MPD: JaxKOMP-EAP genotype: Dtx3<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Dtx3^em1(IMPC)J/Mmjax -/- Gene Dtx3

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-3.5240	5.7320	-1.1889	0.854	0.547
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-5.6175	5.6237	-1.1236	0.752	0.332
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-6.1229	6.3624	-1.3687	0.711	0.349
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-7.4058	7.2145	-1.2263	0.689	0.320
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-10.254	6.3255	-1.3614	0.497	0.123
body composition	body length	-0.11941	0.056798	-1.0500	0.219	0.0458
body composition	body weight (at time of DXA)	-2.2832	0.98462	-1.3554	0.116	0.0285
body composition	bone area, whole body scan, head excluded	-0.056988	0.21177	-0.058740	0.909	0.790
body composition	bone mineral content of whole body scan, head excluded	-0.000056547	0.014595	0.13420	0.998	0.997
body composition	bone mineral content to body weight ratio	-0.000048481	0.00058795	0.080638	0.977	0.935
body composition	bone mineral density of whole body scan, head excluded	3.4521e-7	0.00063954	0.028007	1.00	1.00
body composition	fat tissue mass of whole body scan, head excluded	-1.2201	0.54722	-1.9780	0.171	0.0350
body composition	fat tissue mass to body weight ratio	-0.044672	0.019113	-2.0182	0.128	0.0277
body composition	lean tissue mass of whole body scan, head excluded	0.58939	0.44221	0.98501	0.501	0.195
body composition	lean tissue mass to body weight ratio	0.027238	0.016497	1.3181	0.326	0.111
body composition	percent fat, whole body scan, head excluded	-4.0634	1.8126	-1.9498	0.150	0.0341
body composition	ratio of soft-tissue attenuation coefficients	0.0043840	0.0019971	1.8968	0.158	0.0377
body composition	tissue area	-0.90308	0.22837	-2.1775	0.0170	0.000557
body composition	total tissue mass, whole body scan, head excluded	-0.54601	0.26426	-1.5601	0.191	0.0493
clinical blood chemistry	alanine transaminase (plasma ALT)	1.7927	5.7931	0.18166	0.927	0.762
clinical blood chemistry	albumin (plasma Alb)	1.0093	0.73797	1.4976	0.513	0.192
clinical blood chemistry	alkaline phosphatase (plasma ALP)	6.7103	6.6626	0.66430	0.579	0.330
clinical blood chemistry	aspartate transaminase (plasma AST)	2.2778	6.3414	0.12509	0.910	0.724
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.21214	0.16760	0.67717	0.625	0.226
clinical blood chemistry	blood urea nitrogen (BUN)	-6.0254	2.3725	-1.9671	0.134	0.0227
clinical blood chemistry	calcium (plasma Ca)	-0.14910	0.11663	-0.74163	0.449	0.222
clinical blood chemistry	creatinine (plasma)	-0.34685	0.042936	-2.9421	0.000250	0.00000122
clinical blood chemistry	glucose (plasma GLU, no fast)	25.428	18.509	1.2832	0.383	0.191
clinical blood chemistry	HDL cholesterol (plasma HDL)	-3.2167	3.2426	-1.0086	0.635	0.337
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.013515	0.0076781	0.60676	0.397	0.100
clinical blood chemistry	phosphorus (plasma phosphate)	-0.64135	0.62164	-1.0759	0.607	0.319
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.021632	0.0075094	-1.4334	0.125	0.0114
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-0.36957	4.7607	-0.30390	0.979	0.939
clinical blood chemistry	total protein (plasma TP)	0.092784	1.5617	0.0099924	0.981	0.953
clinical blood chemistry	triglyceride (plasma TG, no fast)	-11.213	12.922	-0.40419	0.675	0.400
glucose tolerance test	amount glucose injected	-0.54018	4.0315	0.19861	0.967	0.895
glucose tolerance test	plasma glucose, 0min	11.162	4.6408	0.89403	0.102	0.0246
glucose tolerance test	plasma glucose, 15min	-22.804	21.619	-0.51780	0.634	0.302
glucose tolerance test	plasma glucose, 30min	-52.199	16.898	-1.3980	0.0774	0.00502
glucose tolerance test	plasma glucose, 60min	-6.7770	18.463	-0.17523	0.900	0.717
glucose tolerance test	plasma glucose, 120min	-5.0676	9.5353	-0.49750	0.824	0.600
grip strength	body weight (at time of grip strength test)	-2.1067	0.37633	-1.5248	0.0000507	0.00000109
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-26.469	7.5843	-1.5624	0.0122	0.00106
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.5687	0.45621	-1.8789	0.0145	0.00125
grip strength	forelimb and hindlimb grip strength by trial, trial1	-32.258	8.2438	-1.7856	0.0103	0.000293
grip strength	forelimb and hindlimb grip strength by trial, trial2	-27.983	9.3003	-1.5430	0.0480	0.00421
grip strength	forelimb and hindlimb grip strength by trial, trial3	-19.867	9.7121	-1.0337	0.211	0.0464
grip strength	forelimb grip strength (mean of trials), average	-9.2181	4.9200	-0.85243	0.251	0.0672
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.39068	0.29736	-0.75803	0.459	0.195
grip strength	forelimb grip strength by trial, trial1	-17.152	6.0141	-1.5773	0.0949	0.00644
grip strength	forelimb grip strength by trial, trial2	-3.1039	7.0043	-0.11352	0.875	0.660
grip strength	forelimb grip strength by trial, trial3	-8.7280	6.5254	-0.69561	0.497	0.187
heart weight	heart weight, normalized to body weight	-0.63002	0.24404	-2.4855	0.103	0.0217
heart weight	heart weight, weight	-15.913	4.6361	-2.3589	0.0344	0.00370
hematology	basophil differential (percent of total WBC)	-0.058333	0.038540	-0.83227	0.594	0.151
hematology	calculated hemoglobin (cHGB)	0.34171	0.35998	0.81081	0.632	0.358
hematology	eosinophil differential (percent of total WBC)	0.21961	0.60269	0.69916	0.910	0.721
hematology	hematocrit (HCT)	1.3456	1.0221	1.1301	0.501	0.209
hematology	hemoglobin concentration distribution width (HDW)	0.020001	0.053939	0.54566	0.874	0.716
hematology	large unstained cells (percent of total WBC)	-0.32130	0.14091	-1.7405	0.265	0.0376
hematology	lymphocyte differential (percent of total WBC)	-2.1016	1.5737	-0.93660	0.456	0.203
hematology	mean corpuscular hemoglobin (CHr)	-0.15199	0.23356	-1.1849	0.744	0.525
hematology	mean platelet volume (MPV)	-0.019899	0.12231	-0.33764	0.943	0.873
hematology	mean RBC corpuscular hemoglobin (MCH)	0.0061650	0.19571	-0.0060968	0.986	0.975
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.74557	0.24451	1.3297	0.116	0.00812
hematology	mean RBC corpuscular volume (MCV)	-1.7015	0.69770	-2.0615	0.117	0.0276
hematology	measured hemoglobin (mHGB)	0.36540	0.29008	0.75074	0.545	0.227
hematology	monocyte differential (percent of total WBC)	-0.19013	0.16109	-0.42524	0.611	0.256
hematology	neutrophil differential (percent of total WBC)	2.1335	1.4063	1.0532	0.387	0.152
hematology	platelet count (PLT; units per volume x 10³)	191.34	97.733	2.0849	0.378	0.0705
hematology	RBC corpuscular distribution width (RDW)	0.25714	0.094907	0.89517	0.122	0.0162
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.46533	0.46721	1.1436	0.598	0.335
hematology	red blood cell count (RBC; per volume x 10⁶)	0.30729	0.27257	1.0106	0.554	0.277
hematology	reticulocyte count (Retic; units per volume x 10⁹)	18.114	12.814	0.82413	0.569	0.178
hematology	reticulocyte differential (percent of total RBC)	0.23739	0.12471	1.1399	0.398	0.0777
hematology	white blood cell count (WBC; units per volume x 10³)	-2.7133	1.3492	-1.5237	0.189	0.0626
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-1.0442	0.77916	-0.99335	0.682	0.185
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-1.0882	0.51261	-1.5784	0.472	0.0375
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.46519	0.48136	-0.70284	0.801	0.337
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.44033	0.87904	-0.36314	0.891	0.618
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-1.2339	0.43073	-1.8571	0.255	0.00557
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.44409	0.36313	-1.2611	0.834	0.226
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.40641	0.24259	-1.1418	0.731	0.0985
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-1.5449	0.58809	-2.5086	0.345	0.0107
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.014643	0.39282	0.13725	0.994	0.970
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.32226	0.21644	-0.85471	0.728	0.141
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.17076	0.22867	-0.43382	0.870	0.458
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-1.7339	0.71236	-2.4714	0.288	0.0176
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.28114	0.72307	-0.19522	0.920	0.699
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-1.8941	0.54767	-2.6489	0.173	0.000956
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.41554	0.44360	-0.56906	0.787	0.352
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.65236	0.76796	-0.52015	0.753	0.399
holeboard	total number of hole pokes, 20 min test	-9.8315	3.9047	-1.2994	0.130	0.0142
light / dark	fecal boli count, 20 min test	-0.34502	0.52580	-0.35405	0.831	0.515
light / dark	latency to enter dark zone, 20 min test	-111.49	35.101	-2.1015	0.121	0.00228
light / dark	number of transitions between light and dark zones, 20 min test	0.72524	7.3582	0.18767	0.966	0.922
light / dark	percentage of total time in dark zone, 20 min test	-8.1223	3.3893	-1.3337	0.230	0.0194
light / dark	percentage of total time in light zone, 20 min test	8.1223	3.3893	1.3304	0.227	0.0194
light / dark	time mobile in dark zone, 20 min test	-2.2192	11.835	-0.24303	0.943	0.852
light / dark	time mobile in light zone, 20 min test	26.550	13.050	1.1682	0.204	0.0459
light / dark	time spent in dark zone, 20 min test	5.6368	51.117	0.29067	0.971	0.913
light / dark	time spent in light zone, 20 min test	-5.6368	51.117	-0.29067	0.971	0.913
open field	average speed in center of arena, 20 min test	0.0084332	0.30201	-0.077276	0.998	0.978
open field	average speed in periphery of arena, 20 min test	0.43207	0.13889	1.0812	0.0242	0.00274
open field	distance traveled habituation ratio, 20 min test	-35.721	6.9980	-2.3400	0.000344	0.00000295
open field	distance traveled in center of arena, 20 min test	83.296	87.369	0.19250	0.603	0.344
open field	distance traveled in periphery of arena, 20 min test	342.70	141.85	0.87934	0.100	0.0184
open field	distance traveled slope, 20 min test	-33.752	6.5354	-2.3004	0.000257	0.00000234
open field	distance traveled, 20 min test, 1st 5min	362.50	75.812	1.9851	0.000430	0.00000991
open field	distance traveled, 20 min test, 2nd 5min	67.105	50.027	0.25030	0.410	0.184
open field	distance traveled, 20 min test, 3rd 5min	14.188	44.565	-0.25584	0.889	0.751
open field	distance traveled, 20 min test, 4th 5min	44.925	47.253	0.046336	0.593	0.345
open field	number of clockwise revolution episodes, 20 min test	2.3431	1.0963	0.88690	0.235	0.0362
open field	number of counter-clockwise revolution episodes, 20 min test	2.4158	1.2945	0.83666	0.283	0.0664
open field	number of fecal boli, 20 min test	-1.1773	0.87994	-0.69127	0.512	0.186
open field	number of rears in 5 min bins, 20 min test, 1st 5min	6.7557	1.6082	1.6110	0.00486	0.0000804
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	2.2418	1.9678	0.22819	0.552	0.259
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-0.20283	2.2300	-0.33581	0.962	0.928
open field	number of rears in 5 min bins, 20 min test, 4th 5min	0.83932	2.4014	-0.17884	0.870	0.728
open field	percentage of total time in center of arena, 20 min test	4.7153	2.7681	0.85586	0.375	0.0931
open field	percentage of total time in center of arena, slope, 20 min test	2.1642	0.96501	1.3245	0.390	0.0282
open field	percentage of total time in center, habituation ratio, 20 min test	2.2488	1.0332	1.3181	0.405	0.0331
open field	percentage of total time in corners of arena, 20 min test	-4.5003	3.6759	-0.52455	0.540	0.225
open field	percentage of total time in corners, habituation ratio, 20 min test	-0.045718	1.3991	-0.32164	0.996	0.974
open field	percentage of total time in corners, slope, 20 min test	0.055406	1.5012	-0.24338	0.995	0.971
open field	permanence time in center of arena, 20 min test	56.590	33.218	0.85586	0.375	0.0931
open field	permanence time in corners of arena, 20 min test	-54.006	44.110	-0.52455	0.540	0.225
open field	permanence time in periphery of arena, 20 min test	-56.615	33.211	-0.85586	0.375	0.0929
open field	total distance traveled, 20 min test	490.14	187.76	0.86754	0.0598	0.0111
open field	total number of rears, 20 min test	9.9286	6.7374	0.33723	0.369	0.145
open field	whole arena average speed, 20 min test	0.40788	0.15638	0.86559	0.0600	0.0112
open field	whole arena resting time, 20 min test	-45.799	19.734	-0.69614	0.0957	0.0233
open field	whole arena time spent mobile, 20 min test	45.875	19.716	0.93194	0.0960	0.0230
open field	whole arena time spent vertical, 20 min test	10.974	6.9505	0.75020	0.386	0.119
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-1.7948	1.6996	-0.55732	0.603	0.297
startle / PPI	average baseline movement during background noise	-2.0112	1.7181	-1.3374	0.759	0.248
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.11673	0.079477	-1.1548	0.488	0.149
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.11423	0.073854	-1.1961	0.459	0.129
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-6.9925	8.2137	-0.71597	0.879	0.399
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-16.798	7.5319	-1.6695	0.295	0.0310
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-7.7228	7.7978	-0.82536	0.626	0.328
startle / PPI	average startle response to full pulse (120 dB)	31.826	45.834	0.83128	0.727	0.491
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	31.820	48.133	0.79809	0.726	0.512
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	85.330	46.545	1.5287	0.224	0.0737
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	20.590	40.530	0.68022	0.767	0.614
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.047784	1.4795	0.11726	0.994	0.974
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.41827	1.5447	-0.28327	0.961	0.788
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-0.79781	2.0657	-0.59939	0.921	0.701
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.069648	0.088088	-0.62304	0.897	0.433
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.17568	0.086509	-1.5465	0.304	0.0485
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.045686	0.083849	-0.54608	0.796	0.589
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	33.939	45.902	0.87565	0.696	0.464
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	32.181	48.237	0.80388	0.718	0.508
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	86.214	46.935	1.5378	0.225	0.0731
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	21.234	40.566	0.70156	0.766	0.603
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.088855	0.10012	-0.75826	0.860	0.380
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.17595	0.090656	-1.4600	0.318	0.0589
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.033188	0.086406	-0.44307	0.865	0.703
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	123.35	157.32	0.85124	0.670	0.437
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	111.58	164.64	0.76013	0.708	0.502
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	165.25	149.88	1.0397	0.496	0.276
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	54.458	143.13	0.53844	0.823	0.705
startle / PPI	maximum baseline movement during background noise	-6.0943	4.4915	-1.5803	0.687	0.182
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-8.6736	9.4697	-0.82536	0.890	0.365
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-17.004	8.2570	-1.5755	0.318	0.0455
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-6.8414	8.4120	-0.74710	0.695	0.421
startle / PPI	maximum startle response to full pulse (120 dB)	117.18	157.14	0.81751	0.690	0.460
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	109.39	164.21	0.74340	0.715	0.509
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	162.83	149.07	1.0253	0.499	0.281
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	52.122	142.82	0.53036	0.836	0.717
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-1.5443	3.5371	-0.39462	0.925	0.665
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-1.7192	3.4152	-0.45132	0.914	0.617
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-2.1509	4.9243	-0.61964	0.880	0.664

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	14.0 %	0.0372
eye morphology	anterior chamber depth	both	6.0 %	0.133
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	14.0 %	0.0337
eye morphology	bulging eye	both	6.0 %	0.109
eye morphology	cornea	females	12.0 %	0.175
eye morphology	cornea	males	14.0 %	0.0693
eye morphology	cornea	both	11.0 %	0.0396
eye morphology	cornea opacity	females	22.0 %	0.0863
eye morphology	cornea opacity	males	14.0 %	0.0498
eye morphology	cornea opacity	both	17.0 %	0.0218
eye morphology	cornea vascularization	females	24.0 %	0.0138
eye morphology	cornea vascularization	males	14.0 %	0.0513
eye morphology	cornea vascularization	both	18.0 %	0.00279
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	14.0 %	0.0687
eye morphology	corneal deposits	both	6.0 %	0.197
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	14.0 %	0.0518
eye morphology	corneal mineralization	both	6.0 %	0.189
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	14.0 %	0.0834
eye morphology	corneal scleralization	both	6.0 %	0.190
eye morphology	corneal ulcer	females	12.0 %	0.0367
eye morphology	corneal ulcer	males	14.0 %	0.0438
eye morphology	corneal ulcer	both	12.0 %	0.00551
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	14.0 %	0.0336
eye morphology	eye closure	both	6.0 %	0.108
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	14.0 %	0.0462
eye morphology	eye hemorrhage or blood presence	both	6.0 %	0.152
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	14.0 %	0.0336
eye morphology	eyelid morphology	both	6.0 %	0.116
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	13.0 %	0.124
eye morphology	fusion between cornea and lens	both	5.0 %	0.347
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	14.0 %	0.0563
eye morphology	iris pigmentation	both	6.0 %	0.206
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	14.0 %	0.0488
eye morphology	iris transillumination	both	6.0 %	0.181
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	14.0 %	0.0550
eye morphology	irispupil	both	6.0 %	0.212
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	13.0 %	0.124
eye morphology	lacrimation	both	6.0 %	0.331
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	13.0 %	0.188
eye morphology	lens	both	6.0 %	0.449
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	13.0 %	0.214
eye morphology	lens opacity	both	5.0 %	0.533
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	14.0 %	0.0437
eye morphology	narrow eye opening	both	6.0 %	0.199
eye morphology	optic disc	females	12.0 %	0.0709
eye morphology	optic disc	males	13.0 %	0.152
eye morphology	optic disc	both	10.0 %	0.0433
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	13.0 %	0.198
eye morphology	persistence of hyaloid vascular system	both	5.0 %	0.603
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	14.0 %	0.0711
eye morphology	pupil dilation	both	6.0 %	0.223
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	14.0 %	0.0637
eye morphology	pupil light response	both	6.0 %	0.223
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	14.0 %	0.0560
eye morphology	pupil position	both	6.0 %	0.224
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	14.0 %	0.0771
eye morphology	pupil shape	both	6.0 %	0.236
eye morphology	retina	females	10.0 %	0.560
eye morphology	retina	males	13.0 %	0.149
eye morphology	retina	both	9.0 %	0.268
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	13.0 %	0.131
eye morphology	retinal blood vessels	both	5.0 %	0.360
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	13.0 %	0.156
eye morphology	retinal blood vessels pattern	both	5.0 %	0.423
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	13.0 %	0.140
eye morphology	retinal blood vessels structure	both	5.0 %	0.375
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	13.0 %	0.297
eye morphology	retinal pigmentation	both	6.0 %	0.567
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	13.0 %	0.145
eye morphology	retinal structure	both	5.0 %	0.380
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	13.0 %	0.126
eye morphology	synechia	both	5.0 %	0.353
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	13.0 %	0.126
eye morphology	vitreous	both	5.0 %	0.355
SHIRPA	activity body position	females	14.0 %	0.0385
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	8.0 %	0.0778
SHIRPA	aggression	females	0.0 %	1.0
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.00
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.0
SHIRPA	coat color abdomen	males	4.0 %	1.00
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.0
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.0
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.0
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.00
SHIRPA	coat hair head texture appearance	females	0.0 %	1.0
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.0
SHIRPA	contact righting	both	5.0 %	1.0
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.0
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.00
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.00
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.00
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.00
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.00
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.0
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.0
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.00
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.00
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.00
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.0
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.00
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.0
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.0
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.00
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.00
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.00
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.00
SHIRPA	limb grasp	females	20.0 %	0.123
SHIRPA	limb grasp	males	34.0 %	0.0293
SHIRPA	limb grasp	both	26.0 %	0.00875
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.00
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.0
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.00
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.00
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.00
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.0
SHIRPA	startle response	males	0.0 %	1.0
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.0
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.0
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.0
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	28.0 %	0.000118
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	17.0 %	0.000200
SHIRPA	trunk curl	females	0.0 %	1.0
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.0
SHIRPA	vocalization	males	2.0 %	1.00
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Dtx3^em1(IMPC)J/Mmjax -/- with genotype: