MPD: JaxKOMP-EAP genotype: Pmpca<sup>em1(IMPC)J</sup>/Mmjax -/+

JaxKOMP-EAP effect sizes: Pmpca^em1(IMPC)J/Mmjax -/+ Gene Pmpca

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	1.1144	2.1596	0.061985	0.879	0.615
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-4.5741	2.3346	-0.94911	0.489	0.0737
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	5.0398	6.1038	0.68914	0.751	0.424
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-0.87631	6.9419	-0.16051	0.971	0.902
body composition	body length	-0.058816	0.094380	-0.49391	0.807	0.597
body composition	body weight (at time of DXA)	1.2810	2.1292	1.1927	0.781	0.609
body composition	bone area, whole body scan, head excluded	0.15709	0.16474	0.85768	0.693	0.441
body composition	bone mineral content of whole body scan, head excluded	0.015276	0.013345	1.0120	0.654	0.371
body composition	bone mineral content to body weight ratio	0.00016291	0.00067726	0.37300	0.933	0.832
body composition	bone mineral density of whole body scan, head excluded	0.00047529	0.00068937	0.55362	0.779	0.562
body composition	fat tissue mass of whole body scan, head excluded	0.23686	0.89766	0.41133	0.914	0.817
body composition	fat tissue mass to body weight ratio	0.0082491	0.024903	0.43973	0.889	0.772
body composition	lean tissue mass of whole body scan, head excluded	0.12211	0.55271	0.095715	0.938	0.846
body composition	lean tissue mass to body weight ratio	-0.0037774	0.010153	-0.26889	0.876	0.746
body composition	percent fat, whole body scan, head excluded	0.72020	2.2769	0.42773	0.902	0.782
body composition	ratio of soft-tissue attenuation coefficients	-0.00078677	0.0025349	-0.41377	0.907	0.786
body composition	tissue area	-0.049907	0.98663	0.017769	0.995	0.964
body composition	total tissue mass, whole body scan, head excluded	0.45681	0.82598	0.73935	0.808	0.636
clinical blood chemistry	alanine transaminase (plasma ALT)	-11.566	6.4227	-0.96704	0.432	0.0861
clinical blood chemistry	albumin (plasma Alb)	0.89985	0.51620	1.3208	0.385	0.0966
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-1.6199	2.2254	-0.81724	0.700	0.475
clinical blood chemistry	aspartate transaminase (plasma AST)	-5.5097	12.593	-0.27714	0.879	0.666
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.20959	0.17007	0.67004	0.632	0.231
clinical blood chemistry	blood urea nitrogen (BUN)	1.2667	1.3173	0.47359	0.622	0.347
clinical blood chemistry	calcium (plasma Ca)	0.045122	0.088681	0.65102	0.784	0.616
clinical blood chemistry	creatinine (plasma)	-0.018802	0.021331	-0.33831	0.629	0.389
clinical blood chemistry	glucose (plasma GLU, no fast)	13.212	19.628	0.80159	0.704	0.509
clinical blood chemistry	HDL cholesterol (plasma HDL)	3.7623	3.3771	0.57166	0.585	0.278
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.029679	0.0096426	1.4240	0.0897	0.00571
clinical blood chemistry	phosphorus (plasma phosphate)	-1.6169	0.62968	-2.0002	0.131	0.0179
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.0076597	0.0087539	-0.58533	0.731	0.392
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-0.87975	4.1733	-0.39614	0.937	0.835
clinical blood chemistry	total protein (plasma TP)	1.6239	0.77046	1.1799	0.240	0.0472
clinical blood chemistry	triglyceride (plasma TG, no fast)	-31.012	13.516	-1.2757	0.184	0.0327
EKG	duration of PQ interval	-1.5809	0.87085	-1.3556	0.615	0.0772
EKG	duration of PR interval	-1.4140	0.84026	-1.2301	0.625	0.100
EKG	duration of QRS interval	0.21627	0.20339	0.44551	0.885	0.294
EKG	duration of QT interval	-1.1130	0.74449	-0.89690	0.653	0.143
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.62547	0.64986	-0.60041	0.861	0.342
EKG	duration of RR interval	-2.0210	1.4256	-0.78771	0.573	0.164
EKG	duration of ST interval	-1.2832	0.72215	-1.0214	0.569	0.0834
EKG	heart rate coefficient of variation (signal intensity)	0.77708	0.91099	0.73652	0.867	0.399
EKG	heart rate variability, mean of differences between sequential beats; beats per min	6.2735	6.1774	0.80152	0.853	0.316
EKG	heart rate, beats per min	19.045	11.338	0.91457	0.477	0.101
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.019591	0.057132	0.043370	0.912	0.734
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.052581	0.093955	0.19996	0.827	0.579
EKG	number of signals	-8.2993	5.6320	-1.4527	0.667	0.149
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	3.8617	6.4925	0.80002	0.893	0.555
EKG	QT dispersion, measured as inter-lead variability of QT intervals	1.8795	2.3937	0.58600	0.939	0.437
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	2.5382	2.3742	0.66189	0.883	0.292
EKG	root mean square of successive differences of neighboring RR intervals	1.8332	1.2182	1.0079	0.843	0.140
glucose tolerance test	amount glucose injected	-2.9072	2.5743	-0.47902	0.643	0.269
glucose tolerance test	plasma glucose, 0min	-7.1053	4.3698	-0.90019	0.285	0.115
glucose tolerance test	plasma glucose, 15min	-18.492	37.607	-0.39436	0.861	0.627
glucose tolerance test	plasma glucose, 30min	-81.204	25.290	-2.1338	0.0599	0.00331
glucose tolerance test	plasma glucose, 60min	-64.849	15.522	-2.2385	0.0176	0.000260
glucose tolerance test	plasma glucose, 120min	-17.841	11.932	-1.3186	0.451	0.146
grip strength	body weight (at time of grip strength test)	1.6597	0.57202	1.6304	0.0308	0.00601
grip strength	forelimb and hindlimb grip strength (mean of trials), average	7.8478	7.1264	0.82355	0.489	0.278
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.13009	0.34025	0.37144	0.832	0.704
grip strength	forelimb and hindlimb grip strength by trial, trial1	16.371	9.0991	1.3349	0.291	0.0797
grip strength	forelimb and hindlimb grip strength by trial, trial2	-1.9334	8.3481	0.12669	0.906	0.818
grip strength	forelimb and hindlimb grip strength by trial, trial3	7.9220	8.7568	0.74072	0.640	0.371
grip strength	forelimb grip strength (mean of trials), average	14.228	3.8189	2.0138	0.0140	0.000601
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.44427	0.19900	1.2769	0.158	0.0314
grip strength	forelimb grip strength by trial, trial1	13.142	4.7330	1.6409	0.118	0.00840
grip strength	forelimb grip strength by trial, trial2	15.967	4.7539	1.8460	0.0422	0.00173
grip strength	forelimb grip strength by trial, trial3	10.976	4.9980	1.3824	0.214	0.0339
heart weight	heart weight, normalized to body weight	0.035059	0.10426	-0.32095	0.860	0.739
heart weight	heart weight, weight	1.9131	3.1401	-0.12941	0.726	0.547
hematology	basophil differential (percent of total WBC)	-0.049709	0.039020	-0.71202	0.654	0.217
hematology	calculated hemoglobin (cHGB)	0.12859	0.18957	0.10099	0.753	0.505
hematology	eosinophil differential (percent of total WBC)	0.071936	0.15621	0.28625	0.885	0.650
hematology	hematocrit (HCT)	0.56456	0.71695	0.26267	0.691	0.440
hematology	hemoglobin concentration distribution width (HDW)	-0.020667	0.028095	-0.58235	0.732	0.470
hematology	large unstained cells (percent of total WBC)	-0.15037	0.071103	-0.96051	0.290	0.0466
hematology	lymphocyte differential (percent of total WBC)	0.73093	1.0162	0.26834	0.697	0.480
hematology	mean corpuscular hemoglobin (CHr)	-0.13919	0.034954	-1.1152	0.00865	0.000678
hematology	mean platelet volume (MPV)	0.23867	0.064938	1.1200	0.0131	0.00141
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.49059	0.23474	-1.1466	0.291	0.0496
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.88679	0.50954	-1.2130	0.413	0.0964
hematology	mean RBC corpuscular volume (MCV)	0.017778	0.31803	0.041014	0.978	0.956
hematology	measured hemoglobin (mHGB)	-0.38199	0.28053	-1.0293	0.495	0.188
hematology	monocyte differential (percent of total WBC)	-0.035695	0.15310	0.091701	0.935	0.818
hematology	neutrophil differential (percent of total WBC)	-0.51956	0.93569	-0.24714	0.766	0.585
hematology	platelet count (PLT; units per volume x 10³)	93.527	57.927	1.2345	0.478	0.121
hematology	RBC corpuscular distribution width (RDW)	-0.14498	0.15123	-0.53023	0.604	0.349
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.20444	0.25627	-0.59153	0.687	0.434
hematology	red blood cell count (RBC; per volume x 10⁶)	0.16750	0.14008	0.40931	0.516	0.246
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-8.6447	9.6567	-0.29758	0.742	0.381
hematology	reticulocyte differential (percent of total RBC)	-0.12774	0.10602	-0.34731	0.613	0.242
hematology	white blood cell count (WBC; units per volume x 10³)	-2.6516	0.60944	-1.4692	0.00500	0.000281
holeboard	number of hole pokes by individual hole number, 20 min test, 1	1.0188	0.73703	0.97690	0.675	0.175
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.028907	0.44132	0.078571	0.989	0.948
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.077079	0.32462	-0.014348	0.951	0.814
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.97710	0.63590	1.0357	0.608	0.132
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.034769	0.69050	0.17046	0.985	0.960
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.015868	0.27123	0.096298	0.999	0.954
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.0049847	0.42402	0.00084512	1.00	0.991
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.35621	0.38801	0.74007	0.807	0.364
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.17676	0.42228	0.42456	0.938	0.678
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.14964	0.24547	0.45123	0.910	0.546
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.15168	0.27539	-0.38969	0.910	0.585
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.72738	0.40901	-1.1398	0.516	0.0829
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.032097	0.66932	0.045560	0.994	0.962
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.26191	0.39039	0.51629	0.845	0.506
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.34235	0.43019	0.61530	0.823	0.431
holeboard	number of hole pokes by individual hole number, 20 min test, 16	1.1718	0.94458	1.0247	0.638	0.222
holeboard	total number of hole pokes, 20 min test	5.3107	3.8538	0.81359	0.456	0.176
light / dark	fecal boli count, 20 min test	0.80241	0.97518	0.90152	0.779	0.420
light / dark	latency to enter dark zone, 20 min test	31.445	29.494	0.49240	0.697	0.295
light / dark	number of transitions between light and dark zones, 20 min test	-12.592	7.1098	-1.1763	0.356	0.0864
light / dark	percentage of total time in dark zone, 20 min test	-3.8281	3.3543	-0.56550	0.625	0.263
light / dark	percentage of total time in light zone, 20 min test	3.8281	3.3543	0.56391	0.625	0.263
light / dark	time mobile in dark zone, 20 min test	-4.1627	11.037	-0.38955	0.882	0.709
light / dark	time mobile in light zone, 20 min test	0.70683	10.825	-0.19594	0.975	0.948
light / dark	time spent in dark zone, 20 min test	-45.747	40.968	-0.48022	0.679	0.273
light / dark	time spent in light zone, 20 min test	45.748	40.968	0.48022	0.679	0.273
open field	average speed in center of arena, 20 min test	0.45902	0.39603	0.71162	0.598	0.253
open field	average speed in periphery of arena, 20 min test	0.23773	0.17667	0.38887	0.392	0.186
open field	distance traveled habituation ratio, 20 min test	-12.754	8.1872	-1.0575	0.429	0.127
open field	distance traveled in center of arena, 20 min test	148.11	111.37	0.57769	0.442	0.191
open field	distance traveled in periphery of arena, 20 min test	120.83	156.48	0.067853	0.681	0.445
open field	distance traveled slope, 20 min test	-13.565	7.8526	-1.1886	0.366	0.0920
open field	distance traveled, 20 min test, 1st 5min	154.95	77.435	0.85007	0.195	0.0522
open field	distance traveled, 20 min test, 2nd 5min	115.26	59.218	0.75198	0.212	0.0588
open field	distance traveled, 20 min test, 3rd 5min	45.286	62.733	0.065162	0.712	0.475
open field	distance traveled, 20 min test, 4th 5min	45.191	65.954	0.051713	0.727	0.497
open field	number of clockwise revolution episodes, 20 min test	1.1293	1.6668	0.25529	0.793	0.502
open field	number of counter-clockwise revolution episodes, 20 min test	2.7419	1.2673	1.0138	0.213	0.0365
open field	number of fecal boli, 20 min test	1.4333	0.96035	1.3080	0.460	0.143
open field	number of rears in 5 min bins, 20 min test, 1st 5min	3.7937	2.0493	0.83437	0.265	0.0715
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	5.9137	2.5420	1.1410	0.150	0.0251
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	3.1817	3.1872	0.44008	0.595	0.324
open field	number of rears in 5 min bins, 20 min test, 4th 5min	3.4509	3.0199	0.41507	0.536	0.260
open field	percentage of total time in center of arena, 20 min test	2.0429	3.0626	0.26001	0.781	0.509
open field	percentage of total time in center of arena, slope, 20 min test	1.0022	1.3283	0.69443	0.840	0.455
open field	percentage of total time in center, habituation ratio, 20 min test	1.3559	1.3543	0.86754	0.786	0.323
open field	percentage of total time in corners of arena, 20 min test	-1.4101	3.6755	0.032900	0.883	0.703
open field	percentage of total time in corners, habituation ratio, 20 min test	1.4122	1.8990	0.34150	0.864	0.461
open field	percentage of total time in corners, slope, 20 min test	1.6417	1.8544	0.47586	0.823	0.381
open field	permanence time in center of arena, 20 min test	24.506	36.752	0.25862	0.782	0.509
open field	permanence time in corners of arena, 20 min test	-16.909	44.107	0.034243	0.884	0.703
open field	permanence time in periphery of arena, 20 min test	-24.503	36.757	-0.26001	0.782	0.509
open field	total distance traveled, 20 min test	342.28	226.05	0.48944	0.319	0.138
open field	total number of rears, 20 min test	16.017	9.5717	0.75376	0.301	0.102
open field	whole arena average speed, 20 min test	0.28614	0.18838	0.49550	0.318	0.137
open field	whole arena resting time, 20 min test	-42.093	21.359	-0.60811	0.178	0.0559
open field	whole arena time spent mobile, 20 min test	41.930	21.338	0.85393	0.178	0.0566
open field	whole arena time spent vertical, 20 min test	10.376	8.0307	0.69443	0.511	0.204
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	2.1236	1.1957	1.0887	0.336	0.0833
startle / PPI	average baseline movement during background noise	-0.67105	1.2827	-0.44048	0.916	0.604
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.043035	0.068075	-0.49204	0.796	0.531
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.017659	0.063712	-0.24438	0.907	0.783
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	3.7181	8.5176	0.45909	0.950	0.665
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-1.0280	6.5411	-0.14695	0.961	0.876
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-2.5380	6.1851	-0.38253	0.882	0.684
startle / PPI	average startle response to full pulse (120 dB)	58.696	40.356	1.2259	0.368	0.154
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	58.993	41.066	1.1882	0.370	0.159
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	44.359	38.025	1.0349	0.469	0.250
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	29.812	31.110	0.90270	0.566	0.344
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.61292	1.6881	-0.41133	0.947	0.718
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.6972	1.3902	-1.1658	0.740	0.229
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	0.57017	2.2255	0.10739	0.949	0.799
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.042414	0.094451	0.44203	0.927	0.656
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.033882	0.072745	-0.39357	0.866	0.644
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.064986	0.077281	-0.67978	0.665	0.405
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	58.219	40.687	1.2200	0.378	0.160
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	59.606	41.239	1.2025	0.365	0.156
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	46.057	38.137	1.0542	0.450	0.234
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	29.242	31.589	0.89850	0.573	0.360
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.0011377	0.098718	0.020318	0.998	0.991
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.053370	0.075343	-0.48365	0.762	0.483
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.075930	0.080917	-0.74853	0.617	0.354
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	223.90	143.66	1.2470	0.323	0.127
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	247.49	140.23	1.2624	0.256	0.0852
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	178.96	135.52	1.0865	0.406	0.194
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	127.33	117.18	0.98814	0.497	0.284
startle / PPI	maximum baseline movement during background noise	-3.4663	3.2460	-0.93910	0.763	0.292
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.011404	9.2094	0.035737	1.00	0.999
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-3.2001	6.9691	-0.35404	0.849	0.649
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-4.4753	7.0235	-0.53682	0.781	0.528
startle / PPI	maximum startle response to full pulse (120 dB)	223.77	143.10	1.2531	0.323	0.126
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	246.12	139.80	1.2593	0.257	0.0860
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	175.13	135.24	1.0665	0.416	0.203
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	129.75	116.10	1.0019	0.490	0.270
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-1.3737	3.5615	-0.33323	0.939	0.702
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-6.9299	3.5150	-1.7478	0.514	0.0558
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	2.4187	5.4163	0.28911	0.880	0.658

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	3.0 %	1.0
eye morphology	cornea vascularization	2.0 %	1.0
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.0
eye morphology	corneal scleralization	2.0 %	1.0
eye morphology	corneal ulcer	1.0 %	1.0
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.0
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.0
eye morphology	iris pigmentation	2.0 %	1.0
eye morphology	iris transillumination	1.0 %	1.0
eye morphology	irispupil	3.0 %	1.0
eye morphology	lacrimation	3.0 %	1.0
eye morphology	lens	9.0 %	1.0
eye morphology	lens opacity	8.0 %	0.495
eye morphology	narrow eye opening	1.0 %	1.00
eye morphology	optic disc	3.0 %	1.0
eye morphology	persistence of hyaloid vascular system	9.0 %	1.00
eye morphology	pupil dilation	2.0 %	1.0
eye morphology	pupil light response	2.0 %	1.0
eye morphology	pupil position	4.0 %	1.0
eye morphology	pupil shape	3.0 %	1.0
eye morphology	retina	13.0 %	1.0
eye morphology	retinal blood vessels	3.0 %	1.0
eye morphology	retinal blood vessels pattern	4.0 %	1.00
eye morphology	retinal blood vessels structure	3.0 %	1.0
eye morphology	retinal pigmentation	13.0 %	1.0
eye morphology	retinal structure	3.0 %	1.0
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	12.0 %	0.00512
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.00
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	12.0 %	0.0000244
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	7.0 %	0.624
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	30.0 %	0.00000403
SHIRPA	vocalization	98.0 %	1.25e-12

GENOTYPE CORRELATION PLOT

Correlate Pmpca^em1(IMPC)J/Mmjax -/+ with genotype: