MPD: JaxKOMP-EAP genotype: Slc9a5<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Slc9a5^em1(IMPC)J/Mmjax -/- Gene Slc9a5

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	4.4596	1.8604	1.0121	0.281	0.0264
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-2.9048	3.1817	-0.64150	0.790	0.373
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	0.42932	2.7479	-0.071781	0.961	0.877
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	0.60142	5.4758	-0.033081	0.973	0.914
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-6.5517	5.4310	-0.98094	0.637	0.242
body composition	body length	-0.11840	0.054262	-1.0312	0.197	0.0387
body composition	body weight (at time of DXA)	-3.2802	1.0008	-1.7797	0.0238	0.00297
body composition	bone area, whole body scan, head excluded	-0.73236	0.14016	-2.0506	0.00120	0.0000186
body composition	bone mineral content of whole body scan, head excluded	-0.031861	0.010998	-1.4269	0.0716	0.00772
body composition	bone mineral content to body weight ratio	-0.0012414	0.00051681	-1.2960	0.131	0.0241
body composition	bone mineral density of whole body scan, head excluded	-0.00014547	0.00057316	-0.12394	0.911	0.802
body composition	fat tissue mass of whole body scan, head excluded	1.1544	0.39480	1.5375	0.0682	0.00724
body composition	fat tissue mass to body weight ratio	0.043957	0.013577	1.6990	0.0371	0.00339
body composition	lean tissue mass of whole body scan, head excluded	-0.67079	0.37899	-1.3973	0.341	0.0889
body composition	lean tissue mass to body weight ratio	-0.026361	0.011622	-1.3756	0.165	0.0322
body composition	percent fat, whole body scan, head excluded	4.0402	1.2968	1.6990	0.0467	0.00457
body composition	ratio of soft-tissue attenuation coefficients	-0.0044867	0.0014413	-1.6979	0.0458	0.00460
body composition	tissue area	0.0079278	0.36178	0.23167	0.998	0.983
body composition	total tissue mass, whole body scan, head excluded	0.48361	0.33942	0.79994	0.402	0.167
clinical blood chemistry	alanine transaminase (plasma ALT)	-3.5839	3.8979	-0.34766	0.716	0.372
clinical blood chemistry	albumin (plasma Alb)	0.099490	0.48502	0.20096	0.946	0.840
clinical blood chemistry	alkaline phosphatase (plasma ALP)	11.216	3.9192	1.2780	0.0764	0.0119
clinical blood chemistry	aspartate transaminase (plasma AST)	-23.917	14.906	-1.0640	0.438	0.129
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.37359	0.22635	-1.1120	0.499	0.120
clinical blood chemistry	blood urea nitrogen (BUN)	4.5489	1.6252	1.7119	0.104	0.0142
clinical blood chemistry	calcium (plasma Ca)	-0.037476	0.084151	0.076140	0.813	0.662
clinical blood chemistry	creatinine (plasma)	0.084907	0.032465	1.9418	0.121	0.0204
clinical blood chemistry	glucose (plasma GLU, no fast)	-22.554	15.731	-0.55497	0.364	0.172
clinical blood chemistry	HDL cholesterol (plasma HDL)	-0.45396	3.1829	-0.44581	0.963	0.888
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.020478	0.012966	0.99857	0.456	0.135
clinical blood chemistry	phosphorus (plasma phosphate)	0.65095	0.56018	0.92106	0.551	0.265
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.0057619	0.0088789	-0.44426	0.796	0.526
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-1.7771	3.8769	-0.54887	0.869	0.654
clinical blood chemistry	total protein (plasma TP)	-0.20411	0.77824	-0.22163	0.906	0.797
clinical blood chemistry	triglyceride (plasma TG, no fast)	26.611	12.986	1.4828	0.250	0.0583
glucose tolerance test	amount glucose injected	-0.32925	2.1037	0.28930	0.958	0.877
glucose tolerance test	plasma glucose, 0min	4.8576	3.8844	0.25959	0.424	0.217
glucose tolerance test	plasma glucose, 15min	-4.5813	17.679	-0.010982	0.934	0.797
glucose tolerance test	plasma glucose, 30min	14.961	14.328	0.56388	0.633	0.302
glucose tolerance test	plasma glucose, 60min	12.256	10.213	0.61450	0.570	0.236
glucose tolerance test	plasma glucose, 120min	-0.014358	4.2287	-0.12110	0.998	0.997
grip strength	body weight (at time of grip strength test)	-0.99177	0.50280	-0.68362	0.154	0.0549
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-10.411	7.1861	-0.49267	0.336	0.154
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.31714	0.35921	-0.25095	0.591	0.382
grip strength	forelimb and hindlimb grip strength by trial, trial1	-19.430	9.1707	-1.0437	0.200	0.0398
grip strength	forelimb and hindlimb grip strength by trial, trial2	-3.4694	10.738	0.0058091	0.883	0.748
grip strength	forelimb and hindlimb grip strength by trial, trial3	-3.6582	7.9005	-0.037768	0.829	0.646
grip strength	forelimb grip strength (mean of trials), average	-16.115	4.5242	-1.6136	0.0163	0.000915
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.70194	0.21216	-1.3900	0.0316	0.00190
grip strength	forelimb grip strength by trial, trial1	-14.749	5.9333	-1.3313	0.167	0.0168
grip strength	forelimb grip strength by trial, trial2	-12.962	6.9469	-1.1440	0.314	0.0689
grip strength	forelimb grip strength by trial, trial3	-22.890	5.5679	-1.9922	0.0115	0.000174
heart weight	heart weight, normalized to body weight	0.23440	0.28871	0.36683	0.634	0.426
heart weight	heart weight, weight	11.964	9.5237	1.1422	0.432	0.222
hematology	basophil differential (percent of total WBC)	0.0013183	0.036061	0.042568	0.996	0.971
hematology	calculated hemoglobin (cHGB)	-0.45348	0.18418	-1.3398	0.162	0.0264
hematology	eosinophil differential (percent of total WBC)	0.070433	0.23643	0.27771	0.928	0.770
hematology	hematocrit (HCT)	-0.32599	0.55656	-0.67192	0.767	0.567
hematology	hemoglobin concentration distribution width (HDW)	-0.068404	0.027961	-1.7094	0.206	0.0282
hematology	large unstained cells (percent of total WBC)	0.31792	0.14257	1.7647	0.279	0.0426
hematology	lymphocyte differential (percent of total WBC)	1.6352	0.86492	0.58368	0.284	0.0782
hematology	mean corpuscular hemoglobin (CHr)	-0.025989	0.056026	-0.18845	0.826	0.649
hematology	mean platelet volume (MPV)	0.53839	0.15596	1.7839	0.0277	0.00389
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.057250	0.25932	-0.24544	0.930	0.828
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.84708	0.60475	-1.1849	0.538	0.182
hematology	mean RBC corpuscular volume (MCV)	0.97928	0.38895	1.5369	0.108	0.0237
hematology	measured hemoglobin (mHGB)	-0.49002	0.33284	-1.1667	0.453	0.162
hematology	monocyte differential (percent of total WBC)	0.024359	0.16658	0.29250	0.957	0.886
hematology	neutrophil differential (percent of total WBC)	-2.0745	0.77390	-0.86881	0.123	0.0171
hematology	platelet count (PLT; units per volume x 10³)	-73.591	62.564	-0.90733	0.626	0.258
hematology	RBC corpuscular distribution width (RDW)	-0.20645	0.12575	-0.77105	0.359	0.123
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-1.0413	0.27448	-2.2004	0.0227	0.00177
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.29305	0.14147	-1.3926	0.252	0.0560
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-44.358	17.142	-1.5758	0.247	0.0206
hematology	reticulocyte differential (percent of total RBC)	-0.29325	0.16502	-1.0193	0.440	0.0973
hematology	white blood cell count (WBC; units per volume x 10³)	-0.064200	0.88579	0.14953	0.973	0.943
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-1.6226	0.83327	-1.5331	0.485	0.0563
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-1.2186	0.55800	-1.6942	0.468	0.0330
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-1.2600	0.45873	-1.9614	0.321	0.00797
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-1.8600	0.66661	-1.7779	0.229	0.00708
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-1.3484	0.46974	-2.0228	0.255	0.00568
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.43250	0.32029	-1.2210	0.811	0.182
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.54000	0.23932	-1.5162	0.605	0.0278
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.90291	0.59435	-1.3732	0.695	0.134
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-1.2693	0.37192	-1.9276	0.108	0.00117
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.065000	0.25930	0.24776	0.961	0.803
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.33162	0.29140	-0.87037	0.807	0.260
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-1.4223	0.72088	-2.1084	0.473	0.0533
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-1.8025	0.68777	-1.7088	0.353	0.0111
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-1.5661	0.51273	-2.3761	0.234	0.00338
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.32377	0.54147	-0.42580	0.876	0.552
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-2.1744	0.68407	-1.8866	0.148	0.00236
holeboard	total number of hole pokes, 20 min test	-16.265	4.2828	-2.0931	0.0227	0.000352
light / dark	fecal boli count, 20 min test	0.84072	0.73580	0.94500	0.662	0.259
light / dark	latency to enter dark zone, 20 min test	11.103	35.220	0.11790	0.935	0.754
light / dark	number of transitions between light and dark zones, 20 min test	-14.297	9.8314	-1.3403	0.460	0.153
light / dark	percentage of total time in dark zone, 20 min test	4.8634	2.9776	0.98265	0.452	0.109
light / dark	percentage of total time in light zone, 20 min test	-4.8634	2.9776	-0.98924	0.451	0.109
light / dark	time mobile in dark zone, 20 min test	-21.126	11.184	-1.2645	0.277	0.0650
light / dark	time mobile in light zone, 20 min test	-29.807	10.753	-2.0659	0.0684	0.00790
light / dark	time spent in dark zone, 20 min test	49.147	42.085	0.96097	0.667	0.249
light / dark	time spent in light zone, 20 min test	-49.147	42.085	-0.96097	0.667	0.249
open field	average speed in center of arena, 20 min test	-0.13135	0.33057	-0.34008	0.885	0.693
open field	average speed in periphery of arena, 20 min test	-0.13914	0.11669	-1.0575	0.453	0.238
open field	distance traveled habituation ratio, 20 min test	2.6077	6.7072	0.26835	0.879	0.699
open field	distance traveled in center of arena, 20 min test	-12.167	77.076	-0.45492	0.932	0.875
open field	distance traveled in periphery of arena, 20 min test	-141.69	131.14	-1.0005	0.526	0.284
open field	distance traveled slope, 20 min test	2.8067	6.3990	0.32164	0.865	0.663
open field	distance traveled, 20 min test, 1st 5min	-55.503	63.081	-0.78444	0.629	0.383
open field	distance traveled, 20 min test, 2nd 5min	-60.145	43.116	-1.1940	0.389	0.168
open field	distance traveled, 20 min test, 3rd 5min	-43.078	42.884	-0.93610	0.576	0.319
open field	distance traveled, 20 min test, 4th 5min	-20.896	45.015	-0.70989	0.813	0.644
open field	number of clockwise revolution episodes, 20 min test	-0.92000	1.0124	-0.96957	0.716	0.367
open field	number of counter-clockwise revolution episodes, 20 min test	-0.93750	1.0978	-0.92163	0.670	0.397
open field	number of fecal boli, 20 min test	0.42903	0.80170	0.57626	0.816	0.595
open field	number of rears in 5 min bins, 20 min test, 1st 5min	0.36750	1.5122	-0.11308	0.919	0.809
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-1.6550	2.1283	-0.77716	0.703	0.440
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-3.3830	2.3642	-1.0934	0.419	0.158
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-1.9883	2.6034	-0.75734	0.698	0.448
open field	percentage of total time in center of arena, 20 min test	1.3517	2.6575	0.10019	0.852	0.613
open field	percentage of total time in center of arena, slope, 20 min test	-1.3219	1.2386	-0.61134	0.749	0.290
open field	percentage of total time in center, habituation ratio, 20 min test	-0.90267	1.2616	-0.34292	0.845	0.477
open field	percentage of total time in corners of arena, 20 min test	-4.2794	3.3490	-0.48641	0.519	0.206
open field	percentage of total time in corners, habituation ratio, 20 min test	1.6497	1.6019	0.44897	0.792	0.307
open field	percentage of total time in corners, slope, 20 min test	1.7730	1.5737	0.53692	0.749	0.264
open field	permanence time in center of arena, 20 min test	16.238	31.888	0.10019	0.852	0.613
open field	permanence time in corners of arena, 20 min test	-51.359	40.187	-0.48641	0.519	0.206
open field	permanence time in periphery of arena, 20 min test	-16.277	31.882	-0.10154	0.852	0.612
open field	total distance traveled, 20 min test	-187.60	157.47	-1.0458	0.451	0.238
open field	total number of rears, 20 min test	-5.9668	7.2421	-0.76092	0.660	0.413
open field	whole arena average speed, 20 min test	-0.15608	0.13138	-1.0458	0.453	0.240
open field	whole arena resting time, 20 min test	25.981	16.331	1.2566	0.278	0.117
open field	whole arena time spent mobile, 20 min test	-25.953	16.299	-1.4666	0.282	0.117
open field	whole arena time spent vertical, 20 min test	-8.4395	6.7660	-0.78810	0.525	0.217
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-2.6670	1.1320	-0.92930	0.178	0.0230
startle / PPI	average baseline movement during background noise	-0.84014	1.9206	-0.58770	0.928	0.666
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.099108	0.060011	-1.0042	0.438	0.111
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.072948	0.053466	-0.82850	0.532	0.185
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-7.8364	9.9662	-0.80776	0.879	0.439
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-2.4632	6.5949	-0.31256	0.903	0.712
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-8.9177	4.8473	-0.94346	0.312	0.0777
startle / PPI	average startle response to full pulse (120 dB)	-104.75	36.547	-1.4767	0.0578	0.00831
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-73.881	34.299	-1.0790	0.156	0.0411
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-66.521	29.133	-1.0542	0.128	0.0312
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-40.812	24.292	-0.76388	0.289	0.105
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	6.6594	2.3549	2.4169	0.382	0.00931
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-2.2460	1.6370	-1.4644	0.692	0.182
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-4.5544	3.3568	-2.1124	0.631	0.187
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.056190	0.10145	-0.49996	0.922	0.585
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.016967	0.067966	-0.24727	0.942	0.805
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.10187	0.066501	-0.94967	0.367	0.138
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-103.91	36.828	-1.4685	0.0611	0.00923
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-77.833	33.625	-1.1148	0.123	0.0291
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-64.275	28.576	-1.0230	0.134	0.0336
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-36.988	25.409	-0.65570	0.353	0.158
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.076785	0.11596	-0.66966	0.917	0.514
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.031595	0.075707	-0.33417	0.861	0.680
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.11455	0.066652	-1.0203	0.303	0.0980
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-328.16	121.91	-1.3104	0.0732	0.0125
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-237.81	126.39	-0.97679	0.227	0.0716
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-215.62	103.03	-0.93259	0.168	0.0467
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-114.74	98.039	-0.51270	0.467	0.253
startle / PPI	maximum baseline movement during background noise	-0.31803	4.2703	0.035737	0.985	0.941
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-9.1098	11.400	-0.86746	0.899	0.432
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-3.0042	7.3404	-0.33768	0.872	0.686
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-4.4633	5.7131	-0.53520	0.716	0.442
startle / PPI	maximum startle response to full pulse (120 dB)	-328.48	120.93	-1.3137	0.0701	0.0118
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-227.96	128.02	-0.94346	0.259	0.0871
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-221.57	104.34	-0.94784	0.160	0.0438
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-126.04	95.163	-0.60107	0.408	0.197
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	16.461	5.0037	2.4438	0.291	0.00309
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-5.9546	3.8356	-1.5517	0.629	0.133
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-12.069	8.0887	-2.3454	0.516	0.148

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	24.0 %	0.00349
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	12.0 %	0.0158
eye morphology	bulging eye	females	24.0 %	0.00318
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	12.0 %	0.00932
eye morphology	cornea	females	24.0 %	0.00941
eye morphology	cornea	males	24.0 %	0.00386
eye morphology	cornea	both	22.0 %	0.000369
eye morphology	cornea opacity	females	32.0 %	0.00318
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	15.0 %	0.0107
eye morphology	cornea vascularization	females	24.0 %	0.00684
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	12.0 %	0.0250
eye morphology	corneal deposits	females	24.0 %	0.00968
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	12.0 %	0.0223
eye morphology	corneal mineralization	females	24.0 %	0.00946
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	12.0 %	0.0257
eye morphology	corneal scleralization	females	24.0 %	0.00983
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	12.0 %	0.0260
eye morphology	corneal ulcer	females	24.0 %	0.00574
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	12.0 %	0.0172
eye morphology	eye closure	females	24.0 %	0.00316
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	12.0 %	0.00663
eye morphology	eye hemorrhage or blood presence	females	24.0 %	0.00644
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	12.0 %	0.0157
eye morphology	eyelid morphology	females	24.0 %	0.00382
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	12.0 %	0.00759
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	73.0 %	3.01e-8
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	36.0 %	0.00000396
eye morphology	iris pigmentation	females	24.0 %	0.00748
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	12.0 %	0.0204
eye morphology	iris transillumination	females	24.0 %	0.00462
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	12.0 %	0.0123
eye morphology	irispupil	females	24.0 %	0.00913
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	12.0 %	0.0313
eye morphology	lacrimation	females	74.0 %	5.80e-9
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	37.0 %	6.01e-7
eye morphology	lens	females	74.0 %	5.69e-8
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	36.0 %	0.00000632
eye morphology	lens opacity	females	73.0 %	2.56e-7
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	36.0 %	0.0000297
eye morphology	narrow eye opening	females	24.0 %	0.00710
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	12.0 %	0.0229
eye morphology	optic disc	females	73.0 %	1.04e-7
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	36.0 %	0.0000129
eye morphology	persistence of hyaloid vascular system	females	73.0 %	7.89e-7
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	36.0 %	0.0000663
eye morphology	pupil dilation	females	24.0 %	0.00802
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	12.0 %	0.0225
eye morphology	pupil light response	females	24.0 %	0.00871
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	12.0 %	0.0244
eye morphology	pupil position	females	24.0 %	0.0103
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	12.0 %	0.0377
eye morphology	pupil shape	females	24.0 %	0.00837
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	12.0 %	0.0265
eye morphology	retina	females	73.0 %	4.62e-7
eye morphology	retina	males	7.0 %	0.750
eye morphology	retina	both	36.0 %	0.0000278
eye morphology	retinal blood vessels	females	73.0 %	3.46e-8
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	36.0 %	0.00000597
eye morphology	retinal blood vessels pattern	females	73.0 %	1.46e-7
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	36.0 %	0.0000166
eye morphology	retinal blood vessels structure	females	73.0 %	9.16e-8
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	36.0 %	0.0000105
eye morphology	retinal pigmentation	females	73.0 %	4.97e-7
eye morphology	retinal pigmentation	males	7.0 %	0.687
eye morphology	retinal pigmentation	both	36.0 %	0.0000305
eye morphology	retinal structure	females	73.0 %	9.00e-8
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	36.0 %	0.0000116
eye morphology	synechia	females	73.0 %	1.93e-8
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	36.0 %	0.00000320
eye morphology	vitreous	females	73.0 %	3.46e-8
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	36.0 %	0.00000438
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	4.0 %	0.524
SHIRPA	limb grasp	males	7.0 %	0.375
SHIRPA	limb grasp	both	5.0 %	0.327
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	12.0 %	0.0876
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	6.0 %	0.109
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Slc9a5^em1(IMPC)J/Mmjax -/- with genotype: