MPD: JaxKOMP-EAP genotype: Krt23<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Krt23^em1(IMPC)J/Mmjax -/- Gene Krt23

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-2.5424	2.5420	-0.97435	0.740	0.333
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-3.6335	2.6375	-0.78020	0.677	0.189
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-5.5496	2.4967	-1.2577	0.298	0.0420
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-5.4371	3.5768	-0.96705	0.522	0.151
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-0.90317	4.4729	-0.16193	0.941	0.843
body composition	body length	-0.042545	0.058933	-0.29327	0.744	0.475
body composition	body weight (at time of DXA)	-0.94822	0.69871	-0.60459	0.390	0.183
body composition	bone area, whole body scan, head excluded	-0.21726	0.18190	-0.70567	0.511	0.240
body composition	bone mineral content of whole body scan, head excluded	-0.021463	0.012885	-0.98501	0.328	0.104
body composition	bone mineral content to body weight ratio	-0.00087702	0.00053111	-0.91844	0.325	0.107
body composition	bone mineral density of whole body scan, head excluded	-0.0011127	0.00049384	-1.1567	0.171	0.0303
body composition	fat tissue mass of whole body scan, head excluded	0.35885	0.37757	0.57812	0.608	0.348
body composition	fat tissue mass to body weight ratio	0.011794	0.012807	0.59271	0.600	0.363
body composition	lean tissue mass of whole body scan, head excluded	-0.0049929	0.36087	-0.17011	0.998	0.989
body composition	lean tissue mass to body weight ratio	-0.0097182	0.011245	-0.58252	0.643	0.393
body composition	percent fat, whole body scan, head excluded	1.1454	1.2633	0.59923	0.615	0.370
body composition	ratio of soft-tissue attenuation coefficients	-0.0010950	0.0013352	-0.55064	0.652	0.417
body composition	tissue area	0.22493	0.27211	0.87681	0.709	0.414
body composition	total tissue mass, whole body scan, head excluded	0.37752	0.36209	0.58946	0.558	0.304
clinical blood chemistry	alanine transaminase (plasma ALT)	-2.9140	3.9303	-0.28656	0.786	0.466
clinical blood chemistry	albumin (plasma Alb)	-0.020169	0.40115	0.027094	0.989	0.960
clinical blood chemistry	alkaline phosphatase (plasma ALP)	3.1292	2.9793	0.027635	0.560	0.304
clinical blood chemistry	aspartate transaminase (plasma AST)	2.6808	7.3609	0.14512	0.908	0.719
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.18847	0.12803	0.62109	0.534	0.154
clinical blood chemistry	blood urea nitrogen (BUN)	1.0934	1.0572	0.39948	0.582	0.311
clinical blood chemistry	calcium (plasma Ca)	0.034583	0.071768	0.56881	0.795	0.634
clinical blood chemistry	creatinine (plasma)	0.025343	0.022585	0.75562	0.524	0.273
clinical blood chemistry	glucose (plasma GLU, no fast)	15.023	10.418	0.87255	0.354	0.163
clinical blood chemistry	HDL cholesterol (plasma HDL)	5.4936	2.1515	0.94246	0.145	0.0178
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.0099849	0.011358	-0.68750	0.704	0.388
clinical blood chemistry	phosphorus (plasma phosphate)	-0.00031715	0.41464	-0.039198	1.00	0.999
clinical blood chemistry	total bilirubin (plasma TBIL)	0.0025737	0.0064779	0.18414	0.884	0.695
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	9.5438	2.9794	1.2477	0.0566	0.00395
clinical blood chemistry	total protein (plasma TP)	-0.21594	0.67430	-0.23042	0.889	0.752
clinical blood chemistry	triglyceride (plasma TG, no fast)	14.607	12.058	0.96971	0.530	0.238
EKG	duration of PQ interval	0.33972	1.4216	0.50874	0.949	0.814
EKG	duration of PR interval	0.52839	1.4016	0.62227	0.938	0.710
EKG	duration of QRS interval	0.66913	0.50906	1.6543	0.885	0.204
EKG	duration of QT interval	0.64212	1.4692	0.78771	0.922	0.667
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	1.3701	1.5901	1.4356	0.885	0.400
EKG	duration of RR interval	-1.1160	1.4327	-0.34312	0.800	0.446
EKG	duration of ST interval	0.80853	1.4178	1.0454	0.891	0.575
EKG	heart rate coefficient of variation (signal intensity)	1.4392	1.6298	1.2563	0.867	0.388
EKG	heart rate variability, mean of differences between sequential beats; beats per min	9.6749	12.476	1.1721	0.887	0.448
EKG	heart rate, beats per min	12.365	13.357	0.48296	0.738	0.366
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.020689	0.12094	-0.29565	0.959	0.866
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.041134	0.14045	0.14265	0.918	0.773
EKG	number of signals	6.3882	11.766	1.1641	0.888	0.594
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	0.42089	5.8862	0.17794	0.990	0.944
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-2.0571	6.4520	-0.59319	0.970	0.753
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-3.4510	7.6885	-0.93054	0.951	0.659
EKG	root mean square of successive differences of neighboring RR intervals	0.82463	3.9535	0.56460	0.963	0.837
glucose tolerance test	amount glucose injected	-1.3748	2.6551	-0.046079	0.867	0.609
glucose tolerance test	plasma glucose, 0min	11.443	5.5191	0.91679	0.157	0.0471
glucose tolerance test	plasma glucose, 15min	-17.952	14.691	-0.38695	0.564	0.232
glucose tolerance test	plasma glucose, 30min	-15.351	13.952	-0.35899	0.617	0.280
glucose tolerance test	plasma glucose, 60min	11.747	12.668	0.59145	0.689	0.362
glucose tolerance test	plasma glucose, 120min	10.241	7.2494	0.59309	0.480	0.169
grip strength	body weight (at time of grip strength test)	-0.57945	0.44662	-0.31864	0.384	0.203
grip strength	forelimb and hindlimb grip strength (mean of trials), average	6.3864	7.5269	0.69376	0.612	0.402
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.33499	0.30309	0.69191	0.485	0.277
grip strength	forelimb and hindlimb grip strength by trial, trial1	-0.57998	8.7454	0.18993	0.979	0.948
grip strength	forelimb and hindlimb grip strength by trial, trial2	6.4842	10.280	0.66812	0.760	0.532
grip strength	forelimb and hindlimb grip strength by trial, trial3	10.685	9.9177	0.93022	0.557	0.289
grip strength	forelimb grip strength (mean of trials), average	7.3587	4.6757	1.2169	0.352	0.125
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.30230	0.19201	1.0263	0.363	0.125
grip strength	forelimb grip strength by trial, trial1	6.0746	6.0805	0.97362	0.667	0.325
grip strength	forelimb grip strength by trial, trial2	5.3072	7.4472	0.82968	0.776	0.481
grip strength	forelimb grip strength by trial, trial3	6.0889	6.4470	0.87564	0.680	0.352
heart weight	heart weight, normalized to body weight	0.097878	0.14768	-0.089982	0.701	0.513
heart weight	heart weight, weight	-4.4671	4.6218	-0.96563	0.556	0.343
hematology	basophil differential (percent of total WBC)	0.039608	0.033975	0.63788	0.690	0.255
hematology	calculated hemoglobin (cHGB)	0.23264	0.12339	0.43773	0.280	0.0711
hematology	eosinophil differential (percent of total WBC)	-0.44797	0.31371	-1.1507	0.560	0.166
hematology	hematocrit (HCT)	1.3785	0.34645	1.1590	0.0188	0.000523
hematology	hemoglobin concentration distribution width (HDW)	-0.019793	0.023326	-0.55578	0.701	0.404
hematology	large unstained cells (percent of total WBC)	0.079582	0.058748	0.52022	0.539	0.188
hematology	lymphocyte differential (percent of total WBC)	3.4598	1.5039	1.1249	0.164	0.0304
hematology	mean corpuscular hemoglobin (CHr)	-0.063921	0.051870	-0.51159	0.462	0.229
hematology	mean platelet volume (MPV)	0.33664	0.15567	1.3803	0.146	0.0403
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.018354	0.085811	-0.095078	0.932	0.832
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.34205	0.23923	-0.67707	0.516	0.166
hematology	mean RBC corpuscular volume (MCV)	0.36530	0.19372	0.65319	0.214	0.0715
hematology	measured hemoglobin (mHGB)	0.23339	0.15703	0.36412	0.438	0.150
hematology	monocyte differential (percent of total WBC)	-0.49209	0.18200	-1.0945	0.182	0.0124
hematology	neutrophil differential (percent of total WBC)	-2.7456	1.3853	-1.0797	0.229	0.0590
hematology	platelet count (PLT; units per volume x 10³)	6.6873	75.217	0.13848	0.973	0.930
hematology	RBC corpuscular distribution width (RDW)	-0.21751	0.17327	-0.82379	0.484	0.221
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.40114	0.17099	-1.1043	0.134	0.0272
hematology	red blood cell count (RBC; per volume x 10⁶)	0.21811	0.086877	0.60235	0.138	0.0189
hematology	reticulocyte count (Retic; units per volume x 10⁹)	31.203	11.965	1.3053	0.223	0.0154
hematology	reticulocyte differential (percent of total RBC)	0.21766	0.10592	1.0736	0.342	0.0505
hematology	white blood cell count (WBC; units per volume x 10³)	0.60070	0.68215	0.58855	0.589	0.387
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.12368	0.70610	-0.054886	0.958	0.862
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.58661	0.59969	-0.76697	0.788	0.332
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.66743	0.41668	-1.0473	0.654	0.115
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.35634	0.81954	-0.26207	0.904	0.665
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.18356	0.46104	0.40861	0.938	0.692
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.0081676	0.30650	0.070906	1.00	0.979
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.24303	0.24159	-0.68460	0.849	0.319
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.41525	0.45396	0.85614	0.807	0.364
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.30824	0.42227	-0.47881	0.865	0.469
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.090721	0.25255	0.30754	0.951	0.721
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.15356	0.24592	-0.39516	0.890	0.535
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.37182	0.43205	-0.54934	0.801	0.393
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.55091	0.80945	-0.44807	0.820	0.499
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.23166	0.49067	-0.27326	0.882	0.639
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.0062500	0.43296	0.10477	0.995	0.989
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.080533	0.68142	-0.037119	0.966	0.906
holeboard	total number of hole pokes, 20 min test	-2.8653	4.2798	-0.30492	0.737	0.506
light / dark	fecal boli count, 20 min test	1.4102	0.59134	1.4551	0.319	0.0213
light / dark	latency to enter dark zone, 20 min test	-37.445	33.106	-0.81269	0.676	0.263
light / dark	number of transitions between light and dark zones, 20 min test	-6.0942	8.3057	-0.49698	0.734	0.466
light / dark	percentage of total time in dark zone, 20 min test	2.1134	3.4526	0.51542	0.811	0.543
light / dark	percentage of total time in light zone, 20 min test	-2.1134	3.4526	-0.51851	0.809	0.543
light / dark	time mobile in dark zone, 20 min test	15.354	12.166	0.77745	0.509	0.212
light / dark	time mobile in light zone, 20 min test	-0.81671	13.129	-0.29490	0.975	0.951
light / dark	time spent in dark zone, 20 min test	56.890	42.385	1.0648	0.616	0.185
light / dark	time spent in light zone, 20 min test	-56.890	42.385	-1.0648	0.616	0.185
open field	average speed in center of arena, 20 min test	0.60665	0.36973	0.94027	0.414	0.106
open field	average speed in periphery of arena, 20 min test	0.26144	0.14998	0.48339	0.235	0.0866
open field	distance traveled habituation ratio, 20 min test	-10.530	7.7426	-0.89326	0.497	0.179
open field	distance traveled in center of arena, 20 min test	57.339	93.434	0.00067130	0.746	0.542
open field	distance traveled in periphery of arena, 20 min test	249.13	155.55	0.52148	0.312	0.115
open field	distance traveled slope, 20 min test	-9.2048	7.2642	-0.80655	0.533	0.210
open field	distance traveled, 20 min test, 1st 5min	136.72	82.788	0.71682	0.297	0.104
open field	distance traveled, 20 min test, 2nd 5min	45.244	52.354	0.011412	0.633	0.391
open field	distance traveled, 20 min test, 3rd 5min	67.150	52.613	0.30472	0.438	0.207
open field	distance traveled, 20 min test, 4th 5min	55.937	44.710	0.15298	0.448	0.216
open field	number of clockwise revolution episodes, 20 min test	1.4064	1.1148	0.41897	0.569	0.212
open field	number of counter-clockwise revolution episodes, 20 min test	0.037060	1.4333	-0.41800	0.991	0.979
open field	number of fecal boli, 20 min test	2.9733	1.0403	2.3344	0.118	0.00722
open field	number of rears in 5 min bins, 20 min test, 1st 5min	2.0044	1.8680	0.35096	0.553	0.288
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-0.37500	2.5121	-0.45939	0.952	0.882
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	1.2293	2.4910	-0.027527	0.804	0.624
open field	number of rears in 5 min bins, 20 min test, 4th 5min	1.8021	2.8887	0.063817	0.755	0.535
open field	percentage of total time in center of arena, 20 min test	0.53972	2.8561	-0.065162	0.952	0.851
open field	percentage of total time in center of arena, slope, 20 min test	-0.16508	0.95691	0.038273	0.963	0.864
open field	percentage of total time in center, habituation ratio, 20 min test	-0.35686	0.92703	-0.073237	0.916	0.702
open field	percentage of total time in corners of arena, 20 min test	-3.9328	3.5201	-0.40193	0.577	0.268
open field	percentage of total time in corners, habituation ratio, 20 min test	0.80347	1.4645	0.088054	0.908	0.585
open field	percentage of total time in corners, slope, 20 min test	0.59976	1.4953	-0.00067130	0.931	0.690
open field	permanence time in center of arena, 20 min test	6.4894	34.269	-0.062471	0.952	0.850
open field	permanence time in corners of arena, 20 min test	-47.191	42.244	-0.40193	0.577	0.269
open field	permanence time in periphery of arena, 20 min test	-6.4941	34.269	0.062471	0.952	0.850
open field	total distance traveled, 20 min test	305.00	206.89	0.39031	0.328	0.146
open field	total number of rears, 20 min test	4.6608	8.4509	-0.014098	0.776	0.583
open field	whole arena average speed, 20 min test	0.25383	0.17251	0.38597	0.330	0.147
open field	whole arena resting time, 20 min test	-41.966	21.877	-0.60649	0.187	0.0600
open field	whole arena time spent mobile, 20 min test	41.990	21.863	0.85780	0.185	0.0597
open field	whole arena time spent vertical, 20 min test	-5.3689	7.4575	-0.56347	0.748	0.474
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	4.3002	1.5748	1.9076	0.119	0.0110
startle / PPI	average baseline movement during background noise	0.43185	1.3286	0.37651	0.952	0.747
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.073008	0.066039	0.56618	0.640	0.276
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.049814	0.061764	0.42868	0.749	0.425
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-7.6242	6.2273	-0.78849	0.859	0.229
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	7.6553	6.7997	0.72142	0.639	0.268
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	4.4476	7.4680	0.37500	0.813	0.555
startle / PPI	average startle response to full pulse (120 dB)	-70.777	42.938	-1.0421	0.297	0.108
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-53.698	40.599	-0.79424	0.422	0.194
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-70.114	40.549	-1.0992	0.259	0.0924
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-55.297	33.004	-1.0230	0.287	0.103
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	3.6696	1.3897	1.7743	0.413	0.0122
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	3.8085	2.4287	1.7288	0.625	0.126
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	1.1036	2.3378	0.34362	0.902	0.640
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.052003	0.071167	-0.46376	0.900	0.470
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.10834	0.079360	0.83644	0.525	0.181
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.088067	0.090128	0.51381	0.600	0.335
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-70.314	43.187	-1.0089	0.298	0.112
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-57.027	40.763	-0.83525	0.385	0.170
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-70.366	40.858	-1.1070	0.262	0.0936
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-55.825	33.593	-1.0136	0.277	0.105
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.026732	0.078134	-0.21103	0.954	0.734
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.14859	0.081682	1.0662	0.362	0.0772
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.081062	0.093720	0.42765	0.647	0.393
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-223.08	153.60	-0.89431	0.372	0.155
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-208.65	147.80	-0.86950	0.386	0.167
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-265.34	146.21	-1.1439	0.231	0.0779
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-195.46	118.68	-0.96779	0.280	0.108
startle / PPI	maximum baseline movement during background noise	-0.15687	2.6564	0.090496	0.986	0.953
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-4.1706	7.0103	-0.38253	0.936	0.556
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	12.093	7.3617	1.0542	0.442	0.109
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	5.4699	8.0898	0.37500	0.768	0.503
startle / PPI	maximum startle response to full pulse (120 dB)	-222.75	152.92	-0.89014	0.365	0.154
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-199.89	147.25	-0.84122	0.406	0.183
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-264.88	145.37	-1.1466	0.229	0.0768
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-194.07	116.96	-0.97228	0.282	0.106
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	8.3950	3.9027	1.7879	0.491	0.0383
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	8.0316	7.1268	1.6528	0.751	0.267
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	2.0100	6.1243	0.20673	0.908	0.745

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.00
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	15.0 %	0.200
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	6.0 %	0.308
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	12.0 %	0.0163
eye morphology	cornea opacity	both	7.0 %	0.128
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.00
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	16.0 %	0.0783
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	7.0 %	0.110
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.00
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.00
eye morphology	eyes (present, absent)	females	1.0 %	1.00
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.00
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.0
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	12.0 %	0.0846
eye morphology	lacrimation	both	7.0 %	0.157
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.00
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	7.0 %	1.00
eye morphology	narrow eye opening	females	2.0 %	1.00
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.00
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.00
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	1.00
eye morphology	retina	males	7.0 %	0.610
eye morphology	retina	both	6.0 %	0.752
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.00
eye morphology	retinal blood vessels pattern	females	5.0 %	1.00
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	12.0 %	1.00
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.00
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.0
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.0
SHIRPA	body length	both	0.0 %	1.0
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.0
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.00
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.00
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	28.0 %	0.000118
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	15.0 %	0.000408
SHIRPA	coat hair distribution head	females	14.0 %	0.0553
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	7.0 %	0.0853
SHIRPA	coat hair head texture appearance	females	0.0 %	1.0
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.0
SHIRPA	contact righting	both	5.0 %	1.0
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.0
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.00
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.0
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.0
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.0
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.0
SHIRPA	head morphology	both	0.0 %	1.00
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.0
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.0
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.0
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	34.0 %	0.0188
SHIRPA	limb grasp	males	44.0 %	0.00333
SHIRPA	limb grasp	both	39.0 %	0.000169
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.0
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.0
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.00
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.0
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.00
SHIRPA	tail elevation	females	1.0 %	1.0
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.0
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.0
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.0
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.00
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.0
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.00
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.0
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Krt23^em1(IMPC)J/Mmjax -/- with genotype: