MPD: JaxKOMP-EAP genotype: Ube2i<sup>em1(IMPC)J</sup>/Mmjax -/+

JaxKOMP-EAP effect sizes: Ube2i^em1(IMPC)J/Mmjax -/+ Gene Ube2i

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	24.700	6.7901	2.5641	0.106	0.00269
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	18.746	8.3931	2.1078	0.386	0.0423
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-1.4583	10.562	-0.50737	0.966	0.892
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	5.8028	10.322	0.80061	0.835	0.583
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	6.0417	9.8673	0.93221	0.819	0.550
body composition	body length	0.053781	0.099146	0.92480	0.822	0.625
body composition	body weight (at time of DXA)	-4.7781	1.3905	-2.5128	0.148	0.0413
body composition	bone area, whole body scan, head excluded	-0.26226	0.16834	-0.84786	0.484	0.217
body composition	bone mineral content of whole body scan, head excluded	-0.028354	0.013548	-1.2897	0.370	0.127
body composition	bone mineral content to body weight ratio	-0.00068192	0.00071113	-0.70567	0.661	0.408
body composition	bone mineral density of whole body scan, head excluded	-0.0015996	0.00078040	-1.4941	0.397	0.133
body composition	fat tissue mass of whole body scan, head excluded	0.46705	0.57898	0.71446	0.708	0.479
body composition	fat tissue mass to body weight ratio	0.012424	0.018826	0.60906	0.761	0.556
body composition	lean tissue mass of whole body scan, head excluded	-0.80884	0.72038	-1.5981	0.641	0.343
body composition	lean tissue mass to body weight ratio	-0.0098698	0.035823	-0.59389	0.904	0.801
body composition	percent fat, whole body scan, head excluded	1.2722	1.9809	0.67107	0.765	0.566
body composition	ratio of soft-tissue attenuation coefficients	-0.0013352	0.0021512	-0.62881	0.773	0.579
body composition	tissue area	-0.37349	0.19994	-1.0414	0.433	0.159
body composition	total tissue mass, whole body scan, head excluded	-0.15947	0.30943	-0.60414	0.811	0.642
clinical blood chemistry	alanine transaminase (plasma ALT)	5.7303	6.7928	0.43955	0.743	0.408
clinical blood chemistry	albumin (plasma Alb)	-0.26576	0.47380	-0.33858	0.833	0.581
clinical blood chemistry	alkaline phosphatase (plasma ALP)	7.3703	4.1978	0.75924	0.285	0.0924
clinical blood chemistry	aspartate transaminase (plasma AST)	3.1909	5.4571	0.16809	0.818	0.564
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.58830	0.21359	-1.6576	0.185	0.0116
clinical blood chemistry	blood urea nitrogen (BUN)	-3.8176	1.4836	-1.4164	0.113	0.0170
clinical blood chemistry	calcium (plasma Ca)	0.46807	0.10918	2.3625	0.00735	0.000275
clinical blood chemistry	creatinine (plasma)	-0.046520	0.018448	-0.92428	0.115	0.0191
clinical blood chemistry	glucose (plasma GLU, no fast)	6.9233	18.033	0.55830	0.833	0.705
clinical blood chemistry	HDL cholesterol (plasma HDL)	-4.9445	4.6458	-1.3141	0.604	0.299
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.024347	0.017975	-1.4520	0.522	0.189
clinical blood chemistry	phosphorus (plasma phosphate)	2.6598	0.82952	2.3855	0.0554	0.00392
clinical blood chemistry	total bilirubin (plasma TBIL)	0.025678	0.017994	1.4255	0.492	0.168
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-4.4552	5.0310	-0.95801	0.688	0.385
clinical blood chemistry	total protein (plasma TP)	-1.2877	0.88796	-1.0697	0.442	0.161
clinical blood chemistry	triglyceride (plasma TG, no fast)	5.5741	10.659	0.52374	0.810	0.606
EKG	duration of PQ interval	0.37667	1.0980	0.55282	0.939	0.734
EKG	duration of PR interval	0.35500	1.0790	0.45891	0.938	0.745
EKG	duration of QRS interval	-0.095046	0.24011	-0.40580	0.967	0.695
EKG	duration of QT interval	-1.1588	0.87912	-0.92744	0.690	0.198
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-1.1826	0.79321	-1.1721	0.725	0.147
EKG	duration of RR interval	-0.10952	1.7587	0.20082	0.973	0.951
EKG	duration of ST interval	-1.0852	0.82335	-0.81549	0.700	0.198
EKG	heart rate coefficient of variation (signal intensity)	1.1925	1.3116	1.0595	0.867	0.371
EKG	heart rate variability, mean of differences between sequential beats; beats per min	9.0367	9.3210	1.0882	0.853	0.341
EKG	heart rate, beats per min	5.5884	14.361	0.065586	0.883	0.700
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.076667	0.059017	-0.75723	0.583	0.205
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.13000	0.097927	-0.80930	0.559	0.195
EKG	number of signals	12.571	8.3039	1.8176	0.660	0.141
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	13.598	7.4021	2.1190	0.758	0.0768
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-1.0391	3.2083	-0.27547	0.969	0.748
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-0.075180	3.9407	-0.020151	0.997	0.985
EKG	root mean square of successive differences of neighboring RR intervals	0.25018	1.7097	0.23591	0.970	0.885
glucose tolerance test	amount glucose injected	-4.8858	8.0187	-1.0005	0.835	0.547
glucose tolerance test	plasma glucose, 0min	0.64351	5.3263	-0.16548	0.958	0.905
glucose tolerance test	plasma glucose, 15min	-76.165	28.015	-1.8790	0.115	0.0108
glucose tolerance test	plasma glucose, 30min	-5.6396	15.922	-0.032952	0.889	0.726
glucose tolerance test	plasma glucose, 60min	-2.7795	22.150	0.037073	0.957	0.901
glucose tolerance test	plasma glucose, 120min	14.771	10.866	0.87576	0.494	0.184
grip strength	body weight (at time of grip strength test)	-3.6376	0.48830	-2.2004	4.76e-7	3.85e-9
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-23.728	7.9473	-1.4132	0.0333	0.00481
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.97509	0.35893	-1.1929	0.0573	0.00970
grip strength	forelimb and hindlimb grip strength by trial, trial1	-10.244	11.395	-0.47146	0.669	0.374
grip strength	forelimb and hindlimb grip strength by trial, trial2	-31.188	8.1907	-1.6995	0.0156	0.000461
grip strength	forelimb and hindlimb grip strength by trial, trial3	-39.210	5.8598	-2.0364	0.0000388	4.50e-8
grip strength	forelimb grip strength (mean of trials), average	-12.569	4.4504	-1.2416	0.0628	0.00735
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.55015	0.20731	-1.1165	0.0873	0.0114
grip strength	forelimb grip strength by trial, trial1	-7.2869	6.7580	-0.58677	0.638	0.287
grip strength	forelimb grip strength by trial, trial2	-11.968	6.8894	-1.0337	0.355	0.0900
grip strength	forelimb grip strength by trial, trial3	-18.754	4.0339	-1.5773	0.00349	0.0000344
heart weight	heart weight, normalized to body weight	0.18391	0.18269	0.20755	0.541	0.325
heart weight	heart weight, weight	2.9788	4.6393	0.014189	0.713	0.527
hematology	basophil differential (percent of total WBC)	0.083696	0.057898	1.1590	0.601	0.162
hematology	calculated hemoglobin (cHGB)	0.35470	0.18883	0.85257	0.281	0.0736
hematology	eosinophil differential (percent of total WBC)	-0.16588	0.20553	-0.39943	0.789	0.428
hematology	hematocrit (HCT)	0.18596	0.56767	-0.18001	0.871	0.746
hematology	hemoglobin concentration distribution width (HDW)	-0.0046249	0.025719	-0.12198	0.939	0.859
hematology	large unstained cells (percent of total WBC)	0.021622	0.080542	0.15434	0.908	0.791
hematology	lymphocyte differential (percent of total WBC)	3.6584	1.6316	1.1862	0.177	0.0349
hematology	mean corpuscular hemoglobin (CHr)	0.80904	0.096346	2.5783	9.86e-7	1.85e-8
hematology	mean platelet volume (MPV)	0.15801	0.071422	0.78322	0.139	0.0371
hematology	mean RBC corpuscular hemoglobin (MCH)	0.61182	0.087523	1.6721	0.0000479	4.00e-7
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.58350	0.17408	-0.98285	0.0656	0.00276
hematology	mean RBC corpuscular volume (MCV)	2.8060	0.42619	2.7790	0.0000480	0.00000102
hematology	measured hemoglobin (mHGB)	0.23841	0.16551	0.38319	0.457	0.164
hematology	monocyte differential (percent of total WBC)	-0.24232	0.19927	-0.58855	0.598	0.237
hematology	neutrophil differential (percent of total WBC)	-2.8401	1.6321	-1.1071	0.298	0.0952
hematology	platelet count (PLT; units per volume x 10³)	-141.97	43.023	-1.5878	0.0700	0.00313
hematology	RBC corpuscular distribution width (RDW)	0.48243	0.17878	1.4211	0.110	0.0128
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.015042	0.21955	-0.059219	0.975	0.946
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.44341	0.12302	-1.7653	0.0304	0.00149
hematology	reticulocyte count (Retic; units per volume x 10⁹)	34.174	12.449	1.3941	0.193	0.0115
hematology	reticulocyte differential (percent of total RBC)	0.51483	0.14028	1.7719	0.0687	0.00127
hematology	white blood cell count (WBC; units per volume x 10³)	2.9884	1.3829	1.9493	0.145	0.0413
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.11667	0.70620	0.16875	0.961	0.870
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.65529	0.38679	1.2065	0.620	0.0978
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.22083	0.39452	-0.29189	0.908	0.579
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.47497	0.54347	-0.40861	0.792	0.387
holeboard	number of hole pokes by individual hole number, 20 min test, 5	1.5371	0.55404	2.0928	0.302	0.00837
holeboard	number of hole pokes by individual hole number, 20 min test, 6	1.0328	0.40632	1.9976	0.384	0.0150
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.34167	0.24510	0.87484	0.739	0.171
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.33186	0.42578	0.69422	0.857	0.440
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.25833	0.39522	0.55213	0.890	0.517
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.12593	0.31148	-0.28280	0.949	0.688
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.055827	0.25859	-0.13213	0.971	0.830
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.026732	0.47582	0.15411	0.986	0.955
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.16390	0.72604	-0.086135	0.953	0.823
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.50169	0.42331	-0.72075	0.682	0.243
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.23293	0.75475	0.42026	0.914	0.759
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.45833	0.95325	-0.37643	0.903	0.633
holeboard	total number of hole pokes, 20 min test	0.084887	3.9180	0.075980	0.986	0.983
light / dark	fecal boli count, 20 min test	0.50147	0.63220	0.61213	0.785	0.432
light / dark	latency to enter dark zone, 20 min test	7.7318	31.638	0.050045	0.954	0.808
light / dark	number of transitions between light and dark zones, 20 min test	-6.3963	7.5028	-0.53404	0.695	0.399
light / dark	percentage of total time in dark zone, 20 min test	-3.5846	2.8016	-0.52782	0.584	0.208
light / dark	percentage of total time in light zone, 20 min test	3.5846	2.8016	0.52471	0.584	0.208
light / dark	time mobile in dark zone, 20 min test	-8.5410	12.073	-0.65008	0.752	0.483
light / dark	time mobile in light zone, 20 min test	2.8327	11.506	-0.059524	0.908	0.807
light / dark	time spent in dark zone, 20 min test	-44.813	41.682	-0.46511	0.691	0.289
light / dark	time spent in light zone, 20 min test	44.813	41.682	0.46511	0.691	0.289
open field	average speed in center of arena, 20 min test	-0.083079	0.38323	-0.25723	0.945	0.829
open field	average speed in periphery of arena, 20 min test	-0.091540	0.16058	-0.86950	0.763	0.572
open field	distance traveled habituation ratio, 20 min test	-0.88363	8.7340	-0.027527	0.963	0.920
open field	distance traveled in center of arena, 20 min test	-99.855	114.12	-1.0138	0.636	0.387
open field	distance traveled in periphery of arena, 20 min test	98.901	206.04	-0.024841	0.804	0.634
open field	distance traveled slope, 20 min test	-3.4051	7.8470	-0.23785	0.867	0.667
open field	distance traveled, 20 min test, 1st 5min	-33.614	83.069	-0.64900	0.850	0.688
open field	distance traveled, 20 min test, 2nd 5min	40.104	59.369	-0.046336	0.723	0.503
open field	distance traveled, 20 min test, 3rd 5min	-16.983	85.317	-0.62924	0.934	0.843
open field	distance traveled, 20 min test, 4th 5min	-35.102	51.346	-0.85200	0.727	0.498
open field	number of clockwise revolution episodes, 20 min test	-1.3208	1.5744	-1.2359	0.744	0.406
open field	number of counter-clockwise revolution episodes, 20 min test	0.42500	1.5051	-0.21856	0.900	0.779
open field	number of fecal boli, 20 min test	2.6500	0.91640	2.0982	0.102	0.00610
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-0.12349	2.1978	-0.24144	0.981	0.955
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	2.1625	3.0129	0.20483	0.718	0.477
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-0.058333	2.6087	-0.31458	0.989	0.982
open field	number of rears in 5 min bins, 20 min test, 4th 5min	1.4208	2.8853	-0.038273	0.814	0.625
open field	percentage of total time in center of arena, 20 min test	-4.3242	3.5828	-1.2685	0.554	0.234
open field	percentage of total time in center of arena, slope, 20 min test	1.5459	1.7470	0.98726	0.808	0.381
open field	percentage of total time in center, habituation ratio, 20 min test	1.9475	1.8753	1.1618	0.777	0.305
open field	percentage of total time in corners of arena, 20 min test	1.7364	4.0067	0.60811	0.858	0.667
open field	percentage of total time in corners, habituation ratio, 20 min test	-5.5650	1.5870	-2.5519	0.0904	0.00111
open field	percentage of total time in corners, slope, 20 min test	-5.5965	1.5493	-2.5884	0.0865	0.000821
open field	permanence time in center of arena, 20 min test	-51.900	42.993	-1.2685	0.554	0.234
open field	permanence time in corners of arena, 20 min test	20.827	48.079	0.60811	0.859	0.667
open field	permanence time in periphery of arena, 20 min test	51.910	43.003	1.2685	0.553	0.234
open field	total distance traveled, 20 min test	-74.693	201.98	-0.72378	0.849	0.713
open field	total number of rears, 20 min test	3.4625	8.7796	-0.10154	0.851	0.695
open field	whole arena average speed, 20 min test	-0.062513	0.16827	-0.72203	0.849	0.712
open field	whole arena resting time, 20 min test	2.2232	20.275	0.62761	0.953	0.913
open field	whole arena time spent mobile, 20 min test	-2.1248	20.273	-0.62924	0.958	0.917
open field	whole arena time spent vertical, 20 min test	-0.74708	7.2952	-0.16930	0.967	0.919
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-2.0452	1.3331	-0.68610	0.433	0.133
startle / PPI	average baseline movement during background noise	-0.78834	2.2254	-0.53844	0.948	0.726
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.16561	0.14569	1.3547	0.631	0.266
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.22506	0.31539	2.0624	0.784	0.482
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.57814	6.7492	0.12997	0.995	0.932
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	13.271	9.9836	1.3038	0.562	0.195
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	5.3137	8.7294	0.47001	0.806	0.548
startle / PPI	average startle response to full pulse (120 dB)	89.330	70.294	1.5470	0.447	0.215
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.61055	54.593	0.19672	0.995	0.991
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	60.180	55.213	1.2593	0.506	0.286
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	68.211	46.151	1.4482	0.349	0.152
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-2.4102	1.4298	-1.6207	0.631	0.104
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.19848	1.6331	-0.12573	0.984	0.904
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	0.54391	2.2422	0.086277	0.952	0.810
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.055215	0.17393	0.56618	0.957	0.753
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.37880	0.29298	2.3675	0.556	0.207
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.18944	0.31518	1.2558	0.770	0.553
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	90.068	70.545	1.5564	0.443	0.213
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	3.1256	55.003	0.26291	0.979	0.955
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	61.833	55.635	1.2749	0.492	0.277
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	71.628	45.252	1.5470	0.307	0.126
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.014793	0.12556	-0.086277	0.990	0.907
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.31217	0.20923	2.0177	0.479	0.148
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.15973	0.23357	0.94308	0.728	0.500
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	300.48	250.30	1.4562	0.479	0.241
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	24.420	206.43	0.29788	0.948	0.907
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-0.38771	147.08	0.18245	0.998	0.998
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	260.11	162.60	1.5066	0.302	0.122
startle / PPI	maximum baseline movement during background noise	-4.1920	3.6173	-1.1466	0.737	0.257
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-3.6843	7.2027	-0.32731	0.938	0.613
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	14.839	10.693	1.3006	0.534	0.177
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	8.1676	9.3228	0.64014	0.669	0.389
startle / PPI	maximum startle response to full pulse (120 dB)	298.98	249.93	1.4522	0.481	0.243
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	18.877	204.96	0.27453	0.958	0.927
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-2.2660	146.35	0.16823	0.992	0.988
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	250.30	164.61	1.4894	0.336	0.141
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-4.8788	4.9953	-1.3071	0.780	0.338
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-0.23174	3.6591	-0.056776	0.996	0.950
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	2.8620	6.1235	0.34213	0.879	0.644

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.00
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	12.0 %	0.146
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	6.0 %	0.141
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	11.0 %	0.223
eye morphology	irispupil	both	5.0 %	0.435
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	9.0 %	0.531
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	3.0 %	0.703
eye morphology	narrow eye opening	females	23.0 %	0.0116
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	11.0 %	0.0177
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	18.0 %	0.373
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	8.0 %	0.504
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	12.0 %	0.0335
eye morphology	pupil dilation	both	6.0 %	0.0469
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	11.0 %	0.230
eye morphology	pupil position	both	5.0 %	0.461
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.0
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	12.0 %	0.0440
SHIRPA	activity body position	males	36.0 %	0.000262
SHIRPA	activity body position	both	24.0 %	0.0000674
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	24.0 %	0.00128
SHIRPA	aggression	both	12.0 %	0.00384
SHIRPA	body length	females	12.0 %	0.0175
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	6.0 %	0.0234
SHIRPA	body position	females	12.0 %	0.0175
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	6.0 %	0.0630
SHIRPA	body thickness	females	24.0 %	0.00126
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	12.0 %	0.00316
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	12.0 %	0.00879
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	6.0 %	0.0118
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	4.0 %	0.524
SHIRPA	limb grasp	males	32.0 %	0.00854
SHIRPA	limb grasp	both	18.0 %	0.0254
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	12.0 %	0.0436
SHIRPA	snout size	both	6.0 %	0.0575
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	12.0 %	0.0876
SHIRPA	transfer arousal	males	36.0 %	0.000276
SHIRPA	transfer arousal	both	24.0 %	0.0000662
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	12.0 %	0.0117
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	6.0 %	0.0291
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	98.0 %	3.38e-9
SHIRPA	vocalization	males	98.0 %	1.67e-7
SHIRPA	vocalization	both	98.0 %	5.40e-16

GENOTYPE CORRELATION PLOT

Correlate Ube2i^em1(IMPC)J/Mmjax -/+ with genotype: