MPD: JaxKOMP-EAP genotype: Mxra8<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Mxra8^em1(IMPC)J/Mmjax -/- Gene Mxra8

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

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Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

body composition	body length	0.16917	0.057860	1.9034	0.106	0.0138
body composition	body weight (at time of DXA)	-0.58278	1.2463	-0.33718	0.812	0.648
body composition	bone area, whole body scan, head excluded	0.30973	0.35773	1.4820	0.661	0.404
body composition	bone mineral content of whole body scan, head excluded	0.057510	0.022516	2.7196	0.144	0.0253
body composition	bone mineral content to body weight ratio	0.00042214	0.00072138	0.75016	0.775	0.570
body composition	bone mineral density of whole body scan, head excluded	0.0043440	0.0011129	3.0646	0.0414	0.00246
body composition	fat tissue mass of whole body scan, head excluded	0.28989	0.71773	0.48378	0.847	0.694
body composition	fat tissue mass to body weight ratio	0.0080428	0.023191	0.42624	0.874	0.735
body composition	lean tissue mass of whole body scan, head excluded	2.1894	0.60701	3.0647	0.0663	0.00412
body composition	lean tissue mass to body weight ratio	0.0096686	0.018452	0.47105	0.811	0.611
body composition	percent fat, whole body scan, head excluded	0.40893	2.1200	0.27938	0.932	0.851
body composition	ratio of soft-tissue attenuation coefficients	-0.00034008	0.0023501	-0.24460	0.955	0.888
body composition	tissue area	0.83315	0.43923	2.1356	0.324	0.0844
body composition	total tissue mass, whole body scan, head excluded	2.0535	0.59151	2.9413	0.0454	0.00523
clinical blood chemistry	alanine transaminase (plasma ALT)	-6.3719	5.6037	-0.59349	0.637	0.270
clinical blood chemistry	albumin (plasma Alb)	-0.73489	0.83022	-0.90767	0.694	0.388
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-2.4384	3.5662	-0.96028	0.723	0.503
clinical blood chemistry	aspartate transaminase (plasma AST)	7.4128	5.1619	0.36221	0.489	0.168
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.44049	0.23994	1.2065	0.442	0.0821
clinical blood chemistry	blood urea nitrogen (BUN)	0.36702	1.1649	0.10698	0.881	0.756
clinical blood chemistry	calcium (plasma Ca)	-0.068163	0.096314	-0.14338	0.701	0.488
clinical blood chemistry	creatinine (plasma)	-0.026679	0.039830	-0.51995	0.726	0.513
clinical blood chemistry	glucose (plasma GLU, no fast)	16.373	29.614	0.92825	0.757	0.587
clinical blood chemistry	HDL cholesterol (plasma HDL)	-9.6051	5.0366	-1.9820	0.295	0.0726
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.00065426	0.010027	-0.12200	0.990	0.949
clinical blood chemistry	phosphorus (plasma phosphate)	1.0832	0.46974	1.5067	0.179	0.0326
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.013257	0.013241	-0.97500	0.684	0.329
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-15.285	6.3845	-2.2083	0.166	0.0278
clinical blood chemistry	total protein (plasma TP)	-1.8643	1.1681	-1.3842	0.408	0.127
clinical blood chemistry	triglyceride (plasma TG, no fast)	-7.8910	9.8316	-0.21628	0.697	0.433
EKG	duration of PQ interval	0.27656	1.0905	0.41238	0.947	0.802
EKG	duration of PR interval	0.30207	1.0789	0.38836	0.941	0.782
EKG	duration of QRS interval	0.20652	0.24337	0.40799	0.897	0.404
EKG	duration of QT interval	-1.7619	0.80026	-1.3971	0.482	0.0364
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-2.0929	0.75567	-1.8966	0.475	0.0100
EKG	duration of RR interval	0.68103	1.5397	0.61495	0.879	0.662
EKG	duration of ST interval	-1.9270	0.75732	-1.5798	0.346	0.0170
EKG	heart rate coefficient of variation (signal intensity)	0.48457	0.51656	0.47689	0.867	0.357
EKG	heart rate variability, mean of differences between sequential beats; beats per min	2.8697	3.3460	0.40799	0.868	0.399
EKG	heart rate, beats per min	-3.8437	13.208	-0.49205	0.919	0.773
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.056301	0.067528	-0.56156	0.751	0.412
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.086919	0.11393	-0.60217	0.760	0.452
EKG	number of signals	-9.8912	8.7169	-1.6703	0.764	0.267
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	2.9861	2.4574	0.63168	0.814	0.235
EKG	QT dispersion, measured as inter-lead variability of QT intervals	2.3414	1.9223	0.72075	0.881	0.234
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	2.4664	2.1426	0.64196	0.873	0.260
EKG	root mean square of successive differences of neighboring RR intervals	0.87632	0.36087	0.60041	0.843	0.0221
glucose tolerance test	amount glucose injected	-3.3092	3.7685	-0.58356	0.741	0.391
glucose tolerance test	plasma glucose, 0min	-3.2083	6.0601	-0.55105	0.783	0.603
glucose tolerance test	plasma glucose, 15min	-59.010	21.367	-1.4550	0.127	0.0128
glucose tolerance test	plasma glucose, 30min	-39.743	20.575	-1.0770	0.320	0.0685
glucose tolerance test	plasma glucose, 60min	-15.078	16.036	-0.51466	0.687	0.359
glucose tolerance test	plasma glucose, 120min	-15.657	9.6077	-1.1975	0.414	0.120
grip strength	body weight (at time of grip strength test)	0.80369	0.99717	0.94678	0.625	0.436
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-27.067	6.5864	-1.6031	0.0150	0.00145
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.1464	0.29583	-1.4292	0.0235	0.00258
grip strength	forelimb and hindlimb grip strength by trial, trial1	-36.000	11.431	-1.9419	0.0757	0.00838
grip strength	forelimb and hindlimb grip strength by trial, trial2	-26.000	13.781	-1.4015	0.272	0.0836
grip strength	forelimb and hindlimb grip strength by trial, trial3	-19.200	8.9208	-0.98065	0.227	0.0524
grip strength	forelimb grip strength (mean of trials), average	-18.678	3.4137	-1.8150	0.00559	0.000143
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.62394	0.23323	-1.2385	0.124	0.0216
grip strength	forelimb grip strength by trial, trial1	-18.233	6.0114	-1.6637	0.129	0.0104
grip strength	forelimb grip strength by trial, trial2	-12.133	4.9654	-1.0512	0.212	0.0310
grip strength	forelimb grip strength by trial, trial3	-25.667	5.4105	-2.2166	0.0212	0.000477
heart weight	heart weight, normalized to body weight	0.29914	0.14945	0.59635	0.188	0.0559
heart weight	heart weight, weight	5.6234	4.0136	0.35961	0.371	0.173
hematology	basophil differential (percent of total WBC)	0.082500	0.057557	1.1404	0.603	0.166
hematology	calculated hemoglobin (cHGB)	-0.21593	0.16022	-0.88811	0.470	0.193
hematology	eosinophil differential (percent of total WBC)	0.39625	0.38136	1.1831	0.700	0.311
hematology	hematocrit (HCT)	-0.091238	0.49161	-0.45991	0.931	0.855
hematology	hemoglobin concentration distribution width (HDW)	-0.020625	0.023600	-0.58029	0.692	0.392
hematology	large unstained cells (percent of total WBC)	-0.0077466	0.12935	-0.011291	0.979	0.953
hematology	lymphocyte differential (percent of total WBC)	-2.3600	1.2184	-1.0090	0.260	0.0663
hematology	mean corpuscular hemoglobin (CHr)	-0.0044334	0.089547	-0.0020739	0.980	0.961
hematology	mean platelet volume (MPV)	-0.14568	0.16699	-1.0226	0.619	0.393
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.066012	0.13811	-0.27608	0.849	0.638
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.33698	0.32221	-0.66165	0.670	0.308
hematology	mean RBC corpuscular volume (MCV)	0.31500	0.31868	0.57883	0.567	0.334
hematology	measured hemoglobin (mHGB)	-0.10812	0.20512	-0.51017	0.809	0.604
hematology	monocyte differential (percent of total WBC)	0.27125	0.20205	1.0532	0.553	0.194
hematology	neutrophil differential (percent of total WBC)	1.5400	0.75110	0.79538	0.219	0.0530
hematology	platelet count (PLT; units per volume x 10³)	-68.843	84.953	-0.83929	0.747	0.427
hematology	RBC corpuscular distribution width (RDW)	0.38355	0.13853	1.2013	0.102	0.0115
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.26250	0.19344	-0.72112	0.436	0.189
hematology	red blood cell count (RBC; per volume x 10⁶)	0.054748	0.13876	-0.10555	0.854	0.697
hematology	reticulocyte count (Retic; units per volume x 10⁹)	18.158	16.143	0.82800	0.661	0.274
hematology	reticulocyte differential (percent of total RBC)	0.14978	0.15604	0.79559	0.695	0.349
hematology	white blood cell count (WBC; units per volume x 10³)	1.6669	0.84147	1.2859	0.186	0.0615
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.15709	0.64872	0.20827	0.943	0.810
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.0086494	0.58694	0.14142	0.993	0.988
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.52443	0.50332	-0.80374	0.781	0.306
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.44122	0.73854	0.51570	0.866	0.555
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.064179	0.48765	0.010972	0.974	0.896
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.13588	0.39608	-0.36199	0.962	0.734
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.0015267	0.29337	-0.014368	1.00	0.996
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.17405	0.68218	0.41596	0.963	0.800
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.13484	0.49775	0.34631	0.965	0.788
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.42748	0.29389	-1.2484	0.732	0.156
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.089313	0.37438	0.26663	0.971	0.813
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.23664	0.42654	-0.31376	0.898	0.583
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.15038	0.79999	0.23666	0.967	0.852
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.070080	0.45477	0.21072	0.981	0.879
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.041985	0.61058	0.028680	0.982	0.946
holeboard	number of hole pokes by individual hole number, 20 min test, 16	1.5359	0.75089	1.3153	0.408	0.0497
holeboard	total number of hole pokes, 20 min test	1.4241	4.1005	0.29081	0.877	0.731
light / dark	latency to enter dark zone, 20 min test	5.6739	46.757	0.0094642	0.974	0.904
light / dark	number of transitions between light and dark zones, 20 min test	4.9534	8.5171	0.54813	0.804	0.564
light / dark	percentage of total time in dark zone, 20 min test	-3.0919	3.1786	-0.42480	0.682	0.337
light / dark	percentage of total time in light zone, 20 min test	3.0919	3.1786	0.42037	0.682	0.337
light / dark	time mobile in dark zone, 20 min test	0.58501	14.065	-0.052753	0.991	0.967
light / dark	time mobile in light zone, 20 min test	12.926	14.205	0.53093	0.634	0.368
light / dark	time spent in dark zone, 20 min test	-24.996	48.297	-0.17119	0.877	0.608
light / dark	time spent in light zone, 20 min test	24.996	48.297	0.17119	0.877	0.608
open field	average speed in center of arena, 20 min test	-0.10306	0.46298	-0.28649	0.943	0.826
open field	average speed in periphery of arena, 20 min test	0.25057	0.20370	0.44600	0.443	0.229
open field	distance traveled habituation ratio, 20 min test	-4.4866	7.8349	-0.34577	0.805	0.572
open field	distance traveled in center of arena, 20 min test	102.02	143.01	0.32306	0.703	0.482
open field	distance traveled in periphery of arena, 20 min test	136.80	207.19	0.11505	0.728	0.515
open field	distance traveled slope, 20 min test	-3.5518	7.0151	-0.25584	0.842	0.617
open field	distance traveled, 20 min test, 1st 5min	80.535	92.537	0.30191	0.637	0.392
open field	distance traveled, 20 min test, 2nd 5min	38.977	79.916	-0.058436	0.814	0.630
open field	distance traveled, 20 min test, 3rd 5min	60.783	68.935	0.23785	0.637	0.386
open field	distance traveled, 20 min test, 4th 5min	60.511	68.101	0.20346	0.620	0.382
open field	number of clockwise revolution episodes, 20 min test	1.6294	1.5344	0.53801	0.655	0.298
open field	number of counter-clockwise revolution episodes, 20 min test	2.0529	1.3993	0.64569	0.424	0.154
open field	number of rears in 5 min bins, 20 min test, 1st 5min	0.73988	2.9651	-0.012090	0.917	0.805
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-1.5668	2.1704	-0.75734	0.718	0.477
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	6.4976	2.8415	1.1513	0.167	0.0306
open field	number of rears in 5 min bins, 20 min test, 4th 5min	0.72536	3.0271	-0.20757	0.912	0.812
open field	percentage of total time in center of arena, 20 min test	3.2342	5.2876	0.51840	0.810	0.546
open field	percentage of total time in center of arena, slope, 20 min test	-2.4529	1.2842	-1.1487	0.478	0.0668
open field	percentage of total time in center, habituation ratio, 20 min test	-1.5879	1.2525	-0.72203	0.694	0.216
open field	percentage of total time in corners of arena, 20 min test	-6.2551	5.1814	-0.87934	0.550	0.238
open field	percentage of total time in corners, habituation ratio, 20 min test	1.1759	2.2017	0.24614	0.912	0.598
open field	percentage of total time in corners, slope, 20 min test	2.1461	2.0753	0.71508	0.782	0.310
open field	permanence time in center of arena, 20 min test	38.794	63.454	0.51994	0.810	0.546
open field	permanence time in corners of arena, 20 min test	-75.040	62.176	-0.87934	0.550	0.238
open field	permanence time in periphery of arena, 20 min test	-38.843	63.459	-0.51994	0.809	0.546
open field	total distance traveled, 20 min test	266.11	269.56	0.26974	0.557	0.332
open field	total number of rears, 20 min test	6.3961	8.4566	0.11099	0.692	0.456
open field	whole arena average speed, 20 min test	0.22351	0.22454	0.27671	0.552	0.328
open field	whole arena resting time, 20 min test	-20.913	25.303	-0.059781	0.616	0.416
open field	whole arena time spent mobile, 20 min test	20.860	25.271	0.30332	0.625	0.416
open field	whole arena time spent vertical, 20 min test	3.6990	8.7017	0.17339	0.872	0.674
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-9.6973	2.2518	-2.8267	0.0440	0.00124
startle / PPI	average baseline movement during background noise	1.6306	2.1339	1.0112	0.877	0.453
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.0038722	0.080484	-0.13138	0.983	0.962
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.011367	0.081878	-0.17838	0.953	0.891
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-5.7534	8.7727	-0.57443	0.906	0.519
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	5.0379	9.8192	0.45442	0.854	0.613
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.73858	9.3018	-0.020318	0.976	0.937
startle / PPI	average startle response to full pulse (120 dB)	1.7871	53.439	0.24699	0.988	0.974
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	5.0067	50.015	0.30375	0.964	0.921
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-15.882	48.993	-0.15970	0.857	0.749
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-2.6217	49.347	0.11021	0.982	0.958
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-1.5139	2.5447	-1.0253	0.908	0.558
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.047222	2.0273	-0.0021017	0.998	0.982
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	1.7028	3.3624	0.59103	0.895	0.618
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.075784	0.096889	-0.68375	0.900	0.443
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.042300	0.10308	0.26902	0.885	0.686
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.00077816	0.10006	-0.17330	0.995	0.994
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	0.16045	54.099	0.21676	0.999	0.998
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	6.5173	50.909	0.34213	0.955	0.899
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-15.813	49.492	-0.14411	0.859	0.752
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-4.3086	49.762	0.091903	0.967	0.932
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.056627	0.094210	-0.48100	0.928	0.554
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.041775	0.098784	0.22622	0.861	0.677
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.0032086	0.10260	-0.15909	0.991	0.975
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-5.6460	197.41	0.16965	0.990	0.977
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-12.799	180.46	0.11585	0.972	0.944
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-75.648	172.32	-0.23833	0.801	0.665
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-42.491	180.39	-0.066603	0.897	0.816
startle / PPI	maximum baseline movement during background noise	7.5639	4.9321	1.6583	0.631	0.139
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-3.8667	8.7908	-0.34510	0.948	0.665
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	5.0999	9.3303	0.38102	0.831	0.590
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	1.2458	9.5900	-0.032933	0.958	0.898
startle / PPI	maximum startle response to full pulse (120 dB)	1.8854	195.44	0.20959	0.996	0.992
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-17.844	178.61	0.086277	0.958	0.921
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-76.398	170.89	-0.25277	0.795	0.659
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-37.604	178.83	-0.055373	0.913	0.835
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-5.0417	6.1959	-1.3374	0.812	0.425
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-0.71389	4.0593	-0.19672	0.977	0.862
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	4.9389	7.4004	0.66441	0.825	0.511

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

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Plot Options Group by Procedure

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value

eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	3.0 %	1.0
eye morphology	cornea vascularization	2.0 %	1.0
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.0
eye morphology	corneal scleralization	2.0 %	1.0
eye morphology	corneal ulcer	1.0 %	1.0
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	7.0 %	0.0830
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.0
eye morphology	iris pigmentation	2.0 %	1.0
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	3.0 %	1.0
eye morphology	lacrimation	3.0 %	1.0
eye morphology	lens	9.0 %	1.0
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.00
eye morphology	optic disc	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	9.0 %	1.00
eye morphology	pupil dilation	2.0 %	1.0
eye morphology	pupil light response	2.0 %	1.0
eye morphology	pupil position	4.0 %	1.0
eye morphology	pupil shape	3.0 %	1.0
eye morphology	retina	6.0 %	0.872
eye morphology	retinal blood vessels	3.0 %	1.0
eye morphology	retinal blood vessels pattern	4.0 %	1.00
eye morphology	retinal blood vessels structure	3.0 %	1.0
eye morphology	retinal pigmentation	13.0 %	1.0
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.0
SHIRPA	activity body position	49.0 %	0.00000889
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	50.0 %	0.00000151
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	96.0 %	2.23e-9
SHIRPA	coat color back	0.0 %	1.0
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.00
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.0
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.0
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.0
SHIRPA	forelimb digit number	0.0 %	1.0
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.0
SHIRPA	genitalia morphology	0.0 %	1.0
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.0
SHIRPA	hindlimb digit number	0.0 %	1.0
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.0
SHIRPA	hindlimb nail length	0.0 %	1.0
SHIRPA	hindlimb nail number	0.0 %	1.0
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	9.0 %	0.365
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.0
SHIRPA	mouth morphology	0.0 %	1.0
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.0
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.00
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.0
SHIRPA	tail morphology	0.0 %	1.0
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.0
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.0
SHIRPA	transfer arousal	50.0 %	2.30e-9
SHIRPA	tremor	0.0 %	1.0
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.0
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.0
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Mxra8^em1(IMPC)J/Mmjax -/- with genotype: