulse (120 dB)	-109.57	40.508	-1.5470	0.0608	0.00888
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-143.01	40.011	-1.9032	0.00940	0.000694
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-95.946	33.337	-1.4603	0.0400	0.00551
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-72.855	27.688	-1.3339	0.0686	0.0108
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-2.3204	1.8272	-1.5517	0.747	0.209
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.9636	1.8015	-1.3339	0.800	0.280
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-4.1640	2.5364	-2.0288	0.530	0.106
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.13143	0.093253	1.2781	0.827	0.164
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.042110	0.080973	-0.45186	0.844	0.605
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.022868	0.069460	-0.37297	0.892	0.743
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-111.58	40.627	-1.5470	0.0544	0.00794
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-140.70	40.668	-1.8781	0.0123	0.000992
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-93.956	33.393	-1.4169	0.0462	0.00658
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-68.627	27.790	-1.2349	0.0860	0.0163
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.14361	0.10118	1.2593	0.804	0.161
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.070871	0.090632	-0.61241	0.732	0.437
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.037991	0.071357	-0.46170	0.796	0.596
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-414.88	153.45	-1.6103	0.0586	0.00891
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-513.84	148.29	-1.9032	0.0118	0.000976
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-347.31	127.18	-1.4851	0.0525	0.00825
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-255.86	105.74	-1.2531	0.0930	0.0185
startle / PPI	maximum baseline movement during background noise	1.5075	6.3220	0.54006	0.964	0.812
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	11.920	8.8794	1.2531	0.884	0.184
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-8.3849	8.5084	-0.80970	0.680	0.328
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-5.0466	6.9103	-0.60949	0.740	0.468
startle / PPI	maximum startle response to full pulse (120 dB)	-408.55	152.87	-1.6052	0.0625	0.00968
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-516.63	146.46	-1.9206	0.00992	0.000804
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-351.03	126.99	-1.5066	0.0488	0.00753
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-265.80	105.49	-1.3238	0.0782	0.0144
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-2.9640	5.2623	-0.82143	0.890	0.575
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-3.6947	4.0945	-1.0349	0.800	0.370
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-9.7357	6.2960	-1.9387	0.502	0.127

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	14.0 %	0.0693
eye morphology	cornea	both	6.0 %	0.326
eye morphology	cornea opacity	females	9.0 %	0.359
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	5.0 %	0.408
eye morphology	cornea vascularization	females	12.0 %	0.189
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	6.0 %	0.221
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.0
eye morphology	corneal scleralization	females	11.0 %	0.220
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	6.0 %	0.277
eye morphology	corneal ulcer	females	12.0 %	0.0367
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	7.0 %	0.0486
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	11.0 %	0.275
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	5.0 %	0.415
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	11.0 %	0.316
eye morphology	lens opacity	males	23.0 %	0.0446
eye morphology	lens opacity	both	13.0 %	0.0615
eye morphology	narrow eye opening	females	12.0 %	0.171
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	6.0 %	0.135
eye morphology	optic disc	females	12.0 %	0.0709
eye morphology	optic disc	males	14.0 %	0.0536
eye morphology	optic disc	both	13.0 %	0.00668
eye morphology	persistence of hyaloid vascular system	females	6.0 %	0.690
eye morphology	persistence of hyaloid vascular system	males	13.0 %	0.115
eye morphology	persistence of hyaloid vascular system	both	5.0 %	0.372
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.00
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	11.0 %	0.301
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	5.0 %	0.440
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.0
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	14.0 %	0.0291
eye morphology	retinal blood vessels pattern	both	6.0 %	0.160
eye morphology	retinal blood vessels structure	females	58.0 %	3.20e-10
eye morphology	retinal blood vessels structure	males	26.0 %	0.000172
eye morphology	retinal blood vessels structure	both	44.0 %	4.20e-13
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	11.0 %	0.478
eye morphology	retinal pigmentation	both	6.0 %	0.770
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.00
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.00
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	14.0 %	0.0458
SHIRPA	aggression	both	6.0 %	0.0825
SHIRPA	body length	females	12.0 %	0.0175
SHIRPA	body length	males	0.0 %	1.0
SHIRPA	body length	both	7.0 %	0.0219
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.00
SHIRPA	body thickness	females	12.0 %	0.0517
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	6.0 %	0.0748
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	11.0 %	0.228
SHIRPA	coat color abdomen	both	3.0 %	0.420
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.0
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.0
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.00
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.0
SHIRPA	coat color pattern back	both	0.0 %	1.00
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.00
SHIRPA	coat color pattern head	both	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.00
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.00
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.0
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.00
SHIRPA	genitalia size	both	0.0 %	1.00
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	12.0 %	0.00879
SHIRPA	head morphology	males	0.0 %	1.0
SHIRPA	head morphology	both	6.0 %	0.0300
SHIRPA	head size	females	12.0 %	0.00294
SHIRPA	head size	males	0.0 %	1.00
SHIRPA	head size	both	7.0 %	0.00828
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.00
SHIRPA	hindlimb digit size	females	12.0 %	0.0117
SHIRPA	hindlimb digit size	males	0.0 %	1.00
SHIRPA	hindlimb digit size	both	7.0 %	0.0165
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.00
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.00
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.620
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.0
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.0
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.0
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	28.0 %	0.000680
SHIRPA	snout size	both	13.0 %	0.00146
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.00
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.00
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.00
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.0
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	12.0 %	0.0876
SHIRPA	transfer arousal	males	2.0 %	1.0
SHIRPA	transfer arousal	both	6.0 %	0.102
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.00
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.00
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.00
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Ier5l^em1(IMPC)J/Mmjax -/- with genotype: