MPD: JaxKOMP-EAP genotype: Emilin2<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Emilin2^em1(IMPC)J/Mmjax -/- Gene Emilin2

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

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Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	4.3750	3.6567	0.98132	0.678	0.255
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-8.7500	7.3625	-1.5507	0.715	0.258
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	1.9907e-8	4.2602	-0.17198	1.00	1.00
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	7.5564	6.0091	1.0787	0.625	0.235
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-1.2500	8.7294	-0.22766	0.967	0.889
body composition	body length	-0.017443	0.043712	-0.010301	0.859	0.694
body composition	body weight (at time of DXA)	-0.54396	0.92716	-0.32133	0.757	0.563
body composition	bone area, whole body scan, head excluded	-0.10028	0.22283	-0.22441	0.831	0.657
body composition	bone mineral content of whole body scan, head excluded	0.0043865	0.017049	0.39209	0.919	0.799
body composition	bone mineral content to body weight ratio	0.000078873	0.00060590	0.26662	0.956	0.898
body composition	bone mineral density of whole body scan, head excluded	0.00099291	0.00077406	1.0899	0.512	0.214
body composition	fat tissue mass of whole body scan, head excluded	0.39443	0.46180	0.63224	0.657	0.403
body composition	fat tissue mass to body weight ratio	0.013581	0.016414	0.65575	0.647	0.417
body composition	lean tissue mass of whole body scan, head excluded	0.17737	0.47115	0.21182	0.882	0.710
body composition	lean tissue mass to body weight ratio	0.0025162	0.014128	0.079997	0.930	0.860
body composition	percent fat, whole body scan, head excluded	1.0117	1.5806	0.55408	0.739	0.529
body composition	ratio of soft-tissue attenuation coefficients	-0.0011598	0.0017562	-0.57469	0.731	0.516
body composition	tissue area	-0.60740	0.23197	-1.6025	0.130	0.0161
body composition	total tissue mass, whole body scan, head excluded	0.49020	0.24055	0.81888	0.202	0.0544
clinical blood chemistry	alanine transaminase (plasma ALT)	2.2990	12.242	0.21635	0.961	0.854
clinical blood chemistry	albumin (plasma Alb)	-0.64943	0.50815	-0.81073	0.533	0.222
clinical blood chemistry	alkaline phosphatase (plasma ALP)	3.2512	3.7804	0.044650	0.649	0.404
clinical blood chemistry	aspartate transaminase (plasma AST)	4.4575	13.017	0.21575	0.912	0.737
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.079756	0.16769	0.27009	0.886	0.642
clinical blood chemistry	blood urea nitrogen (BUN)	-2.2726	1.9478	-0.92153	0.530	0.263
clinical blood chemistry	calcium (plasma Ca)	0.12797	0.058241	1.1823	0.180	0.0453
clinical blood chemistry	creatinine (plasma)	-0.034481	0.021317	-0.67129	0.340	0.127
clinical blood chemistry	glucose (plasma GLU, no fast)	-19.123	12.770	-0.43700	0.342	0.155
clinical blood chemistry	HDL cholesterol (plasma HDL)	3.2726	4.0285	0.45836	0.712	0.430
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.020267	0.013658	-1.2077	0.487	0.160
clinical blood chemistry	phosphorus (plasma phosphate)	0.77218	0.33753	1.0861	0.192	0.0371
clinical blood chemistry	total bilirubin (plasma TBIL)	0.0060633	0.0089866	0.40851	0.787	0.511
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	5.2145	4.7945	0.66338	0.601	0.295
clinical blood chemistry	total protein (plasma TP)	0.77444	0.78544	0.53392	0.614	0.341
clinical blood chemistry	triglyceride (plasma TG, no fast)	14.145	5.6391	0.94706	0.160	0.0251
glucose tolerance test	amount glucose injected	-0.64274	1.8514	0.15253	0.915	0.732
glucose tolerance test	plasma glucose, 0min	-5.5068	5.1583	-0.75332	0.517	0.298
glucose tolerance test	plasma glucose, 15min	72.360	21.190	1.8871	0.0528	0.00275
glucose tolerance test	plasma glucose, 30min	70.617	21.434	1.9567	0.0629	0.00362
glucose tolerance test	plasma glucose, 60min	21.225	21.573	0.93363	0.668	0.337
glucose tolerance test	plasma glucose, 120min	14.972	14.911	0.88588	0.623	0.328
grip strength	body weight (at time of grip strength test)	-0.98040	0.60711	-0.67267	0.266	0.117
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-37.961	5.3774	-2.1839	0.0000217	7.56e-8
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.6539	0.25706	-2.0138	0.000120	4.88e-7
grip strength	forelimb and hindlimb grip strength by trial, trial1	-33.220	7.4206	-1.8226	0.00626	0.000102
grip strength	forelimb and hindlimb grip strength by trial, trial2	-34.587	8.7125	-1.9325	0.0146	0.000415
grip strength	forelimb and hindlimb grip strength by trial, trial3	-45.628	6.8886	-2.4597	0.000107	2.47e-7
grip strength	forelimb grip strength (mean of trials), average	-21.530	3.9369	-2.0723	0.000594	0.00000620
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.89717	0.19886	-1.7577	0.00566	0.0000984
grip strength	forelimb grip strength by trial, trial1	-21.358	4.8606	-2.0029	0.0118	0.000128
grip strength	forelimb grip strength by trial, trial2	-22.687	4.7868	-1.9419	0.00441	0.0000486
grip strength	forelimb grip strength by trial, trial3	-20.234	5.5875	-1.7510	0.0336	0.00107
heart weight	heart weight, normalized to body weight	0.12031	0.26017	-0.010135	0.799	0.647
heart weight	heart weight, weight	-5.3409	7.3609	-1.0844	0.674	0.475
hematology	basophil differential (percent of total WBC)	-0.011627	0.042662	-0.16548	0.945	0.788
hematology	calculated hemoglobin (cHGB)	0.36762	0.27592	0.88040	0.476	0.199
hematology	eosinophil differential (percent of total WBC)	-0.31199	0.33343	-0.75983	0.746	0.361
hematology	hematocrit (HCT)	1.1804	0.69504	0.99320	0.369	0.106
hematology	hemoglobin concentration distribution width (HDW)	0.0021169	0.032109	0.048692	0.970	0.948
hematology	large unstained cells (percent of total WBC)	0.021376	0.091757	0.15259	0.916	0.818
hematology	lymphocyte differential (percent of total WBC)	-3.8002	2.0092	-1.4692	0.276	0.0739
hematology	mean corpuscular hemoglobin (CHr)	-0.013139	0.048620	-0.082357	0.900	0.790
hematology	mean platelet volume (MPV)	0.15704	0.23211	0.77578	0.722	0.507
hematology	mean RBC corpuscular hemoglobin (MCH)	0.064334	0.096734	0.20791	0.795	0.514
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.17149	0.25938	0.40829	0.812	0.517
hematology	mean RBC corpuscular volume (MCV)	0.31448	0.25309	0.57560	0.454	0.229
hematology	measured hemoglobin (mHGB)	0.44235	0.25797	0.92568	0.366	0.104
hematology	monocyte differential (percent of total WBC)	0.44139	0.51956	1.4612	0.727	0.406
hematology	neutrophil differential (percent of total WBC)	3.6599	1.6729	1.5550	0.189	0.0414
hematology	platelet count (PLT; units per volume x 10³)	142.25	89.299	1.7530	0.493	0.128
hematology	RBC corpuscular distribution width (RDW)	0.43389	0.19423	1.3130	0.187	0.0377
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.20526	0.18946	-0.59568	0.558	0.292
hematology	red blood cell count (RBC; per volume x 10⁶)	0.27339	0.20076	0.84240	0.453	0.190
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-4.9339	20.088	-0.13986	0.946	0.809
hematology	reticulocyte differential (percent of total RBC)	-0.11929	0.19245	-0.30000	0.809	0.543
hematology	white blood cell count (WBC; units per volume x 10³)	1.1988	1.0199	0.97326	0.460	0.255
holeboard	number of hole pokes by individual hole number, 20 min test, 1	2.3871	2.3389	1.9500	0.739	0.312
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.018714	0.65117	0.10569	0.990	0.977
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.76437	0.50653	-1.2136	0.661	0.138
holeboard	number of hole pokes by individual hole number, 20 min test, 4	1.1870	1.0354	1.2171	0.715	0.257
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.47465	0.39662	-0.68566	0.734	0.237
holeboard	number of hole pokes by individual hole number, 20 min test, 6	2.8317	2.4091	2.6489	0.834	0.245
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.18508	0.28116	0.49725	0.924	0.513
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.17840	0.61718	0.42333	0.960	0.774
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.037500	0.42487	0.16972	0.992	0.930
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.10000	0.30597	-0.20093	0.951	0.745
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.38639	0.26948	-1.0295	0.735	0.158
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.42500	0.44808	0.76974	0.774	0.347
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.17500	0.64798	0.25927	0.939	0.788
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.32500	0.46061	0.60919	0.845	0.484
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-1.1247	0.37786	-1.7235	0.231	0.00452
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-1.1000	0.83273	-0.92433	0.610	0.193
holeboard	total number of hole pokes, 20 min test	3.9063	6.8242	0.64202	0.780	0.570
light / dark	fecal boli count, 20 min test	0.84158	0.61963	0.94817	0.588	0.183
light / dark	latency to enter dark zone, 20 min test	-2.3766	28.989	-0.15201	0.978	0.935
light / dark	number of transitions between light and dark zones, 20 min test	0.53405	7.3472	0.16433	0.978	0.942
light / dark	percentage of total time in dark zone, 20 min test	-1.9486	2.7221	-0.23052	0.777	0.477
light / dark	percentage of total time in light zone, 20 min test	1.9486	2.7221	0.22497	0.775	0.477
light / dark	time mobile in dark zone, 20 min test	-5.3666	11.561	-0.46210	0.844	0.645
light / dark	time mobile in light zone, 20 min test	-2.6463	10.908	-0.43370	0.909	0.809
light / dark	time spent in dark zone, 20 min test	-18.306	43.216	-0.066297	0.898	0.674
light / dark	time spent in light zone, 20 min test	18.306	43.216	0.066297	0.898	0.674
open field	average speed in center of arena, 20 min test	0.12415	0.28091	0.12722	0.868	0.660
open field	average speed in periphery of arena, 20 min test	0.21398	0.15417	0.31176	0.374	0.171
open field	distance traveled habituation ratio, 20 min test	2.5646	5.9216	0.26140	0.868	0.667
open field	distance traveled in center of arena, 20 min test	-113.25	105.46	-1.0934	0.542	0.288
open field	distance traveled in periphery of arena, 20 min test	324.57	134.80	0.81588	0.103	0.0198
open field	distance traveled slope, 20 min test	1.2454	5.4278	0.19661	0.941	0.819
open field	distance traveled, 20 min test, 1st 5min	0.32953	70.109	-0.34435	0.997	0.996
open field	distance traveled, 20 min test, 2nd 5min	104.33	44.748	0.64074	0.119	0.0238
open field	distance traveled, 20 min test, 3rd 5min	74.590	55.476	0.37443	0.412	0.185
open field	distance traveled, 20 min test, 4th 5min	23.696	54.658	-0.18157	0.830	0.666
open field	number of clockwise revolution episodes, 20 min test	1.5474	1.3875	0.49351	0.623	0.270
open field	number of counter-clockwise revolution episodes, 20 min test	-0.73593	1.4153	-0.80099	0.800	0.605
open field	number of fecal boli, 20 min test	-0.11250	0.71172	0.19130	0.949	0.875
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-1.1441	2.1728	-0.52101	0.805	0.601
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	2.9733	2.4092	0.41946	0.517	0.223
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	3.3174	2.8939	0.47136	0.535	0.257
open field	number of rears in 5 min bins, 20 min test, 4th 5min	1.3629	2.9940	-0.050369	0.822	0.651
open field	percentage of total time in center of arena, 20 min test	-3.8753	3.2221	-1.1859	0.554	0.235
open field	percentage of total time in center of arena, slope, 20 min test	0.97437	1.7974	0.67407	0.888	0.590
open field	percentage of total time in center, habituation ratio, 20 min test	0.70076	1.9406	0.50311	0.928	0.720
open field	percentage of total time in corners of arena, 20 min test	4.9970	3.3230	1.1968	0.440	0.139
open field	percentage of total time in corners, habituation ratio, 20 min test	-0.87994	1.8713	-0.71682	0.930	0.640
open field	percentage of total time in corners, slope, 20 min test	-1.1790	1.6842	-0.86364	0.879	0.487
open field	permanence time in center of arena, 20 min test	-46.504	38.665	-1.1859	0.554	0.235
open field	permanence time in corners of arena, 20 min test	59.958	39.876	1.1968	0.440	0.139
open field	permanence time in periphery of arena, 20 min test	46.521	38.663	1.1886	0.553	0.235
open field	total distance traveled, 20 min test	204.23	195.15	0.11234	0.521	0.300
open field	total number of rears, 20 min test	6.6393	8.7369	0.12993	0.688	0.451
open field	whole arena average speed, 20 min test	0.17130	0.16263	0.11910	0.519	0.297
open field	whole arena resting time, 20 min test	-26.107	19.632	-0.19661	0.376	0.190
open field	whole arena time spent mobile, 20 min test	26.164	19.644	0.44600	0.379	0.189
open field	whole arena time spent vertical, 20 min test	7.4752	7.5168	0.46986	0.630	0.325
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-0.37540	1.8450	0.024317	0.955	0.840
startle / PPI	average baseline movement during background noise	0.45585	1.2767	0.38555	0.948	0.724
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.13183	0.077466	1.0715	0.412	0.0991
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.10517	0.072513	0.92966	0.496	0.157
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	3.8576	8.7214	0.47158	0.949	0.661
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	6.0289	7.9233	0.53844	0.751	0.453
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	5.9083	5.4524	0.52714	0.589	0.287
startle / PPI	average startle response to full pulse (120 dB)	-26.121	36.702	-0.31846	0.720	0.482
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-40.113	37.533	-0.56126	0.530	0.294
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-22.223	28.077	-0.27598	0.635	0.435
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-16.388	21.520	-0.21963	0.649	0.453
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.44766	1.6695	0.38857	0.971	0.790
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	1.4881	1.3376	0.85528	0.793	0.275
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	10.498	2.5722	2.4438	0.0420	0.000305
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.049783	0.099722	0.51590	0.922	0.621
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.086571	0.088228	0.66003	0.664	0.334
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.18421	0.070359	1.2050	0.105	0.0139
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-28.844	37.598	-0.35553	0.687	0.449
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-40.597	38.185	-0.56618	0.531	0.296
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-23.711	27.984	-0.30668	0.611	0.404
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-27.389	21.380	-0.44667	0.422	0.210
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.098415	0.10493	0.86338	0.860	0.356
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.12009	0.091902	0.86299	0.542	0.201
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.17916	0.070211	1.0912	0.113	0.0162
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-107.09	136.68	-0.38253	0.672	0.439
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-163.13	135.95	-0.65918	0.477	0.240
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-94.647	103.31	-0.34957	0.587	0.367
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-94.690	79.458	-0.40372	0.457	0.243
startle / PPI	maximum baseline movement during background noise	2.4558	2.5992	0.74895	0.800	0.353
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	9.0521	9.7711	0.91754	0.890	0.362
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	10.230	8.5969	0.86338	0.612	0.243
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	8.9913	6.0189	0.70515	0.413	0.146
startle / PPI	maximum startle response to full pulse (120 dB)	-104.84	136.28	-0.37050	0.678	0.448
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-162.19	134.67	-0.65396	0.481	0.238
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-91.777	103.87	-0.34362	0.599	0.384
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-68.653	79.996	-0.25422	0.604	0.398
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	0.90321	3.7947	0.41439	0.959	0.813
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	2.6683	3.4473	0.72506	0.830	0.445
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	24.847	6.6636	2.4438	0.0528	0.000831

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	12.0 %	0.175
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	6.0 %	0.248
eye morphology	cornea opacity	females	9.0 %	0.359
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	4.0 %	0.428
eye morphology	cornea vascularization	females	12.0 %	0.189
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	6.0 %	0.234
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	7.0 %	1.00
eye morphology	narrow eye opening	females	12.0 %	0.0311
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	6.0 %	0.0390
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	12.0 %	0.134
eye morphology	persistence of hyaloid vascular system	both	5.0 %	0.564
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.0
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	12.0 %	0.0476
eye morphology	retinal blood vessels structure	both	6.0 %	0.0640
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	12.0 %	0.126
SHIRPA	activity body position	both	6.0 %	0.193
SHIRPA	aggression	females	12.0 %	0.0404
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	6.0 %	0.0878
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	22.0 %	0.0306
SHIRPA	coat color abdomen	males	9.0 %	0.256
SHIRPA	coat color abdomen	both	15.0 %	0.0181
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	24.0 %	0.00365
SHIRPA	coat hair distribution abdomen	both	12.0 %	0.00512
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	16.0 %	0.154
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	5.0 %	0.327
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	25.0 %	0.000342
SHIRPA	skin texture whole body	both	12.0 %	0.000362
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	12.0 %	0.0876
SHIRPA	transfer arousal	males	36.0 %	0.000168
SHIRPA	transfer arousal	both	24.0 %	0.0000662
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	12.0 %	0.0118
SHIRPA	tremor	both	6.0 %	0.0262
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	18.0 %	0.0935
SHIRPA	vocalization	males	48.0 %	0.00229
SHIRPA	vocalization	both	31.0 %	0.000572

GENOTYPE CORRELATION PLOT

Correlate Emilin2^em1(IMPC)J/Mmjax -/- with genotype: