MPD: JaxKOMP-EAP genotype: Ppfia1<sup>em1(IMPC)J</sup>/Mmjax -/+

JaxKOMP-EAP effect sizes: Ppfia1^em1(IMPC)J/Mmjax -/+ Gene Ppfia1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

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Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	1.7797	3.3243	0.29674	0.892	0.646
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-10.245	5.2205	-1.7235	0.677	0.189
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-5.6271	3.8701	-1.2767	0.636	0.283
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-7.3563	7.4106	-1.2174	0.752	0.425
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-7.7627	6.0210	-1.1144	0.681	0.326
body composition	body length	0.081103	0.080191	1.2405	0.630	0.334
body composition	body weight (at time of DXA)	-1.0585	0.86021	-0.66637	0.458	0.242
body composition	bone area, whole body scan, head excluded	0.068835	0.18434	0.46849	0.871	0.716
body composition	bone mineral content of whole body scan, head excluded	0.0033079	0.016973	0.34098	0.939	0.849
body composition	bone mineral content to body weight ratio	0.00041202	0.00062834	0.72507	0.746	0.524
body composition	bone mineral density of whole body scan, head excluded	0.00018079	0.00097701	0.22804	0.945	0.857
body composition	fat tissue mass of whole body scan, head excluded	0.55555	0.52820	0.82462	0.576	0.315
body composition	fat tissue mass to body weight ratio	0.018795	0.017186	0.85178	0.542	0.297
body composition	lean tissue mass of whole body scan, head excluded	-0.75173	0.55344	-1.5070	0.503	0.202
body composition	lean tissue mass to body weight ratio	-0.024211	0.015709	-1.2957	0.393	0.152
body composition	percent fat, whole body scan, head excluded	1.9310	1.6448	0.92261	0.516	0.265
body composition	ratio of soft-tissue attenuation coefficients	-0.0021463	0.0018272	-0.93163	0.518	0.265
body composition	tissue area	0.39203	0.25807	1.3276	0.432	0.157
body composition	total tissue mass, whole body scan, head excluded	-0.19618	0.27176	-0.67278	0.706	0.485
clinical blood chemistry	alanine transaminase (plasma ALT)	-10.180	4.1573	-0.85543	0.305	0.0307
clinical blood chemistry	albumin (plasma Alb)	-0.24664	0.83443	-0.31452	0.921	0.772
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-3.0000	5.1607	-1.0495	0.772	0.571
clinical blood chemistry	aspartate transaminase (plasma AST)	3.8432	10.378	0.19403	0.907	0.717
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.45950	0.15390	1.2303	0.184	0.0105
clinical blood chemistry	blood urea nitrogen (BUN)	-5.4189	3.1136	-1.7917	0.319	0.105
clinical blood chemistry	calcium (plasma Ca)	0.19113	0.066692	1.5730	0.0897	0.0142
clinical blood chemistry	creatinine (plasma)	-0.064655	0.022646	-1.2264	0.0928	0.0135
clinical blood chemistry	glucose (plasma GLU, no fast)	51.470	26.382	2.0549	0.209	0.0748
clinical blood chemistry	HDL cholesterol (plasma HDL)	-15.392	5.3994	-2.7673	0.132	0.0146
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.0063074	0.018075	0.21880	0.916	0.733
clinical blood chemistry	phosphorus (plasma phosphate)	-1.1417	0.39981	-1.6337	0.110	0.0135
clinical blood chemistry	total bilirubin (plasma TBIL)	0.048014	0.012651	2.2427	0.0457	0.00223
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-22.744	6.0162	-2.9287	0.0429	0.00229
clinical blood chemistry	total protein (plasma TP)	-2.2630	1.4594	-1.6012	0.421	0.145
clinical blood chemistry	triglyceride (plasma TG, no fast)	39.411	37.051	1.7996	0.599	0.308
glucose tolerance test	amount glucose injected	-8.8558	4.5154	-1.7829	0.353	0.0599
glucose tolerance test	plasma glucose, 0min	-9.0755	5.0169	-1.0245	0.226	0.0808
glucose tolerance test	plasma glucose, 15min	-28.865	22.919	-0.68227	0.549	0.218
glucose tolerance test	plasma glucose, 30min	-10.775	15.010	-0.20458	0.757	0.479
glucose tolerance test	plasma glucose, 60min	-31.920	22.599	-1.2232	0.480	0.169
glucose tolerance test	plasma glucose, 120min	-7.4725	9.6678	-0.64463	0.708	0.446
grip strength	body weight (at time of grip strength test)	-0.79824	0.54035	-0.51510	0.317	0.150
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-4.3777	6.5176	-0.075590	0.697	0.507
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.18708	0.30600	-0.084332	0.722	0.546
grip strength	forelimb and hindlimb grip strength by trial, trial1	-7.7483	7.6328	-0.29315	0.618	0.318
grip strength	forelimb and hindlimb grip strength by trial, trial2	-3.6371	8.0692	-0.0043568	0.835	0.655
grip strength	forelimb and hindlimb grip strength by trial, trial3	-1.4571	8.0291	0.11791	0.939	0.857
grip strength	forelimb grip strength (mean of trials), average	2.3327	4.6712	0.59542	0.826	0.621
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.11854	0.20051	0.54080	0.779	0.559
grip strength	forelimb grip strength by trial, trial1	-6.1982	7.5797	-0.44886	0.743	0.420
grip strength	forelimb grip strength by trial, trial2	7.4406	5.8363	1.0362	0.540	0.212
grip strength	forelimb grip strength by trial, trial3	5.7558	5.0397	0.84826	0.580	0.263
heart weight	heart weight, normalized to body weight	-0.12316	0.32168	-0.92134	0.839	0.706
heart weight	heart weight, weight	26.062	18.012	2.2794	0.362	0.165
hematology	basophil differential (percent of total WBC)	0.33743	0.10438	2.6212	0.184	0.00654
hematology	calculated hemoglobin (cHGB)	-0.16667	0.17951	-0.76808	0.643	0.370
hematology	eosinophil differential (percent of total WBC)	-0.0080588	0.38470	0.060891	0.991	0.984
hematology	hematocrit (HCT)	2.1214	1.3776	1.7342	0.427	0.150
hematology	hemoglobin concentration distribution width (HDW)	-0.15673	0.062700	-2.7734	0.205	0.0279
hematology	large unstained cells (percent of total WBC)	0.68377	0.15500	2.3947	0.0379	0.000703
hematology	lymphocyte differential (percent of total WBC)	-0.16031	1.0325	-0.11231	0.945	0.879
hematology	mean corpuscular hemoglobin (CHr)	0.56467	0.12490	2.3290	0.00775	0.000575
hematology	mean platelet volume (MPV)	-0.10402	0.16927	-0.83072	0.751	0.550
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.19167	0.33322	-0.69154	0.818	0.575
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.24167	0.74850	-0.50719	0.919	0.752
hematology	mean RBC corpuscular volume (MCV)	1.4919	0.78885	2.0502	0.227	0.0811
hematology	measured hemoglobin (mHGB)	-0.30870	0.36855	-0.90078	0.685	0.419
hematology	monocyte differential (percent of total WBC)	0.041667	0.29658	0.35153	0.958	0.890
hematology	neutrophil differential (percent of total WBC)	-0.041667	0.46825	-0.0027335	0.968	0.930
hematology	platelet count (PLT; units per volume x 10³)	-285.35	80.698	-2.4528	0.0788	0.00365
hematology	RBC corpuscular distribution width (RDW)	0.43512	0.28836	1.3163	0.404	0.155
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.28333	0.29139	0.69651	0.611	0.349
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.13667	0.13124	-0.89631	0.582	0.317
hematology	reticulocyte count (Retic; units per volume x 10⁹)	16.219	12.472	0.75656	0.616	0.216
hematology	reticulocyte differential (percent of total RBC)	0.20833	0.12856	1.0269	0.468	0.129
hematology	white blood cell count (WBC; units per volume x 10³)	2.8493	0.91193	1.9140	0.0521	0.00878
holeboard	number of hole pokes by individual hole number, 20 min test, 1	1.2189	1.0725	1.1202	0.729	0.278
holeboard	number of hole pokes by individual hole number, 20 min test, 2	1.2537	1.1838	1.8764	0.782	0.310
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.17910	0.79633	0.37579	0.953	0.826
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.050256	1.0440	0.041367	0.987	0.962
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.30846	1.5433	0.60459	0.970	0.845
holeboard	number of hole pokes by individual hole number, 20 min test, 6	1.3582	0.70246	2.4055	0.643	0.0771
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.17910	0.46501	-0.52033	0.971	0.707
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.27363	0.95199	0.59046	0.962	0.779
holeboard	number of hole pokes by individual hole number, 20 min test, 9	1.5672	0.80714	2.1571	0.501	0.0760
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.24876	0.54315	0.69050	0.942	0.655
holeboard	number of hole pokes by individual hole number, 20 min test, 11	1.1837	0.72952	2.2122	0.700	0.133
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.17804	0.40959	0.42026	0.934	0.672
holeboard	number of hole pokes by individual hole number, 20 min test, 13	1.0798	1.2461	1.1143	0.759	0.405
holeboard	number of hole pokes by individual hole number, 20 min test, 14	1.0800	1.6810	1.6149	0.851	0.534
holeboard	number of hole pokes by individual hole number, 20 min test, 15	1.6269	0.52980	2.1407	0.300	0.00970
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.87562	0.87101	0.78113	0.730	0.335
holeboard	total number of hole pokes, 20 min test	12.015	5.9712	1.5389	0.287	0.0672
light / dark	latency to enter dark zone, 20 min test	3.8472	28.053	-0.044631	0.971	0.892
light / dark	number of transitions between light and dark zones, 20 min test	8.4312	5.2448	0.87841	0.414	0.118
light / dark	percentage of total time in dark zone, 20 min test	-4.0504	2.5432	-0.61539	0.473	0.122
light / dark	percentage of total time in light zone, 20 min test	4.0504	2.5432	0.61213	0.472	0.122
light / dark	time mobile in dark zone, 20 min test	-0.10225	9.7384	-0.11245	0.997	0.992
light / dark	time mobile in light zone, 20 min test	29.478	9.7317	1.2859	0.0526	0.00511
light / dark	time spent in dark zone, 20 min test	-41.639	37.406	-0.41005	0.679	0.274
light / dark	time spent in light zone, 20 min test	41.639	37.406	0.41005	0.679	0.274
open field	average speed in center of arena, 20 min test	-0.074507	0.35690	-0.23647	0.947	0.836
open field	average speed in periphery of arena, 20 min test	0.34699	0.11048	0.79729	0.0302	0.00377
open field	distance traveled habituation ratio, 20 min test	1.2034	8.6134	0.13805	0.953	0.890
open field	distance traveled in center of arena, 20 min test	84.513	70.935	0.20620	0.498	0.243
open field	distance traveled in periphery of arena, 20 min test	296.12	111.47	0.72029	0.0809	0.0125
open field	distance traveled slope, 20 min test	5.4830	7.8569	0.52764	0.757	0.491
open field	distance traveled, 20 min test, 1st 5min	100.80	51.655	0.46986	0.213	0.0604
open field	distance traveled, 20 min test, 2nd 5min	19.130	50.217	-0.28649	0.846	0.706
open field	distance traveled, 20 min test, 3rd 5min	151.43	44.725	1.1282	0.0239	0.00200
open field	distance traveled, 20 min test, 4th 5min	108.06	53.619	0.70472	0.205	0.0529
open field	number of clockwise revolution episodes, 20 min test	0.61849	1.2215	-0.038966	0.855	0.616
open field	number of counter-clockwise revolution episodes, 20 min test	2.4106	1.2039	0.83285	0.254	0.0544
open field	number of rears in 5 min bins, 20 min test, 1st 5min	1.3350	1.5239	0.16190	0.643	0.388
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	2.3972	2.4534	0.26557	0.621	0.337
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	7.0757	2.7615	1.2626	0.119	0.0157
open field	number of rears in 5 min bins, 20 min test, 4th 5min	5.4657	3.1265	0.84814	0.317	0.0907
open field	percentage of total time in center of arena, 20 min test	1.5709	3.3451	0.15842	0.861	0.642
open field	percentage of total time in center of arena, slope, 20 min test	3.7788	1.9758	2.1994	0.478	0.0657
open field	percentage of total time in center, habituation ratio, 20 min test	3.9395	1.9453	2.1702	0.446	0.0521
open field	percentage of total time in corners of arena, 20 min test	-3.1094	4.3797	-0.24753	0.750	0.483
open field	percentage of total time in corners, habituation ratio, 20 min test	1.0720	2.5170	0.20209	0.937	0.673
open field	percentage of total time in corners, slope, 20 min test	0.76570	2.3696	0.077276	0.943	0.749
open field	permanence time in center of arena, 20 min test	18.825	40.138	0.15842	0.862	0.642
open field	permanence time in corners of arena, 20 min test	-37.305	52.561	-0.24753	0.750	0.483
open field	permanence time in periphery of arena, 20 min test	-18.818	40.133	-0.15706	0.862	0.643
open field	total distance traveled, 20 min test	382.86	126.85	0.58724	0.0353	0.00515
open field	total number of rears, 20 min test	15.232	7.7885	0.69272	0.230	0.0599
open field	whole arena average speed, 20 min test	0.32134	0.10570	0.59523	0.0344	0.00487
open field	whole arena resting time, 20 min test	-52.036	15.914	-0.85393	0.0206	0.00270
open field	whole arena time spent mobile, 20 min test	52.029	15.915	1.0669	0.0215	0.00271
open field	whole arena time spent vertical, 20 min test	12.397	6.6452	0.85007	0.311	0.0719
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-2.1986	1.0998	-0.76274	0.269	0.0547
startle / PPI	average baseline movement during background noise	0.82737	1.3869	0.61964	0.903	0.555
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.072185	0.074002	-0.77140	0.683	0.337
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.080537	0.066539	-0.87899	0.586	0.236
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	4.4932	6.9661	0.54818	0.907	0.524
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-9.3942	7.1463	-0.97003	0.567	0.199
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-8.5479	7.6198	-0.89640	0.572	0.271
startle / PPI	average startle response to full pulse (120 dB)	65.919	37.371	1.3305	0.262	0.0879
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	62.964	38.549	1.2319	0.304	0.113
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	85.094	37.578	1.5198	0.127	0.0309
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	59.686	33.193	1.3442	0.255	0.0822
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.58451	1.6641	0.47001	0.953	0.728
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.82746	1.7922	-0.56290	0.939	0.648
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-0.48357	2.3351	-0.44357	0.963	0.837
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.051273	0.074729	0.53036	0.903	0.498
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.16233	0.082053	-1.4357	0.322	0.0571
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.13240	0.091454	-1.1878	0.392	0.158
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	65.568	37.655	1.3171	0.261	0.0919
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	62.213	39.120	1.2229	0.320	0.122
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	85.921	37.970	1.5243	0.127	0.0310
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	60.083	33.234	1.3833	0.242	0.0807
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.077412	0.082134	0.71236	0.860	0.353
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.13466	0.083849	-1.1302	0.435	0.119
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.12450	0.095146	-1.0912	0.458	0.201
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	249.74	134.06	1.3137	0.230	0.0723
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	214.43	136.78	1.1658	0.327	0.127
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	319.49	132.73	1.5517	0.103	0.0224
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	221.52	120.01	1.3870	0.226	0.0748
startle / PPI	maximum baseline movement during background noise	0.51130	3.0493	0.26726	0.969	0.868
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	7.1822	7.8620	0.76575	0.890	0.368
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-10.338	7.9004	-0.99042	0.564	0.201
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-8.8519	8.6602	-0.89850	0.602	0.315
startle / PPI	maximum startle response to full pulse (120 dB)	248.42	133.27	1.3104	0.229	0.0721
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	215.36	135.51	1.1685	0.320	0.122
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	314.70	132.01	1.5424	0.106	0.0237
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	219.09	120.07	1.3617	0.237	0.0780
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	0.69953	3.7022	0.36151	0.961	0.851
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-4.7852	4.1621	-1.2941	0.751	0.259
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-2.6690	5.2392	-0.73053	0.864	0.614

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	12.0 %	0.119
eye morphology	cornea	both	6.0 %	0.234
eye morphology	cornea opacity	females	11.0 %	0.323
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	5.0 %	0.408
eye morphology	cornea vascularization	females	13.0 %	0.167
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	6.0 %	0.221
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.0
eye morphology	corneal scleralization	females	13.0 %	0.195
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	6.0 %	0.277
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.0
eye morphology	eye closure	females	1.0 %	1.0
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.0
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.0
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.0
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	13.0 %	0.245
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	5.0 %	0.415
eye morphology	lacrimation	females	3.0 %	1.00
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.0
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	14.0 %	0.164
eye morphology	lens opacity	males	10.0 %	0.368
eye morphology	lens opacity	both	6.0 %	0.144
eye morphology	narrow eye opening	females	2.0 %	1.00
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.0
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	11.0 %	0.333
eye morphology	persistence of hyaloid vascular system	both	3.0 %	0.769
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.0
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.0
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.0
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.0
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.0
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.0
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.0
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	14.0 %	0.0385
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	6.0 %	0.0971
SHIRPA	aggression	females	0.0 %	1.0
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.00
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.0
SHIRPA	body position	females	14.0 %	0.0153
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	6.0 %	0.0592
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.00
SHIRPA	coat color abdomen	females	97.0 %	8.47e-11
SHIRPA	coat color abdomen	males	96.0 %	4.02e-12
SHIRPA	coat color abdomen	both	96.0 %	3.24e-22
SHIRPA	coat color back	females	14.0 %	0.0128
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	7.0 %	0.0246
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.00
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.00
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.00
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.0
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.0
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.0
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.00
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.0
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.00
SHIRPA	hindlimb digit size	females	0.0 %	1.0
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.0
SHIRPA	limb grasp	males	7.0 %	0.375
SHIRPA	limb grasp	both	1.0 %	1.0
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	14.0 %	0.0153
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	6.0 %	0.0540
SHIRPA	startle response	females	0.0 %	1.0
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.00
SHIRPA	tail elevation	females	1.0 %	1.0
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.0
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	14.0 %	0.0771
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	6.0 %	0.102
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.0
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.00
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Ppfia1^em1(IMPC)J/Mmjax -/+ with genotype: