MPD: JaxKOMP-EAP genotype: Tmem131<sup>em1(IMPC)J</sup>/Mmjax -/+

JaxKOMP-EAP effect sizes: Tmem131^em1(IMPC)J/Mmjax -/+ Gene Tmem131

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	0.62500	1.9511	-0.079316	0.935	0.765
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	1.6667	3.4949	0.39932	0.902	0.658
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	1.0962	1.8018	0.078902	0.844	0.576
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-3.7858	4.9754	-0.69271	0.789	0.489
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-4.8273	6.7689	-0.75597	0.795	0.515
body composition	body length	0.098616	0.084459	1.4051	0.560	0.257
body composition	body weight (at time of DXA)	-3.1722	1.5402	-1.7109	0.175	0.0527
body composition	bone area, whole body scan, head excluded	0.079028	0.28386	0.51939	0.909	0.784
body composition	bone mineral content of whole body scan, head excluded	0.013997	0.020798	0.95874	0.750	0.509
body composition	bone mineral content to body weight ratio	0.00017438	0.00069750	0.39652	0.917	0.805
body composition	bone mineral density of whole body scan, head excluded	0.0010376	0.00085797	1.1408	0.540	0.241
body composition	fat tissue mass of whole body scan, head excluded	-0.84503	0.59575	-1.5555	0.407	0.172
body composition	fat tissue mass to body weight ratio	-0.031205	0.018421	-1.4010	0.292	0.107
body composition	lean tissue mass of whole body scan, head excluded	1.0257	0.47699	1.6598	0.231	0.0446
body composition	lean tissue mass to body weight ratio	0.027435	0.016364	1.3346	0.324	0.110
body composition	percent fat, whole body scan, head excluded	-2.8914	1.7463	-1.3724	0.309	0.114
body composition	ratio of soft-tissue attenuation coefficients	0.0031357	0.0019939	1.3505	0.338	0.132
body composition	tissue area	-0.034723	0.20308	0.060174	0.961	0.866
body composition	total tissue mass, whole body scan, head excluded	0.94239	0.32514	1.5419	0.0658	0.00921
clinical blood chemistry	alanine transaminase (plasma ALT)	-4.6500	4.4360	-0.45522	0.673	0.306
clinical blood chemistry	albumin (plasma Alb)	-0.55000	0.43726	-0.70616	0.533	0.222
clinical blood chemistry	alkaline phosphatase (plasma ALP)	18.968	5.2323	1.9621	0.0229	0.00169
clinical blood chemistry	aspartate transaminase (plasma AST)	-19.917	10.178	-0.91588	0.331	0.0645
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.085303	0.29586	-0.27304	0.932	0.776
clinical blood chemistry	blood urea nitrogen (BUN)	1.6495	2.2499	0.64642	0.715	0.472
clinical blood chemistry	calcium (plasma Ca)	-0.33500	0.10013	-1.8968	0.0324	0.00306
clinical blood chemistry	creatinine (plasma)	0.018858	0.012178	0.57936	0.356	0.138
clinical blood chemistry	glucose (plasma GLU, no fast)	-22.750	15.002	-0.55997	0.326	0.144
clinical blood chemistry	HDL cholesterol (plasma HDL)	-10.685	3.9163	-2.1347	0.123	0.0126
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.011671	0.024255	0.48928	0.872	0.636
clinical blood chemistry	phosphorus (plasma phosphate)	-0.46352	0.42839	-0.79932	0.581	0.292
clinical blood chemistry	total bilirubin (plasma TBIL)	0.0015048	0.011929	0.10951	0.969	0.901
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-14.350	5.0503	-2.1768	0.0962	0.00978
clinical blood chemistry	total protein (plasma TP)	0.025000	0.81359	-0.035694	0.990	0.976
clinical blood chemistry	triglyceride (plasma TG, no fast)	-17.475	8.9571	-0.72941	0.265	0.0645
EKG	duration of PQ interval	-0.29334	0.88149	-0.17621	0.939	0.742
EKG	duration of PR interval	-0.080499	0.85203	0.018136	0.982	0.925
EKG	duration of QRS interval	0.29429	0.23238	0.70775	0.885	0.216
EKG	duration of QT interval	-0.066960	1.1664	0.084730	0.996	0.955
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.16744	1.2142	-0.13745	0.994	0.891
EKG	duration of RR interval	1.3238	1.0138	0.94619	0.614	0.203
EKG	duration of ST interval	-0.32288	1.0843	-0.11916	0.955	0.768
EKG	heart rate coefficient of variation (signal intensity)	1.4144	0.50104	1.2131	0.524	0.00883
EKG	heart rate variability, mean of differences between sequential beats; beats per min	9.7897	3.5272	1.1842	0.533	0.00989
EKG	heart rate, beats per min	-10.930	9.2340	-0.94881	0.650	0.247
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.034509	0.080478	-0.39195	0.892	0.671
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.078397	0.12879	-0.56156	0.811	0.548
EKG	number of signals	-15.085	9.2743	-2.1229	0.605	0.116
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	7.2854	2.3213	1.3812	0.538	0.00408
EKG	QT dispersion, measured as inter-lead variability of QT intervals	3.7359	1.7073	1.0524	0.832	0.0378
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	3.1422	1.7978	0.82395	0.808	0.0923
EKG	root mean square of successive differences of neighboring RR intervals	0.77978	0.37345	0.53646	0.843	0.0464
glucose tolerance test	amount glucose injected	0.45481	2.1957	0.50540	0.949	0.838
glucose tolerance test	plasma glucose, 0min	6.9387	11.874	0.49439	0.754	0.566
glucose tolerance test	plasma glucose, 15min	20.388	19.717	0.70673	0.642	0.314
glucose tolerance test	plasma glucose, 30min	2.6594	27.836	0.21722	0.971	0.925
glucose tolerance test	plasma glucose, 60min	21.159	18.251	0.93151	0.592	0.261
glucose tolerance test	plasma glucose, 120min	17.865	14.637	1.0624	0.548	0.236
grip strength	body weight (at time of grip strength test)	0.051190	0.43369	0.25964	0.950	0.907
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-35.439	4.4260	-2.0249	7.99e-7	9.26e-10
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.6869	0.20775	-2.0723	3.77e-7	6.55e-10
grip strength	forelimb and hindlimb grip strength by trial, trial1	-38.024	7.5225	-2.0364	0.00190	0.0000105
grip strength	forelimb and hindlimb grip strength by trial, trial2	-33.648	7.8440	-1.8789	0.00787	0.000114
grip strength	forelimb and hindlimb grip strength by trial, trial3	-34.721	7.0668	-1.8460	0.00218	0.0000165
grip strength	forelimb grip strength (mean of trials), average	-19.604	3.3719	-1.8789	0.000180	9.39e-7
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.93310	0.15497	-1.8226	0.000209	4.84e-7
grip strength	forelimb grip strength by trial, trial1	-15.874	4.7070	-1.4332	0.0456	0.00169
grip strength	forelimb grip strength by trial, trial2	-20.364	4.6559	-1.7247	0.00613	0.0000849
grip strength	forelimb grip strength by trial, trial3	-22.451	4.1599	-1.9516	0.000877	0.00000356
heart weight	heart weight, normalized to body weight	0.099467	0.19216	-0.085912	0.774	0.611
heart weight	heart weight, weight	7.7451	5.4370	0.63555	0.371	0.172
hematology	basophil differential (percent of total WBC)	0.37804	0.11629	2.7178	0.154	0.00382
hematology	calculated hemoglobin (cHGB)	-0.027500	0.17298	-0.37355	0.951	0.875
hematology	eosinophil differential (percent of total WBC)	0.016602	0.15367	0.12132	0.970	0.915
hematology	hematocrit (HCT)	-0.45250	0.44886	-0.79726	0.609	0.325
hematology	hemoglobin concentration distribution width (HDW)	-0.0014080	0.036777	-0.026077	0.981	0.970
hematology	large unstained cells (percent of total WBC)	0.31053	0.22325	1.7326	0.528	0.179
hematology	lymphocyte differential (percent of total WBC)	-4.2424	1.2551	-1.5550	0.0470	0.00298
hematology	mean corpuscular hemoglobin (CHr)	0.24299	0.080372	1.6068	0.0419	0.00647
hematology	mean platelet volume (MPV)	0.41340	0.18233	1.5350	0.130	0.0340
hematology	mean RBC corpuscular hemoglobin (MCH)	0.11989	0.12726	0.44350	0.709	0.357
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.33151	0.33137	-0.65654	0.682	0.328
hematology	mean RBC corpuscular volume (MCV)	0.49250	0.39001	0.86086	0.440	0.221
hematology	measured hemoglobin (mHGB)	-0.14250	0.15079	-0.59135	0.647	0.355
hematology	monocyte differential (percent of total WBC)	0.14416	0.34476	0.67879	0.888	0.680
hematology	neutrophil differential (percent of total WBC)	3.3217	0.82147	1.4855	0.0198	0.000635
hematology	platelet count (PLT; units per volume x 10³)	-113.54	109.31	-1.3017	0.661	0.311
hematology	RBC corpuscular distribution width (RDW)	0.32663	0.23002	1.0780	0.422	0.170
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.21000	0.27054	0.52440	0.689	0.446
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.20100	0.13449	-1.1242	0.406	0.150
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-40.943	20.415	-1.4748	0.380	0.0580
hematology	reticulocyte differential (percent of total RBC)	-0.36044	0.22304	-1.2664	0.460	0.121
hematology	white blood cell count (WBC; units per volume x 10³)	-1.6125	0.98329	-0.90940	0.278	0.116
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.89824	1.1737	-0.83922	0.812	0.450
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.042300	0.82336	0.058268	0.990	0.959
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.091603	0.55385	0.24812	0.960	0.870
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.88962	0.89300	0.95270	0.763	0.327
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.62944	0.73252	-0.92905	0.830	0.397
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-1.0767	0.47118	-2.5964	0.484	0.0296
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.61842	0.46689	-1.7611	0.788	0.196
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.31832	0.43212	-0.40311	0.867	0.467
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.11679	0.52104	0.31420	0.971	0.824
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.20763	0.33497	0.59080	0.910	0.540
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.50151	0.67289	1.1923	0.870	0.462
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.61374	0.46685	-0.95316	0.642	0.199
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-1.0281	0.67856	-0.92174	0.547	0.140
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.40305	0.60783	-0.58300	0.845	0.512
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.20229	0.72587	-0.22800	0.915	0.782
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.13069	0.91132	0.14217	0.961	0.887
holeboard	total number of hole pokes, 20 min test	-3.2588	5.8360	-0.34941	0.784	0.581
light / dark	latency to enter dark zone, 20 min test	-10.584	37.782	-0.30197	0.946	0.781
light / dark	number of transitions between light and dark zones, 20 min test	7.2432	8.5411	0.75568	0.696	0.401
light / dark	percentage of total time in dark zone, 20 min test	0.20653	3.1256	0.16707	0.985	0.948
light / dark	percentage of total time in light zone, 20 min test	-0.20653	3.1256	-0.17393	0.985	0.948
light / dark	time mobile in dark zone, 20 min test	7.2678	11.575	0.37790	0.786	0.534
light / dark	time mobile in light zone, 20 min test	9.3945	13.924	0.36631	0.741	0.504
light / dark	time spent in dark zone, 20 min test	7.9221	50.308	0.33182	0.962	0.876
light / dark	time spent in light zone, 20 min test	-7.9221	50.308	-0.33182	0.962	0.876
open field	average speed in center of arena, 20 min test	-0.17739	0.41299	-0.40922	0.871	0.671
open field	average speed in periphery of arena, 20 min test	0.043748	0.19139	-0.36150	0.908	0.821
open field	distance traveled habituation ratio, 20 min test	-6.7190	6.2521	-0.55406	0.616	0.291
open field	distance traveled in center of arena, 20 min test	-160.98	137.75	-1.3677	0.509	0.252
open field	distance traveled in periphery of arena, 20 min test	146.22	167.03	0.15298	0.634	0.388
open field	distance traveled slope, 20 min test	-5.5992	5.7615	-0.46088	0.661	0.339
open field	distance traveled, 20 min test, 1st 5min	-23.535	74.762	-0.53692	0.890	0.755
open field	distance traveled, 20 min test, 2nd 5min	24.151	67.605	-0.20620	0.856	0.723
open field	distance traveled, 20 min test, 3rd 5min	28.711	70.454	-0.11099	0.851	0.687
open field	distance traveled, 20 min test, 4th 5min	-53.666	66.259	-1.0934	0.658	0.424
open field	number of clockwise revolution episodes, 20 min test	1.9533	1.4839	0.73740	0.553	0.198
open field	number of counter-clockwise revolution episodes, 20 min test	-1.0133	1.3404	-0.95924	0.711	0.456
open field	number of rears in 5 min bins, 20 min test, 1st 5min	5.3825	2.6323	1.2159	0.220	0.0497
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	0.69051	2.7405	-0.17748	0.911	0.803
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	0.54351	2.1476	-0.20209	0.906	0.802
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-3.0290	3.3493	-0.97856	0.645	0.373
open field	percentage of total time in center of arena, 20 min test	-4.8073	3.6340	-1.3712	0.510	0.196
open field	percentage of total time in center of arena, slope, 20 min test	0.58632	2.0348	0.45194	0.952	0.775
open field	percentage of total time in center, habituation ratio, 20 min test	0.97965	2.0271	0.65232	0.897	0.632
open field	percentage of total time in corners of arena, 20 min test	5.9229	4.2770	1.3575	0.485	0.176
open field	percentage of total time in corners, habituation ratio, 20 min test	1.1192	2.4673	0.22406	0.932	0.653
open field	percentage of total time in corners, slope, 20 min test	1.3982	2.3871	0.37155	0.900	0.562
open field	permanence time in center of arena, 20 min test	-57.684	43.607	-1.3712	0.510	0.196
open field	permanence time in corners of arena, 20 min test	71.091	51.321	1.3575	0.485	0.176
open field	permanence time in periphery of arena, 20 min test	57.681	43.613	1.3712	0.510	0.196
open field	total distance traveled, 20 min test	4.8808	253.22	-0.49702	0.990	0.985
open field	total number of rears, 20 min test	4.5903	9.5423	-0.024841	0.809	0.634
open field	whole arena average speed, 20 min test	0.0056863	0.21130	-0.48793	0.987	0.979
open field	whole arena resting time, 20 min test	0.60269	24.178	0.58246	0.989	0.980
open field	whole arena time spent mobile, 20 min test	-0.60879	24.163	-0.56190	0.989	0.980
open field	whole arena time spent vertical, 20 min test	7.4012	8.3490	0.46387	0.680	0.382
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-1.2826	1.0401	-0.35431	0.545	0.225
startle / PPI	average baseline movement during background noise	0.52767	1.8388	0.43124	0.963	0.776
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.052467	0.065619	-0.58936	0.754	0.429
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.058373	0.077248	-0.66527	0.768	0.455
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.20247	7.4179	0.030129	0.995	0.978
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	1.2219	6.7304	0.093311	0.959	0.857
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-6.8218	6.8918	-0.73053	0.629	0.329
startle / PPI	average startle response to full pulse (120 dB)	-15.537	48.917	-0.12997	0.900	0.753
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-43.582	44.709	-0.62304	0.572	0.336
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-31.504	41.518	-0.45909	0.652	0.453
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.074585	29.435	0.18673	0.999	0.998
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-1.4404	1.5310	-0.97679	0.818	0.353
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.074566	1.6398	-0.018916	0.993	0.964
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	3.0875	2.5501	1.0740	0.675	0.234
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.049879	0.090440	-0.43586	0.922	0.585
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.012347	0.083019	-0.20696	0.970	0.883
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.099349	0.084013	-0.91502	0.508	0.245
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-15.967	48.817	-0.14978	0.892	0.746
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-42.141	44.903	-0.58770	0.590	0.354
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-31.430	41.257	-0.44977	0.652	0.451
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-3.5762	29.346	0.10457	0.954	0.904
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.058021	0.083377	-0.50155	0.916	0.491
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.018218	0.069357	0.037861	0.915	0.794
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.10057	0.079015	-0.91502	0.471	0.211
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-89.887	177.04	-0.29496	0.814	0.615
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-152.56	164.28	-0.61456	0.589	0.359
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-135.25	154.94	-0.56126	0.602	0.389
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-8.3435	111.44	0.14836	0.964	0.941
startle / PPI	maximum baseline movement during background noise	-0.34467	4.1259	0.023121	0.984	0.934
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-2.1243	7.3585	-0.17534	0.975	0.775
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	2.6255	6.4750	0.14836	0.872	0.688
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-8.2224	7.0609	-0.84522	0.542	0.252
startle / PPI	maximum startle response to full pulse (120 dB)	-90.197	177.18	-0.29057	0.814	0.614
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-156.13	163.50	-0.62815	0.578	0.346
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-135.78	155.59	-0.55634	0.603	0.389
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.62728	111.94	0.19386	0.998	0.996
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-3.5725	4.1448	-0.96556	0.792	0.395
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-0.52548	3.8752	-0.13562	0.988	0.893
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	7.9012	6.1133	1.0591	0.588	0.205

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.00
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.00
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	14.0 %	0.284
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	9.0 %	0.270
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.00
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.0
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.0
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.00
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.00
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	1.0 %	1.0
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.0
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	7.0 %	1.00
eye morphology	narrow eye opening	females	16.0 %	0.131
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	11.0 %	0.0830
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.0
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.00
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	1.00
eye morphology	retina	males	31.0 %	0.166
eye morphology	retina	both	9.0 %	0.464
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.00
eye morphology	retinal blood vessels pattern	males	2.0 %	1.00
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	12.0 %	1.00
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.00
eye morphology	retinal structure	both	3.0 %	1.0
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.00
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.0
SHIRPA	body length	both	0.0 %	1.0
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.00
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.00
SHIRPA	coat color abdomen	females	97.0 %	3.20e-12
SHIRPA	coat color abdomen	males	96.0 %	1.03e-10
SHIRPA	coat color abdomen	both	96.0 %	3.24e-22
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.0
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.0
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.00
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.0
SHIRPA	coat color pattern back	both	0.0 %	1.00
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.00
SHIRPA	coat color pattern head	both	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	27.0 %	0.00276
SHIRPA	coat hair distribution abdomen	both	13.0 %	0.00450
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.00
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.00
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.0
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.00
SHIRPA	genitalia size	both	0.0 %	1.00
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.0
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.00
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.00
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.00
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.00
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.00
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	16.0 %	0.154
SHIRPA	limb grasp	males	23.0 %	0.0569
SHIRPA	limb grasp	both	19.0 %	0.0202
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.0
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.0
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.0
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.00
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.00
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.00
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.0
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.0
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.00
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.00
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Tmem131^em1(IMPC)J/Mmjax -/+ with genotype: