MPD: JaxKOMP-EAP genotype: Hspb9<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Hspb9^em1(IMPC)J/Mmjax -/- Gene Hspb9

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	0.44176	2.1397	-0.15039	0.959	0.839
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-0.87668	4.1178	-0.18887	0.956	0.834
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	9.1188	7.7916	1.3402	0.621	0.263
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	6.6895	5.2356	0.94482	0.611	0.222
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-0.83333	3.9399	-0.15199	0.937	0.836
body composition	body length	-0.019494	0.044978	-0.043279	0.846	0.667
body composition	body weight (at time of DXA)	-0.36326	0.69765	-0.19986	0.780	0.606
body composition	bone area, whole body scan, head excluded	-0.34643	0.15732	-1.0853	0.171	0.0336
body composition	bone mineral content of whole body scan, head excluded	-0.020801	0.011272	-0.96307	0.270	0.0728
body composition	bone mineral content to body weight ratio	-0.00080393	0.00042528	-0.81697	0.245	0.0664
body composition	bone mineral density of whole body scan, head excluded	-0.00015336	0.00059062	-0.13358	0.907	0.797
body composition	fat tissue mass of whole body scan, head excluded	0.61922	0.30294	0.90602	0.203	0.0479
body composition	fat tissue mass to body weight ratio	0.023092	0.0098256	1.0074	0.120	0.0241
body composition	lean tissue mass of whole body scan, head excluded	-0.58049	0.26567	-1.2381	0.207	0.0351
body composition	lean tissue mass to body weight ratio	-0.025427	0.0080304	-1.3346	0.0435	0.00304
body composition	percent fat, whole body scan, head excluded	2.3803	0.93031	1.1027	0.0931	0.0146
body composition	ratio of soft-tissue attenuation coefficients	-0.0026998	0.0010209	-1.1242	0.0823	0.0118
body composition	tissue area	0.29695	0.17050	1.0871	0.331	0.0897
body composition	total tissue mass, whole body scan, head excluded	-0.082993	0.21176	-0.42026	0.841	0.697
clinical blood chemistry	alanine transaminase (plasma ALT)	-2.5310	3.9108	-0.26448	0.820	0.525
clinical blood chemistry	albumin (plasma Alb)	0.46026	0.70805	0.68798	0.797	0.523
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-7.1094	3.6146	-1.6813	0.223	0.0632
clinical blood chemistry	aspartate transaminase (plasma AST)	-6.6998	5.3913	-0.34260	0.546	0.229
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.020282	0.19771	-0.031231	0.980	0.919
clinical blood chemistry	blood urea nitrogen (BUN)	-0.98438	1.5164	-0.44018	0.745	0.524
clinical blood chemistry	calcium (plasma Ca)	-0.25257	0.12205	-1.4445	0.192	0.0517
clinical blood chemistry	creatinine (plasma)	-0.069177	0.037341	-1.3230	0.262	0.0788
clinical blood chemistry	glucose (plasma GLU, no fast)	-4.1719	13.159	0.13106	0.864	0.755
clinical blood chemistry	HDL cholesterol (plasma HDL)	-2.3828	2.7544	-0.83317	0.686	0.398
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.015879	0.014185	0.74453	0.614	0.276
clinical blood chemistry	phosphorus (plasma phosphate)	-0.75165	0.99084	-1.2160	0.719	0.457
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.0035525	0.015965	-0.27451	0.940	0.826
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-5.3425	2.8693	-1.0850	0.301	0.0781
clinical blood chemistry	total protein (plasma TP)	0.20834	1.1441	0.10296	0.937	0.857
clinical blood chemistry	triglyceride (plasma TG, no fast)	4.5491	8.0856	0.47192	0.795	0.580
EKG	duration of PQ interval	0.11243	0.75437	0.24005	0.975	0.882
EKG	duration of PR interval	-0.11893	0.76773	-0.024182	0.976	0.877
EKG	duration of QRS interval	-0.35108	0.30738	-1.0701	0.885	0.259
EKG	duration of QT interval	-0.022502	0.60971	0.12932	0.998	0.971
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.12960	0.65164	-0.098895	0.986	0.843
EKG	duration of RR interval	0.26697	0.79182	0.36888	0.914	0.737
EKG	duration of ST interval	0.34103	0.57649	0.57170	0.883	0.557
EKG	heart rate coefficient of variation (signal intensity)	-1.0379	1.0326	-0.79598	0.863	0.320
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-7.8536	7.5660	-0.86131	0.853	0.304
EKG	heart rate, beats per min	-3.4211	6.6907	-0.46042	0.848	0.611
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.091527	0.070031	0.60943	0.575	0.197
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.12492	0.10747	0.61430	0.617	0.250
EKG	number of signals	11.174	6.4462	1.6868	0.605	0.0889
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-3.7090	4.2127	-0.59971	0.848	0.383
EKG	QT dispersion, measured as inter-lead variability of QT intervals	2.1874	3.4288	0.68464	0.955	0.526
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	2.4193	4.0190	0.62472	0.935	0.550
EKG	root mean square of successive differences of neighboring RR intervals	-1.2308	1.8559	-0.56460	0.899	0.510
glucose tolerance test	amount glucose injected	-4.0027	3.3763	-0.78909	0.639	0.252
glucose tolerance test	plasma glucose, 0min	10.740	4.4604	0.85777	0.108	0.0270
glucose tolerance test	plasma glucose, 15min	61.515	18.273	1.6626	0.0621	0.00366
glucose tolerance test	plasma glucose, 30min	46.844	19.524	1.4710	0.186	0.0282
glucose tolerance test	plasma glucose, 60min	13.961	14.401	0.67019	0.675	0.346
glucose tolerance test	plasma glucose, 120min	11.714	13.906	0.68400	0.684	0.411
grip strength	body weight (at time of grip strength test)	-0.26612	0.44933	-0.037724	0.727	0.557
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-4.9863	5.1391	-0.12669	0.553	0.338
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.41135	0.24111	-0.40589	0.253	0.0962
grip strength	forelimb and hindlimb grip strength by trial, trial1	-7.0049	7.1877	-0.23599	0.629	0.336
grip strength	forelimb and hindlimb grip strength by trial, trial2	-5.8042	6.9824	-0.13254	0.651	0.411
grip strength	forelimb and hindlimb grip strength by trial, trial3	-2.4526	6.2818	0.043582	0.866	0.698
grip strength	forelimb grip strength (mean of trials), average	-0.40313	3.4484	0.21513	0.968	0.908
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.079695	0.17275	0.030503	0.836	0.647
grip strength	forelimb grip strength by trial, trial1	1.0917	4.3352	0.38548	0.926	0.803
grip strength	forelimb grip strength by trial, trial2	1.5841	4.2773	0.38391	0.896	0.713
grip strength	forelimb grip strength by trial, trial3	-2.6766	4.5331	-0.033409	0.797	0.558
heart weight	heart weight, normalized to body weight	-0.031230	0.11881	-0.57549	0.890	0.795
heart weight	heart weight, weight	0.097866	3.5471	-0.36394	0.986	0.978
hematology	basophil differential (percent of total WBC)	0.059375	0.032846	0.87979	0.487	0.0857
hematology	calculated hemoglobin (cHGB)	0.80619	0.27572	1.9043	0.0932	0.00839
hematology	eosinophil differential (percent of total WBC)	0.21728	0.30297	0.68526	0.815	0.482
hematology	hematocrit (HCT)	0.76514	0.43503	0.49823	0.351	0.0947
hematology	hemoglobin concentration distribution width (HDW)	0.046718	0.025330	1.2400	0.338	0.0808
hematology	large unstained cells (percent of total WBC)	-0.020312	0.078138	-0.11228	0.908	0.798
hematology	lymphocyte differential (percent of total WBC)	3.3188	0.91601	1.0970	0.0331	0.00170
hematology	mean corpuscular hemoglobin (CHr)	-0.066667	0.062361	-0.53538	0.536	0.298
hematology	mean platelet volume (MPV)	-0.26531	0.19151	-1.4474	0.385	0.181
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.20312	0.25177	-0.72738	0.759	0.429
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.071166	0.54672	-0.15956	0.961	0.898
hematology	mean RBC corpuscular volume (MCV)	-1.2864	0.58617	-1.7161	0.151	0.0408
hematology	measured hemoglobin (mHGB)	0.46399	0.33824	0.96415	0.491	0.185
hematology	monocyte differential (percent of total WBC)	-0.31566	0.16128	-0.80480	0.363	0.0652
hematology	neutrophil differential (percent of total WBC)	-3.3141	0.80511	-1.2766	0.0184	0.000536
hematology	platelet count (PLT; units per volume x 10³)	-45.800	88.538	-0.57077	0.843	0.611
hematology	RBC corpuscular distribution width (RDW)	-0.33986	0.13273	-1.2567	0.134	0.0187
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.60251	0.26334	1.3740	0.154	0.0332
hematology	red blood cell count (RBC; per volume x 10⁶)	0.63673	0.22568	2.0387	0.0970	0.0105
hematology	reticulocyte count (Retic; units per volume x 10⁹)	41.083	10.977	1.6050	0.0532	0.00128
hematology	reticulocyte differential (percent of total RBC)	0.29782	0.12340	1.3005	0.267	0.0255
hematology	white blood cell count (WBC; units per volume x 10³)	0.78424	1.0413	0.70834	0.649	0.460
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.29995	0.65147	-0.24116	0.896	0.647
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.26306	0.39847	-0.28837	0.877	0.512
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.12250	0.45022	-0.095515	0.949	0.787
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.43647	0.65505	-0.35774	0.855	0.508
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.23000	0.43310	-0.25683	0.903	0.597
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.47758	0.19498	-1.3438	0.414	0.0173
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.0075000	0.25008	-0.046498	1.00	0.976
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.45462	0.39634	-0.66235	0.759	0.256
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.35451	0.32836	0.74401	0.758	0.285
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.38257	0.26319	-1.0697	0.728	0.151
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.19500	0.26192	-0.51512	0.870	0.460
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.61536	0.47519	-0.95582	0.643	0.200
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-1.2744	0.65867	-1.1694	0.413	0.0578
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.28391	0.44522	-0.35479	0.848	0.526
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.45820	0.46707	-0.63995	0.771	0.331
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.15335	0.88209	-0.10647	0.959	0.863
holeboard	total number of hole pokes, 20 min test	-5.0880	3.4316	-0.62757	0.415	0.143
light / dark	fecal boli count, 20 min test	0.23404	0.46586	0.27519	0.869	0.618
light / dark	latency to enter dark zone, 20 min test	-5.6016	27.272	-0.21804	0.965	0.838
light / dark	number of transitions between light and dark zones, 20 min test	4.8819	7.6904	0.54186	0.780	0.529
light / dark	percentage of total time in dark zone, 20 min test	1.0526	2.7191	0.32897	0.895	0.700
light / dark	percentage of total time in light zone, 20 min test	-1.0526	2.7191	-0.33468	0.897	0.700
light / dark	time mobile in dark zone, 20 min test	2.4469	12.134	0.064942	0.939	0.841
light / dark	time mobile in light zone, 20 min test	-5.4967	10.818	-0.65510	0.813	0.614
light / dark	time spent in dark zone, 20 min test	12.955	42.966	0.41741	0.929	0.764
light / dark	time spent in light zone, 20 min test	-12.955	42.966	-0.41741	0.929	0.764
open field	average speed in center of arena, 20 min test	-0.19106	0.30777	-0.41946	0.804	0.537
open field	average speed in periphery of arena, 20 min test	0.25164	0.13504	0.45343	0.198	0.0674
open field	distance traveled habituation ratio, 20 min test	-13.349	6.6296	-1.0909	0.269	0.0486
open field	distance traveled in center of arena, 20 min test	226.76	84.833	1.0161	0.0716	0.00971
open field	distance traveled in periphery of arena, 20 min test	84.778	140.07	-0.084011	0.750	0.547
open field	distance traveled slope, 20 min test	-11.850	6.2478	-1.0320	0.307	0.0628
open field	distance traveled, 20 min test, 1st 5min	158.94	68.654	0.88330	0.120	0.0241
open field	distance traveled, 20 min test, 2nd 5min	48.138	46.536	0.040961	0.549	0.305
open field	distance traveled, 20 min test, 3rd 5min	55.726	43.214	0.17339	0.432	0.202
open field	distance traveled, 20 min test, 4th 5min	38.800	44.558	-0.016783	0.627	0.387
open field	number of clockwise revolution episodes, 20 min test	1.7325	1.0765	0.59319	0.431	0.113
open field	number of counter-clockwise revolution episodes, 20 min test	1.4987	1.2015	0.37299	0.503	0.217
open field	number of fecal boli, 20 min test	0.19750	0.71326	0.40988	0.907	0.783
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-0.64500	1.9669	-0.39561	0.881	0.744
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-3.3200	2.6232	-1.1805	0.502	0.211
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-2.9064	2.5295	-0.97423	0.534	0.255
open field	number of rears in 5 min bins, 20 min test, 4th 5min	0.27750	2.7953	-0.30613	0.963	0.921
open field	percentage of total time in center of arena, 20 min test	5.6933	3.4174	1.0343	0.386	0.101
open field	percentage of total time in center of arena, slope, 20 min test	0.92637	1.6091	0.63252	0.872	0.567
open field	percentage of total time in center, habituation ratio, 20 min test	0.77363	1.6584	0.54469	0.897	0.643
open field	percentage of total time in corners of arena, 20 min test	-8.5271	3.3337	-1.2596	0.132	0.0131
open field	percentage of total time in corners, habituation ratio, 20 min test	1.1424	1.8629	0.22957	0.889	0.542
open field	percentage of total time in corners, slope, 20 min test	0.57733	1.8382	-0.012755	0.945	0.755
open field	permanence time in center of arena, 20 min test	68.332	41.007	1.0343	0.387	0.101
open field	permanence time in corners of arena, 20 min test	-102.33	40.003	-1.2596	0.132	0.0131
open field	permanence time in periphery of arena, 20 min test	-68.367	41.014	-1.0343	0.387	0.101
open field	total distance traveled, 20 min test	298.95	168.82	0.37155	0.227	0.0817
open field	total number of rears, 20 min test	-6.6950	8.7334	-0.81401	0.685	0.446
open field	whole arena average speed, 20 min test	0.24918	0.14077	0.37011	0.228	0.0819
open field	whole arena resting time, 20 min test	-47.036	17.080	-0.73957	0.0449	0.00782
open field	whole arena time spent mobile, 20 min test	47.092	17.067	0.98290	0.0467	0.00770
open field	whole arena time spent vertical, 20 min test	-6.3915	8.6283	-0.64239	0.744	0.462
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	0.84000	0.80455	0.54019	0.610	0.303
startle / PPI	average baseline movement during background noise	-0.94468	1.0079	-0.66791	0.824	0.353
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.0087313	0.057708	-0.024522	0.951	0.880
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.0091031	0.055364	0.0049095	0.943	0.870
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	2.9080	7.5566	0.36450	0.957	0.702
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.097444	6.2177	-0.044150	0.993	0.988
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.33778	5.2903	-0.068007	0.979	0.949
startle / PPI	average startle response to full pulse (120 dB)	-53.011	28.973	-0.74710	0.231	0.0735
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-64.585	30.544	-0.96333	0.154	0.0396
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-41.071	25.580	-0.62986	0.300	0.115
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-28.992	22.287	-0.50951	0.411	0.200
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-2.0659	1.2717	-1.3797	0.634	0.111
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.22578	1.2298	0.17391	0.974	0.855
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-1.8398	1.6987	-1.1200	0.699	0.284
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.014882	0.084615	0.18388	0.973	0.861
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.010438	0.065897	0.013326	0.969	0.875
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.012305	0.061743	-0.078588	0.937	0.843
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-52.282	29.137	-0.71597	0.238	0.0791
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-62.402	30.880	-0.92182	0.171	0.0488
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-41.365	25.882	-0.63157	0.302	0.117
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-27.159	22.685	-0.44512	0.451	0.237
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.00095099	0.091555	0.041345	0.998	0.992
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.017050	0.067772	0.032250	0.917	0.802
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.023958	0.063140	0.0084116	0.866	0.706
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-177.98	111.66	-0.68198	0.309	0.118
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-196.83	112.98	-0.81947	0.260	0.0878
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-141.34	96.827	-0.58271	0.352	0.151
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-103.29	85.872	-0.44667	0.447	0.235
startle / PPI	maximum baseline movement during background noise	-1.3336	2.2444	-0.34510	0.874	0.555
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.89228	8.3957	0.14270	0.999	0.916
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.37292	6.6036	-0.059583	0.983	0.955
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	2.0809	5.7628	0.052567	0.881	0.720
startle / PPI	maximum startle response to full pulse (120 dB)	-178.81	111.18	-0.67845	0.304	0.114
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-200.82	112.08	-0.84722	0.245	0.0794
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-138.31	95.994	-0.56783	0.353	0.156
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-108.98	84.994	-0.49996	0.416	0.206
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-3.7565	3.1197	-1.0066	0.727	0.234
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	2.7875	3.3841	0.75081	0.816	0.414
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-5.4386	3.9896	-1.3071	0.547	0.179

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	11.0 %	0.257
eye morphology	cornea	males	12.0 %	0.119
eye morphology	cornea	both	10.0 %	0.0721
eye morphology	cornea opacity	females	12.0 %	0.195
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	6.0 %	0.249
eye morphology	cornea vascularization	females	12.0 %	0.0829
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	6.0 %	0.102
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	12.0 %	0.146
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	6.0 %	0.141
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	11.0 %	0.223
eye morphology	irispupil	both	5.0 %	0.435
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	22.0 %	0.155
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	10.0 %	0.320
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.0
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	11.0 %	0.230
eye morphology	pupil position	both	5.0 %	0.461
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	7.0 %	0.610
eye morphology	retina	both	7.0 %	0.801
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	47.0 %	0.000103
SHIRPA	coat color abdomen	males	9.0 %	0.256
SHIRPA	coat color abdomen	both	28.0 %	0.000189
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	12.0 %	0.0433
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	6.0 %	0.0603
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	12.0 %	0.00294
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	6.0 %	0.00589
SHIRPA	hindpaw shape	females	12.0 %	0.00587
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	6.0 %	0.00589
SHIRPA	hindpaw size	females	12.0 %	0.00587
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	6.0 %	0.00589
SHIRPA	limb grasp	females	29.0 %	0.0280
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	11.0 %	0.106
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	98.0 %	3.49e-14
SHIRPA	vocalization	males	36.0 %	0.000415
SHIRPA	vocalization	both	67.0 %	9.59e-16

GENOTYPE CORRELATION PLOT

Correlate Hspb9^em1(IMPC)J/Mmjax -/- with genotype: