MPD: JaxKOMP-EAP genotype: Lrfn1<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Lrfn1^em1(IMPC)J/Mmjax -/- Gene Lrfn1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-5.3176	2.9042	-1.5376	0.465	0.0901
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	1.1914	2.7151	0.27624	0.904	0.668
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	0.70836	2.7255	-0.019174	0.937	0.799
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	3.3205	5.4091	0.43485	0.821	0.550
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-11.250	3.9991	-1.4559	0.171	0.0138
body composition	body length	-0.15417	0.053680	-1.3484	0.0867	0.0101
body composition	body weight (at time of DXA)	-1.0639	0.84251	-0.66808	0.437	0.222
body composition	bone area, whole body scan, head excluded	0.20692	0.17760	1.0658	0.523	0.258
body composition	bone mineral content of whole body scan, head excluded	-0.0010346	0.013758	0.062844	0.978	0.941
body composition	bone mineral content to body weight ratio	-0.000095167	0.00061013	0.025943	0.951	0.878
body composition	bone mineral density of whole body scan, head excluded	-0.0013618	0.00075180	-1.3181	0.310	0.0859
body composition	fat tissue mass of whole body scan, head excluded	0.46577	0.32074	0.71269	0.396	0.164
body composition	fat tissue mass to body weight ratio	0.011569	0.011827	0.58783	0.585	0.341
body composition	lean tissue mass of whole body scan, head excluded	-0.23761	0.33073	-0.65745	0.749	0.482
body composition	lean tissue mass to body weight ratio	-0.014883	0.011331	-0.84748	0.457	0.206
body composition	percent fat, whole body scan, head excluded	1.2057	1.1565	0.62392	0.557	0.311
body composition	ratio of soft-tissue attenuation coefficients	-0.0013403	0.0012857	-0.63884	0.562	0.311
body composition	tissue area	0.15807	0.14049	0.69784	0.576	0.275
body composition	total tissue mass, whole body scan, head excluded	0.27622	0.15190	0.38767	0.267	0.0857
clinical blood chemistry	alanine transaminase (plasma ALT)	-4.6685	2.2323	-0.45836	0.365	0.0509
clinical blood chemistry	albumin (plasma Alb)	0.69182	0.37004	1.0188	0.347	0.0779
clinical blood chemistry	alkaline phosphatase (plasma ALP)	6.0276	2.5354	0.55505	0.142	0.0294
clinical blood chemistry	aspartate transaminase (plasma AST)	-17.802	6.2370	-0.81881	0.130	0.0110
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.26298	0.15707	-0.82395	0.490	0.112
clinical blood chemistry	blood urea nitrogen (BUN)	-4.3539	1.4672	-1.5890	0.0759	0.00825
clinical blood chemistry	calcium (plasma Ca)	-0.089281	0.077104	-0.28608	0.490	0.262
clinical blood chemistry	creatinine (plasma)	-0.051846	0.013814	-1.0193	0.0238	0.00146
clinical blood chemistry	glucose (plasma GLU, no fast)	-10.281	14.603	-0.10948	0.688	0.490
clinical blood chemistry	HDL cholesterol (plasma HDL)	-2.6109	3.5937	-0.88439	0.750	0.477
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.041533	0.0093945	-2.1469	0.0199	0.000374
clinical blood chemistry	phosphorus (plasma phosphate)	-1.0652	0.60336	-1.5622	0.313	0.0944
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.016573	0.0068102	-1.1607	0.195	0.0256
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-0.066560	4.6552	-0.25805	0.996	0.989
clinical blood chemistry	total protein (plasma TP)	1.0297	0.74728	0.74426	0.469	0.185
clinical blood chemistry	triglyceride (plasma TG, no fast)	7.5231	7.6280	0.63024	0.621	0.338
glucose tolerance test	amount glucose injected	-5.1124	13.887	-1.0589	0.915	0.737
glucose tolerance test	plasma glucose, 0min	6.8671	14.185	0.48511	0.818	0.661
glucose tolerance test	plasma glucose, 15min	7.2447	69.907	0.31539	0.971	0.924
glucose tolerance test	plasma glucose, 30min	18.555	72.348	0.67191	0.928	0.814
glucose tolerance test	plasma glucose, 60min	-8.7232	37.251	-0.24259	0.930	0.830
glucose tolerance test	plasma glucose, 120min	13.964	25.237	0.82646	0.840	0.619
heart weight	heart weight, normalized to body weight	0.19662	0.15999	0.25195	0.455	0.235
heart weight	heart weight, weight	2.7796	3.3259	-0.014189	0.619	0.414
hematology	basophil differential (percent of total WBC)	-0.078166	0.038312	-1.0794	0.408	0.0548
hematology	calculated hemoglobin (cHGB)	0.24852	0.12156	0.49589	0.253	0.0543
hematology	eosinophil differential (percent of total WBC)	-0.059295	0.20692	-0.099307	0.931	0.778
hematology	hematocrit (HCT)	0.77837	0.41402	0.51377	0.319	0.0747
hematology	hemoglobin concentration distribution width (HDW)	-0.013092	0.029177	-0.33836	0.841	0.659
hematology	large unstained cells (percent of total WBC)	0.019831	0.063817	0.14030	0.898	0.759
hematology	lymphocyte differential (percent of total WBC)	-1.4059	0.74275	-0.64140	0.276	0.0737
hematology	mean corpuscular hemoglobin (CHr)	0.11350	0.064105	0.88293	0.270	0.0919
hematology	mean platelet volume (MPV)	-0.12599	0.15828	-0.92977	0.660	0.435
hematology	mean RBC corpuscular hemoglobin (MCH)	0.24641	0.085235	0.91542	0.120	0.00903
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.68955	0.20617	1.2510	0.0724	0.00340
hematology	mean RBC corpuscular volume (MCV)	-0.10259	0.21881	-0.18835	0.813	0.644
hematology	measured hemoglobin (mHGB)	0.47215	0.14025	0.99061	0.0596	0.00307
hematology	monocyte differential (percent of total WBC)	0.62259	0.14806	1.7790	0.0399	0.000435
hematology	neutrophil differential (percent of total WBC)	1.0877	0.52496	0.56114	0.218	0.0521
hematology	platelet count (PLT; units per volume x 10³)	200.81	69.104	2.1924	0.133	0.00874
hematology	RBC corpuscular distribution width (RDW)	0.0017601	0.10927	-0.0061672	0.994	0.987
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.24664	0.21485	0.58946	0.524	0.265
hematology	red blood cell count (RBC; per volume x 10⁶)	0.12747	0.091543	0.23755	0.443	0.179
hematology	reticulocyte count (Retic; units per volume x 10⁹)	27.557	12.026	1.1723	0.306	0.0329
hematology	reticulocyte differential (percent of total RBC)	0.22114	0.10075	1.0979	0.319	0.0401
hematology	white blood cell count (WBC; units per volume x 10³)	0.75893	0.67588	0.69262	0.481	0.275
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.97530	0.68664	0.95270	0.665	0.164
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.24079	1.0065	-0.24638	0.969	0.812
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.38696	0.68047	0.72023	0.908	0.573
holeboard	number of hole pokes by individual hole number, 20 min test, 4	1.1627	0.67476	1.2031	0.553	0.0940
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.82131	0.51821	1.3229	0.635	0.122
holeboard	number of hole pokes by individual hole number, 20 min test, 6	1.1546	0.58423	2.1407	0.576	0.0563
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.43148	0.34948	1.0883	0.803	0.225
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.10975	0.44235	0.30955	0.963	0.806
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.30941	0.49471	0.66392	0.895	0.536
holeboard	number of hole pokes by individual hole number, 20 min test, 10	1.0941	0.31947	2.2117	0.395	0.00162
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.87017	0.38970	1.7380	0.562	0.0320
holeboard	number of hole pokes by individual hole number, 20 min test, 12	1.8377	0.51689	2.2327	0.0905	0.00113
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.29999	0.70688	0.38187	0.907	0.674
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.24455	0.42581	0.48759	0.867	0.569
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.82996	0.63450	1.3033	0.660	0.200
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.96693	0.92876	0.86886	0.707	0.305
holeboard	total number of hole pokes, 20 min test	10.069	4.2376	1.3233	0.166	0.0231
light / dark	latency to enter dark zone, 20 min test	-45.851	46.602	-0.95242	0.725	0.332
light / dark	number of transitions between light and dark zones, 20 min test	11.016	10.201	1.1113	0.608	0.287
light / dark	percentage of total time in dark zone, 20 min test	-8.6970	3.6520	-1.4284	0.251	0.0225
light / dark	percentage of total time in light zone, 20 min test	8.6970	3.6520	1.4284	0.248	0.0225
light / dark	time mobile in dark zone, 20 min test	14.402	11.104	0.73250	0.498	0.203
light / dark	time mobile in light zone, 20 min test	23.411	13.170	1.0367	0.280	0.0837
light / dark	time spent in dark zone, 20 min test	-55.618	54.871	-0.60887	0.713	0.317
light / dark	time spent in light zone, 20 min test	55.618	54.871	0.60887	0.713	0.317
open field	average speed in center of arena, 20 min test	-0.38114	0.38738	-0.78810	0.665	0.332
open field	average speed in periphery of arena, 20 min test	0.0026531	0.15188	-0.51687	0.993	0.986
open field	distance traveled habituation ratio, 20 min test	-15.309	5.6632	-1.2715	0.124	0.0108
open field	distance traveled in center of arena, 20 min test	-21.526	134.55	-0.51687	0.931	0.874
open field	distance traveled in periphery of arena, 20 min test	-14.094	138.68	-0.51227	0.966	0.920
open field	distance traveled slope, 20 min test	-15.107	5.4045	-1.2837	0.112	0.00858
open field	distance traveled, 20 min test, 1st 5min	91.830	61.905	0.40193	0.363	0.147
open field	distance traveled, 20 min test, 2nd 5min	-22.445	49.171	-0.75913	0.828	0.651
open field	distance traveled, 20 min test, 3rd 5min	-58.718	65.966	-1.1007	0.634	0.380
open field	distance traveled, 20 min test, 4th 5min	-31.427	55.801	-0.81401	0.774	0.577
open field	number of clockwise revolution episodes, 20 min test	-0.90783	1.4034	-0.95888	0.803	0.522
open field	number of counter-clockwise revolution episodes, 20 min test	2.0007	1.3912	0.62597	0.432	0.160
open field	number of rears in 5 min bins, 20 min test, 1st 5min	3.0538	2.3812	0.63045	0.473	0.209
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-3.9206	2.8920	-1.3149	0.469	0.185
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-3.8808	3.0972	-1.2219	0.495	0.219
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-3.0014	3.6499	-0.96993	0.686	0.417
open field	percentage of total time in center of arena, 20 min test	1.1231	4.3148	0.059781	0.926	0.796
open field	percentage of total time in center of arena, slope, 20 min test	3.4170	1.4559	1.9391	0.371	0.0251
open field	percentage of total time in center, habituation ratio, 20 min test	3.1523	1.4272	1.8006	0.405	0.0343
open field	percentage of total time in corners of arena, 20 min test	-1.5150	4.2295	0.018126	0.891	0.722
open field	percentage of total time in corners, habituation ratio, 20 min test	-0.69841	2.0089	-0.62271	0.947	0.730
open field	percentage of total time in corners, slope, 20 min test	-0.91965	1.7977	-0.74488	0.915	0.612
open field	permanence time in center of arena, 20 min test	13.467	51.777	0.062471	0.927	0.796
open field	permanence time in corners of arena, 20 min test	-18.201	50.752	0.018126	0.892	0.722
open field	permanence time in periphery of arena, 20 min test	-13.501	51.773	-0.063817	0.927	0.796
open field	total distance traveled, 20 min test	-19.716	213.05	-0.55719	0.965	0.927
open field	total number of rears, 20 min test	-8.4152	10.381	-0.93818	0.667	0.423
open field	whole arena average speed, 20 min test	-0.017378	0.17800	-0.56033	0.961	0.923
open field	whole arena resting time, 20 min test	-15.641	21.163	0.10289	0.660	0.465
open field	whole arena time spent mobile, 20 min test	15.658	21.117	0.14348	0.664	0.464
open field	whole arena time spent vertical, 20 min test	-9.1858	10.241	-0.83096	0.675	0.376
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-0.29272	1.3014	0.052337	0.947	0.824
startle / PPI	average baseline movement during background noise	0.23245	1.5467	0.24699	0.990	0.881
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.19027	0.067468	-1.7288	0.136	0.00717
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.10372	0.059547	-1.1037	0.378	0.0884
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-8.1902	7.1808	-0.84122	0.877	0.260
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-18.321	7.3514	-1.7811	0.231	0.0165
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-9.6252	5.8868	-1.0159	0.362	0.109
startle / PPI	average startle response to full pulse (120 dB)	-4.4724	39.149	0.096125	0.967	0.910
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	8.7981	38.533	0.39310	0.920	0.820
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	63.318	43.532	1.2908	0.356	0.153
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	24.189	36.101	0.77707	0.690	0.506
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.54659	1.4210	-0.35702	0.946	0.702
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.52230	1.7382	-0.35106	0.960	0.765
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	1.9308	2.1049	0.68198	0.752	0.364
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.094632	0.076582	-0.84722	0.852	0.223
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.21173	0.080672	-1.7874	0.173	0.0119
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.099787	0.065998	-0.92144	0.367	0.138
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-4.7049	39.455	0.10880	0.961	0.906
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	9.3447	38.941	0.39008	0.912	0.811
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	64.271	44.098	1.3006	0.353	0.152
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	22.047	36.322	0.71778	0.724	0.547
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.11271	0.075670	-0.94784	0.804	0.143
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.22741	0.080473	-1.7541	0.150	0.00706
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.10949	0.068520	-0.97868	0.338	0.117
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-45.780	141.23	-0.079247	0.893	0.747
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	208.71	158.57	1.1493	0.424	0.195
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	229.89	159.22	1.2876	0.360	0.156
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	70.671	132.37	0.63157	0.752	0.596
startle / PPI	maximum baseline movement during background noise	2.6532	4.0012	0.80776	0.855	0.511
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-10.258	7.2313	-0.98586	0.878	0.163
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-20.629	7.5520	-1.8237	0.175	0.00904
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-10.578	6.3300	-1.0445	0.348	0.102
startle / PPI	maximum startle response to full pulse (120 dB)	-43.127	140.57	-0.065199	0.904	0.760
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	207.89	157.59	1.1439	0.423	0.194
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	227.97	157.56	1.2812	0.353	0.155
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	77.224	131.82	0.66616	0.724	0.561
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-1.5264	3.3300	-0.39008	0.922	0.649
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-0.59279	4.0269	-0.15829	0.985	0.884
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	2.1341	5.1773	0.23257	0.886	0.682

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	24.0 %	0.0158
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	13.0 %	0.0275
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.0
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.0
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.0
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	12.0 %	0.0969
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	6.0 %	0.285
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	6.0 %	1.00
eye morphology	lens opacity	both	7.0 %	1.00
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.00
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.00
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	12.0 %	0.213
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	6.0 %	0.303
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.0
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.00
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.00
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.00
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	36.0 %	0.000158
SHIRPA	activity body position	both	17.0 %	0.000890
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	24.0 %	0.00114
SHIRPA	body position	both	12.0 %	0.00199
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	9.0 %	0.250
SHIRPA	coat color abdomen	males	46.0 %	0.000115
SHIRPA	coat color abdomen	both	28.0 %	0.000189
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.624
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	48.0 %	3.28e-9
SHIRPA	transfer arousal	both	24.0 %	8.52e-9
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.0
SHIRPA	vocalization	males	2.0 %	1.00
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Lrfn1^em1(IMPC)J/Mmjax -/- with genotype: