MPD: JaxKOMP-EAP genotype: Ttll7<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Ttll7^em1(IMPC)J/Mmjax -/- Gene Ttll7

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	2.0246	2.9303	0.37757	0.827	0.500
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-2.4598	2.8623	-0.52391	0.813	0.404
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-3.7467	2.1902	-0.94093	0.458	0.109
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-1.4058	6.4426	-0.33478	0.935	0.830
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-21.708	6.0497	-2.2303	0.0747	0.00297
body composition	body length	-0.055319	0.048647	-0.44787	0.606	0.307
body composition	body weight (at time of DXA)	-0.12845	1.8735	-0.0061404	0.979	0.948
body composition	bone area, whole body scan, head excluded	-0.29306	0.16239	-0.93946	0.383	0.131
body composition	bone mineral content of whole body scan, head excluded	-0.032247	0.015596	-1.4461	0.311	0.0935
body composition	bone mineral content to body weight ratio	-0.00086960	0.00045626	-0.90191	0.338	0.115
body composition	bone mineral density of whole body scan, head excluded	-0.0016966	0.0012373	-1.5507	0.525	0.229
body composition	fat tissue mass of whole body scan, head excluded	0.32854	0.30901	0.52879	0.594	0.336
body composition	fat tissue mass to body weight ratio	0.0050302	0.010471	0.29788	0.821	0.651
body composition	lean tissue mass of whole body scan, head excluded	-0.42876	0.46990	-1.0257	0.698	0.403
body composition	lean tissue mass to body weight ratio	-0.0089999	0.012314	-0.55044	0.728	0.498
body composition	percent fat, whole body scan, head excluded	0.59032	1.0264	0.34968	0.778	0.590
body composition	ratio of soft-tissue attenuation coefficients	-0.00080470	0.0011417	-0.42873	0.731	0.512
body composition	tissue area	-0.10858	0.21155	-0.19531	0.856	0.630
body composition	total tissue mass, whole body scan, head excluded	-0.070641	0.32675	-0.38620	0.923	0.837
clinical blood chemistry	alanine transaminase (plasma ALT)	9.9342	3.2696	0.74233	0.147	0.00707
clinical blood chemistry	albumin (plasma Alb)	0.72549	0.36111	1.0604	0.307	0.0598
clinical blood chemistry	alkaline phosphatase (plasma ALP)	5.2217	2.5798	0.44581	0.215	0.0590
clinical blood chemistry	aspartate transaminase (plasma AST)	43.045	6.2325	1.3954	0.000374	0.00000254
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.45958	0.16671	1.2334	0.196	0.0130
clinical blood chemistry	blood urea nitrogen (BUN)	5.9624	2.5478	2.1442	0.163	0.0317
clinical blood chemistry	calcium (plasma Ca)	0.18741	0.072308	1.5396	0.102	0.0184
clinical blood chemistry	creatinine (plasma)	0.12029	0.038608	2.2500	0.0563	0.00629
clinical blood chemistry	glucose (plasma GLU, no fast)	-11.245	10.849	-0.14837	0.521	0.314
clinical blood chemistry	HDL cholesterol (plasma HDL)	0.55297	2.6106	-0.19608	0.943	0.835
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.0024461	0.010335	0.00071171	0.952	0.816
clinical blood chemistry	phosphorus (plasma phosphate)	-0.71773	0.39118	-1.1500	0.293	0.0841
clinical blood chemistry	total bilirubin (plasma TBIL)	0.0033824	0.0085109	0.24076	0.884	0.696
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	1.1349	3.6910	-0.033418	0.906	0.762
clinical blood chemistry	total protein (plasma TP)	1.2746	0.61325	0.94636	0.256	0.0531
clinical blood chemistry	triglyceride (plasma TG, no fast)	10.843	10.970	0.80034	0.621	0.336
glucose tolerance test	amount glucose injected	-4.2141	2.4190	-0.83498	0.416	0.0929
glucose tolerance test	plasma glucose, 0min	10.132	3.7567	0.80160	0.0646	0.0119
glucose tolerance test	plasma glucose, 15min	-27.215	23.842	-0.63620	0.599	0.264
glucose tolerance test	plasma glucose, 30min	-20.309	19.311	-0.50840	0.633	0.302
glucose tolerance test	plasma glucose, 60min	-26.711	12.733	-1.0061	0.252	0.0451
glucose tolerance test	plasma glucose, 120min	4.1009	5.4335	0.15158	0.719	0.457
grip strength	body weight (at time of grip strength test)	-1.1221	0.40068	-0.79618	0.0383	0.00782
grip strength	forelimb and hindlimb grip strength (mean of trials), average	15.956	8.6764	1.3824	0.212	0.0733
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.81678	0.46094	1.3601	0.237	0.0842
grip strength	forelimb and hindlimb grip strength by trial, trial1	16.936	12.066	1.3564	0.438	0.168
grip strength	forelimb and hindlimb grip strength by trial, trial2	25.142	11.638	1.7646	0.171	0.0370
grip strength	forelimb and hindlimb grip strength by trial, trial3	4.4576	11.046	0.51741	0.863	0.689
grip strength	forelimb grip strength (mean of trials), average	7.6068	4.3032	1.2448	0.283	0.0847
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.59022	0.24778	1.6465	0.126	0.0222
grip strength	forelimb grip strength by trial, trial1	-2.0010	5.2343	0.036315	0.879	0.704
grip strength	forelimb grip strength by trial, trial2	10.079	7.0219	1.2935	0.474	0.159
grip strength	forelimb grip strength by trial, trial3	15.006	6.3676	1.7247	0.179	0.0234
hematology	basophil differential (percent of total WBC)	-0.0019262	0.062451	-0.012355	0.997	0.976
hematology	calculated hemoglobin (cHGB)	-0.033900	0.21797	-0.38476	0.951	0.878
hematology	eosinophil differential (percent of total WBC)	-0.24709	0.45253	-0.60937	0.869	0.592
hematology	hematocrit (HCT)	0.74805	1.1506	0.47975	0.737	0.524
hematology	hemoglobin concentration distribution width (HDW)	0.0071539	0.046957	0.19594	0.948	0.881
hematology	large unstained cells (percent of total WBC)	-0.026591	0.075717	-0.16314	0.890	0.730
hematology	lymphocyte differential (percent of total WBC)	0.69265	1.1685	0.25137	0.757	0.561
hematology	mean corpuscular hemoglobin (CHr)	-0.081008	0.11598	-0.65938	0.719	0.494
hematology	mean platelet volume (MPV)	0.46213	0.16454	1.6629	0.0612	0.0116
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.28375	0.24980	-0.87895	0.623	0.272
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-1.3225	0.48566	-1.4139	0.157	0.0139
hematology	mean RBC corpuscular volume (MCV)	0.65569	0.44064	1.1045	0.348	0.155
hematology	measured hemoglobin (mHGB)	-0.23649	0.48152	-0.78750	0.820	0.629
hematology	monocyte differential (percent of total WBC)	-0.14280	0.26286	-0.27827	0.840	0.594
hematology	neutrophil differential (percent of total WBC)	-0.74842	0.97849	-0.34282	0.666	0.454
hematology	platelet count (PLT; units per volume x 10³)	-27.375	77.426	-0.32404	0.897	0.728
hematology	RBC corpuscular distribution width (RDW)	0.033349	0.23930	0.11745	0.952	0.891
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.66844	0.41457	-1.5932	0.336	0.124
hematology	red blood cell count (RBC; per volume x 10⁶)	0.018882	0.22566	-0.28712	0.968	0.934
hematology	reticulocyte count (Retic; units per volume x 10⁹)	79.538	24.817	2.2554	0.123	0.00491
hematology	reticulocyte differential (percent of total RBC)	0.68642	0.24065	1.9795	0.190	0.0106
hematology	white blood cell count (WBC; units per volume x 10³)	-2.6773	0.96016	-1.4897	0.0647	0.0126
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-1.3361	0.69782	-1.2682	0.485	0.0614
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.080942	0.45827	0.27432	0.980	0.861
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-1.2290	0.36393	-1.8964	0.178	0.00144
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-1.3041	0.76794	-1.2171	0.554	0.0958
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-1.0931	0.47660	-1.6400	0.402	0.0261
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.12966	0.29167	0.39460	0.943	0.659
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.25420	0.32736	0.67821	0.902	0.441
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.68284	0.42352	-1.0185	0.647	0.113
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.24207	0.35996	-0.36430	0.880	0.504
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.18022	0.30651	-0.43816	0.924	0.559
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.19776	0.39292	-0.52285	0.918	0.617
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-1.3257	0.44392	-1.9734	0.157	0.00444
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.99720	0.59821	-0.88871	0.498	0.102
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-1.6387	0.57642	-2.4714	0.261	0.00655
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.53892	0.44148	-0.76070	0.675	0.228
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-2.1388	0.74721	-1.8669	0.226	0.00617
holeboard	total number of hole pokes, 20 min test	-12.371	3.9046	-1.6026	0.0552	0.00264
light / dark	fecal boli count, 20 min test	-0.090384	0.53885	-0.060878	0.943	0.867
light / dark	latency to enter dark zone, 20 min test	15.897	33.207	0.20836	0.884	0.634
light / dark	number of transitions between light and dark zones, 20 min test	8.9824	8.4116	0.93763	0.611	0.291
light / dark	percentage of total time in dark zone, 20 min test	-0.52224	2.9510	0.036512	0.960	0.860
light / dark	percentage of total time in light zone, 20 min test	0.52224	2.9510	-0.041925	0.960	0.860
light / dark	time mobile in dark zone, 20 min test	-5.6361	11.141	-0.48022	0.833	0.615
light / dark	time mobile in light zone, 20 min test	14.351	9.3508	0.60237	0.359	0.131
light / dark	time spent in dark zone, 20 min test	-21.654	36.968	-0.12198	0.855	0.561
light / dark	time spent in light zone, 20 min test	21.654	36.968	0.12198	0.855	0.561
open field	average speed in center of arena, 20 min test	0.22015	0.31291	0.30472	0.785	0.485
open field	average speed in periphery of arena, 20 min test	0.23095	0.15184	0.36867	0.321	0.135
open field	distance traveled habituation ratio, 20 min test	-7.5818	7.4277	-0.64900	0.634	0.312
open field	distance traveled in center of arena, 20 min test	106.03	73.653	0.35005	0.393	0.156
open field	distance traveled in periphery of arena, 20 min test	197.40	164.41	0.35005	0.472	0.236
open field	distance traveled slope, 20 min test	-8.4359	7.3575	-0.74842	0.587	0.257
open field	distance traveled, 20 min test, 1st 5min	130.20	76.727	0.67070	0.284	0.0961
open field	distance traveled, 20 min test, 2nd 5min	88.607	48.308	0.49854	0.241	0.0728
open field	distance traveled, 20 min test, 3rd 5min	20.987	53.532	-0.18840	0.857	0.697
open field	distance traveled, 20 min test, 4th 5min	62.970	37.927	0.23647	0.290	0.103
open field	number of clockwise revolution episodes, 20 min test	1.5632	1.1705	0.50111	0.541	0.188
open field	number of counter-clockwise revolution episodes, 20 min test	2.0267	1.3594	0.63580	0.407	0.142
open field	number of fecal boli, 20 min test	0.59561	0.81916	0.68868	0.747	0.473
open field	number of rears in 5 min bins, 20 min test, 1st 5min	4.0619	2.7527	0.89289	0.391	0.147
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	6.5029	2.5795	1.2685	0.111	0.0151
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	8.5741	2.4588	1.5241	0.0232	0.00106
open field	number of rears in 5 min bins, 20 min test, 4th 5min	11.472	2.6241	1.9391	0.00409	0.0000658
open field	percentage of total time in center of arena, 20 min test	1.6794	2.4101	0.19524	0.766	0.489
open field	percentage of total time in center of arena, slope, 20 min test	-1.6957	1.1289	-0.79545	0.588	0.139
open field	percentage of total time in center, habituation ratio, 20 min test	-1.8338	1.1423	-0.84239	0.563	0.115
open field	percentage of total time in corners of arena, 20 min test	-1.1724	3.6497	0.084011	0.898	0.749
open field	percentage of total time in corners, habituation ratio, 20 min test	-0.034912	1.4785	-0.31599	0.996	0.981
open field	percentage of total time in corners, slope, 20 min test	-0.0042770	1.3652	-0.27253	1.00	0.998
open field	permanence time in center of arena, 20 min test	20.150	28.920	0.19524	0.765	0.489
open field	permanence time in corners of arena, 20 min test	-14.076	43.796	0.084011	0.898	0.749
open field	permanence time in periphery of arena, 20 min test	-20.117	28.926	-0.19387	0.766	0.490
open field	total distance traveled, 20 min test	339.58	187.63	0.47436	0.218	0.0766
open field	total number of rears, 20 min test	30.569	8.6110	1.5919	0.0157	0.000874
open field	whole arena average speed, 20 min test	0.28338	0.15632	0.47737	0.218	0.0761
open field	whole arena resting time, 20 min test	-34.474	18.561	-0.39321	0.205	0.0694
open field	whole arena time spent mobile, 20 min test	34.591	18.543	0.65565	0.203	0.0682
open field	whole arena time spent vertical, 20 min test	21.253	8.7277	1.4472	0.157	0.0186
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-0.62076	1.3717	-0.077442	0.856	0.653
startle / PPI	average baseline movement during background noise	2.3929	1.7215	1.3617	0.720	0.175
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.020981	0.063470	-0.28473	0.895	0.743
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.0069418	0.062276	-0.023147	0.961	0.912
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	3.9986	9.6155	0.48257	0.952	0.681
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-2.0466	6.6461	-0.24988	0.920	0.760
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-4.8388	6.1501	-0.58105	0.718	0.438
startle / PPI	average startle response to full pulse (120 dB)	9.4957	41.804	0.43894	0.933	0.822
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	1.7927	37.821	0.22681	0.982	0.963
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	24.972	35.925	0.71778	0.689	0.493
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	29.202	35.373	0.89014	0.620	0.416
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	1.0568	1.8676	0.73787	0.913	0.576
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.78706	1.9102	0.51910	0.948	0.683
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-1.0983	2.6105	-0.74525	0.913	0.677
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.072212	0.096593	0.73603	0.900	0.461
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.025920	0.071752	-0.32473	0.901	0.721
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.068399	0.073876	-0.70832	0.624	0.362
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	7.1028	42.149	0.36001	0.947	0.867
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	2.1911	37.864	0.22537	0.979	0.954
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	19.570	33.755	0.59270	0.743	0.567
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	30.161	35.718	0.91328	0.612	0.406
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.047699	0.10295	0.45287	0.938	0.647
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.049552	0.073435	-0.45547	0.776	0.505
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.098626	0.080482	-0.90442	0.491	0.231
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	31.431	136.01	0.38253	0.926	0.819
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	24.509	134.55	0.30082	0.928	0.857
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	100.23	126.19	0.73236	0.638	0.434
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	119.32	129.27	0.94565	0.575	0.364
startle / PPI	maximum baseline movement during background noise	7.4381	4.5264	1.6259	0.593	0.111
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	6.1648	9.7887	0.66266	0.923	0.534
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-4.0927	7.0400	-0.43278	0.820	0.566
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-8.1117	6.7876	-0.82931	0.535	0.242
startle / PPI	maximum startle response to full pulse (120 dB)	38.869	134.87	0.42050	0.907	0.775
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	23.985	134.60	0.30522	0.935	0.860
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	99.479	127.29	0.72142	0.645	0.441
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	117.05	128.71	0.92611	0.581	0.371
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	2.8870	4.2996	0.85730	0.856	0.507
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	1.2252	4.2488	0.38706	0.961	0.775
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-2.6473	6.1071	-0.72142	0.880	0.668

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	12.0 %	0.106
eye morphology	anterior chamber depth	males	28.0 %	0.000646
eye morphology	anterior chamber depth	both	19.0 %	0.000562
eye morphology	bulging eye	females	12.0 %	0.0825
eye morphology	bulging eye	males	28.0 %	0.000531
eye morphology	bulging eye	both	19.0 %	0.000295
eye morphology	cornea	females	21.0 %	0.0268
eye morphology	cornea	males	28.0 %	0.00158
eye morphology	cornea	both	24.0 %	0.000215
eye morphology	cornea opacity	females	20.0 %	0.0455
eye morphology	cornea opacity	males	28.0 %	0.00147
eye morphology	cornea opacity	both	23.0 %	0.000592
eye morphology	cornea vascularization	females	22.0 %	0.0170
eye morphology	cornea vascularization	males	28.0 %	0.00121
eye morphology	cornea vascularization	both	25.0 %	0.000127
eye morphology	corneal deposits	females	12.0 %	0.143
eye morphology	corneal deposits	males	28.0 %	0.00157
eye morphology	corneal deposits	both	19.0 %	0.00102
eye morphology	corneal mineralization	females	12.0 %	0.152
eye morphology	corneal mineralization	males	28.0 %	0.00124
eye morphology	corneal mineralization	both	19.0 %	0.00119
eye morphology	corneal scleralization	females	22.0 %	0.0281
eye morphology	corneal scleralization	males	28.0 %	0.00187
eye morphology	corneal scleralization	both	25.0 %	0.000227
eye morphology	corneal ulcer	females	12.0 %	0.111
eye morphology	corneal ulcer	males	28.0 %	0.000888
eye morphology	corneal ulcer	both	19.0 %	0.000995
eye morphology	eye closure	females	12.0 %	0.0823
eye morphology	eye closure	males	28.0 %	0.000527
eye morphology	eye closure	both	19.0 %	0.000267
eye morphology	eye hemorrhage or blood presence	females	12.0 %	0.117
eye morphology	eye hemorrhage or blood presence	males	28.0 %	0.000984
eye morphology	eye hemorrhage or blood presence	both	19.0 %	0.000782
eye morphology	eyelid morphology	females	12.0 %	0.0905
eye morphology	eyelid morphology	males	28.0 %	0.000527
eye morphology	eyelid morphology	both	19.0 %	0.000428
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	11.0 %	0.264
eye morphology	fusion between cornea and lens	males	27.0 %	0.0117
eye morphology	fusion between cornea and lens	both	18.0 %	0.0112
eye morphology	iris pigmentation	females	12.0 %	0.103
eye morphology	iris pigmentation	males	28.0 %	0.00145
eye morphology	iris pigmentation	both	19.0 %	0.00132
eye morphology	iris transillumination	females	12.0 %	0.0842
eye morphology	iris transillumination	males	28.0 %	0.00109
eye morphology	iris transillumination	both	19.0 %	0.000443
eye morphology	irispupil	females	21.0 %	0.0189
eye morphology	irispupil	males	28.0 %	0.00245
eye morphology	irispupil	both	23.0 %	0.000325
eye morphology	lacrimation	females	22.0 %	0.00580
eye morphology	lacrimation	males	28.0 %	0.00710
eye morphology	lacrimation	both	24.0 %	0.000246
eye morphology	lens	females	11.0 %	0.322
eye morphology	lens	males	28.0 %	0.0162
eye morphology	lens	both	19.0 %	0.0170
eye morphology	lens opacity	females	11.0 %	0.397
eye morphology	lens opacity	males	27.0 %	0.0237
eye morphology	lens opacity	both	18.0 %	0.0348
eye morphology	narrow eye opening	females	12.0 %	0.121
eye morphology	narrow eye opening	males	28.0 %	0.000882
eye morphology	narrow eye opening	both	19.0 %	0.000893
eye morphology	optic disc	females	11.0 %	0.295
eye morphology	optic disc	males	27.0 %	0.0152
eye morphology	optic disc	both	18.0 %	0.0165
eye morphology	persistence of hyaloid vascular system	females	11.0 %	0.429
eye morphology	persistence of hyaloid vascular system	males	27.0 %	0.0240
eye morphology	persistence of hyaloid vascular system	both	18.0 %	0.0435
eye morphology	pupil dilation	females	12.0 %	0.106
eye morphology	pupil dilation	males	28.0 %	0.00231
eye morphology	pupil dilation	both	19.0 %	0.00125
eye morphology	pupil light response	females	12.0 %	0.109
eye morphology	pupil light response	males	28.0 %	0.00185
eye morphology	pupil light response	both	19.0 %	0.00124
eye morphology	pupil position	females	33.0 %	0.00595
eye morphology	pupil position	males	28.0 %	0.00256
eye morphology	pupil position	both	30.0 %	0.000108
eye morphology	pupil shape	females	22.0 %	0.0280
eye morphology	pupil shape	males	28.0 %	0.00235
eye morphology	pupil shape	both	24.0 %	0.000287
eye morphology	retina	females	11.0 %	0.365
eye morphology	retina	males	27.0 %	0.0356
eye morphology	retina	both	18.0 %	0.0430
eye morphology	retinal blood vessels	females	11.0 %	0.273
eye morphology	retinal blood vessels	males	27.0 %	0.0125
eye morphology	retinal blood vessels	both	18.0 %	0.0102
eye morphology	retinal blood vessels pattern	females	11.0 %	0.327
eye morphology	retinal blood vessels pattern	males	27.0 %	0.0136
eye morphology	retinal blood vessels pattern	both	18.0 %	0.0207
eye morphology	retinal blood vessels structure	females	11.0 %	0.282
eye morphology	retinal blood vessels structure	males	27.0 %	0.00906
eye morphology	retinal blood vessels structure	both	18.0 %	0.0143
eye morphology	retinal pigmentation	females	11.0 %	0.380
eye morphology	retinal pigmentation	males	27.0 %	0.0325
eye morphology	retinal pigmentation	both	18.0 %	0.0457
eye morphology	retinal structure	females	11.0 %	0.284
eye morphology	retinal structure	males	27.0 %	0.0120
eye morphology	retinal structure	both	18.0 %	0.0150
eye morphology	synechia	females	11.0 %	0.268
eye morphology	synechia	males	27.0 %	0.0120
eye morphology	synechia	both	18.0 %	0.00893
eye morphology	vitreous	females	11.0 %	0.271
eye morphology	vitreous	males	27.0 %	0.00732
eye morphology	vitreous	both	18.0 %	0.0118
SHIRPA	activity body position	females	12.0 %	0.0193
SHIRPA	activity body position	males	36.0 %	0.00000143
SHIRPA	activity body position	both	24.0 %	3.93e-7
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	4.0 %	0.524
SHIRPA	limb grasp	males	32.0 %	0.00854
SHIRPA	limb grasp	both	18.0 %	0.0254
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	12.0 %	0.0653
SHIRPA	transfer arousal	both	6.0 %	0.109
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Ttll7^em1(IMPC)J/Mmjax -/- with genotype: